Based on BERTopic Model,the paper combines qualitative and quantitative methods to explore the reception of Can Xue’s translated works by analyzing readers’book reviews posted on Goodreads and Lovereading.We first c...Based on BERTopic Model,the paper combines qualitative and quantitative methods to explore the reception of Can Xue’s translated works by analyzing readers’book reviews posted on Goodreads and Lovereading.We first collected book reviews from these two well-known websites by Python.Through topic analysis of these reviews,we identified recurring topics,including details of her translated works and appreciation of their translation quality.Then,employing sentiment and content analysis methods,the paper explored the emotional attitudes and the specific thoughts of readers toward Can Xue and her translated works.The fingdings revealed that,among the 408 reviews,though the reception of Can Xue’s translated works was relatively positive,the current level of attention and recognition remains insufficient.However,based on the research results,the paper can derive valuable insights into the translation and dissemination processes such as adjusting translation and dissemination strategies,so that the global reach of Chinese literature and culture can be better facilitated.展开更多
With the increasing frequency of global medical exchanges,the English translation of clinical medicine disease names has become a key factor affecting medical safety,the quality of academic exchanges,and the level of ...With the increasing frequency of global medical exchanges,the English translation of clinical medicine disease names has become a key factor affecting medical safety,the quality of academic exchanges,and the level of medical education.Meanwhile,there are certain problems in the English translation of clinical medicine disease names in China currently,mainly manifested in the prevalence of multiple translations for one term,prominent issues of literal translation and mistranslation,and inconsistent naming principles.Based on this,this paper focuses on the strategies for standardized English translation of clinical medicine disease names.By explaining the root causes of the problems existing in the current translation field,it further puts forward standardized suggestions from aspects such as establishing authoritative reference standards,following the basic principles of“respecting the originator,following conventions,and adhering to scientific norms”,strengthening medical English education,and using modern tools to assist learning.These efforts aim to gradually unify and standardize disease names,reduce ambiguities and errors,and lay a foundation for international medical exchanges and evidence-based medical research.展开更多
Background:The Vietnamese swine represents a promising animal model due to its anatomical,physiological,and pathophysiological similarities to humans.Notably,the arrangement of lobes and ducts in the mammary glands is...Background:The Vietnamese swine represents a promising animal model due to its anatomical,physiological,and pathophysiological similarities to humans.Notably,the arrangement of lobes and ducts in the mammary glands is highly comparable to that of humans and is histologically indistinguishable.Leveraging these advantages through the chemical induction of carcinogenesis in this model offers a robust approach to mimic human exposure to carcinogenic compounds.Methods:This study elaborates on a protocol for developing a representative model of MNU-induced invasive breast carcinoma in three Vietnamese swine,validated histologically and immunologically.It evaluates not only the tissue similarity with humans,but also the development of chemically induced mammary tumors in an immunologically competent animal.Moreover,this study addresses the existing gap in histological knowledge regarding mammary tissue in the porcine model.Results:Our findings suggest that this model encompasses the full spectrum of cancer.It incorporates the key elements of a tumor microenvironment that enable tumor growth and propagation,such as immune cells,blood vessels,fibroblasts,extracellular matrix,fatty acids,and signaling molecules.Conclusions:This model offers significant potential to advance the understanding of cancer pathogenesis and facilitate the development of innovative therapeutic strategies by closely replicating human tumor biology.展开更多
The concept of equivalence,which expresses the relations between the source text and the target text in the translation process,can be defined as finding the closest equivalent of the source text in the target text.In...The concept of equivalence,which expresses the relations between the source text and the target text in the translation process,can be defined as finding the closest equivalent of the source text in the target text.In order for the translated text to have the same taste in the target language,the equivalence between the two languages should be good.Many novels have been translated from English to Arabic.This translation was translated from English to Arabic.Jane Eyre is in the Victorian England.The novel is about love between two people of different classes,underlining the pressures,class distinction,male