Shallow planting of the rice seedlings is an important factor for getting high yield as it can increase the effective tillers on the lownode of the stem. The 2 ZB-79 shallow rice seedling transplanter combined the adv...Shallow planting of the rice seedlings is an important factor for getting high yield as it can increase the effective tillers on the lownode of the stem. The 2 ZB-79 shallow rice seedling transplanter combined the advantages of shallow planting of the seedling-casting rice transplanter and orderly planting of the traditional rice transplanter. The principle of this kind of machine is firstly to cut the standardization nursery rice seedlings with rug soil into many small pieces,and then to plant the small pieces composed of pot soil and some seedlings on it to the field surface in order,only shallowly planted on the very top part of paddy soil. Not only it can keep the performance of planting shallowly and orderly,but also simplify many mechanisms for transition,separation,and plantation of rice seedlings. It is a new type of rice seedling transplanter called laying-type up to now to get higher efficiency when working and higher yield for rice production. This paper will introduce its developing results and analyze the comparative experiments.展开更多
Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are...Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are consequently lacking.The microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a host.The intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other factors.Such dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many diseases.In recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the brain.Indeed,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s disease.Similarly,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular disorders.Moreover,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable etiologies.As such,the intestinal flora may play an important role in age-related macular degeneration.Given the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic strategies.Currently,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular degeneration.Organ-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the intestinal flora with research on metabolites through metabolomics and other techniques is crucial for understanding their potential mechanisms.展开更多
In order to improve the automatic sorting and transplanting of tray-seedling and reduce labors strength,a new sorting transplanter was designed.According to the feature of normal seedling tray and manual grading metho...In order to improve the automatic sorting and transplanting of tray-seedling and reduce labors strength,a new sorting transplanter was designed.According to the feature of normal seedling tray and manual grading method,the mechanical sorting procedure was defined.The key parts of sorting transplanter are as follows:an efficient transfer mechanism with aerodynamic buffer,a seedling identifying and measuring unit based on linear-structured vision,the extendible multi-grasper with wireless technology and the system controller.The experiments were conducted and showed that the transplanting success rate was 90.0% on the tray of 6×12 holes under the speed of 700 cycles per hour.The vision unit’s failed identifying rate for the superior pepper seedlings on five different trays was less than 10%,and the measurement error of seedling height was about 5 mm.展开更多
An automatic feeding mechanism consisting of a timing shaft,an actuating device and a clutch for feeding paper pot seedlings from a horizontal slat type chain conveyor to a horizontal pusher type chain conveyor of a v...An automatic feeding mechanism consisting of a timing shaft,an actuating device and a clutch for feeding paper pot seedlings from a horizontal slat type chain conveyor to a horizontal pusher type chain conveyor of a vegetable transplanter,was developed.The slat type chain conveyor carried the pot seedlings in upright orientation in the form of a rectangular array with each linear array of pot seedlings on a slat.The pusher type chain conveyor received a linear array of pot seedlings and delivered them to the seedling drop tube.Feeding of each linear array of pot seedlings to the pusher type conveyor at appropriate times was done using an automatic feeding mechanism.The laboratory evaluation indicated that the feeding rate of 33 to 50 pot seedlings per minute can be achieved with single set of conveyors.The feeding mechanism also worked effectively under actual field conditions with 98%to 99%of all the pot seedlings,which were properly separated and fed for planting when the forward speed of the vegetable transplanter was 0.9 km/h.The feeding mechanism has the general application of singulating rectangular array of items on the slat type chain conveyor in any industry and machine in motion on a level surface.展开更多
Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration...Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal cord.Here we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord injury.We report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal directions.Such Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder functions.Importantly,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord injury.These findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.展开更多
Rice transplanting requires the operator to manipulate the rice transplanter in straight trajectories.Various markers are proposed to help experienced drivers in keeping straightforward and parallel to the previous pa...Rice transplanting requires the operator to manipulate the rice transplanter in straight trajectories.Various markers are proposed to help experienced drivers in keeping straightforward and parallel to the previous path,which are extremely boring in terms of large-scale fields.The objective of this research was to develop an autonomous navigation system that automatically guided a rice transplanter working along predetermined paths in the field.The rice transplanter used in this research was commercially available and originally manually-operated.An automatic manipulating system was developed instead of manual functions including steering,stop,going forward and reverse.A sensor fusion algorithm was adopted to integrate measurements of the Real-Time Kinematic Global Navigation Satellite System(RTK-GNSS)and Inertial Measurement Unit(IMU),and calculate the absolute moving direction under the UTM coordinate system.A headland turning control method was proposed to ensure a robust turning process considering that the rice transplanter featured a small turning radius and a relatively large slip rate at extreme steering angles.Experiments were designed and conducted to verify the performance of the newly developed autonomous navigation system.Results showed that both lateral and heading errors were less than 8 cm and 3 degrees,respectively,in terms of following straight paths.And headland turns were robustly executed according to the required pattern.展开更多
This research aimed to solve current problems in the process of maize transplanting in China such as large labor intensity,low working efficiency and poor quality.On the basis of the structure of a seedling-sprouting ...This research aimed to solve current problems in the process of maize transplanting in China such as large labor intensity,low working efficiency and poor quality.On the basis of the structure of a seedling-sprouting tray made of maize straw and the agronomic requirements of maize production,this study developed a new feeding device for such a sprouting tray,determined the dimensions of the key components in a virtual environment via Solid Edge software and obtained optimal working parameters in combination with Matlab.Some tests on field validation and maize production were conducted as well.The test results showed the importance of the working parameters on an upright degree in descending order(as well as the best working parameters)to be the vertical angle of seedling planting(13.14°),the forward speed of locomotion(0.57 m/s),and the horizontal angle of the seedling box(22.5°).The standard deviation of the field validation was 6.04%,which was within the allowable range to meet the requirements of maize transplanting.Compared with maize transplanting machines(and manual transplanting operations)on the current market,the labor inputs,as well as the rates of spacing and upright degree qualification,omitted planting and the yield using the new feeding device for automatic transplanter with maize straw seedling-sprouting trays increased 0(6.9%),0(3.1%),0(4.5%)and 0(−1.0%),respectively;whereas,the manufacturing cost was reduced by 35.5%.The results can provide a technical basis and reference for subsequent development of automatic transplanters with maize straw seedling-sprouting trays.展开更多
