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基于UPLC-Q-TOF-MS/MS技术的牛大力根与薯化学成分比较分析
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作者 羊青 王祝年 +5 位作者 王清隆 汤欢 张旻 冯世秀 王茂媛 顾学金 《分子植物育种》 北大核心 2026年第3期957-972,共16页
采用UPLC-Q-TOF-MS/MS技术与植物代谢组学分析方法,探索牛大力根与薯中主要成分的差异及其在不同年份的动态变化情况。综合前期研究结果、对照品和文献资料,从3个年份的牛大力根与薯中共指认了78个成分,以三萜皂苷和黄酮类为主。结合多... 采用UPLC-Q-TOF-MS/MS技术与植物代谢组学分析方法,探索牛大力根与薯中主要成分的差异及其在不同年份的动态变化情况。综合前期研究结果、对照品和文献资料,从3个年份的牛大力根与薯中共指认了78个成分,以三萜皂苷和黄酮类为主。结合多元统计分析,发现牛大力根、薯之间的化学物质组成存在共性,在不同年份内也存在显著差异,经筛选后鉴定得到24个差异成分,以三萜皂苷为主,还包括2个异黄酮和1个三萜皂苷元,其相对含量呈现复杂的升降变化。整体而言,在2年时两者之间的差异最大,随着生长年份增加,根部膨大速度减缓,差异逐渐减小。研究结果表明,牛大力根与薯不仅在形态上有明显区别,并且在生长发育阶段其内在物质会发生复杂的动态变化。经初步筛选鉴定,其根中具有代表性的成分为三萜皂苷元,薯中为三萜皂苷及异黄酮。由于牛大力既是食品又是药材,单一化学分析结果尚无法对其优劣进行判定,需要结合产量和经济价值,建立一种更加“全面”的牛大力根与薯评价体系,为后续深入研究其化学物质形成的内在调控机制提供基础。 展开更多
关键词 牛大力 根与薯 uplc-q-tof-ms/MS 化学成分 差异代谢物
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基于UPLC-Q-TOF-MS/MS的经典名方金水六君煎基准样品体内外化学成分分析
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作者 杨新跃 李慧宇 +4 位作者 娄亚琪 王星星 于桂芳 章晨峰 王振中 《中国实验方剂学杂志》 北大核心 2026年第3期166-173,共8页
目的:阐明金水六君煎基准样品的化学成分组成及其在大鼠体内的入血与组织分布特征。方法:采用超高效液相色谱-四极杆-飞行时间串联质谱法(UPLC-Q-TOF-MS/MS)分别在正、负离子模式下检测金水六君煎基准样品溶液、血浆和组织样本。结合Qua... 目的:阐明金水六君煎基准样品的化学成分组成及其在大鼠体内的入血与组织分布特征。方法:采用超高效液相色谱-四极杆-飞行时间串联质谱法(UPLC-Q-TOF-MS/MS)分别在正、负离子模式下检测金水六君煎基准样品溶液、血浆和组织样本。结合Qualitative Analysis 10.0软件与自建数据库进行一级质谱匹配,通过与对照品、数据库及参考文献的二级质谱碎片信息和保留时间等进行比对,分析推导化合物的裂解规律,实现对金水六君煎基准样品体内外化学成分的表征。结果:金水六君煎基准样品体外共分析鉴定出122个化合物,包括47个黄酮类、5个氨基酸类、13个环烯醚萜类、16个三萜皂苷类等化合物,其中42个化合物经过对照品比对确认。入血成分共鉴定出21个原型成分;不同组织共鉴定出50个原型成分,分别在心、肝、脾、肺、肾、脑、大肠、胃鉴定出13、10、7、21、11、6、14、40个原型成分;其中阿魏酸、甘草酸、川陈皮素等7个化合物在靶器官肺、肾中均有暴露。结论:该研究表明金水六君煎基准样品以黄酮类、三萜皂苷类成分为主的物质基础及其体内分布特征,可为其质量评价指标的制定提供依据,并为其药效学与药代动力学研究提供参考。 展开更多
关键词 经典名方 金水六君煎 成分分析 物质基础 超高效液相色谱-四极杆-飞行时间串联质谱法(uplc-q-tof-ms/MS)
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基于UPLC-Q-TOF-MS的婴儿脂质吸收特征研究
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作者 毕倩倩 赵媛媛 +5 位作者 张浩俊 王砚熙 叶兴旺 韦伟 刘正冬 王兴国 《中国油脂》 北大核心 2026年第3期154-160,共7页
旨在为研究婴儿的脂质吸收情况提供理论支撑,以母乳喂养和配方奶粉喂养的30 d和90 d健康足月婴儿粪便为研究对象,采用索氏提取法提取中性脂肪,采用高效液相色谱法分析其组成,并采用酸化反应分离粪便中的皂化脂肪酸,测定粪便甘油三酯(TAG... 旨在为研究婴儿的脂质吸收情况提供理论支撑,以母乳喂养和配方奶粉喂养的30 d和90 d健康足月婴儿粪便为研究对象,采用索氏提取法提取中性脂肪,采用高效液相色谱法分析其组成,并采用酸化反应分离粪便中的皂化脂肪酸,测定粪便甘油三酯(TAG)、游离脂肪酸和皂化脂肪酸含量,进一步采用超高效液相色谱-四极杆飞行时间质谱(UPLC-Q-TOF-MS)测定皂化脂肪酸组成,并对中性脂肪进行脂质组学分析。结果表明:婴儿粪便中未消化的TAG含量为3.78%~6.88%(以粪便干物质质量计),游离脂肪酸含量为15.21%~18.35%,皂化脂肪酸含量为7.64%~21.71%;母乳喂养组TAG、游离脂肪酸和皂化脂肪酸含量均低于配方奶粉喂养组,但两者均无显著差异,随着喂养时间的延长,各组分含量降低;婴儿粪便中主要的皂化脂肪酸为饱和脂肪酸,包括棕榈酸和硬脂酸等;婴儿粪便中脂类达到655种,喂养30 d和90 d婴儿粪便中含量最高的脂类均为TAG,前者含量第二高的脂类为固醇脂类(ST),而后者为磷脂酰乙醇胺;母乳喂养和配方奶粉喂养30 d婴儿粪便中差异显著的脂质有ST(28∶2)、TAG(18∶2/18∶2/18∶2)、TAG(10∶0/18∶2/17∶3)、甘油二酯(DAG)(38∶1)和DAG(52∶3)等,而喂养90 d的为ST(28∶2)、TAG(16∶2/16∶2/16∶2)和TAG(18∶1/18∶2/20∶4)等。综上,基于UPLC-Q-TOF-MS分析婴儿粪便脂质组成,可有效评估婴儿的脂质吸收状态。 展开更多
关键词 婴儿 粪便脂质 皂化脂肪酸 uplc-q-tof-ms 脂质组学 脂质吸收
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基于UPLC-Q-TOF-MS技术、网络药理学、分子对接探讨索罗西汤对细菌性肺炎的作用机制
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作者 罗俊聪 白玛卓玛 +5 位作者 叶芬 乔玉凤 李建平 吾坚 邸学 王添敏 《山东化工》 2026年第3期21-27,共7页
目的:基于UPLC-Q-TOF-MS(超高效液相色谱—飞行时间质谱联用技术)、网络药理学及分子对接探讨索罗西汤治疗细菌性肺炎的药效物质及潜在机制。方法:通过UPLC-Q-TOF-MS分析并鉴定索罗西汤的化学成分;通过网络药理学方法分析索罗西汤的活... 目的:基于UPLC-Q-TOF-MS(超高效液相色谱—飞行时间质谱联用技术)、网络药理学及分子对接探讨索罗西汤治疗细菌性肺炎的药效物质及潜在机制。方法:通过UPLC-Q-TOF-MS分析并鉴定索罗西汤的化学成分;通过网络药理学方法分析索罗西汤的活性成分、作用靶点及信号通路;采用分子对接技术分析活性成分与作用靶点的结合情况。结果:共鉴定82种化学成分,通过HERB和SwissADME数据库鉴定出13种活性成分。与BP的交集靶点109个,取degree值前十的核心靶点进行GO、KEGG富集。GO富集分析显示共有575条信号通路,其中包括酶结合、膜筏、脂多糖诱导的细胞反应等关键途径;KEGG富集分析显示共有147条信号通路,其中包括脂质与动脉粥样硬化、AGE-RAGE、TNF信号通路等关键途径。分子对接结果表明脱落酸、羟基阿魏酸等活性成分与关键靶点TNF、STAT3和AKT1均具有较好的结合能力。结论:通过UPLC-Q-TOF-MS结合网络药理学、分子对接,初步阐释了索罗西汤对细菌性肺炎的潜在通路及机制,为索罗西汤的深入开发及应用提供了理论依据。 展开更多