domination in society.Jane Eyre,who was one of the first novels about women’s freedom and rights,is also one of the most important works of romanticism.The author was inspired by his own life.In this study,language plays in Arabic translation of famous novelist Charlotte Bronte’s Jane Eyre were examined in terms of equivalence.In addition to semantic,syntactic,linguistic,and stylistic dimensions,translation of language games such as proverb,idiom,metaphor,personification,and comparison,which are the main material of a decorated language,is emphasized and their equivalence is interpreted in the light of the theories of translation.The analysis of the selected sample sentences from the novel within the context of translation criticism shows that the translator preserves the form and content of the source text in a significant way and provides a translation equivalent to the original in terms of linguistic,syntactic,and semantic.The Arabic reader seems to be able to understand the language games in English in a similar way in their own language.展开更多
Conceptual Blending Theory,as put forward by Gilles Fauconnier and Mark Turner,meets its application in English-Chinese translation with examples from long sentences.Under the foundation of Mental Space and the projec...Conceptual Blending Theory,as put forward by Gilles Fauconnier and Mark Turner,meets its application in English-Chinese translation with examples from long sentences.Under the foundation of Mental Space and the projection among Input Space I,Input Space II,and Generic Space,Blending Space is formed with effect on integration,correlation,and reorganization which function as a possible solution to long-sentence translation when thorough and detailed comprehension of both source and target language is similar.This study is meaningful to the progress and innovation in translatology and real translation practice.展开更多
Chinese food is not only characterized with its special cooking methods but its cultural implications.However,the status quo of English translation of Chinese dish names is not satisfying.For the purpose of spreading ...Chinese food is not only characterized with its special cooking methods but its cultural implications.However,the status quo of English translation of Chinese dish names is not satisfying.For the purpose of spreading Chinese cuisine culture,4 translating principles and several translating methods are put forward in order to promote the exchanging between cultures.展开更多
China is a country that attaches great importance to names,honor,and prestige.The set phrase,to achieve both fame and wealth,gives the true meaning of the word fame.Chinese food culture has a long history,and forms a ...China is a country that attaches great importance to names,honor,and prestige.The set phrase,to achieve both fame and wealth,gives the true meaning of the word fame.Chinese food culture has a long history,and forms a variety of dishes,These Chinese dishes are popular with the whole world.English translation of Chinese dish can be found everywhere in China nowadays.For example:restaurants have bilingual menus;cook books are translated into English;food is discussed and recommended in English on newspaper,magazines and TV programs.Some of the English equivalents are so wordy or awkward that they read like recipes instead of names.Some are confusing and misleading.The problem is that some dish names embedded with cultural connotation are still translated literally,which makes the menus unintelligible and the target language reader lost chances to enjoy Chinese food culture.Owing to these features of the Chinese culinary culture,the names of Chinese food are kaleidoscopic and deny easy forms.展开更多
Translation is a crucial step in gene expression.Over the past decade,the development and application of ribosome profiling(Ribo-seq)have significantly advanced our understanding of translational regulation in vivo.Ho...Translation is a crucial step in gene expression.Over the past decade,the development and application of ribosome profiling(Ribo-seq)have significantly advanced our understanding of translational regulation in vivo.However,the analysis and visualization of Ribo-seq data remain challenging.Despite the availability of various analytical pipelines,improvements in comprehensiveness,accuracy,and user-friendliness are still necessary.In this study,we develop RiboParser/RiboShiny,a robust framework for analyzing and visualizing Ribo-seq data.Building on published methods,we optimize ribosome structure-based and start/stopbased models to improve the accuracy and stability of P-site detection,even in species with a high proportion of leaderless transcripts.Leveraging these improvements,RiboParser offers comprehensive analyses,including quality control,gene-level analysis,codon-level analysis,and the analysis of Ribo-seq variants.Meanwhile,RiboShiny provides a user-friendly and adaptable platform for data visualization,facilitating deeper insights into the translational landscape.Furthermore,the integration of standardized genome annotation renders our platform universally applicable to various organisms with sequenced genomes.This framework has the potential to significantly improve the precision and efficiency of Ribo-seq data interpretation,thereby deepening our understanding of translational regulation.展开更多
