目的:通过Meta分析系统性评估间歇性Theta刺激改善脑卒中患者下肢运动功能、平衡功能以及日常活动能力的效果。方法:检索Cochrane Library、Scopus、PubMed、Embase、ProQuest、Web of Science、中国知网、中国生物医学、维普和万方数据...目的:通过Meta分析系统性评估间歇性Theta刺激改善脑卒中患者下肢运动功能、平衡功能以及日常活动能力的效果。方法:检索Cochrane Library、Scopus、PubMed、Embase、ProQuest、Web of Science、中国知网、中国生物医学、维普和万方数据库,选择各数据库建库至2024年11月期间间歇性Theta刺激治疗脑卒中的随机对照试验。其中,试验组接受小脑/M1区间歇性Theta刺激,对照组进行常规康复治疗。采用RevMan 5.3和Stata 16.0进行Meta分析。结果:共纳入12篇文献,444例患者。Meta分析表明,间歇性Theta刺激有助于提高脑卒中患者下肢Fugl-Meyer量表评分[WMD=2.87,95%CI(1.77,3.98),P<0.00001]、Berg平衡量表评分[WMD=5.79,95%CI(3.80,7.79),P<0.00001]以及改良Barthel指数[WMD=6.32,95%CI(4.02,8.44),P<0.00001]。亚组分析结果显示,相较于600脉冲刺激,1200脉冲刺激更有利于改善下肢Fugl-Meyer量表评分[WMD=4.31,95%CI(2.91,5.71),P<0.00001]、Berg平衡量表评分[WMD=8.12,95%CI(5.27,10.98),P<0.00001]和改良Barthel指数[WMD=8.50,95%CI(6.55,10.45),P<0.00001]。结论:间歇性Theta刺激能够提高脑卒中患者的下肢运动能力、平衡功能及日常生活能力评分。其中,1200脉冲间歇性Theta刺激在改善下肢运动能力、平衡功能和日常生活能力方面,可能具有更大益处。展开更多
背景:相比于常规重复经颅磁刺激,Theta爆发式经颅磁刺激因具有刺激时间短、效率高、安全性好和效果持久等优势,正受到各领域学者的广泛关注,研究热度持续上升。目的:通过对近20年国际Theta爆发式经颅磁刺激研究进行文献计量学的可视化分...背景:相比于常规重复经颅磁刺激,Theta爆发式经颅磁刺激因具有刺激时间短、效率高、安全性好和效果持久等优势,正受到各领域学者的广泛关注,研究热度持续上升。目的:通过对近20年国际Theta爆发式经颅磁刺激研究进行文献计量学的可视化分析,梳理Theta爆发式经颅磁刺激研究的发展脉络,总结研究现状,揭示研究热点和发展趋势,为后续研究提供借鉴和参考。方法:检索Web of Science核心集数据库中2005年1月至2024年6月有关Theta爆发式经颅磁刺激的相关文献,应用CiteSpace软件进行年度发文量分析,国家、机构和作者合作共现分析,参考文献、期刊和作者共被引分析,关键词共现、聚类、时间演化和突现分析等,并绘制可视化知识图谱。结果与结论:①共纳入1914篇文献,近20年Theta爆发式经颅磁刺激研究量呈总体上升趋势,预计未来将继续保持研究热度。②发文量前3位的国家为美国、中国和意大利,机构为加拿大多伦多大学、英国伦敦大学和美国哈佛大学医学院;美国哈佛大学医学院的Pascual-leone,Alvaro研究成果最多,中国长庚大学的HUANG YZ被引频次最高;《NEURON》为影响力最大的期刊。③高频关键词、高被引文献和聚类主题结果显示,近20年Theta爆发式经颅磁刺激研究热点主要集中于:Theta爆发式经颅磁刺激对突触可塑性和神经生理活动的作用机制,Theta爆发式经颅磁刺激刺激不同脑区靶点的作用效果(包括运动皮质、背外侧前额叶皮质、前扣带皮质和小脑等),以及Theta爆发式经颅磁刺激对神经和精神疾病的疗效探讨(包括抑郁症、帕金森病运动障碍、脑卒中后运动障碍和认知障碍,以及阿尔茨海默病记忆障碍等)。此外,综述和临床试验类文献被引频次最高,未来可重点关注。④关键词突现、文献突现和关键词时间演化分析显示,“重度抑郁症、应用指南、评定量表、疗效、障碍、难治性抑郁症、Meta分析”等不仅是当前的研究热点,也是未来的研究趋势。⑤未来,Theta爆发式经颅磁刺激研究应加强核心作者和机构的区域性合作,发掘其在临床难治性疾病中的应用,通过结合前沿技术和优化刺激参数,实现Theta爆发式经颅磁刺激应用的精准化、个性化和最优化,解决更多临床难题。展开更多
An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease prog...An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in PD.Repetitive transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's disease.However,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain unknown.The purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated signaling.Animals with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod test.Immunoblot,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate putamen.Prolonged intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate putamen.Treatment with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor symptoms.After treatment with prolonged intermittent theta burst stimulation,complete motor recovery was observed.This improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst stimulation.Our results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)R.Intermittent theta burst stimulation reversed these effects by restoring the abundances of A_(1)R and A_(2A)R to control levels.The shift in ARs expression likely restored the balance between dopamine-adenosine signaling,ultimately leading to the recovery of motor control.展开更多
