胃癌在世界范围内直接影响着人类的生活质量,癌胚抗原相关细胞粘附分子(CEACAM)亚家族的一些成员在肿瘤中不受调控。对于CEACAM8在胃癌中的功能知之甚少。为了解决这一问题,本研究使用UALCAN、Kaplan-Meier Plotter、metascape数据库研...胃癌在世界范围内直接影响着人类的生活质量,癌胚抗原相关细胞粘附分子(CEACAM)亚家族的一些成员在肿瘤中不受调控。对于CEACAM8在胃癌中的功能知之甚少。为了解决这一问题,本研究使用UALCAN、Kaplan-Meier Plotter、metascape数据库研究了CEACAM8在胃癌预后中的作用。发现CEACAM8的过表达与胃癌患者的临床肿瘤分期和病理肿瘤分级显著相关。此外,CEACAM8 mRNA的高表达与胃癌患者较短的总生存期(OS)显著相关。总的来说,CEACAM8可能是胃癌患者生存的预后生物标志物。Gastric cancer directly affects human quality of life worldwide, and some members of the carcinoembryonic antigen-associated cell adhesion molecule (CEACAM) subfamily are not regulated in tumors. Little is known about the function of CEACAM8 in gastric cancer. In order to solve this problem, this study used UALCAN, Kaplan-Meier Plotter and metascape databases to study the role of CEACAM8 in the prognosis of gastric cancer. It was found that the overexpression of CEACAM8 was significantly correlated with the clinical tumor stage and pathological tumor grade of gastric cancer patients. In addition, high expression of CEACAM8 mRNA was significantly associated with shorter overall survival (OS) in patients with gastric cancer. Overall, CEACAM8 may be a prognostic biomarker for survival in patients with gastric cancer.展开更多
Background:Head and neck squamous cancer(HNSC)frequently occurs in the clinic.Revealing the role of the genes that correlate with cancer cell outgrowth will contribute to potential treatment target identification and ...Background:Head and neck squamous cancer(HNSC)frequently occurs in the clinic.Revealing the role of the genes that correlate with cancer cell outgrowth will contribute to potential treatment target identification and tumor inhibition.Methods:The gene expression profiles and gene ontology of the proton-sensing G-protein-coupled receptor OGR1 were analyzed using the TCGA(The Cancer Genome Atlas)database.The effects of sex,age,race,and degree of malignancy on HNSC were investigated,and the survival times of HNSC patients with high or low/medium expression levels of OGR1 were compared.Methylation of the OGR1 promoter CpG sites was also investigated and OGR1-related genes were analyzed using gene set enrichment analysis.Results:OGR1 is overexpressed in HNSC patients.However,compared with the low/median expression group,the high OGR1 expression group did not have different survival rates.The OGR1 expression level differed across sex,age,race,and degree of malignancy,while the methylation of the OGR1 promoter CpG sites was maintained at a similar level.Gene set enrichment analysis revealed that OGR1 was positively correlated with head and neck cancer,cisplatin resistance,hypoxia,angiogenesis,cell migration,and TGF-β.Conclusion:The expression of OGR1 correlated with HNSC progression and survival and thus can serve as a potential treatment target and prognostic marker.展开更多
文摘胃癌在世界范围内直接影响着人类的生活质量,癌胚抗原相关细胞粘附分子(CEACAM)亚家族的一些成员在肿瘤中不受调控。对于CEACAM8在胃癌中的功能知之甚少。为了解决这一问题,本研究使用UALCAN、Kaplan-Meier Plotter、metascape数据库研究了CEACAM8在胃癌预后中的作用。发现CEACAM8的过表达与胃癌患者的临床肿瘤分期和病理肿瘤分级显著相关。此外,CEACAM8 mRNA的高表达与胃癌患者较短的总生存期(OS)显著相关。总的来说,CEACAM8可能是胃癌患者生存的预后生物标志物。Gastric cancer directly affects human quality of life worldwide, and some members of the carcinoembryonic antigen-associated cell adhesion molecule (CEACAM) subfamily are not regulated in tumors. Little is known about the function of CEACAM8 in gastric cancer. In order to solve this problem, this study used UALCAN, Kaplan-Meier Plotter and metascape databases to study the role of CEACAM8 in the prognosis of gastric cancer. It was found that the overexpression of CEACAM8 was significantly correlated with the clinical tumor stage and pathological tumor grade of gastric cancer patients. In addition, high expression of CEACAM8 mRNA was significantly associated with shorter overall survival (OS) in patients with gastric cancer. Overall, CEACAM8 may be a prognostic biomarker for survival in patients with gastric cancer.
基金This work was supported by grants from the National Natural Science Foundation of China(no.81372253)Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences(2016-I2M-3-019).
文摘Background:Head and neck squamous cancer(HNSC)frequently occurs in the clinic.Revealing the role of the genes that correlate with cancer cell outgrowth will contribute to potential treatment target identification and tumor inhibition.Methods:The gene expression profiles and gene ontology of the proton-sensing G-protein-coupled receptor OGR1 were analyzed using the TCGA(The Cancer Genome Atlas)database.The effects of sex,age,race,and degree of malignancy on HNSC were investigated,and the survival times of HNSC patients with high or low/medium expression levels of OGR1 were compared.Methylation of the OGR1 promoter CpG sites was also investigated and OGR1-related genes were analyzed using gene set enrichment analysis.Results:OGR1 is overexpressed in HNSC patients.However,compared with the low/median expression group,the high OGR1 expression group did not have different survival rates.The OGR1 expression level differed across sex,age,race,and degree of malignancy,while the methylation of the OGR1 promoter CpG sites was maintained at a similar level.Gene set enrichment analysis revealed that OGR1 was positively correlated with head and neck cancer,cisplatin resistance,hypoxia,angiogenesis,cell migration,and TGF-β.Conclusion:The expression of OGR1 correlated with HNSC progression and survival and thus can serve as a potential treatment target and prognostic marker.
