The effect of combination of steel fiber and MgO-type expansive agent （MEA） on strength, air-permeability and porosity of concrete was investigated. The porosity and air-permeability of concrete were determined by m...The effect of combination of steel fiber and MgO-type expansive agent （MEA） on strength, air-permeability and porosity of concrete was investigated. The porosity and air-permeability of concrete were determined by method of evaporated water and Torrent permeability tester, respectively. Pore structures of mortars in concrete were analyzed using mercury intrusion porosimetry （MIP）. Interfacial structures between steel fibers and matrix were examined by use of optical microscope. The experimental results show that improvement of pore structures of mortar and fiber-matrix interfacial structure in concrete by combination of steel fiber and MEA may remarkably increase properties of concrete. In comparison with plain concrete, compressive strength and splitting tensile strength of steel fiber reinforced expansive concrete increased by 15.3% and 38.1%, permeability coefficient Kt, penetration depth L and porosity of concrete decreased by 41.1%, 21.3% and 13.1% at 28 days, respectively.展开更多
代谢功能障碍相关脂肪性肝病(MASLD)与2型糖尿病(T2DM)高度共存,两者在胰岛素抵抗、脂质稳态紊乱及慢性炎症等病理过程中相互促进。MASLD已被视为T2DM的重要共病基础,其显著增加了心血管事件、肝纤维化进展及全因死亡风险。2025年美国...代谢功能障碍相关脂肪性肝病(MASLD)与2型糖尿病(T2DM)高度共存,两者在胰岛素抵抗、脂质稳态紊乱及慢性炎症等病理过程中相互促进。MASLD已被视为T2DM的重要共病基础,其显著增加了心血管事件、肝纤维化进展及全因死亡风险。2025年美国糖尿病学会(ADA)发布的MASLD共识报告Metabolic Dysfunction-Associated Steatotic Liver Disease in People with Diabetes:the Need for Screening and Early Intervention首次将MASLD纳入T2DM的系统管理框架,提出规范化的筛查、风险分层与干预建议,并强调降糖药物在改善肝脏脂肪沉积、炎症及纤维化方面的潜在治疗价值。本文综述了T2DM与MASLD的代谢交互作用机制,系统总结了主要降糖药物(包括肠促胰素类、钠-葡萄糖协同转运蛋白2抑制剂、过氧化物酶体增殖激活受体激动剂等)改善MASLD的临床与转化医学证据;并基于肝纤维化程度及代谢共病,结合ADA共识提出从生活方式干预到药物选择的个体化管理策略,同时强调跨学科协作在T2DM-MASLD综合管理中的关键作用。展开更多
To achieve good metabolic control in diabetes and keep long term, a combination of changes in lifestyle and pharmacological treatment is necessary. Achieving near-normal glycated hemoglobin significantly, decreases ri...To achieve good metabolic control in diabetes and keep long term, a combination of changes in lifestyle and pharmacological treatment is necessary. Achieving near-normal glycated hemoglobin significantly, decreases risk of macrovascular and microvascular complications. At present there are different treatments, both oral and injectable, available for the treatment of type 2 diabetes mellitus(T2DM). Treatment algorithms designed to reduce the development or progression of the complications of diabetes emphasizes the need for good glycaemic control. The aim of this review is to perform an update on the benefits and limitations of different drugs, both current and future, for the treatment of T2 DM. Initial intervention should focus on lifestyle changes. Moreover, changes in lifestyle have proven to be beneficial, but for many patients is a complication keep long term. Physicians should be familiar with the different types of existing drugs for the treatment of diabetes and select the most effective, safe and better tolerated by patients. Metformin remains the first choice of treatment for most patients. Other alternative or second-line treatment options should be individualized depending on the characteristics of each patient. This article reviews the treatments available for patients with T2 DM, with an emphasis on agents introduced within the last decade.展开更多
基金Funded by the National Basic Research Program of China (2009CB623105)the "11th Five-Year Plan" Scientific and Technological Support Project of China (2006BAF02A25)
文摘The effect of combination of steel fiber and MgO-type expansive agent （MEA） on strength, air-permeability and porosity of concrete was investigated. The porosity and air-permeability of concrete were determined by method of evaporated water and Torrent permeability tester, respectively. Pore structures of mortars in concrete were analyzed using mercury intrusion porosimetry （MIP）. Interfacial structures between steel fibers and matrix were examined by use of optical microscope. The experimental results show that improvement of pore structures of mortar and fiber-matrix interfacial structure in concrete by combination of steel fiber and MEA may remarkably increase properties of concrete. In comparison with plain concrete, compressive strength and splitting tensile strength of steel fiber reinforced expansive concrete increased by 15.3% and 38.1%, permeability coefficient Kt, penetration depth L and porosity of concrete decreased by 41.1%, 21.3% and 13.1% at 28 days, respectively.
文摘代谢功能障碍相关脂肪性肝病(MASLD)与2型糖尿病(T2DM)高度共存,两者在胰岛素抵抗、脂质稳态紊乱及慢性炎症等病理过程中相互促进。MASLD已被视为T2DM的重要共病基础,其显著增加了心血管事件、肝纤维化进展及全因死亡风险。2025年美国糖尿病学会(ADA)发布的MASLD共识报告Metabolic Dysfunction-Associated Steatotic Liver Disease in People with Diabetes:the Need for Screening and Early Intervention首次将MASLD纳入T2DM的系统管理框架,提出规范化的筛查、风险分层与干预建议,并强调降糖药物在改善肝脏脂肪沉积、炎症及纤维化方面的潜在治疗价值。本文综述了T2DM与MASLD的代谢交互作用机制,系统总结了主要降糖药物(包括肠促胰素类、钠-葡萄糖协同转运蛋白2抑制剂、过氧化物酶体增殖激活受体激动剂等)改善MASLD的临床与转化医学证据;并基于肝纤维化程度及代谢共病,结合ADA共识提出从生活方式干预到药物选择的个体化管理策略,同时强调跨学科协作在T2DM-MASLD综合管理中的关键作用。
文摘To achieve good metabolic control in diabetes and keep long term, a combination of changes in lifestyle and pharmacological treatment is necessary. Achieving near-normal glycated hemoglobin significantly, decreases risk of macrovascular and microvascular complications. At present there are different treatments, both oral and injectable, available for the treatment of type 2 diabetes mellitus(T2DM). Treatment algorithms designed to reduce the development or progression of the complications of diabetes emphasizes the need for good glycaemic control. The aim of this review is to perform an update on the benefits and limitations of different drugs, both current and future, for the treatment of T2 DM. Initial intervention should focus on lifestyle changes. Moreover, changes in lifestyle have proven to be beneficial, but for many patients is a complication keep long term. Physicians should be familiar with the different types of existing drugs for the treatment of diabetes and select the most effective, safe and better tolerated by patients. Metformin remains the first choice of treatment for most patients. Other alternative or second-line treatment options should be individualized depending on the characteristics of each patient. This article reviews the treatments available for patients with T2 DM, with an emphasis on agents introduced within the last decade.
