The plant cell wall serves as a barrier in defense against pathogen invasion.However,the specific contribution of cell walls in vascular tissues to plant immunity remains largely unexplored.In this study,we demonstrat...The plant cell wall serves as a barrier in defense against pathogen invasion.However,the specific contribution of cell walls in vascular tissues to plant immunity remains largely unexplored.In this study,we demonstrate that OsCSLC3,a member of the rice cellulose synthase-like(CSL)gene family,is predominantly expressed in vascular tissues and that its overexpression promotes hemicellulose biosynthesis.This enhancement of hemicellulose accumulation is associated with improved disease resistance.Targeted editing of conserved cis-regulatory elements in the OsCSLC35′untranslated region(UTR)showed that deletion of the specific fragment(−575 to−824 bp)elevated OsCSLC3 transcript levels,promoted hemicellulose accumulation,enhanced disease resistance,and improved agronomic traits.Our findings highlight a previously underappreciated role for hemicellulose in plant immunity and demonstrate that precise 5′UTR editing is a promising strategy for improving disease resistance and agronomic traits.展开更多
2025年9月26日,北京大学药学院天然药物及仿生药物全国重点实验室汤新景教授团队联合王静博士在国际学术期刊Journal of Medicinal Chemistry发表了题为“Efficient Silencing of Androgen Receptor Gene via UTR-TargetingsiRNAs for A...2025年9月26日,北京大学药学院天然药物及仿生药物全国重点实验室汤新景教授团队联合王静博士在国际学术期刊Journal of Medicinal Chemistry发表了题为“Efficient Silencing of Androgen Receptor Gene via UTR-TargetingsiRNAs for Androgenetic Alopecia Therapy”的研究论文。该研究首次证实靶向雄激素受体基因非编码区的siRNA在雄激素性脱发治疗中的优势,为开发下一代脱发基因疗法提供了有力依据。展开更多
基金supported by the Major Projects in Agricultural Biological Breeding(2022ZD04002)to Xuewei ChenNational Natural Science Foundation of China(32121003 and 32425005)to Xuewei Chen+3 种基金(32172419 and 32372555)to Weitao LiCornerstone Science Foundation through the XPLORER PRIZE and New Cornerstone Investigator Program to Xuewei ChenSichuan Science and Technology Program(2023NSFSC0005)to Xuewei Chen,(2023NSFSC1996)to Weitao Li,(2023NSFSC0155)to Qingqing Hou(2024YFNH0014)to Junjie Yin.
文摘The plant cell wall serves as a barrier in defense against pathogen invasion.However,the specific contribution of cell walls in vascular tissues to plant immunity remains largely unexplored.In this study,we demonstrate that OsCSLC3,a member of the rice cellulose synthase-like(CSL)gene family,is predominantly expressed in vascular tissues and that its overexpression promotes hemicellulose biosynthesis.This enhancement of hemicellulose accumulation is associated with improved disease resistance.Targeted editing of conserved cis-regulatory elements in the OsCSLC35′untranslated region(UTR)showed that deletion of the specific fragment(−575 to−824 bp)elevated OsCSLC3 transcript levels,promoted hemicellulose accumulation,enhanced disease resistance,and improved agronomic traits.Our findings highlight a previously underappreciated role for hemicellulose in plant immunity and demonstrate that precise 5′UTR editing is a promising strategy for improving disease resistance and agronomic traits.
文摘2025年9月26日,北京大学药学院天然药物及仿生药物全国重点实验室汤新景教授团队联合王静博士在国际学术期刊Journal of Medicinal Chemistry发表了题为“Efficient Silencing of Androgen Receptor Gene via UTR-TargetingsiRNAs for Androgenetic Alopecia Therapy”的研究论文。该研究首次证实靶向雄激素受体基因非编码区的siRNA在雄激素性脱发治疗中的优势,为开发下一代脱发基因疗法提供了有力依据。
