Eastern philosophy and western science have convergent and divergent viewpoints for their explanation of consciousness. Convergence is found for the practice of meditation allowing besides a time dependent consciousne...Eastern philosophy and western science have convergent and divergent viewpoints for their explanation of consciousness. Convergence is found for the practice of meditation allowing besides a time dependent consciousness, the experience of a timeless consciousness and its beneficial effect on psychological wellbeing and medical improvements, which are confirmed by multiple scientific publications. Theories of quantum mechanics with non-locality and timelessness also show astonishing correlation to eastern philosophy, such as the theory of Penrose-Hameroff （ORC-OR）, which explains consciousness by reduction of quantum superposition in the brain. Divergence appears in the interpretation of the subjective experience of timeless consciousness. In eastern philosophy, meditation at a higher level of awareness allows the personal experience of timeless and non-dual consciousness, considered as an empirical proof for the existence of pure consciousness or spirituality existing before the material world and creating it by design. Western science acknowledges the subjective, non-dual experience, and its multiple beneficial effects, however, the interpretation of spirituality designing the material universe is in disagreement with the Darwinian Theory of mutation and selection. A design should create an ideal universe without the injustice of 3% congenital birth defects and later genetic health problems. The western viewpoint of selection is more adapted to explain congenital errors. The gap between subjectivity and objectivity, the mind-body problem, is in eastern philosophy reduced to the dominance of subjectivity over objectivity, whereas western science attributes equal values to both. Nevertheless, there remains an astonishing complementarity between eastern and western practices.展开更多
The most enduring clichéabout Shakespeare is that he is timeless and universal,although the first claim is unprovable and the second all too easily disproved.Nevertheless,the extraordinary global popularity and s...The most enduring clichéabout Shakespeare is that he is timeless and universal,although the first claim is unprovable and the second all too easily disproved.Nevertheless,the extraordinary global popularity and significance that he has attained is remarkable.So even if we can dismiss the implausible hyperbole of Shakespeare’s universality and timelessness,there still is something that demands explanation.Why do all those who do care about Shakespeare care(and there are,one must admit,a remarkable number of them)?What is it that they care about?展开更多
Bladder cancer(BLCA)is a highly invasive malignancy with limited targeted therapies.Lu et al reveal the oncogenic role of HOXC6 in BLCA by showing its elevated mRNA and protein levels in cancerous tissues.Silencing HO...Bladder cancer(BLCA)is a highly invasive malignancy with limited targeted therapies.Lu et al reveal the oncogenic role of HOXC6 in BLCA by showing its elevated mRNA and protein levels in cancerous tissues.Silencing HOXC6 sig-nificantly inhibits BLCA cell proliferation,migration and invasion,induces apo-ptosis and arrests the cell cycle at G0/G1.In addition,HOXC6 also regulates pa-thways related to chemical carcinogenesis and reactive oxygen species,with a strong association with the target gene TIMELESS,supported by binding signals in its promoter region.Here,we discuss the role of HOXC6 as a potential bio-marker and therapeutic target,contributing to a deeper understanding of the HOXC6-TIMELESS axis and its implications for advancing BLCA research and therapy.展开更多
Dunhuang,located in the northwestern part of China,is a town that feels like it's carved out of the pages of a history book.Nestled at the edge of the Gobi Desert in China's Gansu Province,this ancient oasis c...Dunhuang,located in the northwestern part of China,is a town that feels like it's carved out of the pages of a history book.Nestled at the edge of the Gobi Desert in China's Gansu Province,this ancient oasis city has been a crossroads of cultures,religions,and trade for over 2,000 years.展开更多
BACKGROUND Bladder cancer(BLCA)is a common urological tumor.Homeobox C6(HOXC6)is an HOX family gene that has an oncogenic effect in various malignancies.AIM To investigate the expression and function of HOXC6 in BLCA....BACKGROUND Bladder cancer(BLCA)is a common urological tumor.Homeobox C6(HOXC6)is an HOX family gene that has an oncogenic effect in various malignancies.AIM To investigate the expression and function of HOXC6 in BLCA.METHODS This study employed immunohistochemistry,along with global chip and sequencing data for BLCA,to comprehensively evaluate the protein and mRNA expression of HOXC6 in BLCA.RNA interference technology was employed to knock down the mRNA expression of HOXC6 in BLCA cells,and the impact of reduced HOXC6 expression on cellular function was assessed.Additionally,we explored the potential mechanisms of HOXC6 in BLCA by aggregating HOXC6 chromatin immunoprecipitation sequencing data.RESULTS The immunohistochemistry results,sequencing data,and microarray data revealed that both the mRNA and protein expressions of HOXC6 in BLCA were notably greater than the expressions in non-cancerous tissues.Knocking down the expression of HOXC6 considerably limited the function of cell proliferation,migration,and invasion abilities of BLCA cells,elevated cell apoptosis,and triggered the G0/G1 phase blockade.The potential target genes of HOXC6 were enriched in pathways such as chemical carcinogenesis and reactive oxygen species.A notable positive correlation between HOXC6 mRNA expression and its target gene timeless circadian regulator(TIMELESS)was revealed.Notable binding peak signals for HOXC6 were identified in the promoter region of TIMELESS.CONCLUSION HOXC6 is upregulated in BLCA and may influence the cellular functions of BLCA by regulating the expression of the target gene TIMELESS.展开更多
Every world cultural heritage is a letter written by humans to the future.They are ancienl symbols on the wall of stones or exquisite patterns in the palace,bearing the wisdom and glory of different civilizations.
