Background:Globally,the use of community pharmacies and pharmacists in the delivery of vaccination services has been hampered by several factors,laws,and regulations that do not support pharmacists to participate in t...Background:Globally,the use of community pharmacies and pharmacists in the delivery of vaccination services has been hampered by several factors,laws,and regulations that do not support pharmacists to participate in the delivery of vaccination services.With the advent of COVID-19 pandemic,many countries have included community pharmacists and pharmacies in vaccination services to improve coverage.This study described the delivery of vaccination services in community pharmacies using the COVID-19 experience and how their involvement impacted vaccination coverage in Nigeria.It also exposed how this experience can be used to support policy revisions to formally recognize pharmacists in immunization delivery.Methods:A descriptive cross-sectional study was conducted among 474 community pharmacists in two southwestern States in Nigeria,using a semi-structured questionnaire.It determines the number of community pharmacists who have been trained in the delivery of vaccination services,the types of vaccination services provided,and vaccines administered in their pharmacies.Data were analyzed with descriptive and inferential statistics and p-value at≤0.05.Results:Response rate was 86.7%.Less than half of the respondents(40.1%)had undergone vaccination training.Of the 129(31.4%)respondents that provide vaccination services,72(55.8%)administer vaccines in their pharmacies.Out of these 72 respondents;45(62.5%)were administering vaccines before their involvement in COVID-19 vaccine administration;57(79.2%)of the health personnel who administer vaccines were pharmacists;60(83.3%)of them administer vaccines on request;22(30.6%)administered COVID-19 vaccines only;and only 7(9.7%)of the respondents had administered over 500 doses of COVID-19 vaccines.Training in vaccination was associated with the vaccination services provided(p<0.05).Respondents suggested government support through legal framework and policy review,training and empowering pharmacists in vaccine administration,and recognition of community pharmacists as PHC providers.展开更多
In 2022,cervical cancer accounted for approximately 662,301 new cases worldwide,representing 6.9%of all cancers diagnosed in women.Furthermore,it was the fourth leading cause of cancer-related deaths among women~1.In ...In 2022,cervical cancer accounted for approximately 662,301 new cases worldwide,representing 6.9%of all cancers diagnosed in women.Furthermore,it was the fourth leading cause of cancer-related deaths among women~1.In China,human papillomavirus(HPV)vaccination is not included in the National Immunization Program,thus creating marked urban±rural disparities:only 5.7%of rural children are vaccinated~2.Local publicly funded initiatives have increased vaccination uptake in some cities(e.g.,Shenzhen pilot;Jinan first-dose coverage>90%among eligible girls)~(3,4).展开更多
Introduction Human papillomavirus(HPV)vaccination is a cornerstone of cervical cancer prevention,particularly in low-and middle-income countries(LMICs),where the burden of disease remains high~1.The World Health Organ...Introduction Human papillomavirus(HPV)vaccination is a cornerstone of cervical cancer prevention,particularly in low-and middle-income countries(LMICs),where the burden of disease remains high~1.The World Health Organization(WHO)HPV Vaccine Introduction Clearing House reported that 147 countries(of 194 reporting)had fully introduced the HPV vaccine into their national schedules as of 20242.After COVID-19 pandemic disruptions,global coverage is again increasing.展开更多
Objective:To assess the complete vaccination coverage and timeliness of childhood vaccinations among Indigenous children in Peninsular Malaysia.Methods:The study utilized data from the 2022 Orang Asli Health Survey,a ...Objective:To assess the complete vaccination coverage and timeliness of childhood vaccinations among Indigenous children in Peninsular Malaysia.Methods:The study utilized data from the 2022 Orang Asli Health Survey,a cross-sectional survey conducted among a representative sample of Orang Asli in Peninsular Malaysia.A total of 68 villages were randomly selected from a pool of 853 villages,encompassing diverse geographic and sociodemographic contexts with a total of 15950 respondents Orang Asli successfully interviewed.However,this study only utilized data from surveyed children aged 12 to 59 months with a total of 1551 children included.Validated structured questionnaires were used to collect sociodemographic data and health status,with nurses verifying vaccination records.Children who received all nine primary vaccinations were defined as having complete vaccination while those who received vaccine within the recommended time were defined as having timely vaccination.Data analysis was conducted using IBM SPSS version 25.0,focusing on descriptive analyses of children's vaccination status.Results:The prevalence of overall complete vaccination among Indigenous children was 87.7%,while timely vaccination was only 40.3%.The prevalence of complete vaccination for Bacillus Calmette-Guérin(BCG),the first dose of hepatitis B,three doses of DTaP-IPV-Hib,and measles,mumps,and rubella(MMR)was above 95.0%,except for the second and third doses of hepatitis B.The prevalence of timely vaccination ranged from above 95.0%for vaccines given at birth,gradually decreasing with increasing age to 57.5%for the first dose of MMR.Moreover,the completion rates for three doses of DtaP-IPV-Hib and the initial dose of MMR surpassed 90%among Indigenous children aged 12-23 months,yet the timeliness remained at a moderate level.Conclusions:While the overall complete vaccination coverage among Indigenous children in Malaysia is relatively high,there are concerning disparities in the timeliness of vaccination,particularly as children age.展开更多
Objective:This review aimed to identify the barriers and facilitators to equitable coronavirus disease 2019(COVID-19)vaccine distribution in Nigeria using the consolidated framework for implementation research(CFIR).M...Objective:This review aimed to identify the barriers and facilitators to equitable coronavirus disease 2019(COVID-19)vaccine distribution in Nigeria using the consolidated framework for implementation research(CFIR).Methods:A comprehensive search strategy was applied across five databases—Web of Science,MEDLINE,EMBASE,CAB Direct,and CINAHL.The search,conducted as part of a scoping review,yielded 2,751 citations.Seven studies met the inclusion criteria after screening.Data were extracted and analyzed using CFIR constructs to identify key barriers and facilitators to equitable vaccine distribution.Results:Six barriers were identified:limited physical and socioeconomic access,bribery,nepotism,and insufficient availability of translated information.Facilitators included community involvement as local monitoring agents,unannounced staff inspections,healthcare worker training tailored to community needs,and localized outreach strategies such as jingles and call-in programs.CFIR constructs,including Local Conditions,Tailoring Strategies,Available Resources,and Physical Infrastructure,provided a framework for analyzing the findings.Conclusion:This review highlights significant barriers and promising facilitators to equitable vaccine distribution in Nigeria.Targeted interventions,such as community engagement,anti-corruption measures,and culturally tailored strategies,are critical to addressing these challenges and improving access.These findings underscore the need for localized,equity-focused approaches to enhance vaccine distribution systems in Nigeria and other low-resource settings.展开更多
