Background: Ingrown toenail often results in a painful cycle of infection and inflammation and can affect the ability to go about everyday activities. In the UK and Europe, there are limited ways to prevent the develo...Background: Ingrown toenail often results in a painful cycle of infection and inflammation and can affect the ability to go about everyday activities. In the UK and Europe, there are limited ways to prevent the development of ingrowing toenail without specialist intervention. Treatments are often invasive and may require periods of time off work. This prospective, single-site, non-comparative clinical study evaluates the performance, safety and convenience of a treatment kit that can be applied at home at the earliest signs of ingrowing toenail. Methods: Patients (n = 36) with mild ingrowing toenail used the Scholl Ingrowing Toenail Treatment kit for 6 weeks, with assessments by study investigators at Days 0, 21 and 42. The kit comprised a set of toenail clips and a spray, correct use of which was monitored at site visits and through patient diaries. Results: All patients enrolled in the study completed the 42-day treatment period. Severity of ingrowing toenail was significantly reduced in 88.9% (95% CI: 78.62, 99.15) of patients at the end of the study. Twenty-two patients (61.1%) exhibited full resolution of ingrowing toenail at Day 42 and none showed an increase in severity. Reduction in pain and severity of ingrowing toenail from baseline was significant at Days 21 and 42 (p Conclusions: The ingrowing toenail treatment kit was convenient and easy for patients to use at home and resulted in reduced pain and severity of ingrowing toenail at early stages of the condition.展开更多
Background: We examined 94 toenails exhibiting clinical signs of severe onychomycosis taking into account multiple contributing factors, not the least of which was Subungual Osteochondroma Deformans (SOD). We hypothes...Background: We examined 94 toenails exhibiting clinical signs of severe onychomycosis taking into account multiple contributing factors, not the least of which was Subungual Osteochondroma Deformans (SOD). We hypothesize that SOD plays a significant role in both the etiology and treatment of onychomycosis. Methods/Results: A retrospective post-treatment outcome analysis was performed comparing two groups of severely mycotic toenails. The first group of 25 fungal nails showed 54.31% improvement following treatment by both surgical nail avulsion and a 1064 YAG laser-based Nail Restoration algorithm. The second group of 69 fungal nails was not only treated using the same nail avulsion/laser-based algorithm but was also evaluated for SOD lesions which were surgically removed when present, resulting in 95.31% improvement. The overall incidence of SOD lesions in the second group of severely mycotic toenails was 73.91%. Conclusion: We submit that at 73.91% Subungual Osteochondroma Deformans has an under-reported and under-appreciated association with toenail fungus. Generally, we find that our success rates in treating severe toenail fungus using our laser-based Nail Restoration Protocols are much higher when SOD lesions are surgically removed.展开更多
文摘Background: Ingrown toenail often results in a painful cycle of infection and inflammation and can affect the ability to go about everyday activities. In the UK and Europe, there are limited ways to prevent the development of ingrowing toenail without specialist intervention. Treatments are often invasive and may require periods of time off work. This prospective, single-site, non-comparative clinical study evaluates the performance, safety and convenience of a treatment kit that can be applied at home at the earliest signs of ingrowing toenail. Methods: Patients (n = 36) with mild ingrowing toenail used the Scholl Ingrowing Toenail Treatment kit for 6 weeks, with assessments by study investigators at Days 0, 21 and 42. The kit comprised a set of toenail clips and a spray, correct use of which was monitored at site visits and through patient diaries. Results: All patients enrolled in the study completed the 42-day treatment period. Severity of ingrowing toenail was significantly reduced in 88.9% (95% CI: 78.62, 99.15) of patients at the end of the study. Twenty-two patients (61.1%) exhibited full resolution of ingrowing toenail at Day 42 and none showed an increase in severity. Reduction in pain and severity of ingrowing toenail from baseline was significant at Days 21 and 42 (p Conclusions: The ingrowing toenail treatment kit was convenient and easy for patients to use at home and resulted in reduced pain and severity of ingrowing toenail at early stages of the condition.
文摘Background: We examined 94 toenails exhibiting clinical signs of severe onychomycosis taking into account multiple contributing factors, not the least of which was Subungual Osteochondroma Deformans (SOD). We hypothesize that SOD plays a significant role in both the etiology and treatment of onychomycosis. Methods/Results: A retrospective post-treatment outcome analysis was performed comparing two groups of severely mycotic toenails. The first group of 25 fungal nails showed 54.31% improvement following treatment by both surgical nail avulsion and a 1064 YAG laser-based Nail Restoration algorithm. The second group of 69 fungal nails was not only treated using the same nail avulsion/laser-based algorithm but was also evaluated for SOD lesions which were surgically removed when present, resulting in 95.31% improvement. The overall incidence of SOD lesions in the second group of severely mycotic toenails was 73.91%. Conclusion: We submit that at 73.91% Subungual Osteochondroma Deformans has an under-reported and under-appreciated association with toenail fungus. Generally, we find that our success rates in treating severe toenail fungus using our laser-based Nail Restoration Protocols are much higher when SOD lesions are surgically removed.
