目的探讨甘油三酯葡萄糖-腰围身高比(triglyceride glucose-waist height ratio,TyG-WHtR)指数与可能肌少症之间的相关性。方法基于中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS)数据进行横断面研究...目的探讨甘油三酯葡萄糖-腰围身高比(triglyceride glucose-waist height ratio,TyG-WHtR)指数与可能肌少症之间的相关性。方法基于中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS)数据进行横断面研究。通过测量握力和重复5次起坐时间诊断可能肌少症,并收集血液生物学标志物及问卷调查等相关数据,运用多因素Logistic回归分析探讨TyG-WHtR指数与可能肌少症的关联,并进行交互作用和亚组分析。结果共纳入分析5496名受访者,其中可能肌少症患者2027例,患病率为36.9%。在调整所有混杂因素的模型中发现,TyG-WHtR指数与可能肌少症呈正相关(OR=1.91,95%CI:1.41~2.60)。对年龄、性别、高血压、糖尿病、血脂异常、慢性肺部疾病、心脏病、BMI进行分层分析发现,各亚组间差异均无统计学意义(P>0.05)。结论TyG-WHtR指数与可能肌少症呈正相关,当ln转化的TyG-WHtR指数每增加1个单位,可能肌少症发生风险相对增加91%。展开更多
目的:分析成年人甘油三酯葡萄糖乘积(TyG)指数与2型糖尿病(T2DM)伴超重/肥胖状况之间的影响因素。方法:本研究选取60例T2DM伴超重/肥胖的患者组成患病组,同时选取30名健康个体构成健康对照组。收集两组的基本信息、检验参数指标,行统计...目的:分析成年人甘油三酯葡萄糖乘积(TyG)指数与2型糖尿病(T2DM)伴超重/肥胖状况之间的影响因素。方法:本研究选取60例T2DM伴超重/肥胖的患者组成患病组,同时选取30名健康个体构成健康对照组。收集两组的基本信息、检验参数指标,行统计学分析。结果:健康组与患病组在TyG指数、甘油三酯水平(TG)、空腹血糖值(FPG)、体重指数(BMI)、糖化血红蛋白(HbA1c)、红细胞计数(RBC)及空腹C肽浓度(FCP)等指标方面有显著差异。TyG指数、BMI的升高以及HbA1c的上升伴随RBC的下降,是T2DM伴超重/肥胖的独立风险因素。ROC曲线下面积(AUC)为0.841。结论:TyG指数在T2DM伴超重/肥胖人群的诊断与预测中发挥着重要作用。Objective: To analyze the influencing factors between adult triglyceride glucose product (TyG) index and type 2 diabetes mellitus (T2DM) with overweight and obesity. Methods: In this study, 60 patients with T2DM with overweight and obesity were selected to form the disease group, and 30 healthy individuals were selected to form the healthy control group to collect basic information of the two groups. The parameters were tested and the difference was compared by binary and multi-factor Logistic regression ROC curve. Results: TyG index, triglyceride level (TG), fasting blood glucose value (FPG), body mass index (BMI), glycosylated hemoglobin (HbA1c) in the healthy group and the diseased group. There were significant differences in red blood cell count (RBC) and fasting C-peptide concentration (FCP), and the increase of TyG BMI and HbA1c were accompanied by the decrease of RBC. The area under ROC curve (AUC) of T2DM with overweight and obesity was 0.841. Conclusion: TyG index plays an important role in the diagnosis and prediction of T2DM patients with overweight and obesity.展开更多
目的:本研究的目的是为了研究TyG与心肌梗死患者残余风险之间的关系。方法:选取712名急性心肌梗的患者进行5年随访,采集患者基本信息、体格检查等资料,检测实验室相关指标。绘制ROC曲线评估TyG对残余风险的预测能力,使用R语言计算分析...目的:本研究的目的是为了研究TyG与心肌梗死患者残余风险之间的关系。方法:选取712名急性心肌梗的患者进行5年随访,采集患者基本信息、体格检查等资料,检测实验室相关指标。绘制ROC曲线评估TyG对残余风险的预测能力,使用R语言计算分析净重分类指数(NRI)和综合判别改善指数(IDI),以进一步评估TyG在心肌梗死后残余风险传统危险因素之上的额外预测价值。结果:ROC曲线显示,TyG指数曲线下面积0.554 (95%CI: 0.503~0.604, P = 0.042),在基线风险模型中纳入TyG的综合判别改善指数[IDI]:0.0082,P = 0.022;纳入TyG的净重新分类指数[NRI]:0.2169,P = 0.017。在基线风险模型中纳入TyG对基线模型对MACE的预测能力有增量效应。结论:TyG对心血管残余风险具有一定的预测能力,在控制传统危险因素的同时,TyG可以指导急性心梗患者的进一步强化治疗。Objective: The purpose of this study was to investigate the relationship between TyG and residual risk in patients with myocardial infarction. Methods: 712 patients with acute myocardial infarction were selected for 5-year follow-up, and basic information, physical examination and other data were collected, and laboratory related indexes were tested. ROC curves were plotted to assess the predictive ability of TyG on residual risk. The net reclassification index (NRI) and integrated discriminant improvement index (IDI) were calculated and analyzed using the R language to further assess the additional predictive value of TyG over and above the traditional risk factors for residual risk after myocardial infarction. Results: ROC curves showed an area under the curve of the TyG index of 0.554 (95% CI: 0.503 to 0.604, P = 0.042), a composite discriminant improvement index [IDI] incorporating TyG in the baseline risk model: 0.0082, P = 0.022, and a net reclassification index [NRI] incorporating TyG: 0.2169, P = 0.017. In the baseline risk model, the inclusion of TyG had an incremental effect on the predictive power of the baseline model for MACE. Conclusion: TyG has a predictive ability for residual cardiovascular risk, and while controlling traditional risk factors, TyG may guide further intensive treatment for patients with acute myocardial infarction.展开更多