Influenza is a significant global public health challenge,with seasonal epidemics imposing substantial burdens on healthcare systems and vulnerable populations,causing 3 to 5 million severe cases and 290,000 to 650,00...Influenza is a significant global public health challenge,with seasonal epidemics imposing substantial burdens on healthcare systems and vulnerable populations,causing 3 to 5 million severe cases and 290,000 to 650,000 respiratory-related deaths worldwide each year[1].Vaccines are an effective means of preventing influenza.In recent years,China has made progress in vaccine development and immunization strategies.The population is recommended to receive influenza vaccines annually;however,their coverage remain suboptimal[2].The World Health Organization(WHO)highlights that all countries should consider implementing seasonal influenza immunization programs,with priority groups determined based on local epidemiological contexts.In alignment with the Immunization Agenda 2030,the use of seasonal influenza vaccines contributes to strengthening the life course of immunization and serves as a critical component for addressing influenza pandemics,as outlined in the WHO Global Influenza Strategy 2019-2030.展开更多
Objective:This study aimed to explore undergraduates’knowledge,attitude,and practice/behavior of human papillomavirus(HPV)vaccination,as well as the essential influencing factors for vaccination decision-making.Metho...Objective:This study aimed to explore undergraduates’knowledge,attitude,and practice/behavior of human papillomavirus(HPV)vaccination,as well as the essential influencing factors for vaccination decision-making.Methods:Through cluster and convenience sampling,2000 undergraduates from the Nursing and Language department of a university in Shanghai were sent a self-designed questionnaire.Chi-square tests,independent sample t-test/ANOVE,and multiple linear regression were used to investigate participants’knowledge and attitude on HPV vaccination,as well as the factors that predicted potential action to receive and promote HPV vaccination in the future.Results:The mean HPV knowledge score was 5.027 out of 10.Health science students showed a significantly higher knowledge mean score than the non-health science students(P<0.000).There was a statistically difference in HPV vaccination attitude among undergraduates in different grades(P<0.05).Awareness of cervical cancer and worries about the risk of cervical cancer were the significant predictors of willingness to receive and promote HPV vaccination in the future.Conclusions:It would take time for a new health product to be aware,understood,accepted,and received.Education providing and information sharing are expected to break the dawn and make the procedure processed.展开更多
Objective:To assess the effectiveness of COVID-19 vaccination in patients with rheumatic diseases undergoing biologic(bDMARDs)or targeted-synthetic disease-modifying anti-rheumatic drugs(tsDMARDs).Methods:This cross-s...Objective:To assess the effectiveness of COVID-19 vaccination in patients with rheumatic diseases undergoing biologic(bDMARDs)or targeted-synthetic disease-modifying anti-rheumatic drugs(tsDMARDs).Methods:This cross-sectional study was conducted at ten rheumatology clinics in Turkey between May 1,2021,and October 30,2022.Patients with rheumatic diseases on bDMARD or tsDMARD therapy who received at least two doses of an mRNA or inactivated SARS-CoV-2 vaccine were included.After vaccination,COVID-19 infection rates,adverse events,and rheumatic disease flares were recorded.Data were collected via face-to-face or telephone interviews.Results:A total of 963 participants were included in the final analysis;44%were male,and the median age was 49 years.The most frequently observed rheumatic diseases were ankylosing spondylitis and rheumatoid arthritis,accounting for 37.2%and 32.6%of cases,respectively.Adalimumab(19.2%)and infliximab(17.8%)were the most commonly used bDMARDs.Of the participants,634(65.9%)received an inactivated vaccine(CoronaVac)and 329(34.1%)an mRNA vaccine(BioNTech).A total of 502(52.1%)patients received a booster dose.Following the first,second,and third vaccine doses,adverse event rates were 19.9%,15.9%,and 26.7%,respectively.Forty-two(4.4%)patients experienced a disease flare within six months after their first vaccination dose.COVID-19 infection occurred in 79 participants(8.2%)after two vaccine doses;most cases were symptomatic but did not require hospitalization.The COVID-19 infection rate was lower in participants who received a booster dose than those who did not(3.4%vs.8.2%,P<0.001).Conclusions:Our study indicates that both mRNA and inactivated SARS-CoV-2 vaccines are effective in preventing severe COVID-19 outcomes,with an acceptable rate of adverse events and disease flares among patients with rheumatic diseases on bDMARD or tsDMARD therapy.展开更多
Background: Hepatitis B virus (HBV) is a primary reason for liver cancer and continues to be a worldwide public health issue. The likelihood of contracting HBV is greater in healthcare workers (HCWs) compared to indiv...Background: Hepatitis B virus (HBV) is a primary reason for liver cancer and continues to be a worldwide public health issue. The likelihood of contracting HBV is greater in healthcare workers (HCWs) compared to individuals who are not in healthcare professions. Medical students are classified as a high-risk demographic since, like HCWs, they often come into contact with bodily fluids and blood during their clinical training. By 2030, a greater proportion of people will have received HBV vaccinations, thereby halting the spread of new infections—The Somali Ministry of Health with the help of various agencies announced to eradicate hepatitis from Somalia. The priority actions are national hepatitis strategy, hepatitis survey, public awareness, training, and capacity building. Objectives: This study aims to assess the knowledge, attitude, and vaccination status of Hepatitis B infection among medical university students in Mogadishu, Somalia, 2024. Methods: Cross-sectional study design was used in this study and the survey was carried out among medical students enrolled in Universities from April 1, 2023 to June 30, 2023. The data was analyzed using SPSS version 26.0 software, Chi-square analysis and Logistic regression analysis to identify associations between demographic factors and HBV knowledge, attitudes, and vaccination status, as well as perspectives and immunization status concerning viral hepatitis. Results: The study achieved a response rate of (96%), with 230 participants. Most students (76.5%) were aged 26 - 30 years, and (60.8%) were male. Nearly half (48.7%) were in their third year of study, and the majority (36.1%) were from the Medicine and Surgery department. While 92.2% had heard of HBV, gaps in understanding were evident. About 37.8% erroneously believed HBV could spread via handshakes, and only 33.9% were aware HBV is treatable. Awareness of HBV’s severe complications, such as liver cirrhosis and liver cancer, was reported by 61.3%, and 83% understood that vaccination could prevent infection. Positive attitudes towards HBV vaccination were prevalent. Most participants (81.3%) supported vaccination before sexual activity, and 78.3% endorsed mandatory HBV vaccination policies for healthcare workers. However, 87.4% expressed concerns about the vaccine promoting unsafe sexual behavior, and 96.1% cited cultural resistance as a barrier to vaccination. A significant proportion (80.86%) of students had not been vaccinated against HBV. Among vaccinated students, 17.4%, 15.7%, and 47.82% had received one, two, and three doses, respectively. Barriers to vaccination included safety concerns (77.4%), lack of time (86.52%), and doubts about efficacy (42.61%). Conclusion: This study highlights gaps in knowledge and vaccination coverage among medical students, which are critical for their health and future clinical practice. Enhancing awareness and vaccination rates can empower students to advocate for preventative measures in their professional environments. Despite high awareness of HBV, knowledge gaps and cultural barriers persist, affecting attitudes and vaccination uptake among medical students. Educational interventions addressing misconceptions, cultural resistance, and vaccine safety are critical. Increased advocacy for mandatory vaccination policies in healthcare settings is also essential to improve HBV prevention methods.展开更多