关键词 索罗西汤 细菌性肺炎 uplc-q-tof-ms 网络药理学 分子对接
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基于UPLC-Q-TOF-MS/MS的枳实-竹茹成分鉴定及其干预慢性胃炎的网络药理学和分子对接研究
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作者 马英华 赵宜乐 +6 位作者 秦亚彬 韩雨 解伟伟 安志华 安娜 姜锡娟 张古英 《中南药学》 2026年第3期125-134,共10页
目的探讨枳实-竹茹药对的化学成分及其干预慢性胃炎的潜在分子机制。方法采用超高效液相色谱-四极杆飞行时间串联质谱(UPLC-Q-TOF-MS/MS)技术对枳实-竹茹药对进行成分分析;利用网络药理学和分子对接预测枳实-竹茹干预慢性胃炎的作用机... 目的探讨枳实-竹茹药对的化学成分及其干预慢性胃炎的潜在分子机制。方法采用超高效液相色谱-四极杆飞行时间串联质谱(UPLC-Q-TOF-MS/MS)技术对枳实-竹茹药对进行成分分析;利用网络药理学和分子对接预测枳实-竹茹干预慢性胃炎的作用机制。结果利用SCIEX OS系统Analytics软件和化合物数据库信息共鉴定出129个化学成分,包括黄酮类成分83个、生物碱类成分6个、有机酸类成分8个、三萜类成分7个、香豆素类成分9个、核苷类成分3个、氨基酸及其衍生物5个、其他类成分8个。基于TCMSP和SwissTargetPrediction数据库对129个化学成分进行靶点预测,得药物相关靶点852个,疾病靶点255个,交集靶点72个,核心靶点6个,核心成分10个。GO富集和KEGG通路分析显示枳实-竹茹药对主要通过NF-κB信号通路、PI3K/AKT信号通路、JAK-STAT信号通路和IL-17信号通路参与慢性胃炎过程。分子对接结果则验证了核心成分与核心靶点具有较好的结合能力。结论通过UPLC-Q-TOF-MS/MS结合网络药理学和分子对接,初步探究了枳实-竹茹药对防治慢性胃炎的药效物质基础和机制,为枳实-竹茹的深入研究和新药开发提供可能性理论支持。 展开更多
关键词 枳实-竹茹药对 uplc-q-tof-ms/MS 慢性胃炎 网络药理学 分子对接
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基于UPLC-Q-TOF-MS/MS和多层次网络药理学探讨玉屏风颗粒的传统功效及其作用机制
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作者 梅晋文 郭奥奥 +4 位作者 李娟 周密思 刘松林 胡俊杰 陈新 《中国医院药学杂志》 北大核心 2026年第5期550-556,共7页
目的:通过超高效液相色谱-四级杆-飞行时间串联质谱(UPLC-Q-TOF-MS/MS)技术,结合多层次网络药理学,深入探讨玉屏风颗粒的传统功效及其作用机制。方法:采用UPLC-Q-TOF-MS/MS方法,对玉屏风颗粒的药效成分及其在大鼠各组织中的成分分布展... 目的:通过超高效液相色谱-四级杆-飞行时间串联质谱(UPLC-Q-TOF-MS/MS)技术,结合多层次网络药理学,深入探讨玉屏风颗粒的传统功效及其作用机制。方法:采用UPLC-Q-TOF-MS/MS方法,对玉屏风颗粒的药效成分及其在大鼠各组织中的成分分布展开分析。建立“组织分布-证候关联-通路调控”三维研究范式,预测玉屏风颗粒由成分作用于靶点、并靶向调控相关通路的内在机制。结果:该研究共鉴定出30种体外化学成分,其中16种成分存在于不同组织中,其潜在核心药效成分包括升麻素、芒柄花素、东莨菪素、毛蕊异黄酮、亥茅酚等,涉及NFKB1、EGFR、TNF、JUN、MAPK3等5个潜在关键靶点,可能作用于Th17细胞分化、IL-17信号通路以及PI3K-Akt信号通路。结论:该研究揭示IL-17与PI3K-Akt信号交叉对话在玉屏风颗粒免疫调节中的作用,通过系统生物学方法验证中药“异病同治”的科学基础。 展开更多
关键词 玉屏风颗粒 传统功效 uplc-q-tof-ms/MS 药效成分 信号通路
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基于UPLC-Q-TOF-MS/MS比较桂枝与炙甘草配伍前后化学成分的变化
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作者 栾飞 王鹤 +5 位作者 雷紫文 王唯翔 王智超 张小飞 邹俊波 史亚军 《天然产物研究与开发》 北大核心 2026年第2期283-293,共11页
为了探讨桂枝与炙甘草配伍前后化学成分的变化,本研究采用UPLC-Q-TOF-MS/MS技术,获得桂枝、炙甘草单煎液及其合煎液的提取离子流色谱图、质谱碎片裂解信息,根据保留时间、相对分子质量及多级碎片等信息,建立化学成分自建库,鉴定桂枝与... 为了探讨桂枝与炙甘草配伍前后化学成分的变化,本研究采用UPLC-Q-TOF-MS/MS技术,获得桂枝、炙甘草单煎液及其合煎液的提取离子流色谱图、质谱碎片裂解信息,根据保留时间、相对分子质量及多级碎片等信息,建立化学成分自建库,鉴定桂枝与炙甘草配伍前后的化学成分。在桂枝、炙甘草单煎液分别鉴定出20、24个化学成分,在桂枝-炙甘草合煎液中共鉴定出36个成分,其中独有成分占13个,包括醛类、苯丙素类、邻苯二甲酸酯类等。本研究通过UPLC-Q-TOF-MS/MS技术,初步探讨桂枝-甘草药对单、合煎前后化学成分的变化,为进一步研究其作用机制提供参考。 展开更多
关键词 uplc-q-tof-ms/MS 桂枝 炙甘草 配伍 化学成分
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基于UPLC-Q-TOF-MS/MS的滋肾健脾化瘀片化学成分定性与定量分析
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作者 杨欣荣 林俊粒 +6 位作者 谢雪晴 邱博增 郑玉莹 郭健敏 潘东风 杨威 林宝琴 《中国医院药学杂志》 北大核心 2026年第5期485-490,共6页
目的:建立滋肾健脾化瘀片化学成分的定性与定量分析方法,阐明其物质基础,为质量控制及药效物质研究提供依据。方法:采用超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF-MS/MS)技术,在电喷雾离子源正、负离子模式下检测。通过解析特征... 目的:建立滋肾健脾化瘀片化学成分的定性与定量分析方法,阐明其物质基础,为质量控制及药效物质研究提供依据。方法:采用超高效液相色谱-四极杆-飞行时间质谱(UPLC-Q-TOF-MS/MS)技术,在电喷雾离子源正、负离子模式下检测。通过解析特征碎片离子及裂解规律,辅以文献比对和对照品验证,对滋肾健脾化瘀片中化学成分结构鉴定。在此基础上,选取15种代表性成分进行同步定量分析,对6批次滋肾健脾化瘀片样品进行含量测定,分析不同生产批次间化学成分的含量差异。结果:滋肾健脾化瘀片共鉴定出185种化学成分,包括皂苷类60种、黄酮类37种、萜类24种、蒽醌类15种、环烯醚萜类12种、有机酸类11种等。定量分析显示滋肾健脾化瘀片中含量较高的化学成分为人参皂苷Rb1[(2.3943±0.3319)mg·g^(-1)]、人参皂苷Rg1[(2.2576±0.3447)mg·g^(-1)]和葛根素[(0.8173±0.1449)mg·g^(-1)]。结论:该研究全面解析了滋肾健脾化瘀片的化学组成,且测定了关键活性成分的含量,为后续研究入血成分和作用机制奠定了基础。 展开更多
关键词 滋肾健脾化瘀片 uplc-q-tof-ms/MS 定性分析 含量测定
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UPLC-Q-TOF-MS/MS法鉴定3种酚类在小鼠体内的代谢产物
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作者 赵蓉 胡蒙蒙 +3 位作者 洪玉冰 雷胜男 赵子康 车彦云 《中成药》 北大核心 2026年第1期33-41,共9页
