The findings of the present study affirm the value of strategy training.On the one hand,it shows strategy training is valid and feasible.On the other hand,it will benefit both language teachers and students in that it...The findings of the present study affirm the value of strategy training.On the one hand,it shows strategy training is valid and feasible.On the other hand,it will benefit both language teachers and students in that it not only helps students become more successful to learn a foreign language but also provides teachers a meaningful way to focus their efforts.However,strategy training in this thesis is tentative,so the present study is subject to several limitations owing to the author’s lack of the experience.展开更多
Objective:To assess the socioeconomic characteristics influencing knowledge,attitudes,and practices in preventing toxocariasis among the adult Khmer population in Tra Vinh Province,Vietnam.Methods:This cross-sectional...Objective:To assess the socioeconomic characteristics influencing knowledge,attitudes,and practices in preventing toxocariasis among the adult Khmer population in Tra Vinh Province,Vietnam.Methods:This cross-sectional study was conducted across 30 communities in eight districts and cities of Tra Vinh Province using a 30-cluster random sampling method during 2023.Results:The study encompassed 760 participants(median age:52 years;interquartile range:39-63 years),female 65.9%.There existed moderate levels of knowledge,attitudes,and preventive practices among participants,with variations across sociodemographic groups.Education(OR 0.53;95%CI 0.36-0.53;P=0.002),and average family income(OR 0.40;95%CI 0.24-0.68;P=0.001)were inversely associated with poor knowledge.Participants aged≥60 years had higher odds of negative attitudes(OR 5.26;95%CI 2.31-11.96;P<0.001)towards toxocariasis prevention.Not owning pets(OR 1.53;95%CI 1.13-2.08;P=0.006)and age≥60 years(OR 5.33;95%CI 2.61-10.86;P<0.001)were associated with significantly higher odds of poor preventive practices.Conversely,higher education(OR 0.11;95%CI 0.06-0.20;P<0.001)and higher income(OR 0.14;95%CI 0.06-0.33;P<0.001)were protective factors,significantly reducing the risk of poor preventive practices.Conclusions:Knowledge,attitudes,and practice levels regarding toxocariasis prevention among Khmer adults in Tra Vinh were moderate and associated with age,education and income.Targeted health education efforts,especially in rural and low-income groups,are essential to improve preventive behaviors and reduce infection risks.展开更多
This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic B and...This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which augmented its antibacterial activity. Results showed a diminished potential for resistance emergence with Antibiotic B, particularly when used in combination with Influximax. The study suggests that optimizing antibiotic delivery into bacterial cells and leveraging syner-gistic adjuvant combinations can enhance drug resistance combat. .展开更多
AIM: To investigate whether transarterial chemoembolization(TACE) before liver transplantation(LT) improves long-term survival in hepatocellular carcinoma(HCC) patients.METHODS: A retrospective study was conducted amo...AIM: To investigate whether transarterial chemoembolization(TACE) before liver transplantation(LT) improves long-term survival in hepatocellular carcinoma(HCC) patients.METHODS: A retrospective study was conducted among 204 patients with HCC who received LT from January 2002 to December 2010 in PLA General Hospital. Among them, 88 patients received TACE before LT. Prognostic factors of serum α-fetoprotein(AFP), intraoperative blood loss, intraoperative blood transfusion, disease-free survival time, survival time with tumor, number of tumor nodules, tumor size, tumor number, presence of blood vessels and bile duct invasion, lymph node metastasis, degree of tumor differentiation, and preoperative liver function were determined in accordance with the Child-TurcottePugh(Child) classification and model for end-stage liver disease. We also determined time of TACE before transplant surgery and tumor recurrence and metastasis according to different organs. Cumulative survival rate and disease-free survival rate curves were prepared using the Kaplan-Meier method, and the logrank and χ2 tests were used for comparisons.RESULTS: In patients with and without TACE before LT, the 1, 3 and 5-year cumulative survival rate was 70.5% ± 4.9% vs 91.4% ± 2.6%, 53.3% ± 6.0% vs 83.1% ± 3.9%, and 46.2% ± 7.0% vs 80.8% ± 4.5%, respectively. The median survival time of patients with and without TACE was 51.857 ± 5.042 mo vs 80.930 ± 3.308 mo(χ2 = 22.547, P < 0.001, P < 0.05). The 1, 3 and 5-year disease-free survival rates for patients with and without TACE before LT were 62.3% ± 5.2% vs98.9% ± 3.0%, 48.7% ± 6.7% vs 82.1% ± 4.1%, and 48.7% ± 6.7% vs 82.1% ± 4.1%, respectively. The median survival time of patients with and without TACE before LT was 50.386 ± 4.901 mo vs 80.281 ± 3.216 mo(χ2 = 22.063, P < 0.001, P < 0.05). TACE before LT can easily lead to pulmonary or distant metastasis of the primary tumor. Although there was no significant difference between the two groups, the chance of metastasis of the primary tumor in the group with TACE was significantly higher than that of the group without TACE.CONCLUSION: TACE pre-LT for HCC patients increased the chances of pulmonary or distant metastasis of the primary tumor, thus reducing the long-term survival rate.展开更多
文摘The findings of the present study affirm the value of strategy training.On the one hand,it shows strategy training is valid and feasible.On the other hand,it will benefit both language teachers and students in that it not only helps students become more successful to learn a foreign language but also provides teachers a meaningful way to focus their efforts.However,strategy training in this thesis is tentative,so the present study is subject to several limitations owing to the author’s lack of the experience.