The Good Wife is an American TV series that focuses on women’s independence,politics,and law.The drama has been remade in China,Japan,and South Korea.This research aims to use Nida’s Functional Equivalence Theory to...The Good Wife is an American TV series that focuses on women’s independence,politics,and law.The drama has been remade in China,Japan,and South Korea.This research aims to use Nida’s Functional Equivalence Theory to analyze the methods of its English-to-Chinese subtitle translation by considering social,cultural,and historic backgrounds between China and America.After data collection and case analysis,the study found that:(1)Five major translation methods are adopted in the subtitle translation of The Good Wife.They are free translation,variation,literal translation,addition,and omission.Among them,free translation is the most frequently used,while omission is used least.(2)The subtitle translation of films and TV series is limited by time and space restrictions,social-cultural differences,and other factors.When translating,translators should try to use humorous words,euphemism,intonation,and other ways,and combine different methods such as literal translation,free translation,variation,addition,omission,and other methods to seek equivalence both in the meaning and function of subtitles under the guidance of Functional Equivalence Theory.展开更多
Over the years,Generative Adversarial Networks(GANs)have revolutionized the medical imaging industry for applications such as image synthesis,denoising,super resolution,data augmentation,and cross-modality translation...Over the years,Generative Adversarial Networks(GANs)have revolutionized the medical imaging industry for applications such as image synthesis,denoising,super resolution,data augmentation,and cross-modality translation.The objective of this review is to evaluate the advances,relevances,and limitations of GANs in medical imaging.An organised literature review was conducted following the guidelines of PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses).The literature considered included peer-reviewed papers published between 2020 and 2025 across databases including PubMed,IEEE Xplore,and Scopus.The studies related to applications of GAN architectures in medical imaging with reported experimental outcomes and published in English in reputable journals and conferences were considered for the review.Thesis,white papers,communication letters,and non-English articles were not included for the same.CLAIM based quality assessment criteria were applied to the included studies to assess the quality.The study classifies diverse GAN architectures,summarizing their clinical applications,technical performances,and their implementation hardships.Key findings reveal the increasing applications of GANs for enhancing diagnostic accuracy,reducing data scarcity through synthetic data generation,and supporting modality translation.However,concerns such as limited generalizability,lack of clinical validation,and regulatory constraints persist.This review provides a comprehensive study of the prevailing scenario of GANs in medical imaging and highlights crucial research gaps and future directions.Though GANs hold transformative capability for medical imaging,their integration into clinical use demands further validation,interpretability,and regulatory alignment.展开更多
Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecul...Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.展开更多
Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomed...Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.展开更多
The lysosomal enzyme β-glucocerebrosidase(GCase) belongs to the family of glycosidases and hydrolyses the glycosphingolipid glucosylceramide(GluCer) into glucose and ceramide. The enzyme is of central importance for ...The lysosomal enzyme β-glucocerebrosidase(GCase) belongs to the family of glycosidases and hydrolyses the glycosphingolipid glucosylceramide(GluCer) into glucose and ceramide. The enzyme is of central importance for two pathologies:(1) the lysosomal storage disorder Gaucher's disease(GD) and(2) the neurodegenerative disorder Parkinson's disease(PD).展开更多
Breast cancer stands as the most prevalent malignancy among women worldwide and a leading cause of cancer-related mortality,posing a persistent challenge to global public health1.In recent decades,the landscape of bre...Breast cancer stands as the most prevalent malignancy among women worldwide and a leading cause of cancer-related mortality,posing a persistent challenge to global public health1.In recent decades,the landscape of breast cancer care has been profoundly reshaped by the rapid development of precision medicine,targeted therapy,immunotherapy,and clinical translational research.展开更多