With the theme of"Timeless Dunhuang:The Symphony of History and Modernity",the exhibition brought together the efforts of four institutions,namely Dunhuang Academy,the Contemporary World Press,Duzhe Publishi...With the theme of"Timeless Dunhuang:The Symphony of History and Modernity",the exhibition brought together the efforts of four institutions,namely Dunhuang Academy,the Contemporary World Press,Duzhe Publishing Group,and Dunhuang Culture and Tourism Group.The exhibition featured four sections:the Dunhuang Culture In-Depth Learning Hall,the Contemporary Dunhuang Technology Experiences,the Dunhuang Cultural and Creative Product Market and the Dunhuang Culture and Art,which fully demonstrated the distinctive charm of Dunhuang Culture as a treasure of the integration of four major civilisations,and presented a painting of civilizations spanning thousands of years for vips both from home and abroad.展开更多
This paper provides a perception that all things are connected. Starting with the perception of Metaphysics and how matter exists out of total void, complementary matter, or dark matter, the incompleteness of Einstein...This paper provides a perception that all things are connected. Starting with the perception of Metaphysics and how matter exists out of total void, complementary matter, or dark matter, the incompleteness of Einstein relativistic theory. Multi spacetime universes and the jump drive for jumping within and between spacetime universes. Warp drive for space travel. DNA as sequence of momentary frequencies and how it related to Ezekiel’s dry bones prophecy. The outcome of neural patterns as cords of consciousness, consciousness as the collection of all cords of consciousness and the lack of uniqueness of individual consciousness. Finally, all things are cords of consciousness.展开更多
文摘Eastern philosophy and western science have convergent and divergent viewpoints for their explanation of consciousness. Convergence is found for the practice of meditation allowing besides a time dependent consciousness, the experience of a timeless consciousness and its beneficial effect on psychological wellbeing and medical improvements, which are confirmed by multiple scientific publications. Theories of quantum mechanics with non-locality and timelessness also show astonishing correlation to eastern philosophy, such as the theory of Penrose-Hameroff （ORC-OR）, which explains consciousness by reduction of quantum superposition in the brain. Divergence appears in the interpretation of the subjective experience of timeless consciousness. In eastern philosophy, meditation at a higher level of awareness allows the personal experience of timeless and non-dual consciousness, considered as an empirical proof for the existence of pure consciousness or spirituality existing before the material world and creating it by design. Western science acknowledges the subjective, non-dual experience, and its multiple beneficial effects, however, the interpretation of spirituality designing the material universe is in disagreement with the Darwinian Theory of mutation and selection. A design should create an ideal universe without the injustice of 3% congenital birth defects and later genetic health problems. The western viewpoint of selection is more adapted to explain congenital errors. The gap between subjectivity and objectivity, the mind-body problem, is in eastern philosophy reduced to the dominance of subjectivity over objectivity, whereas western science attributes equal values to both. Nevertheless, there remains an astonishing complementarity between eastern and western practices.
文摘The most enduring clichéabout Shakespeare is that he is timeless and universal,although the first claim is unprovable and the second all too easily disproved.Nevertheless,the extraordinary global popularity and significance that he has attained is remarkable.So even if we can dismiss the implausible hyperbole of Shakespeare’s universality and timelessness,there still is something that demands explanation.Why do all those who do care about Shakespeare care(and there are,one must admit,a remarkable number of them)?What is it that they care about?
基金Supported by National Key R&D Program of China,No.2023YFC2507904Hubei Strategic Science and Technology Talent Plan,No.2024DJA037+1 种基金National Natural Science Foundation of China,No.32270768,No.82273970 and No.82370715Innovation Group Project of Hubei Province No.2023AFA026.