Immunoprophylaxis is routinely recommended for infants born to mothers with hepatitis B virus(HBV)infection within the first 12-24 hours.Detection of he-patitis B surface antibody(HBsAb)resulting from hepatitis B immu...Immunoprophylaxis is routinely recommended for infants born to mothers with hepatitis B virus(HBV)infection within the first 12-24 hours.Detection of he-patitis B surface antibody(HBsAb)resulting from hepatitis B immunoglobulin administered at birth may be perceived as a real vaccine response.This makes it difficult to detect HBV infection.For this reason,it is recommended that infants born to hepatitis B surface antigen positive mothers and who received immunop-rophylaxis at birth should have HBsAb testing when they are 9-15 months old.展开更多
BACKGROUND Measles is a highly contagious disease that caused by a measles virus.While measles vaccination is highly effective in preventing the disease,those who are unvaccinated or have not completed the vaccine ser...BACKGROUND Measles is a highly contagious disease that caused by a measles virus.While measles vaccination is highly effective in preventing the disease,those who are unvaccinated or have not completed the vaccine series are at significant risk.AIM To assess the clinical characteristics and outcomes of measles in vaccinated vs unvaccinated children in Ramadi city.METHODS Clinically confirmed cases of measles at Al-Ramadi Teaching Hospital for Ma-ternity and Children,identified between June and December 2023,were enrolled in this prospective cohort study.The cases were divided into two groups(va-ccinated and unvaccinated).The clinical characteristics and outcomes were com-pared between unvaccinated and vaccinated children.RESULTS Of 289 kids,there were 222(76.8%)children under 5 years old,and 161(55.7%)boys.Around 2/3rd children were unvaccinated.Besides,only 5(4.9%)kids from the vaccinated group received three doses.Fever,maculopapular rashes,and cough were the most common manifestations.Unvaccinated children had higher rate of developing complications(pneumonia and diarrhea with P values 0.001 and 0.01 respectively),longer hospital admission period(P value=0.008),and the need for respiratory care unit(RCU)admission comparing with the vaccinated children(4 cases for unvaccinated group vs 1 case for vaccinated group).CONCLUSION Unvaccinated kids were associated with more complications,longer admission hospital stays,and RCU admission.We recommend that public health directors utilize artificial intelligence tools to help control future measles epidemics.展开更多
Introduction: Vaccination faces several obstacles in the fight against COVID-19, yet it has been identified as one of the most effective means of preventing new epidemics of COVID-19. The aim was to contribute to impr...Introduction: Vaccination faces several obstacles in the fight against COVID-19, yet it has been identified as one of the most effective means of preventing new epidemics of COVID-19. The aim was to contribute to improving vaccination coverage against COVID-19 in the Kindu health zone. Method: We conducted a cross-sectional descriptive study with an analytical focus, using a questionnaire that enabled us to carry out a survey from October 03 to 30, 2022. Our target study population was residents of the Kindu health zone. A total of 420 subjects participated in our study, including 42 per site. Results: The study revealed a low proportion of vaccinated subjects (38.3%) and a high proportion of non-vaccinated subjects (61.70%). Non-belief in the efficacy of vaccines (p = 0.001), infodemia (p = 0.001) and respect for ethnic norms (p = 0.001) were identified as perceived barriers to vaccination. Fear of being branded with the “666” beast badge (p = 0.004) as the perceived severity. Respondents’ perceptions of mass vaccination against COVID-19 are mixed, and their opinions and expectations of COVID-19 vaccination in the town of Kindu are divided. Conclusion: In order to increase the proportion of people vaccinated against COVID-19, it is suggested here to increase the population’s ability to detect false information through a well-structured communication and health education program.展开更多
Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt pro...Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt protective measures.However, whether to disseminate specific information is also a behavioral decision. In light of this understanding, we develop a coupled information–vaccination–epidemic model to depict these co-evolutionary dynamics in a three-layer network. Negative information dissemination and vaccination are treated as separate decision-making processes. We then examine the combined effects of herd and risk motives on information dissemination and vaccination decisions through the lens of game theory. The microscopic Markov chain approach(MMCA) is used to describe the dynamic process and to derive the epidemic threshold. Simulation results indicate that increasing the cost of negative information dissemination and providing timely clarification can effectively control the epidemic. Furthermore, a phenomenon of diminishing marginal utility is observed as the cost of dissemination increases, suggesting that authorities do not need to overinvest in suppressing negative information. Conversely, reducing the cost of vaccination and increasing vaccine efficacy emerge as more effective strategies for outbreak control. In addition, we find that the scale of the epidemic is greater when the herd motive dominates behavioral decision-making. In conclusion, this study provides a new perspective for understanding the complexity of epidemic spreading by starting with the construction of different behavioral decisions.展开更多
BACKGROUND Rabies is a zoonotic viral disease affecting the central nervous system,caused by the rabies virus,with a case-fatality rate of 100%once symptoms appear.AIM To analyze high-risk factors associated with ment...BACKGROUND Rabies is a zoonotic viral disease affecting the central nervous system,caused by the rabies virus,with a case-fatality rate of 100%once symptoms appear.AIM To analyze high-risk factors associated with mental disorders induced by rabies vaccination and to construct a risk prediction model to inform strategies for improving patients’mental health.METHODS Patients who received rabies vaccinations at the Department of Infusion Yiwu Central Hospital between August 2024 and July 2025 were included,totaling 384 cases.Data were collected from medical records and included demographic characteristics(age,gender,occupation),lifestyle habits,and details regarding vaccine type,dosage,and injection site.The incidence of psychiatric disorders following vaccination was assessed using standardized anxiety and depression rating scales.Patients were categorized into two groups based on the presence or absence of anxiety and depression symptoms:The psychiatric disorder group and the non-psychiatric disorder group.Differences between the two groups were compared,and high-risk factors were identified using multivariate logistic regression analysis.A predictive model was then developed based on these factors to evaluate its predictive performance.RESULTS Among the 384 patients who received rabies vaccinations,36 cases(9.38%)were diagnosed with anxiety,52 cases(13.54%)with depression,and 88 cases(22.92%)with either condition.Logistic regression analysis identified the following signi ficant risk factors for psychiatric disorders:Education level of primary school or below,exposure site at the head and neck,exposure classified as grade III,family status of divorced/widowed/unmarried/living alone,number of wounds greater than one,and low awareness of rabies prevention and control(P<0.05).The risk prediction model demonstrated good performance,with an area under the receiver operating characteristic curve of 0.859,a specificity of 74.42%,and a sensitivity of 93.02%.CONCLUSION In real-world settings,psychiatric disorders following rabies vaccination are relatively common and are associated with factors such as lower education level,higher exposure severity,vulnerable family status,and limited awareness of rabies prevention and control.The developed risk prediction model may aid in early identification of high-risk individuals and support timely clinical intervention.展开更多