“By successfully integrating artificial intelligence(AI)into research workflows,researchers could substantially increase scientific productivity”[1].In biofabrication,AI is dr iving a paradigm shift from empiricism ...“By successfully integrating artificial intelligence(AI)into research workflows,researchers could substantially increase scientific productivity”[1].In biofabrication,AI is dr iving a paradigm shift from empiricism toward intelligen t,data centric manufacturing[2].By integrating computation,automation,and biology,AI gives rise to self-evolving,adaptive systems that learn from data,predict complex behaviors,and autonomously optimize fabrication outcomes.Such systems translate experimental insights into patient-specific and clinically relevant solutions,bridging laboratory research and regenerative therapies[3].This emerging frontier is rapidly advancing from concept to application.This Special Column highlights how AI-driven advanc es in materials,design,and manufacturing are reshaping biof abrication for regenerative medicine and clinical translation.展开更多
In this study,tropical cyclone(TC)translation speed was introduced as a new similarity factor within the generalized initial value(GIV)framework,enhancing the disaster preassessment capability of the dynamical statist...In this study,tropical cyclone(TC)translation speed was introduced as a new similarity factor within the generalized initial value(GIV)framework,enhancing the disaster preassessment capability of the dynamical statistical analog ensemble forecast model for landfalling TC disasters(DSAEF_LTD model).Three TC translation speed indicators most relevant to TC precipitation were incorporated:the maximum speed on Day 1(the first day of TC-induced precipitation and wind occurring on land)and the average and minimum speeds over All Days(all days of TC-induced precipitation and wind occurring on land),all classified using the Kmeans clustering algorithm.Simulation experiments showed that integrating TC translation speed enhanced the model's performance.The model provided a better optimal common scheme,with the TSS UM(sum of threat scores for severe and above and extremely severe and above disasters)increasing by 2.66%(from 0.5117 to 0.5253)compared with the original model.More importantly,its preassessment ability improved significantly,with the average TSS UM for independent samples increasing by 6.43%(from 0.6488 to0.6905).The modified model demonstrated greater accuracy in capturing disaster severity and distribution of TCs with significant speed characteristics or with regular tracks.This improvement stemmed from reduced false alarms due to the selection of analogs that are more similar to the target TC.The enhanced preassessment ability can be attributed to the key role of TC translation speed,which significantly influences TC precipitation patterns and improves TC precipitation forecasting.Since precipitation is one of the most crucial disaster-causing factors,better TC precipitation forecasting leads to improved disaster preassessment outcomes.These findings emphasize the promising potential of the DSAEF_LTD model for future TC disaster research and management,contributing to the achievement of the Sustainable Development Goals set by the United Nations 2030 Agenda by strengthening coastal resilience.展开更多
This review comprehensively summarized the potential of artificial intelligence(AI)in the management of esophageal cancer.It highlighted the significance of AI-assisted endoscopy in Japan where endoscopy is central to...This review comprehensively summarized the potential of artificial intelligence(AI)in the management of esophageal cancer.It highlighted the significance of AI-assisted endoscopy in Japan where endoscopy is central to both screening and diagnosis.For the clinical adaptation of AI,several challenges remain for its effective translation.The establishment of high-quality clinical databases,such as the National Clinical Database and Japan Endoscopy Database in Japan,which covers almost all cases of esophageal cancer,is essential for validating multimodal AI models.This requires rigorous external validation using diverse datasets,including those from different endoscope manufacturers and image qualities.Furthermore,endoscopists’skills significantly affect diagnostic accuracy,suggesting that AI should serve as a supportive tool rather than a replacement.Addressing these challenges,along with country-specific legal and ethical considerations,will facilitate the successful integration of multimodal AI into the management of esophageal cancer,particularly in endoscopic diagnosis,and contribute to improved patient outcomes.Although this review focused on Japan as a case study,the challenges and solutions described are broadly applicable to other high-incidence regions.展开更多
Journal of Nutritional Oncology(JNO)is an international,open-access,peer-reviewed academic journal that aims to reflect the latest findings in basic,clinical,and translational research in cancer metabolism,nutrition,a...Journal of Nutritional Oncology(JNO)is an international,open-access,peer-reviewed academic journal that aims to reflect the latest findings in basic,clinical,and translational research in cancer metabolism,nutrition,and nutritional intervention.It publishes edge-cutting scientific studies in the field.It reports recent development and advances to its audience.展开更多
基金supported by the 2023 Youth Fund for Humanities and Social Sciences Research by the Ministry of Education of the People’s Republic of China(Grant No.23YJC740004).