The rotary plug seedling pick-up mechanism for vegetable automatic transplanter is the technical bottleneck to improve the mechanization level of vegetable planting in China.In order to solve the problems of rotary se...The rotary plug seedling pick-up mechanism for vegetable automatic transplanter is the technical bottleneck to improve the mechanization level of vegetable planting in China.In order to solve the problems of rotary seedling pick-up mechanism proposed in previous study,such as low success ratio of seedling pick-up at high speed,and interference between the seedling bowl and the end of the other seedling pick-up arm,a novel kind of rotary seedling pick-up mechanism of planetary gear train with combined type gears of incomplete denatured-eccentric-circular and non-circular gears was proposed.Through kinematic analysis of the seedling pick-up mechanism,the kinematics model was established.The computer-aided analysis and optimization software with human-computer interaction method was developed to realize parameters optimization of the seedling pick-up mechanism.Three-dimensional parametric design system of seedling pick-up mechanisms with combined non-circular gear transmission was developed for mechanism virtual simulation to verify the correctness of theoretical model and design results of the mechanism.The physical prototype of the mechanism was manufactured,and high-speed camera kinematics tests of the mechanism were conducted in the laboratory to study its kinematic characteristics.Laboratory seedling pick-up tests were carried out.The mechanism has the success ratio of seedling pick-up 96.3%without interference during seedling transporting when the rotation speed of the mechanism is 50 r/min and the seedling transplanting efficiency is 100 plants/min per row,showing that the novel mechanism has better working performance than the original one and could be applied in vegetable plug seedling transplanter.展开更多
To improve the precision of deep fertilization of paddy fields,a six-row centralized pneumatic deep precision fertilization device for a rice transplanter was designed.This device included a spiral fertilizer distribu...To improve the precision of deep fertilization of paddy fields,a six-row centralized pneumatic deep precision fertilization device for a rice transplanter was designed.This device included a spiral fertilizer distribution system,centralized pneumatic fertilizer delivery system,an opener system,and a fertilization control system.The centralized airflow distribution method was used in the fertilizer delivery system to ensure that the airflow in each fertilizer pipe was evenly distributed.The rotational speeds of the power take-off(PTO)and fertilizer shaft were measured synchronously using photoelectric sensors and matched proportionately in real-time using PID closed-loop control algorithms to achieve precise fertilization rates at each working speed of the rice transplanter.There were two key considerations in the design of the control system to ensure precise fertilization.Firstly,a photoelectric sensor was used to measure the speed of the PTO;the high rotational speed of the PTO could provide a high signal frequency and improve the precision of the measurement of the transplanter’s working speed.Secondly,the fertilizer shaft speed measurement subprogram was set to sleep for a short period to reduce the vibration caused by the engine.During the tests of pneumatic fertilizer delivery system,single-factor tests on airflow distribution methods were conducted.The results showed that the coefficient of variation of the airflow speed for the centralized airflow distribution method was 1.67%,which was the least among the coefficients of the three distribution methods.In the bench tests,the rotational speeds of the fertilizer shaft were set at 10 r/min,20 r/min,30 r/min,and 40 r/min.The maximum coefficient of variation of the fertilization consistency in different rows was 1.49%at the rotational speed of 20 r/min.The maximum coefficient of variation of the fertilization stability was 2.86%at the rotational speed of 40 r/min,while the average fertilizer amount per lap for each distributor was 26.25 g/r.The results of the dynamic fertilization tests showed that the maximum relative error of the fertilizer distribution amount was 2.00%when the target fertilizer rates were 20,30,and 40 kg/667 m2.The results of the field tests showed that the average relative error of the fertilization amount was 3.53%,which satisfies the design standard.This research provides a reference for optimizing pneumatic fertilizer delivery systems and improving fertilization control systems and other pneumatic precision fertilizer application devices.展开更多
Considering both high efficiency and high seedling standing quality is a significant objective for crop mechanized transplanting.Rape blanket seedling transplanting is an innovative and efficient transplanting techniq...Considering both high efficiency and high seedling standing quality is a significant objective for crop mechanized transplanting.Rape blanket seedling transplanting is an innovative and efficient transplanting technique.However,falling off phenomenon has become a common problem facing rape blanket seedling transplanting fields that causes seedling standing quality decrease and restricts crop growth.In this study,the rape blanket seedling of Ningza-1838 varieties and 35 d of seedling age was taken as the research object.The critical falling off equations of seedling was established by dynamic analysis.Main factors affecting seedling falling off were obtained.The critical value of each factor was calculated which were as follows:the rotation speed of the planting mechanism was 24.6 rad/s,the substrate moisture content was 50.4%and the longitudinal picking seedling quantity was 14.7 mm.Taking the seedling falling off rate as evaluation index,the measured critical value of seedling falling off was determined by high speed photography experiment.Under the condition that substrate moisture content was 55%and the longitudinal seedling quantity was 15 mm,the seedling falling off rate sharply increased when the transplanting mechanism rotation speed was increased from 24 rad/s to 26 rad/s.Under the condition that the rotation speed was 22 rad/s and the longitudinal picking seedling quantity was 15 mm,the seedling falling off rate rapidly decreased when the moisture content was increased from 47%to 53%.When moisture content exceeded 53%,this exhibited no obvious change.Under the condition that the moisture content was 50%and the rotation speed was 22 rad/s,the seedling falling off rate swiftly raised when the longitudinal picking seedling quantity was increased from 14 mm to 17 mm.The experimental results showed that the seedling falling off rate increased significantly near the critical value.The experimental results showed that the seedling falling off rate changed significantly near the critical value.It proved that the model was correct.Response surface experiments with the Box-Behnken design were conducted to determine the optimal combination parameters,which were as follows:substrate moisture content was 56.24%,planting mechanism rotation speed was 22.04 rad/s,and longitudinal picking seedling quantity was 14.91 mm.At this time,the seedling falling off rate was 1.36%,which ensured that seedlings could be transplanted stably under the carrier of seedling needle.The verification test was conducted,and the working parameters were adjusted according to the optimization results in experiment.The results of verification test were highly consistent with the optimization solution.The present study may provide a theoretical method for improving seedling standing quality of rape blanket seedling,and laid a foundation for the popularization and development of rape carpet seedling transplanting.展开更多
Over the past six decades,liver transplantation(LT)has evolved from an experimental procedure into a standardized and life-saving intervention,reshaping the landscape of organ transplantation.Driven by pioneering brea...Over the past six decades,liver transplantation(LT)has evolved from an experimental procedure into a standardized and life-saving intervention,reshaping the landscape of organ transplantation.Driven by pioneering breakthroughs,technological advancements,and a deepened understanding of immunology,LT has seen remarkable progress.Some of the most notable breakthroughs in the field include advances in immunosuppression,a revised model for end-stage liver disease,and artificial intelligence(AI)-integrated imaging modalities serving diagnostic and therapeutic roles in LT,paired with ever-evolving technological advances.Additionally,the refinement of transplantation procedures,resulting in the introduction of alternative transplantation methods,such as living donor LT,split LT,and the use of marginal grafts,has addressed the challenge of organ shortage.Moreover,precision medicine,guiding personalized immunosuppressive strategies,has significantly improved patient and graft survival rates while addressing emergent issues,such as short-term complications and early allograft dysfunction,leading to a more refined strategy and enhanced postoperative recovery.Looking ahead,ongoing research explores regenerative medicine,diagnostic tools,and AI to optimize organ allocation and posttransplantation car.In summary,the past six decades have marked a transformative journey in LT with a commitment to advancing science,medicine,and patient-centered care,offering hope and extending life to individuals worldwide.展开更多
BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths worldwide.Liver transplantation(LT)offers the most effective treatment.HCC recurrence is the strongest risk factor that decreases pos...BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths worldwide.Liver transplantation(LT)offers the most effective treatment.HCC recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for HCC.The rate of HCC recurrence is generally reported as 8%-20%in the literature.Many predictors of HCC have already been researched,however,to our knowledge there are no published studies on this topic using Australian data.AIM To determine the rate and identify predictors of HCC recurrence in a contemporary Western Australian LT cohort.METHODS We performed a retrospective cohort study of all liver transplants in patients with HCC at Sir Charles Gairdner Hospital between 2006 and 2021.Data was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of recurrence.Overall survival of HCC patients post-LT,stratified for recurrence,was calculated by Kaplan Meier analysis.Univariate and multivariate Cox regression was used to determine predictors of HCC recurrence post-LT.RESULTS Between 1/1/2006 and 12/31/2021,119 patients were transplanted with HCC.8.4%of subjects developed recurrent HCC after LT with median follow-up time of 5.4 years.The median time to recurrence was 2.9 years±0.75 years.When comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(P=0.001),vascular invasion(P=0.003)and poorly differentiated HCC(P=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with HCC recurrence compared to those without HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank P<0.001).CONCLUSION HCC recurrence was low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT survival.Further studies are required to confirm predictors of recurrence and improve recipient outcomes.展开更多
In China pediatric liver transplantation(PLT)has become a safe and standardized procedure.Innovations and measures to further improve long-term survival and quality of life for children should be the next focus.In par...In China pediatric liver transplantation(PLT)has become a safe and standardized procedure.Innovations and measures to further improve long-term survival and quality of life for children should be the next focus.In particular better strategies related to the surgical treatment of high-risk recipients as well as the long-term follow-up of pediatric liver recipients have to be addressed.A particular attention should be given to children presenting significant co-morbidities and those needing retransplantation.A tight mul-tidisciplinary follow-up system addressing both short-and long-term issues of pediatric liver recipients is still a challenge for the Chinese pediatric transplant community.展开更多
The endothelium modulates vascular homeostasis owing to a variety of vasoconstrictors and vasodilators.Endothelial dysfunction(ED),characterized by impaired vasodilation,inflammation,and thrombosis,triggers future car...The endothelium modulates vascular homeostasis owing to a variety of vasoconstrictors and vasodilators.Endothelial dysfunction(ED),characterized by impaired vasodilation,inflammation,and thrombosis,triggers future cardiovascular(CV)diseases.Chronic kidney disease,a state of chronic inflammation caused by oxidative stress,metabolic abnormalities,infection,and uremic toxins damages the endothelium.ED is also associated with a decline in estimated glomerular filtration rate.After kidney transplantation,endothelial functions undergo immediate but partial restoration,promising graft longevity and enhanced CV health.However,the anticipated CV outcomes do not happen due to various transplant-related and unrelated risk factors for ED,culminating in poor CV health and graft survival.ED in kidney transplant recipients is an underrecognized and poorly studied entity.CV diseases are the leading cause of death among kidney transplant candidates with functioning grafts.ED contributes to the pathogenesis of many of the CV diseases.Various biomarkers and vasoreactivity tests are available to study endothelial functions.With an increasing number of transplants happening every year,and improved graft rejection rates due to the availability of effective immunosuppressants,the focus has now shifted to endothelial protection for the prevention,early recognition,and treatment of CV diseases.展开更多
BACKGROUND Family caregivers of cirrhosis patients(CPs)often experience burden,stress,and depression.Investigating whether these conditions improve following the patient undergoing liver transplantation(LT)is crucial,...BACKGROUND Family caregivers of cirrhosis patients(CPs)often experience burden,stress,and depression.Investigating whether these conditions improve following the patient undergoing liver transplantation(LT)is crucial,as it would elucidate the compre-hensive benefits of the procedure and demonstrate the positive impacts not only on the patients but also on their caregivers and society.AIM To compare the levels of burden,stress and depression among family caregivers of cirrhotic and liver transplant patients.METHODS This cross-sectional observational study evaluated caregivers of CPs and LT recipients at a quaternary Brazilian hospital.Instruments included identification cards,interview scripts,the caregiver burden scale Inventory,Lipp’s Stress Symptom Inventory,and the Beck Depression Inventory-Second Edition.Psychometric analyses involved confirmatory factor analysis and calculation of McDonald’s omega and composite reliability.Factor scores were compared with the Mann-Whitney U test,with effect size as the rank-biserial correlation coefficient(r).Statistical analysis was performed with R software(P<0.05).RESULTS Seventy-seven CP caregivers and 65 LT recipient caregivers were included.Most were female(CP:85.7%vs LT:84.6%)and the patients’spouses(76.6%vs 63.1%).The median age and caregiving duration were 55.4(23.3-76.3)vs 54.6(25.7-82.1)and 3.9(1-20)vs 8(1.5-24)years,respectively(P=0.001).LT caregivers were less likely to be at risk of overload(21.5%vs 49.4%),to be under stress(33.8%vs 36.4%)and to show symptoms of depression(15.4%vs 35.1%).Compared with LT caregivers,CP caregivers had greater median factor scores for burden(general tension,P=0.012;isolation,P=0.014;disappointment,P=0.004),depression(P=0.008),and stress(P=0.047),with small to moderate effect sizes.The disappointment(r=0.240)and depression(r=0.225)dimensions had the largest effect sizes.CONCLUSION Family caregivers of LT recipients are less likely to exhibit symptoms of burden,stress,and depression,suggesting that the benefits of LT extend to the patients’family members.展开更多
In China, liver transplantation is an important discipline in the field of organ transplantation. China Liver Transplant Registry (CLTR) is a scientific project that has been set up to advance surgical techniques and ...In China, liver transplantation is an important discipline in the field of organ transplantation. China Liver Transplant Registry (CLTR) is a scientific project that has been set up to advance surgical techniques and procedures and to improve both short-and long-term post-transplant follow-up and outcome of the liver recipients. CLTR also serves as a robust data support platform for the National Liver Transplant Quality Control Center in the quest to upscale its quality control protocols. The mission of CLTR is to register all liver transplantation activities in the mainland of China and to conduct scientific analyses of the collected data. The huge number of compiled cases and the scientific research conducted over the past decade based on this database drastically revolutionized the clinical practice in the country. All CLTR activities and projects will be a guarantee to foster progresses of liver transplantation in China in a more scientific way, to standardize the systematic care in the field of liver transplantation.展开更多