Objective Despite the global decrease in influenza infections during the coronavirus disease 2019(COVID-19)pandemic,seasonal influenza remains a significant health issue.South Korea,known for its robust pandemic respo...Objective Despite the global decrease in influenza infections during the coronavirus disease 2019(COVID-19)pandemic,seasonal influenza remains a significant health issue.South Korea,known for its robust pandemic response and high influenza vaccination rates,offers a unique context for examining changes in vaccination trends during the pandemic.Using nationally representative data,we aimed to understand the impact of the pandemic on influenza vaccination behavior over a 12-year period and to identify vulnerable groups.Methods We analyzed influenza vaccination rates in South Korea between 2011-2022,focusing on pandemic-related impacts.The data of 2,426,139 adults(≥19 years)from the Korea Community Health Survey were used to assess demographic and sociological factors influencing vaccination behaviors.Results We observed an increase in influenza vaccination rates during the pre-COVID-19 period from 2011-2013(weighted prevalence:46.68%[95%confidence interval(CI):46.55-46.82])to 2017-2019(weighted prevalence:52.50%[95%CI:52.38-52.63]).However,a significant decline was observed in 2022,the late-COVID-19 pandemic period(weighted prevalence:55.78%[95%CI:55.56-56.01]),compared with the mid-pandemic period in 2021(weighted prevalence:59.12%[95%CI:58.91-59.32]),particularly among populations traditionally prioritized for influenza vaccination,including older adults(≥65 years)and patients with chronic diseases and low educational and income levels.Conclusion The influenza vaccination rate in South Korea was significantly affected by the COVID-19 pandemic,showing a notable decrease among vulnerable demographic groups.This suggests the need for targeted public health strategies to address vaccine hesitancy and improve vaccination rates,particularly among high-risk populations.展开更多
The study aims to investigate county-level variations of the COVID-19 disease and vaccination rate. The COVID-19 data was acquired from usafact.org, and the vaccination records were acquired from the Ohio vaccination ...The study aims to investigate county-level variations of the COVID-19 disease and vaccination rate. The COVID-19 data was acquired from usafact.org, and the vaccination records were acquired from the Ohio vaccination tracker dashboard. GIS-based exploratory analysis was conducted to select four variables (poverty, black race, population density, and vaccination) to explain COVID-19 occurrence during the study period. Consequently, spatial statistical techniques such as Moran’s I, Hot Spot Analysis, Spatial Lag Model (SLM), and Spatial Error Model (SEM) were used to explain the COVID-19 occurrence and vaccination rate across the 88 counties in Ohio. The result of the Local Moran’s I analysis reveals that the epicenters of COVID-19 and vaccination followed the same patterns. Indeed, counties like Summit, Franklin, Fairfield, Hamilton, and Medina were categorized as epicenters for both COVID-19 occurrence and vaccination rate. The SEM seems to be the best model for both COVID-19 and vaccination rates, with R2 values of 0.68 and 0.70, respectively. The GWR analysis proves to be better than Ordinary Least Squares (OLS), and the distribution of R2 in the GWR is uneven throughout the study area for both COVID-19 cases and vaccinations. Some counties have a high R2 of up to 0.70 for both COVID-19 cases and vaccinations. The outcomes of the regression analyses show that the SEM models can explain 68% - 70% of COVID-19 cases and vaccination across the entire counties within the study period. COVID-19 cases and vaccination rates exhibited significant positive associations with black race and poverty throughout the study area.展开更多
Peste des petits ruminants virus (PPRV) antibodies were studied in Sudanese sheep and goats (n = 855) before and after vaccination with a locally produced Nigeria 75/1 vaccine using a commercial competitive ELISA (cEL...Peste des petits ruminants virus (PPRV) antibodies were studied in Sudanese sheep and goats (n = 855) before and after vaccination with a locally produced Nigeria 75/1 vaccine using a commercial competitive ELISA (cELISA) kit. Animals were kept healthy under field conditions, in four states: Blue Nile (n = 250), North Kordofan (n = 189), South Darfur (n = 225) and the Northern State (n = 191). Before vaccination, the overall sero-prevalence of PPRV antibodies was 54.6% (53.2% - 56%, 95% CI);high (64.8% - 76.4%, 95% CI) in Blue Nile State, medium (50.5% - 61.9%, 95% CI) in North Kordofan State and South Darfur State and low (28.6% - 35.2% 95%, CI) in Northern State. In high-risk areas (high sero-prevalence), Blue Nile (70.4%) and North Kordofan (57.7%), middle age groups (7 - 12 and 13 - 18 months) were identified as high-risk age. Middle age groups showed lower sero-prevalence than preceding (3 - 6 months) and subsequent (>18 months) age groups while the risk of exposure increased with age. Current and previous findings suggested a transmission pathway of PPRV involving the South Eastern border (Blue Nile) and neighbouring Central Sudan to North Kordofan. One month after vaccination 88.4% (343/388) of sero-negative animals were sero-converted suggesting the efficacy of the locally produced Nigeria 75/1 vaccine. Even if only individuals in the high-risk age group (7 - 18 months) were vaccinated, the overall population immunity (OPI) in high-risk areas (the Blue Nile and North Kordofan) would have surpassed the threshold of 70%, which is indicated for blocking PPRV transmission. However, lower vaccination coverage is expected in wider vaccination programmes. These findings primarily justified the targeting of PPR control in Sudan through the vaccination of high-risk age groups in high-risk areas.展开更多
In this paper,based on the SVIQR model we develop a stochastic epidemic model with multiple vaccinations and time delay.Firstly,we prove the existence and uniqueness of the global positive solution of the model,and co...In this paper,based on the SVIQR model we develop a stochastic epidemic model with multiple vaccinations and time delay.Firstly,we prove the existence and uniqueness of the global positive solution of the model,and construct suitable functions to obtain sufficient conditions for disease extinction.Secondly,in order to effectively control the spread of the disease,appropriate control strategies are formulated by using optimal control theory.Finally,the results are verified by numerical simulation.展开更多
Unheralded cardiac arrest among previously healthy young people without antecedent illness,months or years after coronavirus disease 2019(COVID-19)vaccination,highlights the urgent need for risk stratification.The mos...Unheralded cardiac arrest among previously healthy young people without antecedent illness,months or years after coronavirus disease 2019(COVID-19)vaccination,highlights the urgent need for risk stratification.The most likely underlying pathophysiology is subclinical myopericarditis and reentrant ventri-cular tachycardia or spontaneous ventricular fibrillation that is commonly preci-pitated after a surge in catecholamines during exercise or the waking hours of terminal sleep.Small patches of inflammation and/or edema can be missed on cardiac imaging and autopsy,and the heart can appear grossly normal.This paper reviews evidence linking COVID-19 vaccines to cardiac arrest where unfortu-nately the majority of victims have had no antecedent clinical evaluation.We propose a comprehensive strategy for evaluating cardiovascular risk post-vaccination,incorporating detailed patient history,antibody testing,and cardiac diagnostics in the best attempt to detect abnormalities before sudden cardiac death.This approach aims to identify individuals at higher risk of cardiac events after COVID-19 vaccination and guide appropriate clinical management.It is prudent for each primary care physician to have a pre-established plan when addressing this issue in their practice.展开更多