目的建立UPLC-Q-TOF-MS/MS法鉴定没食子酸、鞣花酸、柯里拉京在小鼠体内的代谢产物。方法给药组小鼠分别灌胃给予3种成分的0.5%CMC-Na混悬液(400 mg/kg),空白组小鼠灌胃给予0.5%CMC-Na混悬液(400 mg/kg),采集血浆、尿液、粪便。分析采用... 目的建立UPLC-Q-TOF-MS/MS法鉴定没食子酸、鞣花酸、柯里拉京在小鼠体内的代谢产物。方法给药组小鼠分别灌胃给予3种成分的0.5%CMC-Na混悬液(400 mg/kg),空白组小鼠灌胃给予0.5%CMC-Na混悬液(400 mg/kg),采集血浆、尿液、粪便。分析采用Acquity UPLC HSS T3色谱柱(100 mm×2.1 mm,1.8μm);流动相水(含0.1%甲酸)-乙腈,梯度洗脱;体积流量0.27 mL/min;柱温30℃;电喷雾离子源;负离子扫描。结果共鉴定出27种没食子酸代谢产物、13种鞣花酸代谢产物、37种柯里拉京代谢产物,这3种成分主要发生水解、脱羧等Ⅰ相代谢,以及甲基化、硫酸化、葡萄糖醛酸化等Ⅱ相代谢。结论该方法稳定可靠,可为探究其他天然酚类的体内代谢规律提供参考。 展开更多
关键词 没食子酸 鞣花酸 柯里拉京 代谢产物 uplc-q-tof-ms/MS
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Screening and determination of 23 local anesthetics in cosmetics using UPLC-Q-TOF-MS and HPLC-QQQ-MS/MS
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作者 Ruotong Yang Fangyuan Wu +3 位作者 Guangqian Xu Guiwen Guo Haiyan Wang Lingyun Jia 《日用化学工业(中英文)》 北大核心 2026年第2期260-270,共11页
The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of ris... The laboratory established an efficient reversed-phase ultra-high-performance liquid chromatographyquadrupole time-of-flight mass spectrometry(UPLC-Q-TOF-MS)qualitative method for screening more than 2000 kinds of risk substances(including local anesthetics,LAs)in cosmetics,which has been successfully applied in the analysis of actual samples.This work aims to develop a more convenient high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)method for the quantitative determination of LAs.Samples were ultrasonically extracted with methanol,separated on an Agilent Poroshell 120 EC-C18 column(2.1 mm×100 mm,2.7μm),and eluted with a gradient mobile phase consisting of 0.1%formic acid aqueous solution and methanol.Quantification was performed using the external standard method.The results show that all 23 LAs are effectively separated within 12 minutes,with good linearity in the corresponding concentration ranges and the correlation coefficients all greater than 0.99.The limits of detection(LOD)range from 0.0025 to 0.05μg/g,and the limits of quantification(LOQ)range from 0.01 to 0.1μg/g.The average recoveries of the 23 LAs in 5 blank cosmetic matrices are 80.68%-117.57%,with the relative standard deviations(RSDs)less than 5.98%.This method has good precision and high accuracy,and is suitable for the determination of LAs in 5 cosmetic matrices. 展开更多
关键词 local anesthetics chemical analysis ultra-high-performance liquid chromatography-quadrupole time-offlight mass spectrometry(uplc-q-tof-ms) high performance liquid chromatography triple quadrupole mass spectrometry(HPLC-QQQ-MS/MS)
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Research on the Optimal Allocation of Community Elderly Care Service Resources Based on Big Data Technology
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作者 Shuying Li 《Journal of Clinical and Nursing Research》 2026年第1期241-246,共6页
With the accelerating aging process of China’s population,the demand for community elderly care services has shown diversified and personalized characteristics.However,problems such as insufficient total care service... With the accelerating aging process of China’s population,the demand for community elderly care services has shown diversified and personalized characteristics.However,problems such as insufficient total care service resources,uneven distribution,and prominent supply-demand contradictions have seriously affected service quality.Big data technology,with core advantages including data collection,analysis and mining,and accurate prediction,provides a new solution for the allocation