目的探讨VERGE蛋白在小鼠大脑中动脉梗死模型(MCAO)中蛋白表达的变化及其机制。方法C57BL/6小鼠30只,随机分为2组:30 min MCAO模型组、90 min MCAO模型组,制备MCAO模型,应用激光多普勒血流仪进行术中脑血流监测,应用Western印迹法观察...目的探讨VERGE蛋白在小鼠大脑中动脉梗死模型(MCAO)中蛋白表达的变化及其机制。方法C57BL/6小鼠30只,随机分为2组:30 min MCAO模型组、90 min MCAO模型组,制备MCAO模型,应用激光多普勒血流仪进行术中脑血流监测,应用Western印迹法观察各组梗死侧及非梗死侧的VERGE、p-JNK2、p-ERK1/2、P-38蛋白表达的变化。结果30 min、90 min MCAO模型组梗死侧VERGE、p-JNK2的蛋白表达明显增高,p-ERK1/2、P-38蛋白表达无变化;两组MCAO模型非梗死侧的VERGE、p-JNK2、p-ERK1/2、P-38蛋白表达均无变化。结论VERGE蛋白表达在小鼠MCAO的早期明显升高可能与JNK2通路有关而与ERK、P38通路无关。展开更多
Several research studies have proven that eliciting and predicting the impact of human activity on ecosystem services will be crucial to support stakeholders’ awareness and to decide how to interact with the environm...Several research studies have proven that eliciting and predicting the impact of human activity on ecosystem services will be crucial to support stakeholders’ awareness and to decide how to interact with the environment in a more sustainable manner. In this sense, the ecosystems known as road verges are particularly important because of their length and surface at an international scale, and their role in mitigating the damage done by roads. Plant pollination by insects is one of the most important ecosystem services. Because of its nature and the fact that they extend across a variety of landscapes, roadside can contribute to the maintenance of healthy ecosystems, under the condition of adapted management practices. This research is the first attempt to develop a System Dynamics-based aiming to estimate the ecological and economic impact of maintenance on the road verge pollination service in France. Maintenance strategies of road verges are simulated to compare their performance. The results show that there are ways to improve current maintenance strategies in terms of pollination value, but also that the model needs to consider other ecosystem services and synergistic effects that could further affect pollination to obtain more accurate estimations.展开更多
Whenever we laboriously packed our bags in July--always, oddly enough, on a marvelously warm summerevening--sooner or later I would say to my wife, 'Herewe are on the verge of a collapse while the birdsare singing...Whenever we laboriously packed our bags in July--always, oddly enough, on a marvelously warm summerevening--sooner or later I would say to my wife, 'Herewe are on the verge of a collapse while the birdsare singing outside, and the best thing would be to goand sit on terrace with a glass of beer. Can you tellme why we go away at all?' Then we solemnly swore that next year we展开更多
Three passions,simple but overwhelmingly strong,have governed my life:thelonging for love,the search for knowledge,and unbearable pity for the sufferingof mankind.These passions,like great winds,have blown me hither a...Three passions,simple but overwhelmingly strong,have governed my life:thelonging for love,the search for knowledge,and unbearable pity for the sufferingof mankind.These passions,like great winds,have blown me hither and thither,ina wayward course,over a deep ocean of anguish,reaching to the very verge ofdespair.I have sought love,first,because it brings ecstasy—ecstasy so great that展开更多
Construction of the“Presidential Mansion(总统官邸)”began in 1792.Stillunfinished,and drafty(通风的)and uncomfortable,it was first occupied by JohnAdams and his family in 1800.Mrs Adams made most of her new home and ...Construction of the“Presidential Mansion(总统官邸)”began in 1792.Stillunfinished,and drafty(通风的)and uncomfortable,it was first occupied by JohnAdams and his family in 1800.Mrs Adams made most of her new home and hungthe wash in the East Room.The British burned the White House in the war of 1812.President James Madisonfled,but his wife Dolley Madison saved the famous Gilbert stuart portrait of Washington.展开更多
Let D（?）Cn be a connected Reinhardt domain containing the origin. If f=（f1, ..., fn）’: D→Cn is a holomorphic mapping, where '’' represents the transpose, f（0）=0, then every component of f can be expan...Let D（?）Cn be a connected Reinhardt domain containing the origin. If f=（f1, ..., fn）’: D→Cn is a holomorphic mapping, where '’' represents the transpose, f（0）=0, then every component of f can be expanded into a power展开更多