[Objectives]This study was conducted to evaluate the practical efficacy of Haemophilus parasuis(Hps)vaccines and determine whether the continuous use of vaccines leads to changes in Hps serotypes.[Methods]A swine prod...[Objectives]This study was conducted to evaluate the practical efficacy of Haemophilus parasuis(Hps)vaccines and determine whether the continuous use of vaccines leads to changes in Hps serotypes.[Methods]A swine production group that had used a bivalent vaccine of Hps serotypes 4 and 5 for two consecutive years were investigated and retrospectively analyzed.Data on Hps detection rate,nursery production and disease indexes,as well as serotype shifts after continuous vaccination,were collected to assess vaccine effectiveness.[Results]Continuous vaccination reduced the total nursery culling and mortality rate by 1.75%.Hps infection persisted in the farms,and the pathogen could still be isolated.However,serotyping revealed a significant shift in the dominant prevalent serotypes,indicating that the vaccine was indeed effective.[Conclusions]The matched Hps vaccine demonstrated effective results.However,whether replacing serotypes or adding more prevalent serotypes could further improve the control of Hps disease requires further investigation.展开更多
文摘Background:Globally,the use of community pharmacies and pharmacists in the delivery of vaccination services has been hampered by several factors,laws,and regulations that do not support pharmacists to participate in the delivery of vaccination services.With the advent of COVID-19 pandemic,many countries have included community pharmacists and pharmacies in vaccination services to improve coverage.This study described the delivery of vaccination services in community pharmacies using the COVID-19 experience and how their involvement impacted vaccination coverage in Nigeria.It also exposed how this experience can be used to support policy revisions to formally recognize pharmacists in immunization delivery.Methods:A descriptive cross-sectional study was conducted among 474 community pharmacists in two southwestern States in Nigeria,using a semi-structured questionnaire.It determines the number of community pharmacists who have been trained in the delivery of vaccination services,the types of vaccination services provided,and vaccines administered in their pharmacies.Data were analyzed with descriptive and inferential statistics and p-value at≤0.05.Results:Response rate was 86.7%.Less than half of the respondents(40.1%)had undergone vaccination training.Of the 129(31.4%)respondents that provide vaccination services,72(55.8%)administer vaccines in their pharmacies.Out of these 72 respondents;45(62.5%)were administering vaccines before their involvement in COVID-19 vaccine administration;57(79.2%)of the health personnel who administer vaccines were pharmacists;60(83.3%)of them administer vaccines on request;22(30.6%)administered COVID-19 vaccines only;and only 7(9.7%)of the respondents had administered over 500 doses of COVID-19 vaccines.Training in vaccination was associated with the vaccination services provided(p<0.05).Respondents suggested government support through legal framework and policy review,training and empowering pharmacists in vaccine administration,and recognition of community pharmacists as PHC providers.
基金supported by grants from the China Association for Science and Technology(KXYJS2024012)the Gates Foundation(INV-006373 and INV-023808)+1 种基金Capital’s Funds for Health Improvement and Research(2024-2-30117)Beijing Municipal Health Commission’s Funds for the Highqualified Public Health Professionals Development Project(Discipline Core-03-36)。
文摘In 2022,cervical cancer accounted for approximately 662,301 new cases worldwide,representing 6.9%of all cancers diagnosed in women.Furthermore,it was the fourth leading cause of cancer-related deaths among women~1.In China,human papillomavirus(HPV)vaccination is not included in the National Immunization Program,thus creating marked urban±rural disparities:only 5.7%of rural children are vaccinated~2.Local publicly funded initiatives have increased vaccination uptake in some cities(e.g.,Shenzhen pilot;Jinan first-dose coverage>90%among eligible girls)~(3,4).
文摘Introduction Human papillomavirus(HPV)vaccination is a cornerstone of cervical cancer prevention,particularly in low-and middle-income countries(LMICs),where the burden of disease remains high~1.The World Health Organization(WHO)HPV Vaccine Introduction Clearing House reported that 147 countries(of 194 reporting)had fully introduced the HPV vaccine into their national schedules as of 20242.After COVID-19 pandemic disruptions,global coverage is again increasing.
文摘Objective:To assess the complete vaccination coverage and timeliness of childhood vaccinations among Indigenous children in Peninsular Malaysia.Methods:The study utilized data from the 2022 Orang Asli Health Survey,a cross-sectional survey conducted among a representative sample of Orang Asli in Peninsular Malaysia.A total of 68 villages were randomly selected from a pool of 853 villages,encompassing diverse geographic and sociodemographic contexts with a total of 15950 respondents Orang Asli successfully interviewed.However,this study only utilized data from surveyed children aged 12 to 59 months with a total of 1551 children included.Validated structured questionnaires were used to collect sociodemographic data and health status,with nurses verifying vaccination records.Children who received all nine primary vaccinations were defined as having complete vaccination while those who received vaccine within the recommended time were defined as having timely vaccination.Data analysis was conducted using IBM SPSS version 25.0,focusing on descriptive analyses of children's vaccination status.Results:The prevalence of overall complete vaccination among Indigenous children was 87.7%,while timely vaccination was only 40.3%.The prevalence of complete vaccination for Bacillus Calmette-Guérin(BCG),the first dose of hepatitis B,three doses of DTaP-IPV-Hib,and measles,mumps,and rubella(MMR)was above 95.0%,except for the second and third doses of hepatitis B.The prevalence of timely vaccination ranged from above 95.0%for vaccines given at birth,gradually decreasing with increasing age to 57.5%for the first dose of MMR.Moreover,the completion rates for three doses of DtaP-IPV-Hib and the initial dose of MMR surpassed 90%among Indigenous children aged 12-23 months,yet the timeliness remained at a moderate level.Conclusions:While the overall complete vaccination coverage among Indigenous children in Malaysia is relatively high,there are concerning disparities in the timeliness of vaccination,particularly as children age.
文摘Objective:This review aimed to identify the barriers and facilitators to equitable coronavirus disease 2019(COVID-19)vaccine distribution in Nigeria using the consolidated framework for implementation research(CFIR).Methods:A comprehensive search strategy was applied across five databases—Web of Science,MEDLINE,EMBASE,CAB Direct,and CINAHL.The search,conducted as part of a scoping review,yielded 2,751 citations.Seven studies met the inclusion criteria after screening.Data were extracted and analyzed using CFIR constructs to identify key barriers and facilitators to equitable vaccine distribution.Results:Six barriers were identified:limited physical and socioeconomic access,bribery,nepotism,and insufficient availability of translated information.Facilitators included community involvement as local monitoring agents,unannounced staff inspections,healthcare worker training tailored to community needs,and localized outreach strategies such as jingles and call-in programs.CFIR constructs,including Local Conditions,Tailoring Strategies,Available Resources,and Physical Infrastructure,provided a framework for analyzing the findings.Conclusion:This review highlights significant barriers and promising facilitators to equitable vaccine distribution in Nigeria.Targeted interventions,such as community engagement,anti-corruption measures,and culturally tailored strategies,are critical to addressing these challenges and improving access.These findings underscore the need for localized,equity-focused approaches to enhance vaccine distribution systems in Nigeria and other low-resource settings.
