Objective: to study the correlation between the preeclampsia IgG antibody A(B) titer and hemolytic disease of the newborn (HDN). Methods: from February 2018 to February 2020, the clinical data of 36 pregnant women wit...Objective: to study the correlation between the preeclampsia IgG antibody A(B) titer and hemolytic disease of the newborn (HDN). Methods: from February 2018 to February 2020, the clinical data of 36 pregnant women with blood type not blood O in our hospital were retrospectively analyzed, and the IgG anti-A (B) titer was measured and the relationship with HDN was observed. Results: in 36 cases of blood O pregnant women, IgG antibody A(B) titer less than 1:64 was 41.67%, HDN production rate was 6.67%;IgG antibody A(B) titer equal to 1:64 was 19.44%, and HDN production rate was 28.57%. IgG antibody A(B) titer = 1:128 was 13.89%, and HDN production rate was 40.00%. The titer of IgG against A(B) was 1:256, which was 16.67%, and the HDN production rate was 50.00%. The titer of IgG anti-A (B) was more than or equal to 1:552, 8.33%, and the HDN production rate was 66.67%. The titer of IgG anti-A (B) was positively correlated with the HDN production rate, and the difference was very significant (P < 0.05). Conclusion: the pregnant female IgG anti-A (B) titer of blood O is closely related to HDN. The higher the IgG anti-A (B) titer is, the more people suffer from HDN. Clinical should be to IgG anti-a (B) titer high pregnant women and fetus, newborn increased observation, as early as possible to take intervention measures.展开更多
目的基于“紧急输血由急诊科授权医生启动,输血科15 min内发放不超过4 U O型未交叉配血悬浮红细胞”的单中心临床实践,了解该实践背景下紧急输O型未交叉配血悬浮红细胞策略的实施现状,为血液管理提供参考。方法回顾性分析2019年8月—202...目的基于“紧急输血由急诊科授权医生启动,输血科15 min内发放不超过4 U O型未交叉配血悬浮红细胞”的单中心临床实践,了解该实践背景下紧急输O型未交叉配血悬浮红细胞策略的实施现状,为血液管理提供参考。方法回顾性分析2019年8月—2024年4月四川大学华西医院紧急输O型血患者病例信息,包括申请紧急输血原因、输血申请送达输血科所需时间、输血科血液发放所需时间、患者输血前后总胆红素、间接胆红素、乳酸脱氢酶、患者血型、病情转归等。结果2019年8月—2024年4月本院申请紧急输O型血的患者有39例,共输注未经交叉配血的O型悬浮红细胞90 U。患者均为Rh(D)阳性,其中A型14例;B型6例;O型16例;AB型2例;暂无法定型1例,抗体筛查阳性2例,紧急输O型血的患者中车祸伤是主要原因,占46%(18/39),死亡率51.28%(20/39),死亡原因均为原发伤,无溶血性输血反应的临床指征:输血前后总胆红素(TBTL)、间接胆红素(IBIL)、乳酸脱氢酶(LDH)无统计学差异,P值均>0.05。患者从入院到输血科接收输血申请单和输血科从收到申请单到血液发放的中位时间分别为30.20 min和5.30 min。结论基于“紧急输血由急诊科授权医生启动,输血科15 min内发放不超过4 U O型未交叉配血悬浮红细胞”的单中心临床实践具有安全性,但申请紧急输O型血流程中在输血申请单送达输血科之前有优化空间。展开更多
为掌握塔什库尔干县帕米尔牦牛O型口蹄疫(foot and mouth disease,FMD)免疫效果,从辖区10个乡镇560个场(点)随机采集帕米尔牦牛血清共3984份,采用液相阻断ELISA方法检测O型FMD免疫抗体效价。结果显示,2021—2024年塔什库尔干县帕米尔牦...为掌握塔什库尔干县帕米尔牦牛O型口蹄疫(foot and mouth disease,FMD)免疫效果,从辖区10个乡镇560个场(点)随机采集帕米尔牦牛血清共3984份,采用液相阻断ELISA方法检测O型FMD免疫抗体效价。结果显示,2021—2024年塔什库尔干县帕米尔牦牛O型FMD免疫抗体合格率(抗体效价≥1∶128)分别为77.21%、91.21%、86.41%、88.51%,平均免疫抗体合格率为85.72%,均达到农业农村部要求的70%以上的标准。2021—2022年秋季合格率普遍高于春季,2023年后差异不大;2022—2024年免疫抗体合格率相近,均极显著高于2021年(P<0.01)。研究表明,塔什库尔干县2021—2024年帕米尔牦牛FMD免疫工作达到预期效果,但在不同年份和季节,抗体合格率存在一定程度的波动,应继续加强牦牛防疫体系建设,提高牦牛群免疫抗体水平,从而提高免疫效果,为帕米尔牦牛养殖业的持续健康发展提供保障。展开更多
