目的探讨临床药师个体化量化点评在提高医院Ⅰ类切口预防性使用抗菌药物合理性的应用价值。方法回顾性分析2022年1—12月上饶市中心医院医院信息系统(Hospital Information System,HIS)中收治的88例Ⅰ类切口患者的临床资料,以临床药师...目的探讨临床药师个体化量化点评在提高医院Ⅰ类切口预防性使用抗菌药物合理性的应用价值。方法回顾性分析2022年1—12月上饶市中心医院医院信息系统(Hospital Information System,HIS)中收治的88例Ⅰ类切口患者的临床资料,以临床药师个体化量化点评实施时间为分界点分为对照组(2022年1—6月)与优化组(2022年7—12月),每组44例。对照组采用常规抗菌药物管理干预方案,优化组实施临床药师个体化量化点评方案。比较两组用药合理化程度、抗菌药物品种占比、用药时间占比、用药疗程占比、抗菌药物使用不合理发生情况及术后感染发生率。结果优化组Ⅰ类切口抗菌药物使用率、药物利用指数(drug utilization index,DUI)均低于对照组,差异有统计学意义(P<0.05)。优化组第3代头孢菌素占比低于对照组,差异有统计学意义(P<0.05)。优化组术前0.5 h用药时间占比低于对照组,差异有统计学意义(P<0.05)。优化组24~48 h用药疗程占比低于对照组,差异有统计学意义(P<0.05)。优化组抗菌药物不合理使用发生率低于对照组,差异有统计学意义(P<0.05)。优化组术后感染发生率低于对照组,但差异无统计学意义。结论开展临床药师个体化量化点评可提高医院Ⅰ类切口预防性抗菌药物的使用合理性,更为准确有效地选择预防性抗菌药物品种、疗程和时机,减少抗菌药物不合理使用的发生。展开更多
Goji(Lycium barbarum L.)leaves are widely processed as a healthy tea(GT)in China for their multiple biological activities.In this study,different polar segments from GT ethanolic extract were obtained using the liquid...Goji(Lycium barbarum L.)leaves are widely processed as a healthy tea(GT)in China for their multiple biological activities.In this study,different polar segments from GT ethanolic extract were obtained using the liquid-liquid fractionation method.n-Butanol fraction(GN)had the highest antioxidant activity while ethyl acetate fraction(GE)showed the highest inhibitory effect on theα-glucosidase enzyme.The anti-diabetic effect of GE was further investigated in type 2 diabetic mellitus(T2DM)mice.The oral administration of GE(300 or 600 mg/kg)reduced fasting blood glucose levels,improved glucose tolerance ability,and ameliorated insulin resistance in T2DM mice.GE intervention could enhance the cholesterol transportation in the serum in coincidence with decreased total cholesterol,triglyceride levels,and non-esterified fatty acid.Transcriptomic,immunofluorescence and western blotting analysis revealed that GE significantly up-regulated insulin receptor substrate 1,phosphatidylinositol-3-kinase,protein kinase B,glycogen synthesis,and glucose transporter 4.AMP-activated protein kinases-mediate gluconeogenesis and glycogenolysis,such as phosphoenolpyruvate carboxy kinase1 and glucose-6-phosphatase in the liver and kidney tissues of GE groups were decreased.Thus,GE alleviated the liver,kidney,and pancreatic tissue damage.The phytoconstituents of GE were characterized,and rutin,neochlorogenic acid,and its acylated derivatives have hypoglycemic effects.Furthermore,these findings suggested that GT might be used as a promising hypoglycemic candidate.展开更多
基金supported by the Yunnan High-Level Talents Innovation Program(YNWR-QNBJ-2020-226,YNWR-QNBJ-2020-246)the Major Science and Technology Project(202202AG050009+1 种基金2023530000241013)High-Level Talent Promotion and Training Project of Kunming(2022SCP003).
文摘Goji(Lycium barbarum L.)leaves are widely processed as a healthy tea(GT)in China for their multiple biological activities.In this study,different polar segments from GT ethanolic extract were obtained using the liquid-liquid fractionation method.n-Butanol fraction(GN)had the highest antioxidant activity while ethyl acetate fraction(GE)showed the highest inhibitory effect on theα-glucosidase enzyme.The anti-diabetic effect of GE was further investigated in type 2 diabetic mellitus(T2DM)mice.The oral administration of GE(300 or 600 mg/kg)reduced fasting blood glucose levels,improved glucose tolerance ability,and ameliorated insulin resistance in T2DM mice.GE intervention could enhance the cholesterol transportation in the serum in coincidence with decreased total cholesterol,triglyceride levels,and non-esterified fatty acid.Transcriptomic,immunofluorescence and western blotting analysis revealed that GE significantly up-regulated insulin receptor substrate 1,phosphatidylinositol-3-kinase,protein kinase B,glycogen synthesis,and glucose transporter 4.AMP-activated protein kinases-mediate gluconeogenesis and glycogenolysis,such as phosphoenolpyruvate carboxy kinase1 and glucose-6-phosphatase in the liver and kidney tissues of GE groups were decreased.Thus,GE alleviated the liver,kidney,and pancreatic tissue damage.The phytoconstituents of GE were characterized,and rutin,neochlorogenic acid,and its acylated derivatives have hypoglycemic effects.Furthermore,these findings suggested that GT might be used as a promising hypoglycemic candidate.