基金supported by the Chinese Association of Preventive Medicine-Vaccine and Immunization Youth Talent Support Project(CPMAQT-YM0314)。
文摘Influenza is a significant global public health challenge,with seasonal epidemics imposing substantial burdens on healthcare systems and vulnerable populations,causing 3 to 5 million severe cases and 290,000 to 650,000 respiratory-related deaths worldwide each year[1].Vaccines are an effective means of preventing influenza.In recent years,China has made progress in vaccine development and immunization strategies.The population is recommended to receive influenza vaccines annually;however,their coverage remain suboptimal[2].The World Health Organization(WHO)highlights that all countries should consider implementing seasonal influenza immunization programs,with priority groups determined based on local epidemiological contexts.In alignment with the Immunization Agenda 2030,the use of seasonal influenza vaccines contributes to strengthening the life course of immunization and serves as a critical component for addressing influenza pandemics,as outlined in the WHO Global Influenza Strategy 2019-2030.
文摘Objective:This study aimed to explore undergraduates’knowledge,attitude,and practice/behavior of human papillomavirus(HPV)vaccination,as well as the essential influencing factors for vaccination decision-making.Methods:Through cluster and convenience sampling,2000 undergraduates from the Nursing and Language department of a university in Shanghai were sent a self-designed questionnaire.Chi-square tests,independent sample t-test/ANOVE,and multiple linear regression were used to investigate participants’knowledge and attitude on HPV vaccination,as well as the factors that predicted potential action to receive and promote HPV vaccination in the future.Results:The mean HPV knowledge score was 5.027 out of 10.Health science students showed a significantly higher knowledge mean score than the non-health science students(P<0.000).There was a statistically difference in HPV vaccination attitude among undergraduates in different grades(P<0.05).Awareness of cervical cancer and worries about the risk of cervical cancer were the significant predictors of willingness to receive and promote HPV vaccination in the future.Conclusions:It would take time for a new health product to be aware,understood,accepted,and received.Education providing and information sharing are expected to break the dawn and make the procedure processed.
文摘Objective:To assess the effectiveness of COVID-19 vaccination in patients with rheumatic diseases undergoing biologic(bDMARDs)or targeted-synthetic disease-modifying anti-rheumatic drugs(tsDMARDs).Methods:This cross-sectional study was conducted at ten rheumatology clinics in Turkey between May 1,2021,and October 30,2022.Patients with rheumatic diseases on bDMARD or tsDMARD therapy who received at least two doses of an mRNA or inactivated SARS-CoV-2 vaccine were included.After vaccination,COVID-19 infection rates,adverse events,and rheumatic disease flares were recorded.Data were collected via face-to-face or telephone interviews.Results:A total of 963 participants were included in the final analysis;44%were male,and the median age was 49 years.The most frequently observed rheumatic diseases were ankylosing spondylitis and rheumatoid arthritis,accounting for 37.2%and 32.6%of cases,respectively.Adalimumab(19.2%)and infliximab(17.8%)were the most commonly used bDMARDs.Of the participants,634(65.9%)received an inactivated vaccine(CoronaVac)and 329(34.1%)an mRNA vaccine(BioNTech).A total of 502(52.1%)patients received a booster dose.Following the first,second,and third vaccine doses,adverse event rates were 19.9%,15.9%,and 26.7%,respectively.Forty-two(4.4%)patients experienced a disease flare within six months after their first vaccination dose.COVID-19 infection occurred in 79 participants(8.2%)after two vaccine doses;most cases were symptomatic but did not require hospitalization.The COVID-19 infection rate was lower in participants who received a booster dose than those who did not(3.4%vs.8.2%,P<0.001).Conclusions:Our study indicates that both mRNA and inactivated SARS-CoV-2 vaccines are effective in preventing severe COVID-19 outcomes,with an acceptable rate of adverse events and disease flares among patients with rheumatic diseases on bDMARD or tsDMARD therapy.
文摘Background: Hepatitis B virus (HBV) is a primary reason for liver cancer and continues to be a worldwide public health issue. The likelihood of contracting HBV is greater in healthcare workers (HCWs) compared to individuals who are not in healthcare professions. Medical students are classified as a high-risk demographic since, like HCWs, they often come into contact with bodily fluids and blood during their clinical training. By 2030, a greater proportion of people will have received HBV vaccinations, thereby halting the spread of new infections—The Somali Ministry of Health with the help of various agencies announced to eradicate hepatitis from Somalia. The priority actions are national hepatitis strategy, hepatitis survey, public awareness, training, and capacity building. Objectives: This study aims to assess the knowledge, attitude, and vaccination status of Hepatitis B infection among medical university students in Mogadishu, Somalia, 2024. Methods: Cross-sectional study design was used in this study and the survey was carried out among medical students enrolled in Universities from April 1, 2023 to June 30, 2023. The data was analyzed using SPSS version 26.0 software, Chi-square analysis and Logistic regression analysis to identify associations between demographic factors and HBV knowledge, attitudes, and vaccination status, as well as perspectives and immunization status concerning viral hepatitis. Results: The study achieved a response rate of (96%), with 230 participants. Most students (76.5%) were aged 26 - 30 years, and (60.8%) were male. Nearly half (48.7%) were in their third year of study, and the majority (36.1%) were from the Medicine and Surgery department. While 92.2% had heard of HBV, gaps in understanding were evident. About 37.8% erroneously believed HBV could spread via handshakes, and only 33.9% were aware HBV is treatable. Awareness of HBV’s severe complications, such as liver cirrhosis and liver cancer, was reported by 61.3%, and 83% understood that vaccination could prevent infection. Positive attitudes towards HBV vaccination were prevalent. Most participants (81.3%) supported vaccination before sexual activity, and 78.3% endorsed mandatory HBV vaccination policies for healthcare workers. However, 87.4% expressed concerns about the vaccine promoting unsafe sexual behavior, and 96.1% cited cultural resistance as a barrier to vaccination. A significant proportion (80.86%) of students had not been vaccinated against HBV. Among vaccinated students, 17.4%, 15.7%, and 47.82% had received one, two, and three doses, respectively. Barriers to vaccination included safety concerns (77.4%), lack of time (86.52%), and doubts about efficacy (42.61%). Conclusion: This study highlights gaps in knowledge and vaccination coverage among medical students, which are critical for their health and future clinical practice. Enhancing awareness and vaccination rates can empower students to advocate for preventative measures in their professional environments. Despite high awareness of HBV, knowledge gaps and cultural barriers persist, affecting attitudes and vaccination uptake among medical students. Educational interventions addressing misconceptions, cultural resistance, and vaccine safety are critical. Increased advocacy for mandatory vaccination policies in healthcare settings is also essential to improve HBV prevention methods.