BACKGROUND Working memory serves as a fundamental cognitive function that substantially impacts performance in various cognitive tasks.Extensive neurophysiological research has established that theta oscillations(4-8 ...BACKGROUND Working memory serves as a fundamental cognitive function that substantially impacts performance in various cognitive tasks.Extensive neurophysiological research has established that theta oscillations(4-8 Hz)play an essential role in supporting working memory operations.Theta-band transcranial alternating current stimulation(tACS)offers a potential mechanism for working memory enhancement through direct modulation of these fundamental neural oscillations.Nevertheless,current empirical evidence shows substantial variability in the observed effects of theta-tACS across studies.AIM To conduct a systematic review and meta-analysis evaluating the effects of thetatACS on working memory performance in healthy adults.METHODS A systematic literature search was performed on PubMed,EMBASE,and Web of Science up to March 10,2025.Effect sizes were computed using Hedges’g with 95%confidence intervals(CIs),with separate meta-analyses for all included studies and for distinct working memory paradigms[n-back and delayed matchto-sample(DMTS)tasks]to examine potential task-specific effects.Subgroup analyses and meta-regression were performed to evaluate the influence of key moderating variables.RESULTS The systematic review included 21 studies(67 effect sizes).Initial meta-analysis showed theta-tACS moderately improved working memory(Hedges’g=0.405,95%CI:0.212-0.598).However,this effect became nonsignificant after correcting for publication bias(trim-and-fill adjusted Hedges’g=0.082,95%CI:-0.052 to 0.217).Task-specific analyses revealed significant benefits in n-back tasks(Hedges’g=0.463,95%CI:0.193-0.733)but not in DMTS tasks(Hedges’g=0.257,95%CI:-0.186 to 0.553).Moderator analyses showed that performance in n-back tasks was influenced by stimulation frequency(P=0.001),concurrent status(P=0.014),task modality(P=0.005),and duration(P=0.013),whereas only the region of targeted stimulation(P=0.012)moderated DMTS tasks.CONCLUSION Theta-tACS enhances working memory in healthy adults,with effects modulated by the task type and protocol parameters,offering dual implications for cognitive enhancement and clinical interventions.展开更多
In this paper,the convergence of the split-step theta method for stochastic differential equations is analyzed using stochastic C-stability and stochastic B-consistency.The fact that the numerical scheme,which is both...In this paper,the convergence of the split-step theta method for stochastic differential equations is analyzed using stochastic C-stability and stochastic B-consistency.The fact that the numerical scheme,which is both stochastically C-stable and stochastically B-consistent,is convergent has been proved in a previous paper.In order to analyze the convergence of the split-step theta method(θ∈[1/2,1]),the stochastic C-stability and stochastic B-consistency under the condition of global monotonicity have been researched,and the rate of convergence 1/2 has been explored in this paper.It can be seen that the convergence does not require the drift function should satisfy the linear growth condition whenθ=1/2 Furthermore,the rate of the convergence of the split-step scheme for stochastic differential equations with additive noise has been researched and found to be 1.Finally,an example is given to illustrate the convergence with the theoretical results.展开更多
To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective dis...To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective disorders in children and adolescents,with major depressive disorder(MDD)at 2.00%and bipolar disorder at 0.86%.展开更多