文摘Based on BERTopic Model,the paper combines qualitative and quantitative methods to explore the reception of Can Xue’s translated works by analyzing readers’book reviews posted on Goodreads and Lovereading.We first collected book reviews from these two well-known websites by Python.Through topic analysis of these reviews,we identified recurring topics,including details of her translated works and appreciation of their translation quality.Then,employing sentiment and content analysis methods,the paper explored the emotional attitudes and the specific thoughts of readers toward Can Xue and her translated works.The fingdings revealed that,among the 408 reviews,though the reception of Can Xue’s translated works was relatively positive,the current level of attention and recognition remains insufficient.However,based on the research results,the paper can derive valuable insights into the translation and dissemination processes such as adjusting translation and dissemination strategies,so that the global reach of Chinese literature and culture can be better facilitated.
文摘With the increasing frequency of global medical exchanges,the English translation of clinical medicine disease names has become a key factor affecting medical safety,the quality of academic exchanges,and the level of medical education.Meanwhile,there are certain problems in the English translation of clinical medicine disease names in China currently,mainly manifested in the prevalence of multiple translations for one term,prominent issues of literal translation and mistranslation,and inconsistent naming principles.Based on this,this paper focuses on the strategies for standardized English translation of clinical medicine disease names.By explaining the root causes of the problems existing in the current translation field,it further puts forward standardized suggestions from aspects such as establishing authoritative reference standards,following the basic principles of“respecting the originator,following conventions,and adhering to scientific norms”,strengthening medical English education,and using modern tools to assist learning.These efforts aim to gradually unify and standardize disease names,reduce ambiguities and errors,and lay a foundation for international medical exchanges and evidence-based medical research.
基金C.E.Vera-Tizatl(CVU:708156)thank the National Council for Science and Technology(CONACYT,Mexico)for the scholarship granted。
文摘Background:The Vietnamese swine represents a promising animal model due to its anatomical,physiological,and pathophysiological similarities to humans.Notably,the arrangement of lobes and ducts in the mammary glands is highly comparable to that of humans and is histologically indistinguishable.Leveraging these advantages through the chemical induction of carcinogenesis in this model offers a robust approach to mimic human exposure to carcinogenic compounds.Methods:This study elaborates on a protocol for developing a representative model of MNU-induced invasive breast carcinoma in three Vietnamese swine,validated histologically and immunologically.It evaluates not only the tissue similarity with humans,but also the development of chemically induced mammary tumors in an immunologically competent animal.Moreover,this study addresses the existing gap in histological knowledge regarding mammary tissue in the porcine model.Results:Our findings suggest that this model encompasses the full spectrum of cancer.It incorporates the key elements of a tumor microenvironment that enable tumor growth and propagation,such as immune cells,blood vessels,fibroblasts,extracellular matrix,fatty acids,and signaling molecules.Conclusions:This model offers significant potential to advance the understanding of cancer pathogenesis and facilitate the development of innovative therapeutic strategies by closely replicating human tumor biology.
文摘The concept of equivalence,which expresses the relations between the source text and the target text in the translation process,can be defined as finding the closest equivalent of the source text in the target text.In order for the translated text to have the same taste in the target language,the equivalence between the two languages should be good.Many novels have been translated from English to Arabic.This translation was translated from English to Arabic.Jane Eyre is in the Victorian England.The novel is about love between two people of different classes,underlining the pressures,class distinction,male domination in society.Jane Eyre,who was one of the first novels about women’s freedom and rights,is also one of the most important works of romanticism.The author was inspired by his own life.In this study,language plays in Arabic translation of famous novelist Charlotte Bronte’s Jane Eyre were examined in terms of equivalence.In addition to semantic,syntactic,linguistic,and stylistic dimensions,translation of language games such as proverb,idiom,metaphor,personification,and comparison,which are the main material of a decorated language,is emphasized and their equivalence is interpreted in the light of the theories of translation.The analysis of the selected sample sentences from the novel within the context of translation criticism shows that the translator preserves the form and content of the source text in a significant way and provides a translation equivalent to the original in terms of linguistic,syntactic,and semantic.The Arabic reader seems to be able to understand the language games in English in a similar way in their own language.