To improve the low transplanting efficiencies and simplify the complex structures of current automatic transplanters,a mechanical high-speed transplanter for picking plug seedlings that is suitable for planting on pla...To improve the low transplanting efficiencies and simplify the complex structures of current automatic transplanters,a mechanical high-speed transplanter for picking plug seedlings that is suitable for planting on plastic filmswas designed.Themain components were an automatic seedling picking systemand a basket-type planting system,whichwere used for the following processes:automatic picking,planting,soil covering,and suppression of plug seedlings.The performance test was performed on the automatic transplanter with 60-day-old pepper seedlings.The transplanting efficiency was tested at speeds of 40,60,90,and 120 plants·min−1.The results showed that the coefficient of variation(CV)of the plant spacing and the missed transplanting rate increased with the planting frequency,whereas the qualified rate of planting perpendicularity and the qualified rate of planting decreasedwith the increase in the planting frequency.All planting indicesmet the JB/T 102912013 standards.The results of this study showed that the auto-transplanter could performhigh-speed transplanting on the basis of completing the following functions:automatic picking,planting,soil covering,and suppression of plug seedlings.展开更多
The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established b...The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.展开更多
This paper presents the study reports on evaluating a new transplanting operation by taking into accounts the interactions between soil,plant,and machine in line with the System of Rice Intensification(SRI)practices.T...This paper presents the study reports on evaluating a new transplanting operation by taking into accounts the interactions between soil,plant,and machine in line with the System of Rice Intensification(SRI)practices.The objective was to modify planting claw(kuku-kambing)of a paddy transplanter in compliance with SRI guidelines to determine the best planting spacing(S),seed rate(G)and planting pattern that results in a maximum number of seedling,tillers per hill,and yield.Two separate experiments were carried out in two different paddy fields,one to determine the best planting spacing(S=4 levels:s_(1)=0.16 m×0.3 m,s_(2)=0.18 m×0.3 m,s_(3)=0.21 m×0.3 m,and s_(4)=0.24 m×0.3 m)for a specific planting pattern(row mat or scattered planting pattern),and the other to determine the best combination of spacing with seed rate treatments(G=2 levels:g1=75 g/tray,and g2=240 g/tray).Main SRI management practices such as soil characteristics of the sites,planting depth,missing hill,hill population,the number of seedling per hill,and yield components were evaluated.Results of two-way analysis of variance with three replications showed that spacing,planting pattern and seed rate affected the number of one-seedling in all experiment.It was also observed that the increase in spacing resulted in more tillers and more panicle per plant,however hill population and sterility ratio increased with the decrease in spacing.While the maximum number of panicles were resulted from scattered planting at s_(4)=0.24 m×0.3 m spacing with the seed rate of g1=75 g/tray,the maximum number of one seedling were observed at s_(4)=0.16 m×0.3 m.The highest and lowest yields were obtained from 75 g seeds per tray scattered and 70 g seeds per tray scattered treatment respectively.For all treatments,the result clearly indicates an increase in yield with an increase in spacing.展开更多
The vibration problem during the operation of rice transplanters is the most common phenomenon.In order that the static and dynamic characteristics of the rice transplanter chassis can meet the requirements of more st...The vibration problem during the operation of rice transplanters is the most common phenomenon.In order that the static and dynamic characteristics of the rice transplanter chassis can meet the requirements of more stable operation,the research took the 2ZG-6DK rice transplanter as the research object to carry out a vibration reduction optimization study.In the research,the Pro/Engineer 5.0 software was first used to model the chassis of the rice transplanter.The constructed finite element model was revised by using the structural parameter revision method and the mixed penalty function method.The model was imported into ANSYS Workbench to solve the modal frequency and vibration shape of the rice transplanter chassis.Based on the MAC(modal assurance criterion)criterion,modal tests were carried out to verify the accuracy of the finite element theoretical analysis.Through the analysis of the characteristics of the external excitation frequency,the chassis is structurally optimized to avoid resonance caused by the natural frequency of the chassis falling within the road excitation frequency range.The final optimization results showed that the first four orders of modal frequencies of the chassis were adjusted to 32.083 Hz,33.751 Hz,42.517 Hz,and 50.362 Hz,respectively,in the case that the chassis mass was increased by 6.714 kg(8.8%).They all avoid the range of road excitation frequency(10-30 Hz)so that the rice transplanter can effectively avoid the resonance phenomenon during operation.This study can provide a reference for the design and optimization of the chassis structure of transplanter.展开更多
基金Brand Discipline Construction Project of Colleges and Universities in Jiangsu Province(PPZY2015A087)
文摘Shallow planting of the rice seedlings is an important factor for getting high yield as it can increase the effective tillers on the lownode of the stem. The 2 ZB-79 shallow rice seedling transplanter combined the advantages of shallow planting of the seedling-casting rice transplanter and orderly planting of the traditional rice transplanter. The principle of this kind of machine is firstly to cut the standardization nursery rice seedlings with rug soil into many small pieces,and then to plant the small pieces composed of pot soil and some seedlings on it to the field surface in order,only shallowly planted on the very top part of paddy soil. Not only it can keep the performance of planting shallowly and orderly,but also simplify many mechanisms for transition,separation,and plantation of rice seedlings. It is a new type of rice seedling transplanter called laying-type up to now to get higher efficiency when working and higher yield for rice production. This paper will introduce its developing results and analyze the comparative experiments.
基金supported by the National Natural Science Foundation of China,No.82171080Nanjing Medical Science and Technology Development Project,No.YKK23264Postgraduate Research&Practice Innovation Program of Jiangsu Province,Nos.JX10414151,JX10414152(all to KL)。
文摘Age-related macular degeneration is a serious neurodegenerative disease of the retina that significantly impacts vision.Unfortunately,the specific pathogenesis remains unclear,and effective early treatment options are consequently lacking.The microbiome is defined as a large ecosystem of microorganisms living within and coexisting with a host.The intestinal microbiome undergoes dynamic changes owing to age,diet,genetics,and other factors.Such dysregulation of the intestinal flora can disrupt the microecological balance,resulting in immunological and metabolic dysfunction in the host,and affecting the development of many diseases.In recent decades,significant evidence has indicated that the intestinal flora also influences systems outside of the digestive tract,including the brain.Indeed,several studies have demonstrated the critical role of the gut-brain axis in the development of brain neurodegenerative diseases,including Alzheimer’s disease and Parkinson’s disease.Similarly,the role of the“gut-eye axis”has been confirmed to play a role in the pathogenesis of many ocular disorders.Moreover,age-related macular degeneration and many brain neurodegenerative diseases have been shown to share several risk factors and to exhibit comparable etiologies.As such,the intestinal flora may play an important role in age-related macular degeneration.Given the above context,the present review aims to clarify the gut-brain and gut-eye connections,assess the effect of intestinal flora and metabolites on age-related macular degeneration,and identify potential diagnostic markers and therapeutic strategies.Currently,direct research on the role of intestinal flora in age-related macular degeneration is still relatively limited,while studies focusing solely on intestinal flora are insufficient to fully elucidate its functional role in age-related macular degeneration.Organ-on-a-chip technology has shown promise in clarifying the gut-eye interactions,while integrating analysis of the intestinal flora with research on metabolites through metabolomics and other techniques is crucial for understanding their potential mechanisms.