文摘背景:相比于常规重复经颅磁刺激,Theta爆发式经颅磁刺激因具有刺激时间短、效率高、安全性好和效果持久等优势,正受到各领域学者的广泛关注,研究热度持续上升。目的:通过对近20年国际Theta爆发式经颅磁刺激研究进行文献计量学的可视化分析,梳理Theta爆发式经颅磁刺激研究的发展脉络,总结研究现状,揭示研究热点和发展趋势,为后续研究提供借鉴和参考。方法:检索Web of Science核心集数据库中2005年1月至2024年6月有关Theta爆发式经颅磁刺激的相关文献,应用CiteSpace软件进行年度发文量分析,国家、机构和作者合作共现分析,参考文献、期刊和作者共被引分析,关键词共现、聚类、时间演化和突现分析等,并绘制可视化知识图谱。结果与结论:①共纳入1914篇文献,近20年Theta爆发式经颅磁刺激研究量呈总体上升趋势,预计未来将继续保持研究热度。②发文量前3位的国家为美国、中国和意大利,机构为加拿大多伦多大学、英国伦敦大学和美国哈佛大学医学院;美国哈佛大学医学院的Pascual-leone,Alvaro研究成果最多,中国长庚大学的HUANG YZ被引频次最高;《NEURON》为影响力最大的期刊。③高频关键词、高被引文献和聚类主题结果显示,近20年Theta爆发式经颅磁刺激研究热点主要集中于:Theta爆发式经颅磁刺激对突触可塑性和神经生理活动的作用机制,Theta爆发式经颅磁刺激刺激不同脑区靶点的作用效果(包括运动皮质、背外侧前额叶皮质、前扣带皮质和小脑等),以及Theta爆发式经颅磁刺激对神经和精神疾病的疗效探讨(包括抑郁症、帕金森病运动障碍、脑卒中后运动障碍和认知障碍,以及阿尔茨海默病记忆障碍等)。此外,综述和临床试验类文献被引频次最高,未来可重点关注。④关键词突现、文献突现和关键词时间演化分析显示,“重度抑郁症、应用指南、评定量表、疗效、障碍、难治性抑郁症、Meta分析”等不仅是当前的研究热点,也是未来的研究趋势。⑤未来,Theta爆发式经颅磁刺激研究应加强核心作者和机构的区域性合作,发掘其在临床难治性疾病中的应用,通过结合前沿技术和优化刺激参数,实现Theta爆发式经颅磁刺激应用的精准化、个性化和最优化,解决更多临床难题。
基金supported by a grant from Ministry of Science,Technological Development and Innovation,Serbia,No.451-03-68/2022-14/200178(to NN)University of Defence,No.MFVMA/02/22-24(to MN)。
文摘An imbalance in adenosine-mediated signaling,particularly the increased A_(2A)R-mediated signaling,plays a role in the pathogenesis of Parkinson's disease.Existing therapeutic approaches fail to alter disease progression,demonstrating the need for novel approaches in PD.Repetitive transcranial magnetic stimulation is a non-invasive approach that has been shown to improve motor and non-motor symptoms of Parkinson's disease.However,the underlying mechanisms of the beneficial effects of repetitive transcranial magnetic stimulation remain unknown.The purpose of this study is to investigate the extent to which the beneficial effects of prolonged intermittent theta burst stimulation in the 6-hydroxydopamine model of experimental parkinsonism are based on modulation of adenosine-mediated signaling.Animals with unilateral 6-hydroxydopamine lesions underwent intermittent theta burst stimulation for 3 weeks and were tested for motor skills using the Rotarod test.Immunoblot,quantitative reverse transcription polymerase chain reaction,immunohistochemistry,and biochemical analysis of components of adenosine-mediated signaling were performed on the synaptosomal fraction of the lesioned caudate putamen.Prolonged intermittent theta burst stimulation improved motor symptoms in 6-hydroxydopamine-lesioned animals.A 6-hydroxydopamine lesion resulted in progressive loss of dopaminergic neurons in the caudate putamen.Treatment with intermittent theta burst stimulation began 7 days after the lesion,coinciding with the onset of motor symptoms.After treatment with prolonged intermittent theta burst stimulation,complete motor recovery was observed.This improvement was accompanied by downregulation of the e N/CD73-A_(2A)R pathway and a return to physiological levels of A_(1)R-adenosine deaminase 1 after 3 weeks of intermittent theta burst stimulation.Our results demonstrated that 6-hydroxydopamine-induced degeneration reduced the expression of A_(1)R and elevated the expression of A_(2A)R.Intermittent theta burst stimulation reversed these effects by restoring the abundances of A_(1)R and A_(2A)R to control levels.The shift in ARs expression likely restored the balance between dopamine-adenosine signaling,ultimately leading to the recovery of motor control.