文摘Objective: to study the correlation between the preeclampsia IgG antibody A(B) titer and hemolytic disease of the newborn (HDN). Methods: from February 2018 to February 2020, the clinical data of 36 pregnant women with blood type not blood O in our hospital were retrospectively analyzed, and the IgG anti-A (B) titer was measured and the relationship with HDN was observed. Results: in 36 cases of blood O pregnant women, IgG antibody A(B) titer less than 1:64 was 41.67%, HDN production rate was 6.67%;IgG antibody A(B) titer equal to 1:64 was 19.44%, and HDN production rate was 28.57%. IgG antibody A(B) titer = 1:128 was 13.89%, and HDN production rate was 40.00%. The titer of IgG against A(B) was 1:256, which was 16.67%, and the HDN production rate was 50.00%. The titer of IgG anti-A (B) was more than or equal to 1:552, 8.33%, and the HDN production rate was 66.67%. The titer of IgG anti-A (B) was positively correlated with the HDN production rate, and the difference was very significant (P < 0.05). Conclusion: the pregnant female IgG anti-A (B) titer of blood O is closely related to HDN. The higher the IgG anti-A (B) titer is, the more people suffer from HDN. Clinical should be to IgG anti-a (B) titer high pregnant women and fetus, newborn increased observation, as early as possible to take intervention measures.
文摘目的基于“紧急输血由急诊科授权医生启动,输血科15 min内发放不超过4 U O型未交叉配血悬浮红细胞”的单中心临床实践,了解该实践背景下紧急输O型未交叉配血悬浮红细胞策略的实施现状,为血液管理提供参考。方法回顾性分析2019年8月—2024年4月四川大学华西医院紧急输O型血患者病例信息,包括申请紧急输血原因、输血申请送达输血科所需时间、输血科血液发放所需时间、患者输血前后总胆红素、间接胆红素、乳酸脱氢酶、患者血型、病情转归等。结果2019年8月—2024年4月本院申请紧急输O型血的患者有39例,共输注未经交叉配血的O型悬浮红细胞90 U。患者均为Rh(D)阳性,其中A型14例;B型6例;O型16例;AB型2例;暂无法定型1例,抗体筛查阳性2例,紧急输O型血的患者中车祸伤是主要原因,占46%(18/39),死亡率51.28%(20/39),死亡原因均为原发伤,无溶血性输血反应的临床指征:输血前后总胆红素(TBTL)、间接胆红素(IBIL)、乳酸脱氢酶(LDH)无统计学差异,P值均>0.05。患者从入院到输血科接收输血申请单和输血科从收到申请单到血液发放的中位时间分别为30.20 min和5.30 min。结论基于“紧急输血由急诊科授权医生启动,输血科15 min内发放不超过4 U O型未交叉配血悬浮红细胞”的单中心临床实践具有安全性,但申请紧急输O型血流程中在输血申请单送达输血科之前有优化空间。
文摘为掌握塔什库尔干县帕米尔牦牛O型口蹄疫(foot and mouth disease,FMD)免疫效果,从辖区10个乡镇560个场(点)随机采集帕米尔牦牛血清共3984份,采用液相阻断ELISA方法检测O型FMD免疫抗体效价。结果显示,2021—2024年塔什库尔干县帕米尔牦牛O型FMD免疫抗体合格率(抗体效价≥1∶128)分别为77.21%、91.21%、86.41%、88.51%,平均免疫抗体合格率为85.72%,均达到农业农村部要求的70%以上的标准。2021—2022年秋季合格率普遍高于春季,2023年后差异不大;2022—2024年免疫抗体合格率相近,均极显著高于2021年(P<0.01)。研究表明,塔什库尔干县2021—2024年帕米尔牦牛FMD免疫工作达到预期效果,但在不同年份和季节,抗体合格率存在一定程度的波动,应继续加强牦牛防疫体系建设,提高牦牛群免疫抗体水平,从而提高免疫效果,为帕米尔牦牛养殖业的持续健康发展提供保障。