基金the National High Technology Research and Development Program of China(2012AA101903).
文摘In order to improve the automatic sorting and transplanting of tray-seedling and reduce labors strength,a new sorting transplanter was designed.According to the feature of normal seedling tray and manual grading method,the mechanical sorting procedure was defined.The key parts of sorting transplanter are as follows:an efficient transfer mechanism with aerodynamic buffer,a seedling identifying and measuring unit based on linear-structured vision,the extendible multi-grasper with wireless technology and the system controller.The experiments were conducted and showed that the transplanting success rate was 90.0% on the tray of 6×12 holes under the speed of 700 cycles per hour.The vision unit’s failed identifying rate for the superior pepper seedlings on five different trays was less than 10%,and the measurement error of seedling height was about 5 mm.
文摘An automatic feeding mechanism consisting of a timing shaft,an actuating device and a clutch for feeding paper pot seedlings from a horizontal slat type chain conveyor to a horizontal pusher type chain conveyor of a vegetable transplanter,was developed.The slat type chain conveyor carried the pot seedlings in upright orientation in the form of a rectangular array with each linear array of pot seedlings on a slat.The pusher type chain conveyor received a linear array of pot seedlings and delivered them to the seedling drop tube.Feeding of each linear array of pot seedlings to the pusher type conveyor at appropriate times was done using an automatic feeding mechanism.The laboratory evaluation indicated that the feeding rate of 33 to 50 pot seedlings per minute can be achieved with single set of conveyors.The feeding mechanism also worked effectively under actual field conditions with 98%to 99%of all the pot seedlings,which were properly separated and fed for planting when the forward speed of the vegetable transplanter was 0.9 km/h.The feeding mechanism has the general application of singulating rectangular array of items on the slat type chain conveyor in any industry and machine in motion on a level surface.
基金supported in part by NIH R01 NS100531,R01 NS103481NIH R21NS130241(to LD)+3 种基金Merit Review Award I01 BX002356,I01 BX003705 from the U.S.Department of Veterans AffairsIndiana Spinal Cord and Brain Injury Research Foundation(No.19919)Mari Hulman George Endowment Funds(to XMX)Indiana Spinal Cord&Brain Injury Research Fund from ISDH(to NKL and LD)。
文摘Schwann cell transplantation is considered one of the most promising cell-based therapy to repair injured spinal cord due to its unique growth-promoting and myelin-forming properties.A the Food and Drug Administration-approved Phase I clinical trial has been conducted to evaluate the safety of transplanted human autologous Schwann cells to treat patients with spinal cord injury.A major challenge for Schwann cell transplantation is that grafted Schwann cells are confined within the lesion cavity,and they do not migrate into the host environment due to the inhibitory barrier formed by injury-induced glial scar,thus limiting axonal reentry into the host spinal cord.Here we introduce a combinatorial strategy by suppressing the inhibitory extracellular environment with injection of lentivirus-mediated transfection of chondroitinase ABC gene at the rostral and caudal borders of the lesion site and simultaneously leveraging the repair capacity of transplanted Schwann cells in adult rats following a mid-thoracic contusive spinal cord injury.We report that when the glial scar was degraded by chondroitinase ABC at the rostral and caudal lesion borders,Schwann cells migrated for considerable distances in both rostral and caudal directions.Such Schwann cell migration led to enhanced axonal regrowth,including the serotonergic and dopaminergic axons originating from supraspinal regions,and promoted recovery of locomotor and urinary bladder functions.Importantly,the Schwann cell survival and axonal regrowth persisted up to 6 months after the injury,even when treatment was delayed for 3 months to mimic chronic spinal cord injury.These findings collectively show promising evidence for a combinatorial strategy with chondroitinase ABC and Schwann cells in promoting remodeling and recovery of function following spinal cord injury.
基金This research was financially supported by National Natural Science Foundation of China(No.31501230)Shandong Province Natural Science Foundation of China for Youths(No.ZR2014CQ058)+1 种基金the National Key Research and Development Program of China Sub-project(No.2017YFD0700405)Shandong Province Science and Technology Planning Project of Higher Education(No.J17KA145).
文摘Rice transplanting requires the operator to manipulate the rice transplanter in straight trajectories.Various markers are proposed to help experienced drivers in keeping straightforward and parallel to the previous path,which are extremely boring in terms of large-scale fields.The objective of this research was to develop an autonomous navigation system that automatically guided a rice transplanter working along predetermined paths in the field.The rice transplanter used in this research was commercially available and originally manually-operated.An automatic manipulating system was developed instead of manual functions including steering,stop,going forward and reverse.A sensor fusion algorithm was adopted to integrate measurements of the Real-Time Kinematic Global Navigation Satellite System(RTK-GNSS)and Inertial Measurement Unit(IMU),and calculate the absolute moving direction under the UTM coordinate system.A headland turning control method was proposed to ensure a robust turning process considering that the rice transplanter featured a small turning radius and a relatively large slip rate at extreme steering angles.Experiments were designed and conducted to verify the performance of the newly developed autonomous navigation system.Results showed that both lateral and heading errors were less than 8 cm and 3 degrees,respectively,in terms of following straight paths.And headland turns were robustly executed according to the required pattern.
基金This study was funded by Scientific and Technological Project(Grant Number:2014BAD06 B01-1)Universities Science and Technology Innovation Team(Project Number:2014TD010)in Heilongjiang Province and Heilongjiang Land Reclamation Bureau Project(HNK125B-06-02A).