of community elderly care service resources.This paper systematically studies the application value of big data technology in the allocation of community elderly care service resources from three aspects:resource allocation efficiency,service accuracy,and management intelligence.Combined with practical needs,it proposes optimal allocation strategies such as building a big data analysis platform and accurately grasping the elderly’s care needs,striving to provide operable path references for the construction of community elderly care service systems,promoting the early realization of the elderly care service goal of“adequate support and proper care for the elderly”,and boosting the high-quality development of China’s elderly care service industry. 展开更多
关键词 Big data technology COMMUNITY Elderly care Service resources
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Application and Practice of RPA Technology in FinTech Field-University-enterprise Cooperation Course Construction for Software Engineering Characteristic Talents Cultivation
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作者 Yixian Liu Jun Guo +2 位作者 Hongjuan Liu Dongming Chen Zhiliang Zhu 《计算机教育》 2026年第3期109-118,共10页
In response to the Ministry of Education’s requirements for building distinctive model software schools,Software College of Northeastern University and Shenzhen Kingdom Technology Co.,Ltd.jointly developed the specia... In response to the Ministry of Education’s requirements for building distinctive model software schools,Software College of Northeastern University and Shenzhen Kingdom Technology Co.,Ltd.jointly developed the specialized course“Application and Practice of RPA Technology in FinTech”.Addressing pain points in financial digital transformation,the course integrates robotic process automation(RPA)principles,financial domain knowledge,and RPA platform practice into a“technology-scenario-capability”trinity teaching system.Through 64 credit hours of integrated theory and practice,it covers RPA fundamentals,financial applications,RPA operations(including core skills like Web/desktop automation),and AI integration,cultivating students’ability to design and implement automated financial workflows.It innovatively features a RPA simulation platform,30+financial case studies,and modular task resources,creating a“teacher-machine-student”interactive model.Practice demonstrates the course effectively enhances students’integration of technical application and business acumen,providing a scalable paradigm for cultivating interdisciplinary FinTech talent. 展开更多
关键词 RPA technology FinTech field Characteristic talents cultivation University-enterprise cooperation Course construction
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Tracking a High-Tech Transition--How technology is powering Guangdong’s manufacturing transformation
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作者 HU FAN 《ChinAfrica》 2026年第1期30-32,共3页
The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them w... The moment a media delegation from the Republic of the Congo arrived at the Othello Kitchenware Museum on 18 November 2025,they were greeted with a vivid show of Guangdong’s industrial strength.Standing before them was not a typical exhibition hall,but a building shaped like a gleaming stainless-steel cooking pot. 展开更多
关键词 othello kitchenware museum technology industrial strength high tech transition guangdong manufacturing transformation
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Setting the standard! The technology that shapes 40% of the world's denim finishing
