Objective： To study the principle of clearing Fei （肺）, cooling blood, and detoxification as well as nourishing yin and moisening Fei （abbr. as CCD-NM） in regulating the levels of peripheral T-lymphocyte subsets ...Objective： To study the principle of clearing Fei （肺）, cooling blood, and detoxification as well as nourishing yin and moisening Fei （abbr. as CCD-NM） in regulating the levels of peripheral T-lymphocyte subsets Th and Tc cells to explore its mechanism for lowering the incidence of infection in patients with systemic lupus erythematosus iSLE）. Methods： Sixty SLE patients without complicated infection were assigned to the treatment group and the control group, 30 in each group. The control group was treated with Western medicine alone, while the treatment group was treated with the same program of Western medicine, but additionally administered with either Langchuang No.1 （狼疮 Ⅰ号） or 2 （狼疮 Ⅱ 号）, serial concerted Chinese recipes, applied respectively in patients in the active stage or in the resting stage. The total time of treatment for both groups was 1 year. Further, a healthy control group was set up with 20 healthy subjects. The expressions of Thl, Th2, and Tcl and Tc2 cells in peripheral blood were detected and compared with those in the healthy control group. Results： （1） As compared with the healthy control group, ratios of Thl/Th2 and Tcl/Tc2 in SLE patients, whether complicated with infection or not, were significantly lower （P〈0.05 or P〈0.01）. （2） Comparison between patients with complications and those uncomplicated with infection showed that the two ratios and Thl expression were lower and Tc2 was higher in the former than those in the latter （all P〈0.05）. （3） Ratios of Thl/Th2 and Tcl/Tc2 increased after treatment in patients of both the treatment group and the control group （P〈0.05 and P〈0.01）, but the changes in the treatment group were more significant （P〈0.05）. Conclusion： The principle of CCD-NM could regulate the Th and Tc subsets toward equilibrium in SLE patients, which might be one of the mechanisms of action for alleviating complicated infection.展开更多
文摘目的:本研究试图通过评价乙型病毒性肝炎患者的部分T细胞免疫指标与病毒复制水平和肝细胞损伤水平之间的关系,了解乙型病毒性肝炎患者的T细胞免疫在疾病发生发展过程中的作用.方法:将慢性乙型病毒性肝炎患者31例按照HBV DNA水平分为高、中、低复制3组,比较3组间CD3+、CD4+、CD8+、CD4+/CD8+、Th1、Th2、Th1/Th2、Tc1、Th17、Tc17、Th17/Tc17、Treg、Th17/Treg等多项T细胞亚群细胞数量;按照谷丙转氨酶水平分为肝细胞轻、中、重损伤3组,比较3组间多项T细胞亚群细胞数量,以此评价慢性乙型病毒性肝炎患者的部分T细胞免疫指标与病毒复制水平和肝细胞损伤水平之间的关系.结果:病毒低度复制患者Th17细胞(5.81%)和Th17/Treg(23.54)显著高于中/高度复制患者Th17细胞(2.51%/2.23%)和Th17/Tr e g(19.42/9.85);正常肝功患者T h2细胞(6.75%)、Tc1细胞(70.43%)、Th17/Tc17(71.18)均显著高于轻/重度肝细胞损伤患者Th2细胞(3.09%/3.58%)、Tc1细胞(36.97%/35.86%)、Th17/Tc17(11.35/12.58),重度损伤患者Tc17细胞(0.42%)显著少于轻度损伤患者Tc17细胞(1.69%).结论:慢性乙型病毒性肝炎患者T细胞免疫状态与病毒复制水平和肝细胞损伤水平关系密切,其中Th17/Tc17起重要作用.
基金the Funds of Hangzhou Municipal Medical Key Subjects(No.2005633Q14)
文摘Objective： To study the principle of clearing Fei （肺）, cooling blood, and detoxification as well as nourishing yin and moisening Fei （abbr. as CCD-NM） in regulating the levels of peripheral T-lymphocyte subsets Th and Tc cells to explore its mechanism for lowering the incidence of infection in patients with systemic lupus erythematosus iSLE）. Methods： Sixty SLE patients without complicated infection were assigned to the treatment group and the control group, 30 in each group. The control group was treated with Western medicine alone, while the treatment group was treated with the same program of Western medicine, but additionally administered with either Langchuang No.1 （狼疮 Ⅰ号） or 2 （狼疮 Ⅱ 号）, serial concerted Chinese recipes, applied respectively in patients in the active stage or in the resting stage. The total time of treatment for both groups was 1 year. Further, a healthy control group was set up with 20 healthy subjects. The expressions of Thl, Th2, and Tcl and Tc2 cells in peripheral blood were detected and compared with those in the healthy control group. Results： （1） As compared with the healthy control group, ratios of Thl/Th2 and Tcl/Tc2 in SLE patients, whether complicated with infection or not, were significantly lower （P〈0.05 or P〈0.01）. （2） Comparison between patients with complications and those uncomplicated with infection showed that the two ratios and Thl expression were lower and Tc2 was higher in the former than those in the latter （all P〈0.05）. （3） Ratios of Thl/Th2 and Tcl/Tc2 increased after treatment in patients of both the treatment group and the control group （P〈0.05 and P〈0.01）, but the changes in the treatment group were more significant （P〈0.05）. Conclusion： The principle of CCD-NM could regulate the Th and Tc subsets toward equilibrium in SLE patients, which might be one of the mechanisms of action for alleviating complicated infection.