文摘Conceptual Blending Theory,as put forward by Gilles Fauconnier and Mark Turner,meets its application in English-Chinese translation with examples from long sentences.Under the foundation of Mental Space and the projection among Input Space I,Input Space II,and Generic Space,Blending Space is formed with effect on integration,correlation,and reorganization which function as a possible solution to long-sentence translation when thorough and detailed comprehension of both source and target language is similar.This study is meaningful to the progress and innovation in translatology and real translation practice.
文摘Chinese food is not only characterized with its special cooking methods but its cultural implications.However,the status quo of English translation of Chinese dish names is not satisfying.For the purpose of spreading Chinese cuisine culture,4 translating principles and several translating methods are put forward in order to promote the exchanging between cultures.
文摘China is a country that attaches great importance to names,honor,and prestige.The set phrase,to achieve both fame and wealth,gives the true meaning of the word fame.Chinese food culture has a long history,and forms a variety of dishes,These Chinese dishes are popular with the whole world.English translation of Chinese dish can be found everywhere in China nowadays.For example:restaurants have bilingual menus;cook books are translated into English;food is discussed and recommended in English on newspaper,magazines and TV programs.Some of the English equivalents are so wordy or awkward that they read like recipes instead of names.Some are confusing and misleading.The problem is that some dish names embedded with cultural connotation are still translated literally,which makes the menus unintelligible and the target language reader lost chances to enjoy Chinese food culture.Owing to these features of the Chinese culinary culture,the names of Chinese food are kaleidoscopic and deny easy forms.
基金supported by the National Key Research and Development Program of China(2022YFA0912100)the National Natural Science Foundation of China(32270098 and 32470073)+1 种基金the Fundamental Research Funds for the Central Universities(2662024JC015)the National Key Laboratory of Agricultural Microbiology(AML2024D02)to Z.Z.
文摘Translation is a crucial step in gene expression.Over the past decade,the development and application of ribosome profiling(Ribo-seq)have significantly advanced our understanding of translational regulation in vivo.However,the analysis and visualization of Ribo-seq data remain challenging.Despite the availability of various analytical pipelines,improvements in comprehensiveness,accuracy,and user-friendliness are still necessary.In this study,we develop RiboParser/RiboShiny,a robust framework for analyzing and visualizing Ribo-seq data.Building on published methods,we optimize ribosome structure-based and start/stopbased models to improve the accuracy and stability of P-site detection,even in species with a high proportion of leaderless transcripts.Leveraging these improvements,RiboParser offers comprehensive analyses,including quality control,gene-level analysis,codon-level analysis,and the analysis of Ribo-seq variants.Meanwhile,RiboShiny provides a user-friendly and adaptable platform for data visualization,facilitating deeper insights into the translational landscape.Furthermore,the integration of standardized genome annotation renders our platform universally applicable to various organisms with sequenced genomes.This framework has the potential to significantly improve the precision and efficiency of Ribo-seq data interpretation,thereby deepening our understanding of translational regulation.
文摘The Good Wife is an American TV series that focuses on women’s independence,politics,and law.The drama has been remade in China,Japan,and South Korea.This research aims to use Nida’s Functional Equivalence Theory to analyze the methods of its English-to-Chinese subtitle translation by considering social,cultural,and historic backgrounds between China and America.After data collection and case analysis,the study found that:(1)Five major translation methods are adopted in the subtitle translation of The Good Wife.They are free translation,variation,literal translation,addition,and omission.Among them,free translation is the most frequently used,while omission is used least.(2)The subtitle translation of films and TV series is limited by time and space restrictions,social-cultural differences,and other factors.When translating,translators should try to use humorous words,euphemism,intonation,and other ways,and combine different methods such as literal translation,free translation,variation,addition,omission,and other methods to seek equivalence both in the meaning and function of subtitles under the guidance of Functional Equivalence Theory.