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《China Textile》 2026年第1期44-44,共1页
Jeanologia celebrated its 30th anniversary reaffirming the mission it was born with in 1994,to transform the textile industry into a more sustainable,efficient,and human-centered sector.Three decades later,that vision... Jeanologia celebrated its 30th anniversary reaffirming the mission it was born with in 1994,to transform the textile industry into a more sustainable,efficient,and human-centered sector.Three decades later,that vision has become a global reality.Today,more than 40 percent of all jeans produced worldwide are made using technologies developed by the Valencia-based company.What started in a small laboratory in Valencia(Spain),with a pioneering team and a visionary idea,has evolved into a global benchmark in sustainable innovation.From the beginning,Jeanologia believed in technology as a driver of change,introducing solutions that eliminated harmful practices and opened the door to a new,cleaner way of making garments. 展开更多
关键词 technological transformation environmental impact textile industry garment production DENIM jeanologia sustainability innovation
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In-situ synthesis of rare earth Y-type zeolite enhanced by high-gravity technology
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作者 Lang Xu Wenhui Hou +3 位作者 Houmei You Baochang Sun Guangwen Chu Jianfeng Chen 《Chinese Journal of Chemical Engineering》 2026年第1期240-248,共9页
Rare earth(RE)Y-type zeolite was synthesized in situ by acidic co-hydrolysis route and hydrothermal method.The key process parameters were optimized based on the RE utilization rate.The effect of inducing a rotating p... Rare earth(RE)Y-type zeolite was synthesized in situ by acidic co-hydrolysis route and hydrothermal method.The key process parameters were optimized based on the RE utilization rate.The effect of inducing a rotating packed bed(RPB)in premixing and crystallization on crystallinity and RE utilization rate was further investigated.The results indicate that lanthanide(La)cations are successfully introduced into the sodalite cage of Y-type zeolite.The optimized conditions are that the molar ratio of Si/La is 150,premixing for 5 h,crystallization at 90℃ for 18 h,and calcination at 550℃ for 3.5 h.At this stage,the RE utilization rate reaches 74.5%.Compared with the conventional stirred tank reactor(STR),RPB can effectively shorten the premixing time and crystallization time by 4.3 h and 6 h,improve the crystallinity by 23%and RE utilization rate by 7.5%.The RE utilization rate is more than 80%by RPB,surpassing the effectiveness of using the one-exchange one-calcination process in the traditional liquid ion exchange process.It is expected to provide a reference for the in-situ efficient and green synthesis of RE zeolite. 展开更多
关键词 High-gravity technology Rare earth zeolite In-situ synthesis Rare earth utilization rate
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Reform of Teacher-Machine-Student Interactive Teaching Model of“HarmonyOS Development Technology”Course Based on Congyou Platform
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作者 Yixian Liu Jun Guo +1 位作者 Dongming Chen Zhiliang Zhu 《计算机教育》 2026年第3期158-166,共9页
