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CLIC3在胰腺癌中的表达及预后相关性的生物信息学分析

Bioinformatics analysis of the association between CLIC3 expression and prognosis in pancreatic adenocarcinoma(PAAD)
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摘要 目的:通过GEPIA和Ualcan数据库分析CLIC3在胰腺癌中的表达及意义。方法:分析CLIC3在胰腺癌中的表达水平,同时分析其与肿瘤分期、性别、年龄、病理亚型和甲基化之间的关系;利用GEPIA数据库分析CLIC3在胰腺癌的预后和无病生存期的表达情况,对胰腺癌中CLIC3与MMP28和TRIM29的协同表达情况进行分析。结果:CLIC3在胰腺癌组织中的表达高于正常组织,与肿瘤年龄、性别和病理组织学分级存在部分相关性,CLIC3高表达的胰腺癌患者预后较差,CLIC3与MMP28和TRIM29的表达存在明显的正相关性。结论:CLIC3可能是治疗胰腺癌的潜在靶点。 Objective:To discuss the expression of CLIC3 and its prognostic role in Pancreatic adenocarcinoma(PAAD)by GEPIA and Ualcan database.Method:CLIC3 expression data was retrieved from GEPIA database and its relationship with the stage of cancer,gender,age,histological subtypes and methylation was analyzed from Ualcan database.The overall survival and disease free survival of CLIC3 was analysed,and then there is analysis about the correlated expression of CLIC3,MMP28 and TRIM29 in PAAD.Results:The expression level of CLIC3 was more upregulated in PAAD than in the normal tissue,indicating a relating worse prognosis.The expression of CLIC3 was correlated with MMP28 and TRIM29.Conclusions:CLIC3 might be a potential target in the treatment of PAAD.
作者 龚治忠 李清月 刘刚 GONG Zhi-zhong;LI Qing-yue;LIU Gang(Anhui Medical University,Hefei 230032,Anhui)
机构地区 安徽医科大学生命科学学院
出处 《安徽卫生职业技术学院学报》 2020年第6期85-87,共3页 Journal of Anhui Health Vocational & Technical College
关键词 CLIC3 PAAD GEPIA数据库 Ualcan数据库 CLIC3 PAAD GEPIA database ualcan database
分类号 R735.9 [医药卫生—肿瘤]
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  • 1Yang D, Hendifar A, Lenz C, et al. Survival of metastatic gastric cancer: significance of age, sex and race/ethnicity [J]. J Gastrointest Oncol, 2011,2(2):77.
  • 2Takai Y, Sasaki T, Matozaki T. Small GTP-binding proteins [J]. Physiol Rev, 2001,81 ( 1 ):153-208.
  • 3Cheng K W, Lahad J P, Gray J W, et ah Emerging role of RAB GT- Pases in cancer and human disease [J]. Cancer Res, 2005,65 (7): 2516-2519.
  • 4Kunzelmann K. Ion channels and cancer [J]. J Membr Biol,2005,205(3):159-173.
  • 5Agola J O, Jirh P A, Ward H H, et al. Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities[J]. Clin Genet, 2011,80(4):305-318.
  • 6Cheng K W, Lahad J P, Kuo W, et al. The RAB25 small GTPase determines aggressiveness of ovarian and breast cancers [J]. Nat Med, 2004, 10(11):1251-1256.
  • 7Dozynkiewicz M A, Jamieson N B, MacPherson I, et al. Rab25 and CLIC3 collaborate to promote integrin recycling from late endo- somes/lysosomes and drive cancer progression[J]. Dev Cell, 2012,22 (1):131-145.
  • 8Habela C W, Olsen M L, Sontheimer H. C1C3 is a critical regulator of the cell cycle in normal and malignant glial cells [J]. J Neurosci, 2008,28 (37):9205-9217.
  • 9Zuo W, Zhu L, Bai Z, et al. Chloride channels involve in hydrogen peroxide-induced apoptosis of PC12 cells[J]. Biochem Biophys Res Commun, 2009,387(4):666-670.
  • 10Sontheimer H. Ion channels and amino acid transporters support the growth and invasion of primary brain tumors[J]. Mol Neurobiol, 2004,29 ( 1 ) :61-71.

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安徽卫生职业技术学院学报
2020年 第6期

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