The method to enhance the precis io n of a grey model GM (1, 1) for predicting the development of vibration severity of a pump is investigated. The rectifying procedures involve the structure and the parameters rega...The method to enhance the precis io n of a grey model GM (1, 1) for predicting the development of vibration severity of a pump is investigated. The rectifying procedures involve the structure and the parameters regarding GM(1,1). A new model based on GM(1, 1), which is GM (E,1,1), is proposed. In GM(E,1,1), the distribution of relative errors rati os between the original series and predicting series obtained by the mean of GM( 1,1) are considered in special points to set up the threshold and adjusting coef ficients to control the modified action and the rectified amount based on distri bution of the original series. The case shows that GM(E, 1, 1) is good at predic ting the vibration severity development of the pump.展开更多
Polyoxin is a group of structurally-related peptidyl nucleoside antibiotics bearing C-5 modifications on the nucleoside skeleton. Although the structural diversity and bioactivity preference of polyoxin are, to some e...Polyoxin is a group of structurally-related peptidyl nucleoside antibiotics bearing C-5 modifications on the nucleoside skeleton. Although the structural diversity and bioactivity preference of polyoxin are, to some extent, affected by such modifications, the biosynthetic logic for their occurence remains obscure. Here we report the identification of PolB in polyoxin pathway as an unusual UMP C-5 methylase with thymidylate syn- thase activity which is responsible for the C-5 methyla- tion of the nucleoside skeleton. To probe its molecular mechanism, we determined the crystal structures of PolB alone and in complexes with 5-Br UMP and 5-Br dUMP at 2.15 A, 1.76 A and 2.28 A resolutions, respec- tively. Loop 1 （residues 117-131）, Loop 2 （residues 192- 201） and the substrate recognition peptide （residues 94- 102） of PolB exhibit considerable conformational flexi-bility and adopt distinct structures upon binding to different substrate analogs. Consistent with the structural findings, a PolB homolog that harbors an identical function from Streptomyces viridochromogenes DSM 40736 was identified. The discovery of UMP C5-methy-lase opens the way to rational pathway engineering for polyoxin component optimization, and will also enrich the toolbox for natural nucleotide chemistry.展开更多
In this paper the problem of testing the one sided hypothesis in the exponential family against θ>θ is considered. By using stopping time, it is pointed out that under certain condition, the resulting test depend...In this paper the problem of testing the one sided hypothesis in the exponential family against θ>θ is considered. By using stopping time, it is pointed out that under certain condition, the resulting test depending on the incomplete data is proved to be equivalent to the UMP test which depends on the full time spans of the instruments. Finally, the optimal stopping time, which generates the UMP test with level α and has the minimum total experiment time as well. is obtained.展开更多
利用Argo网格化数据分析日本以南小范围海区内的温跃层时空特征,其主跃层和季节性跃层的双跃层结构明显。依此利用UMPE(University of Miami Parabolic Equation)抛物方程模型分析与仿真深海温跃层及其季节变化对水声场的影响。分析发现...利用Argo网格化数据分析日本以南小范围海区内的温跃层时空特征,其主跃层和季节性跃层的双跃层结构明显。依此利用UMPE(University of Miami Parabolic Equation)抛物方程模型分析与仿真深海温跃层及其季节变化对水声场的影响。分析发现:相似系数为1的两个声速剖面的传播损失几乎完全相同;夏季声源较浅时,会在以声源为中心小直径圆形区域内形成声影区;声源深度相对于跃层越大,跃层对水声场的影响越小;高频较低频受跃层影响更大。展开更多
海洋水声环境时空变化显著,评估其对主动声纳探测效能的影响具有重要的理论意义和应用价值。提出HMG方法用以评估水声环境效应对主动声纳探测的影响。采用UMPE(The university of miami parabolic equation)、CANARY、JACKSON模型模拟...海洋水声环境时空变化显著,评估其对主动声纳探测效能的影响具有重要的理论意义和应用价值。提出HMG方法用以评估水声环境效应对主动声纳探测的影响。采用UMPE(The university of miami parabolic equation)、CANARY、JACKSON模型模拟特定海洋环境下的传播损失、环境噪声、混响分布,将模拟结果融入主动声纳检测概率模型,计算检测概率。评估结果发现近场检测概率较高,远场可检测的区域与声能汇聚区一致。展开更多
文摘The method to enhance the precis io n of a grey model GM (1, 1) for predicting the development of vibration severity of a pump is investigated. The rectifying procedures involve the structure and the parameters regarding GM(1,1). A new model based on GM(1, 1), which is GM (E,1,1), is proposed. In GM(E,1,1), the distribution of relative errors rati os between the original series and predicting series obtained by the mean of GM( 1,1) are considered in special points to set up the threshold and adjusting coef ficients to control the modified action and the rectified amount based on distri bution of the original series. The case shows that GM(E, 1, 1) is good at predic ting the vibration severity development of the pump.
文摘Polyoxin is a group of structurally-related peptidyl nucleoside antibiotics bearing C-5 modifications on the nucleoside skeleton. Although the structural diversity and bioactivity preference of polyoxin are, to some extent, affected by such modifications, the biosynthetic logic for their occurence remains obscure. Here we report the identification of PolB in polyoxin pathway as an unusual UMP C-5 methylase with thymidylate syn- thase activity which is responsible for the C-5 methyla- tion of the nucleoside skeleton. To probe its molecular mechanism, we determined the crystal structures of PolB alone and in complexes with 5-Br UMP and 5-Br dUMP at 2.15 A, 1.76 A and 2.28 A resolutions, respec- tively. Loop 1 （residues 117-131）, Loop 2 （residues 192- 201） and the substrate recognition peptide （residues 94- 102） of PolB exhibit considerable conformational flexi-bility and adopt distinct structures upon binding to different substrate analogs. Consistent with the structural findings, a PolB homolog that harbors an identical function from Streptomyces viridochromogenes DSM 40736 was identified. The discovery of UMP C5-methy-lase opens the way to rational pathway engineering for polyoxin component optimization, and will also enrich the toolbox for natural nucleotide chemistry.
文摘In this paper the problem of testing the one sided hypothesis in the exponential family against θ>θ is considered. By using stopping time, it is pointed out that under certain condition, the resulting test depending on the incomplete data is proved to be equivalent to the UMP test which depends on the full time spans of the instruments. Finally, the optimal stopping time, which generates the UMP test with level α and has the minimum total experiment time as well. is obtained.
文摘利用Argo网格化数据分析日本以南小范围海区内的温跃层时空特征,其主跃层和季节性跃层的双跃层结构明显。依此利用UMPE(University of Miami Parabolic Equation)抛物方程模型分析与仿真深海温跃层及其季节变化对水声场的影响。分析发现:相似系数为1的两个声速剖面的传播损失几乎完全相同;夏季声源较浅时,会在以声源为中心小直径圆形区域内形成声影区;声源深度相对于跃层越大,跃层对水声场的影响越小;高频较低频受跃层影响更大。
文摘海洋水声环境时空变化显著,评估其对主动声纳探测效能的影响具有重要的理论意义和应用价值。提出HMG方法用以评估水声环境效应对主动声纳探测的影响。采用UMPE(The university of miami parabolic equation)、CANARY、JACKSON模型模拟特定海洋环境下的传播损失、环境噪声、混响分布,将模拟结果融入主动声纳检测概率模型,计算检测概率。评估结果发现近场检测概率较高,远场可检测的区域与声能汇聚区一致。