文摘Objective:To assess the socioeconomic characteristics influencing knowledge,attitudes,and practices in preventing toxocariasis among the adult Khmer population in Tra Vinh Province,Vietnam.Methods:This cross-sectional study was conducted across 30 communities in eight districts and cities of Tra Vinh Province using a 30-cluster random sampling method during 2023.Results:The study encompassed 760 participants(median age:52 years;interquartile range:39-63 years),female 65.9%.There existed moderate levels of knowledge,attitudes,and preventive practices among participants,with variations across sociodemographic groups.Education(OR 0.53;95%CI 0.36-0.53;P=0.002),and average family income(OR 0.40;95%CI 0.24-0.68;P=0.001)were inversely associated with poor knowledge.Participants aged≥60 years had higher odds of negative attitudes(OR 5.26;95%CI 2.31-11.96;P<0.001)towards toxocariasis prevention.Not owning pets(OR 1.53;95%CI 1.13-2.08;P=0.006)and age≥60 years(OR 5.33;95%CI 2.61-10.86;P<0.001)were associated with significantly higher odds of poor preventive practices.Conversely,higher education(OR 0.11;95%CI 0.06-0.20;P<0.001)and higher income(OR 0.14;95%CI 0.06-0.33;P<0.001)were protective factors,significantly reducing the risk of poor preventive practices.Conclusions:Knowledge,attitudes,and practice levels regarding toxocariasis prevention among Khmer adults in Tra Vinh were moderate and associated with age,education and income.Targeted health education efforts,especially in rural and low-income groups,are essential to improve preventive behaviors and reduce infection risks.
文摘This study explores the efficacy of advanced antibiotic compounds against P. aeruginosa, focusing on Antibiotic B, an enhanced derivative of Ceftriaxone. The study measured the intracellular uptake of Antibiotic B and introduced a novel adjuvant, Influximax, which augmented its antibacterial activity. Results showed a diminished potential for resistance emergence with Antibiotic B, particularly when used in combination with Influximax. The study suggests that optimizing antibiotic delivery into bacterial cells and leveraging syner-gistic adjuvant combinations can enhance drug resistance combat. .
基金Supported by National Science and Technology Major Project for Infectious Diseases of China,No.2012ZX10002-017National Key Technology Research And Development Program of China,No.2012BAI06B01the Grants from Natural Science Foundation of China,No.81302123
文摘AIM: To investigate whether transarterial chemoembolization(TACE) before liver transplantation(LT) improves long-term survival in hepatocellular carcinoma(HCC) patients.METHODS: A retrospective study was conducted among 204 patients with HCC who received LT from January 2002 to December 2010 in PLA General Hospital. Among them, 88 patients received TACE before LT. Prognostic factors of serum α-fetoprotein(AFP), intraoperative blood loss, intraoperative blood transfusion, disease-free survival time, survival time with tumor, number of tumor nodules, tumor size, tumor number, presence of blood vessels and bile duct invasion, lymph node metastasis, degree of tumor differentiation, and preoperative liver function were determined in accordance with the Child-TurcottePugh(Child) classification and model for end-stage liver disease. We also determined time of TACE before transplant surgery and tumor recurrence and metastasis according to different organs. Cumulative survival rate and disease-free survival rate curves were prepared using the Kaplan-Meier method, and the logrank and χ2 tests were used for comparisons.RESULTS: In patients with and without TACE before LT, the 1, 3 and 5-year cumulative survival rate was 70.5% ± 4.9% vs 91.4% ± 2.6%, 53.3% ± 6.0% vs 83.1% ± 3.9%, and 46.2% ± 7.0% vs 80.8% ± 4.5%, respectively. The median survival time of patients with and without TACE was 51.857 ± 5.042 mo vs 80.930 ± 3.308 mo(χ2 = 22.547, P < 0.001, P < 0.05). The 1, 3 and 5-year disease-free survival rates for patients with and without TACE before LT were 62.3% ± 5.2% vs98.9% ± 3.0%, 48.7% ± 6.7% vs 82.1% ± 4.1%, and 48.7% ± 6.7% vs 82.1% ± 4.1%, respectively. The median survival time of patients with and without TACE before LT was 50.386 ± 4.901 mo vs 80.281 ± 3.216 mo(χ2 = 22.063, P < 0.001, P < 0.05). TACE before LT can easily lead to pulmonary or distant metastasis of the primary tumor. Although there was no significant difference between the two groups, the chance of metastasis of the primary tumor in the group with TACE was significantly higher than that of the group without TACE.CONCLUSION: TACE pre-LT for HCC patients increased the chances of pulmonary or distant metastasis of the primary tumor, thus reducing the long-term survival rate.