基金supported by Deanship of Research and Graduate Studies at King Khalid University for funding this work through Large Research Project under grant number RGP2/540/46.
文摘Over the years,Generative Adversarial Networks(GANs)have revolutionized the medical imaging industry for applications such as image synthesis,denoising,super resolution,data augmentation,and cross-modality translation.The objective of this review is to evaluate the advances,relevances,and limitations of GANs in medical imaging.An organised literature review was conducted following the guidelines of PRISMA(Preferred Reporting Items for Systematic Reviews and Meta-Analyses).The literature considered included peer-reviewed papers published between 2020 and 2025 across databases including PubMed,IEEE Xplore,and Scopus.The studies related to applications of GAN architectures in medical imaging with reported experimental outcomes and published in English in reputable journals and conferences were considered for the review.Thesis,white papers,communication letters,and non-English articles were not included for the same.CLAIM based quality assessment criteria were applied to the included studies to assess the quality.The study classifies diverse GAN architectures,summarizing their clinical applications,technical performances,and their implementation hardships.Key findings reveal the increasing applications of GANs for enhancing diagnostic accuracy,reducing data scarcity through synthetic data generation,and supporting modality translation.However,concerns such as limited generalizability,lack of clinical validation,and regulatory constraints persist.This review provides a comprehensive study of the prevailing scenario of GANs in medical imaging and highlights crucial research gaps and future directions.Though GANs hold transformative capability for medical imaging,their integration into clinical use demands further validation,interpretability,and regulatory alignment.
基金Ministry of Research,Innovation and Digitization,CCCDI-UEFISCDI,Grant/Award Number:PN-IV-P7-7.1-PED-2024-1578,within PNCDI Ⅳ.
文摘Pathological scarring,manifested in the form of hypertrophic scars(HTS)and keloid scars(KS),represents a major clinical challenge due to its aesthetic and functional implications for patients.Understanding the molecular mechanisms involved in these types of scars and developing effective treatments requires the use of controlled ex-perimental models,especially animals,to overcome the limitations of clinical studies.The aim of this sistematic review is to critically analyze the animal models used in the last five years(2020-2025)for the study of pathological scars,highlighting their advantages,limitations and applicability in the development of new therapeutic strat-egies.Murine,rabbit and porcine models,as well as alternative models,offer varied perspectives on the formation and treatment of HTS and KS,with an emphasis on histological and molecular correlations with human pathology.By synthesizing recent data,the paper highlights the essential role of preclinical research in optimizing an-tifibrotic treatments and in advancing the translation of data into the clinical sphere.Overall,animal models remain essential for bridging mechanistic insights with clinical translation,supporting the development of more effective and personalized anti-scar therapies.
基金supported by the National Natural Science Foundation of China[82003956]the National Key Research and Development Program of China[No.2022YFA1205802]+2 种基金financially supported by Henan Province Health Science and Technology Innovation Youth Talent Project(YQRC2023013 and YQRC2024013)the Key Project of Medical Science and Technology of Henan Province(SBGJ202302072)the Science and Technology Research Project of Henan Province(252102311236).
文摘Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.
基金supported by the Michael J Fox Foundation (to PA and FZ)。
文摘The lysosomal enzyme β-glucocerebrosidase(GCase) belongs to the family of glycosidases and hydrolyses the glycosphingolipid glucosylceramide(GluCer) into glucose and ceramide. The enzyme is of central importance for two pathologies:(1) the lysosomal storage disorder Gaucher's disease(GD) and(2) the neurodegenerative disorder Parkinson's disease(PD).
文摘Breast cancer stands as the most prevalent malignancy among women worldwide and a leading cause of cancer-related mortality,posing a persistent challenge to global public health1.In recent decades,the landscape of breast cancer care has been profoundly reshaped by the rapid development of precision medicine,targeted therapy,immunotherapy,and clinical translational research.
