In a view of viral infections emerging and reemerging worldwide,a development of unconventional virus disinfection methods is of great importance.Light in the deep ultraviolet range(UVC)is widely used for germs disinf...In a view of viral infections emerging and reemerging worldwide,a development of unconventional virus disinfection methods is of great importance.Light in the deep ultraviolet range(UVC)is widely used for germs disinfection,which is mostly associated with a photoinduced damage of nucleic acids.Praseodymium(Ⅲ)-doped silicate materials emitting upconversion(UC)luminescence in UVC range under visible(VIS)excitation have been recently reported,revealing antiviral and antibacterial activities.In this work,we report synthesis of a series of Pr^(3+)-doped fluoride(NaYF_(4)and LiYF_(4))nanoparticles(NPs)and microcrystals(MCs)using wet chemistry techniques.The synthesized NPs and MCs are different in size,internal structure,doping composition and manifest UC photoluminescence(PL)in UVC range(at~255-275nm)under VIS excitation.Based on the results of PL spectroscopy and the essay on UVC UC PL-induced DNA degradation,the most promising LiYF_(4)and NaYF_(4)NPs and MCs were selected and their antiviral efficacy was evaluated toward two types of human viruses:(Ⅰ)theenveloped virus—herpes simplex virus,HSV-1,and(Ⅱ)the naked virus—adenovirus type 5,HAdV-C5.The experiments on photoactivated disinfection revealed a great potential of Pr^(3+)-doped fluoride NPs and MCs for inactivation of human viruses.Under laser exposure,all tested materials showed a high virucidal efficacy,especially against HAdV-C5 adenovirus:the adenovirus inactivation capacity by the NPs and MCs was shown to be up to≥99.99%.The presented proof-of-concept studies open new perspectives for nano-and micro-sized fluoride materials,paving the way to the design and development of light-activated self-disinfecting surfaces and fabrics with sterilizing properties.展开更多
There has been some extensive research investigating the effect of Far Ultraviolet Radiation (UVC) on SARS and MARS. However, to the best of our knowledge, there have not been any detailed experiments looking at the e...There has been some extensive research investigating the effect of Far Ultraviolet Radiation (UVC) on SARS and MARS. However, to the best of our knowledge, there have not been any detailed experiments looking at the effect of UVC on COVID-19 (now is called SARS-CoV2). Many researchers in this field believe that UVC destroys SARS-CoV2 because it warps the genetic material of the virus hurdling the viral particles from reproduction. In this paper, we report the result of our novel experiments on the effect of UVC on SARS-CoV2 using a commercially available UVC source, i.e. Krypton Disinfection lighting CM15W12V Series (wavelength of 222 nm), which is sold and marketed for the disinfection of pathogens. The experiments were extended to study the effect of UVC exposure to Bacteria and Fungus. Our experiments show that UVC has no effects on SARS-CoV2 when it is close to the SARS-CoV2 culture plate (4 - 5 cm) or at a distance (2.0 to 2.9 m), i.e. when fixed at the ceiling. This observation is important as the public seems to have the impression that commercial UVC ceiling light can kill SARS-CoV2 while this study has proven the opposite. Moreover, it shows no effect even when the UVC ceiling light is radiating on SARS-CoV2 for overnight. This proves that the intensity of the UVC from these devices is relatively low. However, the UVC light is found to be effective in destroying Bacteria and Fungus (part of pathogens), substantially, in 30 sec, and completely kills them when it’s at 2.9 m (or less) away from them and exposure for one day. This indicates that the UVC light is effective for bacteria disinfection.展开更多
基金financially supported by the National Science Centre of Poland(NCN)under SHENG I research grant(UMO-2018/30/Q/ST5/00634)supported in part by the National Natural Science Foundation of China(grant62361136586)
文摘In a view of viral infections emerging and reemerging worldwide,a development of unconventional virus disinfection methods is of great importance.Light in the deep ultraviolet range(UVC)is widely used for germs disinfection,which is mostly associated with a photoinduced damage of nucleic acids.Praseodymium(Ⅲ)-doped silicate materials emitting upconversion(UC)luminescence in UVC range under visible(VIS)excitation have been recently reported,revealing antiviral and antibacterial activities.In this work,we report synthesis of a series of Pr^(3+)-doped fluoride(NaYF_(4)and LiYF_(4))nanoparticles(NPs)and microcrystals(MCs)using wet chemistry techniques.The synthesized NPs and MCs are different in size,internal structure,doping composition and manifest UC photoluminescence(PL)in UVC range(at~255-275nm)under VIS excitation.Based on the results of PL spectroscopy and the essay on UVC UC PL-induced DNA degradation,the most promising LiYF_(4)and NaYF_(4)NPs and MCs were selected and their antiviral efficacy was evaluated toward two types of human viruses:(Ⅰ)theenveloped virus—herpes simplex virus,HSV-1,and(Ⅱ)the naked virus—adenovirus type 5,HAdV-C5.The experiments on photoactivated disinfection revealed a great potential of Pr^(3+)-doped fluoride NPs and MCs for inactivation of human viruses.Under laser exposure,all tested materials showed a high virucidal efficacy,especially against HAdV-C5 adenovirus:the adenovirus inactivation capacity by the NPs and MCs was shown to be up to≥99.99%.The presented proof-of-concept studies open new perspectives for nano-and micro-sized fluoride materials,paving the way to the design and development of light-activated self-disinfecting surfaces and fabrics with sterilizing properties.
文摘There has been some extensive research investigating the effect of Far Ultraviolet Radiation (UVC) on SARS and MARS. However, to the best of our knowledge, there have not been any detailed experiments looking at the effect of UVC on COVID-19 (now is called SARS-CoV2). Many researchers in this field believe that UVC destroys SARS-CoV2 because it warps the genetic material of the virus hurdling the viral particles from reproduction. In this paper, we report the result of our novel experiments on the effect of UVC on SARS-CoV2 using a commercially available UVC source, i.e. Krypton Disinfection lighting CM15W12V Series (wavelength of 222 nm), which is sold and marketed for the disinfection of pathogens. The experiments were extended to study the effect of UVC exposure to Bacteria and Fungus. Our experiments show that UVC has no effects on SARS-CoV2 when it is close to the SARS-CoV2 culture plate (4 - 5 cm) or at a distance (2.0 to 2.9 m), i.e. when fixed at the ceiling. This observation is important as the public seems to have the impression that commercial UVC ceiling light can kill SARS-CoV2 while this study has proven the opposite. Moreover, it shows no effect even when the UVC ceiling light is radiating on SARS-CoV2 for overnight. This proves that the intensity of the UVC from these devices is relatively low. However, the UVC light is found to be effective in destroying Bacteria and Fungus (part of pathogens), substantially, in 30 sec, and completely kills them when it’s at 2.9 m (or less) away from them and exposure for one day. This indicates that the UVC light is effective for bacteria disinfection.