文摘This research aimed to solve current problems in the process of maize transplanting in China such as large labor intensity,low working efficiency and poor quality.On the basis of the structure of a seedling-sprouting tray made of maize straw and the agronomic requirements of maize production,this study developed a new feeding device for such a sprouting tray,determined the dimensions of the key components in a virtual environment via Solid Edge software and obtained optimal working parameters in combination with Matlab.Some tests on field validation and maize production were conducted as well.The test results showed the importance of the working parameters on an upright degree in descending order(as well as the best working parameters)to be the vertical angle of seedling planting(13.14°),the forward speed of locomotion(0.57 m/s),and the horizontal angle of the seedling box(22.5°).The standard deviation of the field validation was 6.04%,which was within the allowable range to meet the requirements of maize transplanting.Compared with maize transplanting machines(and manual transplanting operations)on the current market,the labor inputs,as well as the rates of spacing and upright degree qualification,omitted planting and the yield using the new feeding device for automatic transplanter with maize straw seedling-sprouting trays increased 0(6.9%),0(3.1%),0(4.5%)and 0(−1.0%),respectively;whereas,the manufacturing cost was reduced by 35.5%.The results can provide a technical basis and reference for subsequent development of automatic transplanters with maize straw seedling-sprouting trays.
基金The authors thank the editors and the anonymous reviewers whose constructive comments have notably contributed to the improved quality and clarity of this paper.This article was supported in part by the Zhejiang Provincial Natural Science Foundation of China(Grant No.LZ16E05003)the Natural Key Research and Development Program of China(Project No.2017YFD0700800)and the Science Foundation of Zhejiang Sci-Tech University(Grant No.15022011-Y).
文摘The rotary plug seedling pick-up mechanism for vegetable automatic transplanter is the technical bottleneck to improve the mechanization level of vegetable planting in China.In order to solve the problems of rotary seedling pick-up mechanism proposed in previous study,such as low success ratio of seedling pick-up at high speed,and interference between the seedling bowl and the end of the other seedling pick-up arm,a novel kind of rotary seedling pick-up mechanism of planetary gear train with combined type gears of incomplete denatured-eccentric-circular and non-circular gears was proposed.Through kinematic analysis of the seedling pick-up mechanism,the kinematics model was established.The computer-aided analysis and optimization software with human-computer interaction method was developed to realize parameters optimization of the seedling pick-up mechanism.Three-dimensional parametric design system of seedling pick-up mechanisms with combined non-circular gear transmission was developed for mechanism virtual simulation to verify the correctness of theoretical model and design results of the mechanism.The physical prototype of the mechanism was manufactured,and high-speed camera kinematics tests of the mechanism were conducted in the laboratory to study its kinematic characteristics.Laboratory seedling pick-up tests were carried out.The mechanism has the success ratio of seedling pick-up 96.3%without interference during seedling transporting when the rotation speed of the mechanism is 50 r/min and the seedling transplanting efficiency is 100 plants/min per row,showing that the novel mechanism has better working performance than the original one and could be applied in vegetable plug seedling transplanter.
基金This research was supported by the National Key Research and Development Project of China(2017YFD0301404-05)and the Fundamental Research Funds for the Central Universities(2662018PY038).
文摘To improve the precision of deep fertilization of paddy fields,a six-row centralized pneumatic deep precision fertilization device for a rice transplanter was designed.This device included a spiral fertilizer distribution system,centralized pneumatic fertilizer delivery system,an opener system,and a fertilization control system.The centralized airflow distribution method was used in the fertilizer delivery system to ensure that the airflow in each fertilizer pipe was evenly distributed.The rotational speeds of the power take-off(PTO)and fertilizer shaft were measured synchronously using photoelectric sensors and matched proportionately in real-time using PID closed-loop control algorithms to achieve precise fertilization rates at each working speed of the rice transplanter.There were two key considerations in the design of the control system to ensure precise fertilization.Firstly,a photoelectric sensor was used to measure the speed of the PTO;the high rotational speed of the PTO could provide a high signal frequency and improve the precision of the measurement of the transplanter’s working speed.Secondly,the fertilizer shaft speed measurement subprogram was set to sleep for a short period to reduce the vibration caused by the engine.During the tests of pneumatic fertilizer delivery system,single-factor tests on airflow distribution methods were conducted.The results showed that the coefficient of variation of the airflow speed for the centralized airflow distribution method was 1.67%,which was the least among the coefficients of the three distribution methods.In the bench tests,the rotational speeds of the fertilizer shaft were set at 10 r/min,20 r/min,30 r/min,and 40 r/min.The maximum coefficient of variation of the fertilization consistency in different rows was 1.49%at the rotational speed of 20 r/min.The maximum coefficient of variation of the fertilization stability was 2.86%at the rotational speed of 40 r/min,while the average fertilizer amount per lap for each distributor was 26.25 g/r.The results of the dynamic fertilization tests showed that the maximum relative error of the fertilizer distribution amount was 2.00%when the target fertilizer rates were 20,30,and 40 kg/667 m2.The results of the field tests showed that the average relative error of the fertilization amount was 3.53%,which satisfies the design standard.This research provides a reference for optimizing pneumatic fertilizer delivery systems and improving fertilization control systems and other pneumatic precision fertilizer application devices.
基金supported by the National Natural Science Foundation of China(51575284)the National Key Research and Development Program of China(2017YFD0700804)Funds for Modern Agricultural Industry Technology System Construction of China(CARS-13).
文摘Considering both high efficiency and high seedling standing quality is a significant objective for crop mechanized transplanting.Rape blanket seedling transplanting is an innovative and efficient transplanting technique.However,falling off phenomenon has become a common problem facing rape blanket seedling transplanting fields that causes seedling standing quality decrease and restricts crop growth.In this study,the rape blanket seedling of Ningza-1838 varieties and 35 d of seedling age was taken as the research object.The critical falling off equations of seedling was established by dynamic analysis.Main factors affecting seedling falling off were obtained.The critical value of each factor was calculated which were as follows:the rotation speed of the planting mechanism was 24.6 rad/s,the substrate moisture content was 50.4%and the longitudinal picking seedling quantity was 14.7 mm.Taking the seedling falling off rate as evaluation index,the measured critical value of seedling falling off was determined by high speed photography experiment.Under the condition that substrate moisture content was 55%and the longitudinal seedling quantity was 15 mm,the seedling falling off rate sharply increased when the transplanting mechanism rotation speed was increased from 24 rad/s to 26 rad/s.Under the condition that the rotation speed was 22 rad/s and the longitudinal picking seedling quantity was 15 mm,the seedling falling off rate rapidly decreased when the moisture content was increased from 47%to 53%.When moisture content exceeded 53%,this exhibited no obvious change.Under the condition that the moisture content was 50%and the rotation speed was 22 rad/s,the seedling falling off rate swiftly raised when the longitudinal picking seedling quantity was increased from 14 mm to 17 mm.The experimental results showed that the seedling falling off rate increased significantly near the critical value.The experimental results showed that the seedling falling off rate changed significantly near the critical value.It proved that the model was correct.Response surface experiments with the Box-Behnken design were conducted to determine the optimal combination parameters,which were as follows:substrate moisture content was 56.24%,planting mechanism rotation speed was 22.04 rad/s,and longitudinal picking seedling quantity was 14.91 mm.At this time,the seedling falling off rate was 1.36%,which ensured that seedlings could be transplanted stably under the carrier of seedling needle.The verification test was conducted,and the working parameters were adjusted according to the optimization results in experiment.The results of verification test were highly consistent with the optimization solution.The present study may provide a theoretical method for improving seedling standing quality of rape blanket seedling,and laid a foundation for the popularization and development of rape carpet seedling transplanting.
