In this manuscript, we describe the novel method for preparing the microcapsules containing α-tocopherol oil droplets as the first core material, calcium chloride powder as the second core material and the fine water...In this manuscript, we describe the novel method for preparing the microcapsules containing α-tocopherol oil droplets as the first core material, calcium chloride powder as the second core material and the fine water droplets as the third core material by the interfacial condensation reaction between hydroxyl propyl methyl cellulose and tannic acid. The interfacial condensation reaction was performed between hydroxyl propyl methyl cellulose dissolved in the continuous water phase and tannic acid dissolved in the inner fine water droplets as the third core material. The calcium chloride powder as the second core material was dispersed in the α-tocopherol oil droplet as the first core material beforehand. The α-tocopherol oil containing the second and the third core materials was dispersed in the continuous water phase to form the [(S + W)/O/W] emulsion. The α-tocopherol oil as the first core material was microencapsulated satisfactorily and the contents of the second core material were increased with the concentration of stearic acid as the oil soluble stabilizer. The mechanical strength of microcapsules increased with the concentration of hydroxyl propyl methyl cellulose. Thermal energy could be released by breaking the microcapsules in water and by dissolving calcium chloride in the continuous water phase.展开更多
Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cel...Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cells of epithelial origin that promotes metastasis, drug resistance and cancer stem cell formation. Since the information regarding differential gene expression in TNBC cells and cell signaling events leading to EMT is limited, this investigation was done by comparing transcriptomic data generated by RNA isolation and sequencing of a EMT model TNBC cell line in comparison to regular TNBC cells. RNA sequencing and Ingenuity Pathway Software Analysis (IPA) of the transcriptomic data revealed several upregulated and downregulated gene expressions along with novel core canonical pathways including Sirtuin signaling, Oxidative Phosphorylation and Mitochondrial dysfunction events involved in EMT changes of the TNBC cells.展开更多
Purpose:The collaboration relationships between innovation actors at a geographic level may be considered as grouping two separate layers,the domestic and the foreign.At the level of each layer,the relationships and t...Purpose:The collaboration relationships between innovation actors at a geographic level may be considered as grouping two separate layers,the domestic and the foreign.At the level of each layer,the relationships and the actors involved constitute a Triple Helix game.The paper distinguished three levels of analysis:the global grouping together all actors,the domestic grouping together domestic actors,and the foreign related to only actors from partner countries.Design/methodology/approach:Bibliographic records data from the Web of Science for South Korea and West Africa breakdown per innovation actors and distinguishing domestic and international collaboration are analyzed with game theory.The core,the Shapley value,and the nucleolus are computed at the three levels to measure the synergy between actors.Findings:The synergy operates more in South Korea than in West Africa;the government is more present in West Africa than in South Korea;domestic actors create more synergy in South Korea,but foreign more in West Africa;South Korea can consume all the foreign synergy,which is not the case of West Africa.Research limitations:Research data are limited to publication records;techniques and methods used may be extended to other research outputs.Practical implications:West African governments should increase their investment in science,technology,and innovation to benefit more from the synergy their innovation actors contributed at the foreign level.However,the results of the current study may not be sufficient to prove that greater investment will yield benefits from foreign synergies.Originality/value:This paper uses game theory to assess innovation systems by computing the contribution of foreign actors to knowledge production at an area level.It proposes an indicator to this end.展开更多
文摘In this manuscript, we describe the novel method for preparing the microcapsules containing α-tocopherol oil droplets as the first core material, calcium chloride powder as the second core material and the fine water droplets as the third core material by the interfacial condensation reaction between hydroxyl propyl methyl cellulose and tannic acid. The interfacial condensation reaction was performed between hydroxyl propyl methyl cellulose dissolved in the continuous water phase and tannic acid dissolved in the inner fine water droplets as the third core material. The calcium chloride powder as the second core material was dispersed in the α-tocopherol oil droplet as the first core material beforehand. The α-tocopherol oil containing the second and the third core materials was dispersed in the continuous water phase to form the [(S + W)/O/W] emulsion. The α-tocopherol oil as the first core material was microencapsulated satisfactorily and the contents of the second core material were increased with the concentration of stearic acid as the oil soluble stabilizer. The mechanical strength of microcapsules increased with the concentration of hydroxyl propyl methyl cellulose. Thermal energy could be released by breaking the microcapsules in water and by dissolving calcium chloride in the continuous water phase.
文摘Triple Negative Breast Cancer (TNBC) is a malignant form of cancer with very high mortality and morbidity. Epithelial to Mesenchymal Transition (EMT) is the most common pathophysiological change observed in cancer cells of epithelial origin that promotes metastasis, drug resistance and cancer stem cell formation. Since the information regarding differential gene expression in TNBC cells and cell signaling events leading to EMT is limited, this investigation was done by comparing transcriptomic data generated by RNA isolation and sequencing of a EMT model TNBC cell line in comparison to regular TNBC cells. RNA sequencing and Ingenuity Pathway Software Analysis (IPA) of the transcriptomic data revealed several upregulated and downregulated gene expressions along with novel core canonical pathways including Sirtuin signaling, Oxidative Phosphorylation and Mitochondrial dysfunction events involved in EMT changes of the TNBC cells.
文摘Purpose:The collaboration relationships between innovation actors at a geographic level may be considered as grouping two separate layers,the domestic and the foreign.At the level of each layer,the relationships and the actors involved constitute a Triple Helix game.The paper distinguished three levels of analysis:the global grouping together all actors,the domestic grouping together domestic actors,and the foreign related to only actors from partner countries.Design/methodology/approach:Bibliographic records data from the Web of Science for South Korea and West Africa breakdown per innovation actors and distinguishing domestic and international collaboration are analyzed with game theory.The core,the Shapley value,and the nucleolus are computed at the three levels to measure the synergy between actors.Findings:The synergy operates more in South Korea than in West Africa;the government is more present in West Africa than in South Korea;domestic actors create more synergy in South Korea,but foreign more in West Africa;South Korea can consume all the foreign synergy,which is not the case of West Africa.Research limitations:Research data are limited to publication records;techniques and methods used may be extended to other research outputs.Practical implications:West African governments should increase their investment in science,technology,and innovation to benefit more from the synergy their innovation actors contributed at the foreign level.However,the results of the current study may not be sufficient to prove that greater investment will yield benefits from foreign synergies.Originality/value:This paper uses game theory to assess innovation systems by computing the contribution of foreign actors to knowledge production at an area level.It proposes an indicator to this end.