Aiming at the problems of lagging curriculum,weak practice,and single evaluation in the cultivation of HarmonyOS Development talents,this study constructs a“teacher-machine-student”ternary interactive teaching model... Aiming at the problems of lagging curriculum,weak practice,and single evaluation in the cultivation of HarmonyOS Development talents,this study constructs a“teacher-machine-student”ternary interactive teaching model based on the Congyou platform.Through the building block curriculum system,the HarmonyOS technology stack is decoupled into dynamic capability units,and a multi-disciplinary cross-case library is jointly built with Huawei,which significantly improves the synchronization of teaching content and industrial technology.This paper innovatively designs an AI collaborative teaching system,which employs knowledge graphs to plan learning paths,utilizes virtual equipment clusters to simulate development environments,and establishes a“diagnosis-feedback-enhancement”closed loop through AI-based review,thereby effectively improving students’development efficiency and code reuse rate.A three-dimensional evaluation model integrating task outcomes,process performance,and innovation is constructed,incorporating indicators such as code standardization and an innovation index to strengthen the cultivation of engineering thinking and innovative ability.Furthermore,a data-driven support platform is built to generate student competency profiles,open up the“credit-competency-certification”pathway,promote the transformation of course achievements into contributions to the Huawei ecosystem,and significantly shorten the job adaptation cycle for graduates.The research results provide a replicable paradigm for the cultivation of domestic operating system talents. 展开更多
关键词 Interactive teaching model HarmonyOS development technology Building-block curriculum system Domestic software ecosystem
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Chinese Rural Women's Social Media Use: An Empirical Study Adopting the Technology Acceptance Model
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作者 Zhang Hui Mahadevan Krishnan 《Contemporary Social Sciences》 2026年第1期104-122,共19页
Given the growing importance of social media in digital rural development, this study systematically investigated the influence pathways of social media use among rural women in China, drawing on the Technology Accept... Given the growing importance of social media in digital rural development, this study systematically investigated the influence pathways of social media use among rural women in China, drawing on the Technology Acceptance Model(TAM). Employing quantitative research methods, the study conducted empirical tests based on 367 valid questionnaires using Partial Least Squares Structural Equation Modeling(PLS-SEM) via SmartPLS 4.0 software. Results indicate that significant associations exist between perceived ease of use, perceived usefulness, attitudes toward use, behavioral intention, and actual usage behavior. Specifically, the study finds that rural women's perceived ease of use of social media has a significant and positive influence on both perceived usefulness and attitudes toward use. Perceived usefulness further significantly promotes attitudes toward use and behavioral intention. Moreover, positive attitudes toward usage and strong behavioral intentions were effectively converted into actual social media usage behaviors. This study not only validates the applicability and explanatory power of the TAM model in understanding the digital behavior of Chinese rural women but also provides quantitative evidence for how social media enhances their “digital visibility.” These findings offer practical insights for governments and platform providers to optimize user experiences and strengthen digital skills training. Despite its limitations, including a cross-sectional design and a regional sample, this research holds significant theoretical and practical implications. 展开更多