In a matter of 3 years,HunanZhicheng Chemicals Co.,Ltd.hasturned from a large state-owned en-terprise on the verge of bankruptcyto an enterprise that has thoroughlygot rid of losses and is included inthe first lot of ...In a matter of 3 years,HunanZhicheng Chemicals Co.,Ltd.hasturned from a large state-owned en-terprise on the verge of bankruptcyto an enterprise that has thoroughlygot rid of losses and is included inthe first lot of pilot companies forcyclic economy in China.The "3R"(reduce,reuse and recycle)modehas played an important role andthe cyclic economy has displayed aboundless charm in the develop-ment of the company.Hunan Zhicheng Chemicals Co.,Ltd.is established based on展开更多
文摘目的探讨VERGE蛋白在小鼠大脑中动脉梗死模型(MCAO)中蛋白表达的变化及其机制。方法C57BL/6小鼠30只,随机分为2组:30 min MCAO模型组、90 min MCAO模型组,制备MCAO模型,应用激光多普勒血流仪进行术中脑血流监测,应用Western印迹法观察各组梗死侧及非梗死侧的VERGE、p-JNK2、p-ERK1/2、P-38蛋白表达的变化。结果30 min、90 min MCAO模型组梗死侧VERGE、p-JNK2的蛋白表达明显增高,p-ERK1/2、P-38蛋白表达无变化;两组MCAO模型非梗死侧的VERGE、p-JNK2、p-ERK1/2、P-38蛋白表达均无变化。结论VERGE蛋白表达在小鼠MCAO的早期明显升高可能与JNK2通路有关而与ERK、P38通路无关。
文摘Several research studies have proven that eliciting and predicting the impact of human activity on ecosystem services will be crucial to support stakeholders’ awareness and to decide how to interact with the environment in a more sustainable manner. In this sense, the ecosystems known as road verges are particularly important because of their length and surface at an international scale, and their role in mitigating the damage done by roads. Plant pollination by insects is one of the most important ecosystem services. Because of its nature and the fact that they extend across a variety of landscapes, roadside can contribute to the maintenance of healthy ecosystems, under the condition of adapted management practices. This research is the first attempt to develop a System Dynamics-based aiming to estimate the ecological and economic impact of maintenance on the road verge pollination service in France. Maintenance strategies of road verges are simulated to compare their performance. The results show that there are ways to improve current maintenance strategies in terms of pollination value, but also that the model needs to consider other ecosystem services and synergistic effects that could further affect pollination to obtain more accurate estimations.
文摘Whenever we laboriously packed our bags in July--always, oddly enough, on a marvelously warm summerevening--sooner or later I would say to my wife, 'Herewe are on the verge of a collapse while the birdsare singing outside, and the best thing would be to goand sit on terrace with a glass of beer. Can you tellme why we go away at all?' Then we solemnly swore that next year we
文摘Three passions,simple but overwhelmingly strong,have governed my life:thelonging for love,the search for knowledge,and unbearable pity for the sufferingof mankind.These passions,like great winds,have blown me hither and thither,ina wayward course,over a deep ocean of anguish,reaching to the very verge ofdespair.I have sought love,first,because it brings ecstasy—ecstasy so great that
文摘Construction of the“Presidential Mansion(总统官邸)”began in 1792.Stillunfinished,and drafty(通风的)and uncomfortable,it was first occupied by JohnAdams and his family in 1800.Mrs Adams made most of her new home and hungthe wash in the East Room.The British burned the White House in the war of 1812.President James Madisonfled,but his wife Dolley Madison saved the famous Gilbert stuart portrait of Washington.
文摘Let D（?）Cn be a connected Reinhardt domain containing the origin. If f=（f1, ..., fn）’: D→Cn is a holomorphic mapping, where '’' represents the transpose, f（0）=0, then every component of f can be expanded into a power
文摘In a matter of 3 years,HunanZhicheng Chemicals Co.,Ltd.hasturned from a large state-owned en-terprise on the verge of bankruptcyto an enterprise that has thoroughlygot rid of losses and is included inthe first lot of pilot companies forcyclic economy in China.The "3R"(reduce,reuse and recycle)modehas played an important role andthe cyclic economy has displayed aboundless charm in the develop-ment of the company.Hunan Zhicheng Chemicals Co.,Ltd.is established based on