文摘Immunoprophylaxis is routinely recommended for infants born to mothers with hepatitis B virus(HBV)infection within the first 12-24 hours.Detection of he-patitis B surface antibody(HBsAb)resulting from hepatitis B immunoglobulin administered at birth may be perceived as a real vaccine response.This makes it difficult to detect HBV infection.For this reason,it is recommended that infants born to hepatitis B surface antigen positive mothers and who received immunop-rophylaxis at birth should have HBsAb testing when they are 9-15 months old.
文摘BACKGROUND Measles is a highly contagious disease that caused by a measles virus.While measles vaccination is highly effective in preventing the disease,those who are unvaccinated or have not completed the vaccine series are at significant risk.AIM To assess the clinical characteristics and outcomes of measles in vaccinated vs unvaccinated children in Ramadi city.METHODS Clinically confirmed cases of measles at Al-Ramadi Teaching Hospital for Ma-ternity and Children,identified between June and December 2023,were enrolled in this prospective cohort study.The cases were divided into two groups(va-ccinated and unvaccinated).The clinical characteristics and outcomes were com-pared between unvaccinated and vaccinated children.RESULTS Of 289 kids,there were 222(76.8%)children under 5 years old,and 161(55.7%)boys.Around 2/3rd children were unvaccinated.Besides,only 5(4.9%)kids from the vaccinated group received three doses.Fever,maculopapular rashes,and cough were the most common manifestations.Unvaccinated children had higher rate of developing complications(pneumonia and diarrhea with P values 0.001 and 0.01 respectively),longer hospital admission period(P value=0.008),and the need for respiratory care unit(RCU)admission comparing with the vaccinated children(4 cases for unvaccinated group vs 1 case for vaccinated group).CONCLUSION Unvaccinated kids were associated with more complications,longer admission hospital stays,and RCU admission.We recommend that public health directors utilize artificial intelligence tools to help control future measles epidemics.
文摘Introduction: Vaccination faces several obstacles in the fight against COVID-19, yet it has been identified as one of the most effective means of preventing new epidemics of COVID-19. The aim was to contribute to improving vaccination coverage against COVID-19 in the Kindu health zone. Method: We conducted a cross-sectional descriptive study with an analytical focus, using a questionnaire that enabled us to carry out a survey from October 03 to 30, 2022. Our target study population was residents of the Kindu health zone. A total of 420 subjects participated in our study, including 42 per site. Results: The study revealed a low proportion of vaccinated subjects (38.3%) and a high proportion of non-vaccinated subjects (61.70%). Non-belief in the efficacy of vaccines (p = 0.001), infodemia (p = 0.001) and respect for ethnic norms (p = 0.001) were identified as perceived barriers to vaccination. Fear of being branded with the “666” beast badge (p = 0.004) as the perceived severity. Respondents’ perceptions of mass vaccination against COVID-19 are mixed, and their opinions and expectations of COVID-19 vaccination in the town of Kindu are divided. Conclusion: In order to increase the proportion of people vaccinated against COVID-19, it is suggested here to increase the population’s ability to detect false information through a well-structured communication and health education program.
基金Project supported by the National Natural Science Foundation of China (Grant No. 72174121)the Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning, and the Soft Science Research Project of Shanghai (Grant No. 22692112600)。
文摘Information plays a crucial role in guiding behavioral decisions during public health emergencies. Individuals communicate to acquire relevant knowledge about an epidemic, which influences their decisions to adopt protective measures.However, whether to disseminate specific information is also a behavioral decision. In light of this understanding, we develop a coupled information–vaccination–epidemic model to depict these co-evolutionary dynamics in a three-layer network. Negative information dissemination and vaccination are treated as separate decision-making processes. We then examine the combined effects of herd and risk motives on information dissemination and vaccination decisions through the lens of game theory. The microscopic Markov chain approach(MMCA) is used to describe the dynamic process and to derive the epidemic threshold. Simulation results indicate that increasing the cost of negative information dissemination and providing timely clarification can effectively control the epidemic. Furthermore, a phenomenon of diminishing marginal utility is observed as the cost of dissemination increases, suggesting that authorities do not need to overinvest in suppressing negative information. Conversely, reducing the cost of vaccination and increasing vaccine efficacy emerge as more effective strategies for outbreak control. In addition, we find that the scale of the epidemic is greater when the herd motive dominates behavioral decision-making. In conclusion, this study provides a new perspective for understanding the complexity of epidemic spreading by starting with the construction of different behavioral decisions.
基金Supported by the 2024 Yiwu City Research Plan Project,No.24-3-102.
文摘BACKGROUND Rabies is a zoonotic viral disease affecting the central nervous system,caused by the rabies virus,with a case-fatality rate of 100%once symptoms appear.AIM To analyze high-risk factors associated with mental disorders induced by rabies vaccination and to construct a risk prediction model to inform strategies for improving patients’mental health.METHODS Patients who received rabies vaccinations at the Department of Infusion Yiwu Central Hospital between August 2024 and July 2025 were included,totaling 384 cases.Data were collected from medical records and included demographic characteristics(age,gender,occupation),lifestyle habits,and details regarding vaccine type,dosage,and injection site.The incidence of psychiatric disorders following vaccination was assessed using standardized anxiety and depression rating scales.Patients were categorized into two groups based on the presence or absence of anxiety and depression symptoms:The psychiatric disorder group and the non-psychiatric disorder group.Differences between the two groups were compared,and high-risk factors were identified using multivariate logistic regression analysis.A predictive model was then developed based on these factors to evaluate its predictive performance.RESULTS Among the 384 patients who received rabies vaccinations,36 cases(9.38%)were diagnosed with anxiety,52 cases(13.54%)with depression,and 88 cases(22.92%)with either condition.Logistic regression analysis identified the following signi ficant risk factors for psychiatric disorders:Education level of primary school or below,exposure site at the head and neck,exposure classified as grade III,family status of divorced/widowed/unmarried/living alone,number of wounds greater than one,and low awareness of rabies prevention and control(P<0.05).The risk prediction model demonstrated good performance,with an area under the receiver operating characteristic curve of 0.859,a specificity of 74.42%,and a sensitivity of 93.02%.CONCLUSION In real-world settings,psychiatric disorders following rabies vaccination are relatively common and are associated with factors such as lower education level,higher exposure severity,vulnerable family status,and limited awareness of rabies prevention and control.The developed risk prediction model may aid in early identification of high-risk individuals and support timely clinical intervention.
基金supported by the Basic Science Research Program through the National Research Foundation of Korea,funded by the Ministry of Education(RS-2024-00460379).