文摘Over the past six decades,liver transplantation(LT)has evolved from an experimental procedure into a standardized and life-saving intervention,reshaping the landscape of organ transplantation.Driven by pioneering breakthroughs,technological advancements,and a deepened understanding of immunology,LT has seen remarkable progress.Some of the most notable breakthroughs in the field include advances in immunosuppression,a revised model for end-stage liver disease,and artificial intelligence(AI)-integrated imaging modalities serving diagnostic and therapeutic roles in LT,paired with ever-evolving technological advances.Additionally,the refinement of transplantation procedures,resulting in the introduction of alternative transplantation methods,such as living donor LT,split LT,and the use of marginal grafts,has addressed the challenge of organ shortage.Moreover,precision medicine,guiding personalized immunosuppressive strategies,has significantly improved patient and graft survival rates while addressing emergent issues,such as short-term complications and early allograft dysfunction,leading to a more refined strategy and enhanced postoperative recovery.Looking ahead,ongoing research explores regenerative medicine,diagnostic tools,and AI to optimize organ allocation and posttransplantation car.In summary,the past six decades have marked a transformative journey in LT with a commitment to advancing science,medicine,and patient-centered care,offering hope and extending life to individuals worldwide.
文摘BACKGROUND Hepatocellular carcinoma(HCC)is a leading cause of cancer-related deaths worldwide.Liver transplantation(LT)offers the most effective treatment.HCC recurrence is the strongest risk factor that decreases post-LT survival in patients transplanted for HCC.The rate of HCC recurrence is generally reported as 8%-20%in the literature.Many predictors of HCC have already been researched,however,to our knowledge there are no published studies on this topic using Australian data.AIM To determine the rate and identify predictors of HCC recurrence in a contemporary Western Australian LT cohort.METHODS We performed a retrospective cohort study of all liver transplants in patients with HCC at Sir Charles Gairdner Hospital between 2006 and 2021.Data was collected from various health record databases and included recipient demographics,serum biochemistry,radiology,operation notes,explant histopathology and details of recurrence.Overall survival of HCC patients post-LT,stratified for recurrence,was calculated by Kaplan Meier analysis.Univariate and multivariate Cox regression was used to determine predictors of HCC recurrence post-LT.RESULTS Between 1/1/2006 and 12/31/2021,119 patients were transplanted with HCC.8.4%of subjects developed recurrent HCC after LT with median follow-up time of 5.4 years.The median time to recurrence was 2.9 years±0.75 years.When comparing baseline characteristics,a greater proportion of subjects with recurrence had common characteristics on explant histopathology,including>3 viable nodules(P=0.001),vascular invasion(P=0.003)and poorly differentiated HCC(P=0.03).Unadjusted survival curves showed lower 1-year,3-year,5-year and 10-year survival rates in subjects with HCC recurrence compared to those without HCC recurrence(90%vs 92%,70%vs 88%,42%vs 80%,14%vs 76%,respectively;log rank P<0.001).CONCLUSION HCC recurrence was low at 8.4%in this contemporary Australian cohort,however it significantly impacted post-LT survival.Further studies are required to confirm predictors of recurrence and improve recipient outcomes.
文摘In China pediatric liver transplantation(PLT)has become a safe and standardized procedure.Innovations and measures to further improve long-term survival and quality of life for children should be the next focus.In particular better strategies related to the surgical treatment of high-risk recipients as well as the long-term follow-up of pediatric liver recipients have to be addressed.A particular attention should be given to children presenting significant co-morbidities and those needing retransplantation.A tight mul-tidisciplinary follow-up system addressing both short-and long-term issues of pediatric liver recipients is still a challenge for the Chinese pediatric transplant community.
文摘The endothelium modulates vascular homeostasis owing to a variety of vasoconstrictors and vasodilators.Endothelial dysfunction(ED),characterized by impaired vasodilation,inflammation,and thrombosis,triggers future cardiovascular(CV)diseases.Chronic kidney disease,a state of chronic inflammation caused by oxidative stress,metabolic abnormalities,infection,and uremic toxins damages the endothelium.ED is also associated with a decline in estimated glomerular filtration rate.After kidney transplantation,endothelial functions undergo immediate but partial restoration,promising graft longevity and enhanced CV health.However,the anticipated CV outcomes do not happen due to various transplant-related and unrelated risk factors for ED,culminating in poor CV health and graft survival.ED in kidney transplant recipients is an underrecognized and poorly studied entity.CV diseases are the leading cause of death among kidney transplant candidates with functioning grafts.ED contributes to the pathogenesis of many of the CV diseases.Various biomarkers and vasoreactivity tests are available to study endothelial functions.With an increasing number of transplants happening every year,and improved graft rejection rates due to the availability of effective immunosuppressants,the focus has now shifted to endothelial protection for the prevention,early recognition,and treatment of CV diseases.
文摘BACKGROUND Family caregivers of cirrhosis patients(CPs)often experience burden,stress,and depression.Investigating whether these conditions improve following the patient undergoing liver transplantation(LT)is crucial,as it would elucidate the compre-hensive benefits of the procedure and demonstrate the positive impacts not only on the patients but also on their caregivers and society.AIM To compare the levels of burden,stress and depression among family caregivers of cirrhotic and liver transplant patients.METHODS This cross-sectional observational study evaluated caregivers of CPs and LT recipients at a quaternary Brazilian hospital.Instruments included identification cards,interview scripts,the caregiver burden scale Inventory,Lipp’s Stress Symptom Inventory,and the Beck Depression Inventory-Second Edition.Psychometric analyses involved confirmatory factor analysis and calculation of McDonald’s omega and composite reliability.Factor scores were compared with the Mann-Whitney U test,with effect size as the rank-biserial correlation coefficient(r).Statistical analysis was performed with R software(P<0.05).RESULTS Seventy-seven CP caregivers and 65 LT recipient caregivers were included.Most were female(CP:85.7%vs LT:84.6%)and the patients’spouses(76.6%vs 63.1%).The median age and caregiving duration were 55.4(23.3-76.3)vs 54.6(25.7-82.1)and 3.9(1-20)vs 8(1.5-24)years,respectively(P=0.001).LT caregivers were less likely to be at risk of overload(21.5%vs 49.4%),to be under stress(33.8%vs 36.4%)and to show symptoms of depression(15.4%vs 35.1%).Compared with LT caregivers,CP caregivers had greater median factor scores for burden(general tension,P=0.012;isolation,P=0.014;disappointment,P=0.004),depression(P=0.008),and stress(P=0.047),with small to moderate effect sizes.The disappointment(r=0.240)and depression(r=0.225)dimensions had the largest effect sizes.CONCLUSION Family caregivers of LT recipients are less likely to exhibit symptoms of burden,stress,and depression,suggesting that the benefits of LT extend to the patients’family members.
