This paper presents the design of a low-power multi-channel analog front-end(AFE) for bio-potential recording. By using time division multiplexing(TDM), a successive approximation register analog-to-digital converter(...This paper presents the design of a low-power multi-channel analog front-end(AFE) for bio-potential recording. By using time division multiplexing(TDM), a successive approximation register analog-to-digital converter(SAR ADC) is shared among all 20 channels. A charge-sharing multiplexer(MUX) is proposed to transmit the output signals from the respective channels to the ADC. By separately pre sampling the output of each channel, the sampling time of each channel is greatly extended and additional active buffers are avoided. The AFE is fabricated in a 65-nm CMOS process, and the whole system consumes 28.2 μW under 1 V supply. Each analog acquisition channel consumes 1.25 μW and occupies a chip area of 0.14 mm2. Measurement results show that the AFE achieves an input referred noise of 1.8 μV·rms in a 350 Hz bandwidth and a noise efficiency factor(NEF) of 4.1. The 12-bit SAR ADC achieves an ENOB of 9.8 bit operating at 25 k S/s. The AFE is experimented on real-world applications by measuring human ECG and a clear ECG waveform is captured.展开更多
目的:探究基于治疗药物血药浓度监测(Treatment Drug Monitoring,TDM)治疗癫痫的效果,并探讨患者个体化用药监护策略及其临床实践意义。方法:纳入2024年11月至2025年6月在仁怀市人民医院收治的80例住院患者病例,采用掷硬币法将符合标准...目的:探究基于治疗药物血药浓度监测(Treatment Drug Monitoring,TDM)治疗癫痫的效果,并探讨患者个体化用药监护策略及其临床实践意义。方法:纳入2024年11月至2025年6月在仁怀市人民医院收治的80例住院患者病例,采用掷硬币法将符合标准的患者分为干预组(n=40,实施个体化用药监护)与对照组(n=40,常规治疗),对比两组血药浓度达标率、癫痫发作次数、不合理用药情况、癫痫发作情况、患者用药依从性、临床效果及安全性。结果:相较于对照组,研究组血药浓度达标率更高,不合理用药次数及癫痫发作次数更低,不良反应总发生率更低,治疗后3个月、6个月,观察组用药依从性评分更高,P<0.05。结论:基于TDM的癫痫患者个体化用药监护策略能有效优化用药方案,提高治疗效果,减少不良反应,提升患者用药依从性,具有显著的临床实践意义。展开更多
为了适应工程中多通道振动数据的快速存储和准确查询。基于LabVIEW的TDMS(technical data management streaming)数据逻辑方式,设计实现了一套完整的某试车台振动数据存储查询虚拟仪器系统。该系统可以通过手动存储和报警自动触发存储...为了适应工程中多通道振动数据的快速存储和准确查询。基于LabVIEW的TDMS(technical data management streaming)数据逻辑方式,设计实现了一套完整的某试车台振动数据存储查询虚拟仪器系统。该系统可以通过手动存储和报警自动触发存储两种方式对多通道、多类型海量数据进行快速存储。同时,还具有对指定通道指定类型数据的准确查询、导出以及打印功能等。在某型号试车台背景下开发出来的这套性能和操控界面兼备的监测系统,对于类似工程实践具有一定的借鉴意义。展开更多
基金supported by the National Key R&D Program of China under Grant 2018YFA0701400 and 2018YFA0701401.
文摘This paper presents the design of a low-power multi-channel analog front-end(AFE) for bio-potential recording. By using time division multiplexing(TDM), a successive approximation register analog-to-digital converter(SAR ADC) is shared among all 20 channels. A charge-sharing multiplexer(MUX) is proposed to transmit the output signals from the respective channels to the ADC. By separately pre sampling the output of each channel, the sampling time of each channel is greatly extended and additional active buffers are avoided. The AFE is fabricated in a 65-nm CMOS process, and the whole system consumes 28.2 μW under 1 V supply. Each analog acquisition channel consumes 1.25 μW and occupies a chip area of 0.14 mm2. Measurement results show that the AFE achieves an input referred noise of 1.8 μV·rms in a 350 Hz bandwidth and a noise efficiency factor(NEF) of 4.1. The 12-bit SAR ADC achieves an ENOB of 9.8 bit operating at 25 k S/s. The AFE is experimented on real-world applications by measuring human ECG and a clear ECG waveform is captured.
文摘目的:探究基于治疗药物血药浓度监测(Treatment Drug Monitoring,TDM)治疗癫痫的效果,并探讨患者个体化用药监护策略及其临床实践意义。方法:纳入2024年11月至2025年6月在仁怀市人民医院收治的80例住院患者病例,采用掷硬币法将符合标准的患者分为干预组(n=40,实施个体化用药监护)与对照组(n=40,常规治疗),对比两组血药浓度达标率、癫痫发作次数、不合理用药情况、癫痫发作情况、患者用药依从性、临床效果及安全性。结果:相较于对照组,研究组血药浓度达标率更高,不合理用药次数及癫痫发作次数更低,不良反应总发生率更低,治疗后3个月、6个月,观察组用药依从性评分更高,P<0.05。结论:基于TDM的癫痫患者个体化用药监护策略能有效优化用药方案,提高治疗效果,减少不良反应,提升患者用药依从性,具有显著的临床实践意义。
文摘为了适应工程中多通道振动数据的快速存储和准确查询。基于LabVIEW的TDMS(technical data management streaming)数据逻辑方式,设计实现了一套完整的某试车台振动数据存储查询虚拟仪器系统。该系统可以通过手动存储和报警自动触发存储两种方式对多通道、多类型海量数据进行快速存储。同时,还具有对指定通道指定类型数据的准确查询、导出以及打印功能等。在某型号试车台背景下开发出来的这套性能和操控界面兼备的监测系统,对于类似工程实践具有一定的借鉴意义。