文摘Objective Despite the global decrease in influenza infections during the coronavirus disease 2019(COVID-19)pandemic,seasonal influenza remains a significant health issue.South Korea,known for its robust pandemic response and high influenza vaccination rates,offers a unique context for examining changes in vaccination trends during the pandemic.Using nationally representative data,we aimed to understand the impact of the pandemic on influenza vaccination behavior over a 12-year period and to identify vulnerable groups.Methods We analyzed influenza vaccination rates in South Korea between 2011-2022,focusing on pandemic-related impacts.The data of 2,426,139 adults(≥19 years)from the Korea Community Health Survey were used to assess demographic and sociological factors influencing vaccination behaviors.Results We observed an increase in influenza vaccination rates during the pre-COVID-19 period from 2011-2013(weighted prevalence:46.68%[95%confidence interval(CI):46.55-46.82])to 2017-2019(weighted prevalence:52.50%[95%CI:52.38-52.63]).However,a significant decline was observed in 2022,the late-COVID-19 pandemic period(weighted prevalence:55.78%[95%CI:55.56-56.01]),compared with the mid-pandemic period in 2021(weighted prevalence:59.12%[95%CI:58.91-59.32]),particularly among populations traditionally prioritized for influenza vaccination,including older adults(≥65 years)and patients with chronic diseases and low educational and income levels.Conclusion The influenza vaccination rate in South Korea was significantly affected by the COVID-19 pandemic,showing a notable decrease among vulnerable demographic groups.This suggests the need for targeted public health strategies to address vaccine hesitancy and improve vaccination rates,particularly among high-risk populations.
文摘The study aims to investigate county-level variations of the COVID-19 disease and vaccination rate. The COVID-19 data was acquired from usafact.org, and the vaccination records were acquired from the Ohio vaccination tracker dashboard. GIS-based exploratory analysis was conducted to select four variables (poverty, black race, population density, and vaccination) to explain COVID-19 occurrence during the study period. Consequently, spatial statistical techniques such as Moran’s I, Hot Spot Analysis, Spatial Lag Model (SLM), and Spatial Error Model (SEM) were used to explain the COVID-19 occurrence and vaccination rate across the 88 counties in Ohio. The result of the Local Moran’s I analysis reveals that the epicenters of COVID-19 and vaccination followed the same patterns. Indeed, counties like Summit, Franklin, Fairfield, Hamilton, and Medina were categorized as epicenters for both COVID-19 occurrence and vaccination rate. The SEM seems to be the best model for both COVID-19 and vaccination rates, with R2 values of 0.68 and 0.70, respectively. The GWR analysis proves to be better than Ordinary Least Squares (OLS), and the distribution of R2 in the GWR is uneven throughout the study area for both COVID-19 cases and vaccinations. Some counties have a high R2 of up to 0.70 for both COVID-19 cases and vaccinations. The outcomes of the regression analyses show that the SEM models can explain 68% - 70% of COVID-19 cases and vaccination across the entire counties within the study period. COVID-19 cases and vaccination rates exhibited significant positive associations with black race and poverty throughout the study area.
文摘Peste des petits ruminants virus (PPRV) antibodies were studied in Sudanese sheep and goats (n = 855) before and after vaccination with a locally produced Nigeria 75/1 vaccine using a commercial competitive ELISA (cELISA) kit. Animals were kept healthy under field conditions, in four states: Blue Nile (n = 250), North Kordofan (n = 189), South Darfur (n = 225) and the Northern State (n = 191). Before vaccination, the overall sero-prevalence of PPRV antibodies was 54.6% (53.2% - 56%, 95% CI);high (64.8% - 76.4%, 95% CI) in Blue Nile State, medium (50.5% - 61.9%, 95% CI) in North Kordofan State and South Darfur State and low (28.6% - 35.2% 95%, CI) in Northern State. In high-risk areas (high sero-prevalence), Blue Nile (70.4%) and North Kordofan (57.7%), middle age groups (7 - 12 and 13 - 18 months) were identified as high-risk age. Middle age groups showed lower sero-prevalence than preceding (3 - 6 months) and subsequent (>18 months) age groups while the risk of exposure increased with age. Current and previous findings suggested a transmission pathway of PPRV involving the South Eastern border (Blue Nile) and neighbouring Central Sudan to North Kordofan. One month after vaccination 88.4% (343/388) of sero-negative animals were sero-converted suggesting the efficacy of the locally produced Nigeria 75/1 vaccine. Even if only individuals in the high-risk age group (7 - 18 months) were vaccinated, the overall population immunity (OPI) in high-risk areas (the Blue Nile and North Kordofan) would have surpassed the threshold of 70%, which is indicated for blocking PPRV transmission. However, lower vaccination coverage is expected in wider vaccination programmes. These findings primarily justified the targeting of PPR control in Sudan through the vaccination of high-risk age groups in high-risk areas.
基金supported by the Fundamental Research Funds for the Central Universities(No.3122025090)。
文摘In this paper,based on the SVIQR model we develop a stochastic epidemic model with multiple vaccinations and time delay.Firstly,we prove the existence and uniqueness of the global positive solution of the model,and construct suitable functions to obtain sufficient conditions for disease extinction.Secondly,in order to effectively control the spread of the disease,appropriate control strategies are formulated by using optimal control theory.Finally,the results are verified by numerical simulation.
文摘Unheralded cardiac arrest among previously healthy young people without antecedent illness,months or years after coronavirus disease 2019(COVID-19)vaccination,highlights the urgent need for risk stratification.The most likely underlying pathophysiology is subclinical myopericarditis and reentrant ventri-cular tachycardia or spontaneous ventricular fibrillation that is commonly preci-pitated after a surge in catecholamines during exercise or the waking hours of terminal sleep.Small patches of inflammation and/or edema can be missed on cardiac imaging and autopsy,and the heart can appear grossly normal.This paper reviews evidence linking COVID-19 vaccines to cardiac arrest where unfortu-nately the majority of victims have had no antecedent clinical evaluation.We propose a comprehensive strategy for evaluating cardiovascular risk post-vaccination,incorporating detailed patient history,antibody testing,and cardiac diagnostics in the best attempt to detect abnormalities before sudden cardiac death.This approach aims to identify individuals at higher risk of cardiac events after COVID-19 vaccination and guide appropriate clinical management.It is prudent for each primary care physician to have a pre-established plan when addressing this issue in their practice.
基金Supported by New Era Vocational School famous teachers and Principals Training Program of Hubei ProvinceAction Plan for Science and Technology Support in Rural Revitalization of Higher Education Institutions of Department of Education of Hubei Province(BXLBX1376)Horizontal Project of Animal Epidemic Diagnosis Technology Research and Product Development.
文摘[Objectives]This study was conducted to evaluate the practical efficacy of Haemophilus parasuis(Hps)vaccines and determine whether the continuous use of vaccines leads to changes in Hps serotypes.[Methods]A swine production group that had used a bivalent vaccine of Hps serotypes 4 and 5 for two consecutive years were investigated and retrospectively analyzed.Data on Hps detection rate,nursery production and disease indexes,as well as serotype shifts after continuous vaccination,were collected to assess vaccine effectiveness.[Results]Continuous vaccination reduced the total nursery culling and mortality rate by 1.75%.Hps infection persisted in the farms,and the pathogen could still be isolated.However,serotyping revealed a significant shift in the dominant prevalent serotypes,indicating that the vaccine was indeed effective.[Conclusions]The matched Hps vaccine demonstrated effective results.However,whether replacing serotypes or adding more prevalent serotypes could further improve the control of Hps disease requires further investigation.