文摘Bladder cancer(BLCA)is a highly invasive malignancy with limited targeted therapies.Lu et al reveal the oncogenic role of HOXC6 in BLCA by showing its elevated mRNA and protein levels in cancerous tissues.Silencing HOXC6 sig-nificantly inhibits BLCA cell proliferation,migration and invasion,induces apo-ptosis and arrests the cell cycle at G0/G1.In addition,HOXC6 also regulates pa-thways related to chemical carcinogenesis and reactive oxygen species,with a strong association with the target gene TIMELESS,supported by binding signals in its promoter region.Here,we discuss the role of HOXC6 as a potential bio-marker and therapeutic target,contributing to a deeper understanding of the HOXC6-TIMELESS axis and its implications for advancing BLCA research and therapy.
文摘Dunhuang,located in the northwestern part of China,is a town that feels like it's carved out of the pages of a history book.Nestled at the edge of the Gobi Desert in China's Gansu Province,this ancient oasis city has been a crossroads of cultures,religions,and trade for over 2,000 years.
基金Supported by the Science and Technology Major Project of Guangxi,No.AA22096030 and No.AA22096032the Yongjiang Program of Nanning+3 种基金the Creative Research Development from The First Affiliated Hospital of Guangxi Medical University,No.Medical Excellence Award 202303Guangxi Medical University Undergraduate Education and Teaching Reform Project,No.2024XJGYC20Guangxi Medical University Student Innovation and Entrepreneurship Training Program Project,No.202310598002X,No.202310598041,No.202410598039X,and No.202410598044the“Future Academic Star”of the Guangxi Medical University,No.WLXSZX24096.
文摘BACKGROUND Bladder cancer(BLCA)is a common urological tumor.Homeobox C6(HOXC6)is an HOX family gene that has an oncogenic effect in various malignancies.AIM To investigate the expression and function of HOXC6 in BLCA.METHODS This study employed immunohistochemistry,along with global chip and sequencing data for BLCA,to comprehensively evaluate the protein and mRNA expression of HOXC6 in BLCA.RNA interference technology was employed to knock down the mRNA expression of HOXC6 in BLCA cells,and the impact of reduced HOXC6 expression on cellular function was assessed.Additionally,we explored the potential mechanisms of HOXC6 in BLCA by aggregating HOXC6 chromatin immunoprecipitation sequencing data.RESULTS The immunohistochemistry results,sequencing data,and microarray data revealed that both the mRNA and protein expressions of HOXC6 in BLCA were notably greater than the expressions in non-cancerous tissues.Knocking down the expression of HOXC6 considerably limited the function of cell proliferation,migration,and invasion abilities of BLCA cells,elevated cell apoptosis,and triggered the G0/G1 phase blockade.The potential target genes of HOXC6 were enriched in pathways such as chemical carcinogenesis and reactive oxygen species.A notable positive correlation between HOXC6 mRNA expression and its target gene timeless circadian regulator(TIMELESS)was revealed.Notable binding peak signals for HOXC6 were identified in the promoter region of TIMELESS.CONCLUSION HOXC6 is upregulated in BLCA and may influence the cellular functions of BLCA by regulating the expression of the target gene TIMELESS.
文摘Every world cultural heritage is a letter written by humans to the future.They are ancienl symbols on the wall of stones or exquisite patterns in the palace,bearing the wisdom and glory of different civilizations.
文摘With the theme of"Timeless Dunhuang:The Symphony of History and Modernity",the exhibition brought together the efforts of four institutions,namely Dunhuang Academy,the Contemporary World Press,Duzhe Publishing Group,and Dunhuang Culture and Tourism Group.The exhibition featured four sections:the Dunhuang Culture In-Depth Learning Hall,the Contemporary Dunhuang Technology Experiences,the Dunhuang Cultural and Creative Product Market and the Dunhuang Culture and Art,which fully demonstrated the distinctive charm of Dunhuang Culture as a treasure of the integration of four major civilisations,and presented a painting of civilizations spanning thousands of years for vips both from home and abroad.
文摘This paper provides a perception that all things are connected. Starting with the perception of Metaphysics and how matter exists out of total void, complementary matter, or dark matter, the incompleteness of Einstein relativistic theory. Multi spacetime universes and the jump drive for jumping within and between spacetime universes. Warp drive for space travel. DNA as sequence of momentary frequencies and how it related to Ezekiel’s dry bones prophecy. The outcome of neural patterns as cords of consciousness, consciousness as the collection of all cords of consciousness and the lack of uniqueness of individual consciousness. Finally, all things are cords of consciousness.