文摘“By successfully integrating artificial intelligence(AI)into research workflows,researchers could substantially increase scientific productivity”[1].In biofabrication,AI is dr iving a paradigm shift from empiricism toward intelligen t,data centric manufacturing[2].By integrating computation,automation,and biology,AI gives rise to self-evolving,adaptive systems that learn from data,predict complex behaviors,and autonomously optimize fabrication outcomes.Such systems translate experimental insights into patient-specific and clinically relevant solutions,bridging laboratory research and regenerative therapies[3].This emerging frontier is rapidly advancing from concept to application.This Special Column highlights how AI-driven advanc es in materials,design,and manufacturing are reshaping biof abrication for regenerative medicine and clinical translation.
基金supported by the Key Laboratory of South China Sea Meteorological Disaster Prevention and Mitigation of Hainan Province(No.SCSF202307)the Basic Research Fund of CAMS(No.2023Z016)+1 种基金the National Natural Scientific Foundation of China(No.42275037)the Jiangsu Collaborative Innovation Center for Climate Change。
文摘In this study,tropical cyclone(TC)translation speed was introduced as a new similarity factor within the generalized initial value(GIV)framework,enhancing the disaster preassessment capability of the dynamical statistical analog ensemble forecast model for landfalling TC disasters(DSAEF_LTD model).Three TC translation speed indicators most relevant to TC precipitation were incorporated:the maximum speed on Day 1(the first day of TC-induced precipitation and wind occurring on land)and the average and minimum speeds over All Days(all days of TC-induced precipitation and wind occurring on land),all classified using the Kmeans clustering algorithm.Simulation experiments showed that integrating TC translation speed enhanced the model's performance.The model provided a better optimal common scheme,with the TSS UM(sum of threat scores for severe and above and extremely severe and above disasters)increasing by 2.66%(from 0.5117 to 0.5253)compared with the original model.More importantly,its preassessment ability improved significantly,with the average TSS UM for independent samples increasing by 6.43%(from 0.6488 to0.6905).The modified model demonstrated greater accuracy in capturing disaster severity and distribution of TCs with significant speed characteristics or with regular tracks.This improvement stemmed from reduced false alarms due to the selection of analogs that are more similar to the target TC.The enhanced preassessment ability can be attributed to the key role of TC translation speed,which significantly influences TC precipitation patterns and improves TC precipitation forecasting.Since precipitation is one of the most crucial disaster-causing factors,better TC precipitation forecasting leads to improved disaster preassessment outcomes.These findings emphasize the promising potential of the DSAEF_LTD model for future TC disaster research and management,contributing to the achievement of the Sustainable Development Goals set by the United Nations 2030 Agenda by strengthening coastal resilience.
基金Supported by Japan Society for the Promotion of Science,No.24K11935.
文摘This review comprehensively summarized the potential of artificial intelligence(AI)in the management of esophageal cancer.It highlighted the significance of AI-assisted endoscopy in Japan where endoscopy is central to both screening and diagnosis.For the clinical adaptation of AI,several challenges remain for its effective translation.The establishment of high-quality clinical databases,such as the National Clinical Database and Japan Endoscopy Database in Japan,which covers almost all cases of esophageal cancer,is essential for validating multimodal AI models.This requires rigorous external validation using diverse datasets,including those from different endoscope manufacturers and image qualities.Furthermore,endoscopists’skills significantly affect diagnostic accuracy,suggesting that AI should serve as a supportive tool rather than a replacement.Addressing these challenges,along with country-specific legal and ethical considerations,will facilitate the successful integration of multimodal AI into the management of esophageal cancer,particularly in endoscopic diagnosis,and contribute to improved patient outcomes.Although this review focused on Japan as a case study,the challenges and solutions described are broadly applicable to other high-incidence regions.
文摘Journal of Nutritional Oncology(JNO)is an international,open-access,peer-reviewed academic journal that aims to reflect the latest findings in basic,clinical,and translational research in cancer metabolism,nutrition,and nutritional intervention.It publishes edge-cutting scientific studies in the field.It reports recent development and advances to its audience.