关键词 Chinese rural women social media technology Acceptance Model(TAM) digital visibility
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The evolution of China's green technology innovation cooperation network and the effect of carbon emission reduction
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作者 Sufan Gao Brian Fath +3 位作者 Feiyan Liang Saige Wang Zhiming Yang Xiuqian Chen 《Ecological Frontiers》 2026年第1期351-367,共17页
This study analyzes the evolution of China's green technology innovation cooperation network from 2011 to 2020,utilizing green patent application data.Employing a Spatial Durbin Model(SDM),we scrutinized the netwo... This study analyzes the evolution of China's green technology innovation cooperation network from 2011 to 2020,utilizing green patent application data.Employing a Spatial Durbin Model(SDM),we scrutinized the network's influence on urban carbon emissions,utilizing panel data encompassing 323 city nodes.Results show network expansion and a shift in central nodes from eastern coastal areas to interior cities,with Beijing,Shenzhen,Nanjing,and Shanghai consistently acting as key innovation hubs.A core-periphery structure emerged,clustering cities into high-and low-cooperation clusters.Core cities,particularly Beijing,which gain informational advantages by bridging non-overlapping nodes and exhibit distinct characteristics in terms of the structural hole indexes,reflecting their multifaceted roles within the network.SDM analysis indicates that the green technology innovation cooperation network has a significant positive impact on urban carbon reduction efforts.Specifically,degree centrality,closeness centrality,effective size,efficiency,and hierarchy of node cities exhibit a negative correlation with carbon emissions,suggesting that higher centrality and efficiency within the network correlate with lower emissions.Conversely,betweenness centrality and constraint have a positive impact on emissions,indicating that cities that act as bridges in the network may paradoxically contribute to higher emissions.Moreover,the network's influence on carbon emissions is nuanced across different green technology sectors.Cooperation in areas such as waste management,alternative energy production,energy conservation,agriculture and forestry,and transportation is found to have a more substantial impact on carbon reduction than cooperation in nuclear power,and administrative,regulatory,and design fields. 展开更多
关键词 Green technology innovation cooperation network Carbon emissions Social network analysis Spatial Durbin model
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Between Themis and Prometheus:a history of the ethics of science and technology
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作者 Jia-Yun Chen Zong-Zhen Wu +7 位作者 Qiang-Yu Xiang Lu Zhang Jia-Lin Diao Ya-Hui Zhang Shen-Shen Yan Kun-Lan Zuo Jian-Liang Huang Huan Liu 《History and Philosophy of Medicine》 2026年第1期49-59,共11页
Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide ... Background:With the rapid development of modern emerging technologies,the ethical dilemmas and social controversies triggered by scientific and technological activities have become increasingly prominent.How to guide technology for good and prevent and control technological risks has become an important issue of global concern.Research on science and technology ethics is dedicated to integrating ethical theories into governance practices and constructing ethical models that adapt to the development of the times.Methods:This article systematically reviews the six core approaches of scientific and technological ethics thought,including technological autonomy and political philosophy criticism,responsibility ethics and intergenerational obligations,technological intermediation and the integration of life and the world,ethical principles and normative frameworks,participatory governance and ethical practice innovation,as well as domain-specific ethical norms,thereby constructing an ethical analysis framework applicable to medical technology risks.And cross-analysis was conducted by taking medical events such as gene editing and xenotransplantation as examples.Results:Research shows that a single ethical approach has limitations in addressing complex medical ethical challenges,while the six approaches are complementary and synergistic.By criticizing technological autonomy,establishing a responsibility ethics orientation,setting the bottom line of ethical principles,promoting participatory governance,formulating domain norms,and continuously reflecting on the intermediary nature of technology,a multi-level and dynamically adaptive governance system for scientific and technological ethics can be constructed.Conclusion:The key to addressing contemporary medical ethics challenges lies in the comprehensive application of science and technology ethics theories and the integration of ethical considerations throughout the entire process of scientific and technological research and development.In the future,a governance framework that adapts to the development of new technologies should be established to promote cross-cultural and cross-disciplinary ethical dialogue and public participation,ensuring that scientific and technological innovation always serves the dignity of human life and overall well-being. 展开更多
关键词 ethics of science and technology history of science ethical governance responsible innovation medical ethics
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Teaching Reform of Chinese Medicine Processing Technology Course under the Integration of Technical and Higher Vocational Education
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作者 Lianfang LI 《Medicinal Plant》 2026年第1期72-77,82,共7页
Against the backdrop of integrated development between technical education and higher vocational education,the teaching of Chinese Medicine Processing Technology courses faces new opportunities and challenges.This pap... Against the backdrop of integrated development between technical education and higher vocational education,the teaching of Chinese Medicine Processing Technology courses faces new opportunities and challenges.This paper analyzes the existing problems in the current teaching of Chinese Medicine Processing Technology courses,discusses the necessity of reforming the teaching model under the context of integration,and proposes the construction of a"Dual-Capability Progression,Six-Dimensional Empowerment"teaching model.The aim is to enhance the teaching quality of Chinese Medicine Processing Technology courses and cultivate high-quality skilled talents in Chinese medicine processing who can meet industry demands. 展开更多
关键词 Technical education Higher vocational education Integrated development Chinese Medicine Processing technology Course Teaching reform
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