近年来,甘油三酯葡萄糖(The triglyceride-glucose, TyG)指数在心血管疾病相关研究中备受关注。TyG指数是基于甘油三酯(TG)与空腹血糖(FBG)构建的一个指标,与动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease, ASCVD)有...近年来,甘油三酯葡萄糖(The triglyceride-glucose, TyG)指数在心血管疾病相关研究中备受关注。TyG指数是基于甘油三酯(TG)与空腹血糖(FBG)构建的一个指标,与动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease, ASCVD)有着紧密联系。多项研究发现,TyG指数水平的变化和ASCVD的发生、发展以及预后情况息息相关。本研究旨在对TyG指数与ASCVD相关性的现有研究成果进行梳理总结,为进一步探究二者关系以及提升TyG指数在ASCVD防治中的应用价值提供参考依据。In recent years, the triglyceride-glucose (TyG) index has received extensive attention in cardiovascular disease-related research. The TyG index is an indicator constructed based on triglycerides (TG) and fasting blood glucose (FBG), and it has a close connection with atherosclerotic cardiovascular disease (ASCVD). A number of studies have found that changes in the TyG index level are closely related to the occurrence, development, and prognosis of ASCVD. The aim of this study is to comprehensively review and summarize the existing research results on the correlation between the TyG index and ASCVD, so as to provide a reference basis for further exploring the relationship between the two and enhancing the application value of the TyG index in the prevention and treatment of ASCVD.展开更多
文摘目的探讨甘油三酯葡萄糖-腰围身高比(triglyceride glucose-waist height ratio,TyG-WHtR)指数与可能肌少症之间的相关性。方法基于中国健康与养老追踪调查(China Health and Retirement Longitudinal Study,CHARLS)数据进行横断面研究。通过测量握力和重复5次起坐时间诊断可能肌少症,并收集血液生物学标志物及问卷调查等相关数据,运用多因素Logistic回归分析探讨TyG-WHtR指数与可能肌少症的关联,并进行交互作用和亚组分析。结果共纳入分析5496名受访者,其中可能肌少症患者2027例,患病率为36.9%。在调整所有混杂因素的模型中发现,TyG-WHtR指数与可能肌少症呈正相关(OR=1.91,95%CI:1.41~2.60)。对年龄、性别、高血压、糖尿病、血脂异常、慢性肺部疾病、心脏病、BMI进行分层分析发现,各亚组间差异均无统计学意义(P>0.05)。结论TyG-WHtR指数与可能肌少症呈正相关,当ln转化的TyG-WHtR指数每增加1个单位,可能肌少症发生风险相对增加91%。
文摘目的:分析成年人甘油三酯葡萄糖乘积(TyG)指数与2型糖尿病(T2DM)伴超重/肥胖状况之间的影响因素。方法:本研究选取60例T2DM伴超重/肥胖的患者组成患病组,同时选取30名健康个体构成健康对照组。收集两组的基本信息、检验参数指标,行统计学分析。结果:健康组与患病组在TyG指数、甘油三酯水平(TG)、空腹血糖值(FPG)、体重指数(BMI)、糖化血红蛋白(HbA1c)、红细胞计数(RBC)及空腹C肽浓度(FCP)等指标方面有显著差异。TyG指数、BMI的升高以及HbA1c的上升伴随RBC的下降,是T2DM伴超重/肥胖的独立风险因素。ROC曲线下面积(AUC)为0.841。结论:TyG指数在T2DM伴超重/肥胖人群的诊断与预测中发挥着重要作用。Objective: To analyze the influencing factors between adult triglyceride glucose product (TyG) index and type 2 diabetes mellitus (T2DM) with overweight and obesity. Methods: In this study, 60 patients with T2DM with overweight and obesity were selected to form the disease group, and 30 healthy individuals were selected to form the healthy control group to collect basic information of the two groups. The parameters were tested and the difference was compared by binary and multi-factor Logistic regression ROC curve. Results: TyG index, triglyceride level (TG), fasting blood glucose value (FPG), body mass index (BMI), glycosylated hemoglobin (HbA1c) in the healthy group and the diseased group. There were significant differences in red blood cell count (RBC) and fasting C-peptide concentration (FCP), and the increase of TyG BMI and HbA1c were accompanied by the decrease of RBC. The area under ROC curve (AUC) of T2DM with overweight and obesity was 0.841. Conclusion: TyG index plays an important role in the diagnosis and prediction of T2DM patients with overweight and obesity.