基金supported by grants from the National Natural Science Foundation of China (82470690 and 92159202)the Major Research Plan of Key Research and Development Project of Zhejiang Province (2024C03149 and 2023C03046)。
文摘In China, liver transplantation is an important discipline in the field of organ transplantation. China Liver Transplant Registry (CLTR) is a scientific project that has been set up to advance surgical techniques and procedures and to improve both short-and long-term post-transplant follow-up and outcome of the liver recipients. CLTR also serves as a robust data support platform for the National Liver Transplant Quality Control Center in the quest to upscale its quality control protocols. The mission of CLTR is to register all liver transplantation activities in the mainland of China and to conduct scientific analyses of the collected data. The huge number of compiled cases and the scientific research conducted over the past decade based on this database drastically revolutionized the clinical practice in the country. All CLTR activities and projects will be a guarantee to foster progresses of liver transplantation in China in a more scientific way, to standardize the systematic care in the field of liver transplantation.
基金supported by the National Key Research Program of China(2017YFD0700800)the National Natural Science Foundation of China(50905153,51565059)+1 种基金Autonomous Region Key Research Projects(2018B01001-3)Autonomous Region Tianshan Youth Program(2017Q018).
文摘To improve the low transplanting efficiencies and simplify the complex structures of current automatic transplanters,a mechanical high-speed transplanter for picking plug seedlings that is suitable for planting on plastic filmswas designed.Themain components were an automatic seedling picking systemand a basket-type planting system,whichwere used for the following processes:automatic picking,planting,soil covering,and suppression of plug seedlings.The performance test was performed on the automatic transplanter with 60-day-old pepper seedlings.The transplanting efficiency was tested at speeds of 40,60,90,and 120 plants·min−1.The results showed that the coefficient of variation(CV)of the plant spacing and the missed transplanting rate increased with the planting frequency,whereas the qualified rate of planting perpendicularity and the qualified rate of planting decreasedwith the increase in the planting frequency.All planting indicesmet the JB/T 102912013 standards.The results of this study showed that the auto-transplanter could performhigh-speed transplanting on the basis of completing the following functions:automatic picking,planting,soil covering,and suppression of plug seedlings.
文摘The reform stems from honesty and determination. Since 2005, organ donation and transplantation in China has undergone thorough reform, which complies with legislation requirements and ethical principles established by the World Health Organization(WHO). Reform in China has demonstrated the unwavering confidence and utmost determination of the Chinese government and the Chinese transplantation community. The year 2015 marked a historic turning point when voluntary donations from Chinese citizens became the sole legitimate source for organ transplantation. Since 2015, China has gradually established and refined the “Chinese Mode” and “China System” for organ donation and transplantation, fulfilling its political pledge of reform, and has garnered international recognition, and fostered a social culture which promotes organ donation. This article reviewed the history of reform on organ donation and transplantation in China, presented a new pattern of establishment of organ donation system in the new era of the country, and the direction of advances in the future.
基金We acknowledge the financial support by the German Research Foundation and the Open Access Publication Fund of the Technische Universitaet Berlin.
文摘This paper presents the study reports on evaluating a new transplanting operation by taking into accounts the interactions between soil,plant,and machine in line with the System of Rice Intensification(SRI)practices.The objective was to modify planting claw(kuku-kambing)of a paddy transplanter in compliance with SRI guidelines to determine the best planting spacing(S),seed rate(G)and planting pattern that results in a maximum number of seedling,tillers per hill,and yield.Two separate experiments were carried out in two different paddy fields,one to determine the best planting spacing(S=4 levels:s_(1)=0.16 m×0.3 m,s_(2)=0.18 m×0.3 m,s_(3)=0.21 m×0.3 m,and s_(4)=0.24 m×0.3 m)for a specific planting pattern(row mat or scattered planting pattern),and the other to determine the best combination of spacing with seed rate treatments(G=2 levels:g1=75 g/tray,and g2=240 g/tray).Main SRI management practices such as soil characteristics of the sites,planting depth,missing hill,hill population,the number of seedling per hill,and yield components were evaluated.Results of two-way analysis of variance with three replications showed that spacing,planting pattern and seed rate affected the number of one-seedling in all experiment.It was also observed that the increase in spacing resulted in more tillers and more panicle per plant,however hill population and sterility ratio increased with the decrease in spacing.While the maximum number of panicles were resulted from scattered planting at s_(4)=0.24 m×0.3 m spacing with the seed rate of g1=75 g/tray,the maximum number of one seedling were observed at s_(4)=0.16 m×0.3 m.The highest and lowest yields were obtained from 75 g seeds per tray scattered and 70 g seeds per tray scattered treatment respectively.For all treatments,the result clearly indicates an increase in yield with an increase in spacing.
基金financially supported by the National Key Research and Development Program of China Subproject(Grant No.2021YFD2000601)Innovation Scientists and Technicians Talent Projects of Henan Provincial Department of Education(Grant No.23IRTSTHN015,No.202300410124)。
文摘The vibration problem during the operation of rice transplanters is the most common phenomenon.In order that the static and dynamic characteristics of the rice transplanter chassis can meet the requirements of more stable operation,the research took the 2ZG-6DK rice transplanter as the research object to carry out a vibration reduction optimization study.In the research,the Pro/Engineer 5.0 software was first used to model the chassis of the rice transplanter.The constructed finite element model was revised by using the structural parameter revision method and the mixed penalty function method.The model was imported into ANSYS Workbench to solve the modal frequency and vibration shape of the rice transplanter chassis.Based on the MAC(modal assurance criterion)criterion,modal tests were carried out to verify the accuracy of the finite element theoretical analysis.Through the analysis of the characteristics of the external excitation frequency,the chassis is structurally optimized to avoid resonance caused by the natural frequency of the chassis falling within the road excitation frequency range.The final optimization results showed that the first four orders of modal frequencies of the chassis were adjusted to 32.083 Hz,33.751 Hz,42.517 Hz,and 50.362 Hz,respectively,in the case that the chassis mass was increased by 6.714 kg(8.8%).They all avoid the range of road excitation frequency(10-30 Hz)so that the rice transplanter can effectively avoid the resonance phenomenon during operation.This study can provide a reference for the design and optimization of the chassis structure of transplanter.