基金Supported by Shanghai Municipal Health Commission’s Special Clinical Research Project for the Hygiene Industry,No.20244Y0041Youth Initiation Fund of Naval Medical University,No.2023QN028 and No.2023QN030。
文摘BACKGROUND Working memory serves as a fundamental cognitive function that substantially impacts performance in various cognitive tasks.Extensive neurophysiological research has established that theta oscillations(4-8 Hz)play an essential role in supporting working memory operations.Theta-band transcranial alternating current stimulation(tACS)offers a potential mechanism for working memory enhancement through direct modulation of these fundamental neural oscillations.Nevertheless,current empirical evidence shows substantial variability in the observed effects of theta-tACS across studies.AIM To conduct a systematic review and meta-analysis evaluating the effects of thetatACS on working memory performance in healthy adults.METHODS A systematic literature search was performed on PubMed,EMBASE,and Web of Science up to March 10,2025.Effect sizes were computed using Hedges’g with 95%confidence intervals(CIs),with separate meta-analyses for all included studies and for distinct working memory paradigms[n-back and delayed matchto-sample(DMTS)tasks]to examine potential task-specific effects.Subgroup analyses and meta-regression were performed to evaluate the influence of key moderating variables.RESULTS The systematic review included 21 studies(67 effect sizes).Initial meta-analysis showed theta-tACS moderately improved working memory(Hedges’g=0.405,95%CI:0.212-0.598).However,this effect became nonsignificant after correcting for publication bias(trim-and-fill adjusted Hedges’g=0.082,95%CI:-0.052 to 0.217).Task-specific analyses revealed significant benefits in n-back tasks(Hedges’g=0.463,95%CI:0.193-0.733)but not in DMTS tasks(Hedges’g=0.257,95%CI:-0.186 to 0.553).Moderator analyses showed that performance in n-back tasks was influenced by stimulation frequency(P=0.001),concurrent status(P=0.014),task modality(P=0.005),and duration(P=0.013),whereas only the region of targeted stimulation(P=0.012)moderated DMTS tasks.CONCLUSION Theta-tACS enhances working memory in healthy adults,with effects modulated by the task type and protocol parameters,offering dual implications for cognitive enhancement and clinical interventions.
基金Supported by the National Natural Science Foundation of China (Grant No. 12301521)the Natural Science Foundation of Shanxi Province (Grant No. 20210302124081)。
文摘In this paper,the convergence of the split-step theta method for stochastic differential equations is analyzed using stochastic C-stability and stochastic B-consistency.The fact that the numerical scheme,which is both stochastically C-stable and stochastically B-consistent,is convergent has been proved in a previous paper.In order to analyze the convergence of the split-step theta method(θ∈[1/2,1]),the stochastic C-stability and stochastic B-consistency under the condition of global monotonicity have been researched,and the rate of convergence 1/2 has been explored in this paper.It can be seen that the convergence does not require the drift function should satisfy the linear growth condition whenθ=1/2 Furthermore,the rate of the convergence of the split-step scheme for stochastic differential equations with additive noise has been researched and found to be 1.Finally,an example is given to illustrate the convergence with the theoretical results.
基金the Tianjin Health Research Project(Grant No.TJWJ2023MS038)Tianjin Education Commission Research Project(Grant No.2023KJ044)S&T Program of Hebei(SG2021189)。
文摘To the editor:A wide range of affective disorders affects people of all ages globally and contributes significantly to the global disease burden.1 In China,a nationwide survey found a 3.21% prevalence of affective disorders in children and adolescents,with major depressive disorder(MDD)at 2.00%and bipolar disorder at 0.86%.