文摘目的:本研究的目的是为了研究TyG与心肌梗死患者残余风险之间的关系。方法:选取712名急性心肌梗的患者进行5年随访,采集患者基本信息、体格检查等资料,检测实验室相关指标。绘制ROC曲线评估TyG对残余风险的预测能力,使用R语言计算分析净重分类指数(NRI)和综合判别改善指数(IDI),以进一步评估TyG在心肌梗死后残余风险传统危险因素之上的额外预测价值。结果:ROC曲线显示,TyG指数曲线下面积0.554 (95%CI: 0.503~0.604, P = 0.042),在基线风险模型中纳入TyG的综合判别改善指数[IDI]:0.0082,P = 0.022;纳入TyG的净重新分类指数[NRI]:0.2169,P = 0.017。在基线风险模型中纳入TyG对基线模型对MACE的预测能力有增量效应。结论:TyG对心血管残余风险具有一定的预测能力,在控制传统危险因素的同时,TyG可以指导急性心梗患者的进一步强化治疗。Objective: The purpose of this study was to investigate the relationship between TyG and residual risk in patients with myocardial infarction. Methods: 712 patients with acute myocardial infarction were selected for 5-year follow-up, and basic information, physical examination and other data were collected, and laboratory related indexes were tested. ROC curves were plotted to assess the predictive ability of TyG on residual risk. The net reclassification index (NRI) and integrated discriminant improvement index (IDI) were calculated and analyzed using the R language to further assess the additional predictive value of TyG over and above the traditional risk factors for residual risk after myocardial infarction. Results: ROC curves showed an area under the curve of the TyG index of 0.554 (95% CI: 0.503 to 0.604, P = 0.042), a composite discriminant improvement index [IDI] incorporating TyG in the baseline risk model: 0.0082, P = 0.022, and a net reclassification index [NRI] incorporating TyG: 0.2169, P = 0.017. In the baseline risk model, the inclusion of TyG had an incremental effect on the predictive power of the baseline model for MACE. Conclusion: TyG has a predictive ability for residual cardiovascular risk, and while controlling traditional risk factors, TyG may guide further intensive treatment for patients with acute myocardial infarction.
文摘近年来,甘油三酯葡萄糖(The triglyceride-glucose, TyG)指数在心血管疾病相关研究中备受关注。TyG指数是基于甘油三酯(TG)与空腹血糖(FBG)构建的一个指标,与动脉粥样硬化性心血管病(atherosclerotic cardiovascular disease, ASCVD)有着紧密联系。多项研究发现,TyG指数水平的变化和ASCVD的发生、发展以及预后情况息息相关。本研究旨在对TyG指数与ASCVD相关性的现有研究成果进行梳理总结,为进一步探究二者关系以及提升TyG指数在ASCVD防治中的应用价值提供参考依据。In recent years, the triglyceride-glucose (TyG) index has received extensive attention in cardiovascular disease-related research. The TyG index is an indicator constructed based on triglycerides (TG) and fasting blood glucose (FBG), and it has a close connection with atherosclerotic cardiovascular disease (ASCVD). A number of studies have found that changes in the TyG index level are closely related to the occurrence, development, and prognosis of ASCVD. The aim of this study is to comprehensively review and summarize the existing research results on the correlation between the TyG index and ASCVD, so as to provide a reference basis for further exploring the relationship between the two and enhancing the application value of the TyG index in the prevention and treatment of ASCVD.
