Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterp...Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterpene and flavonoids. The major pharmacological functions of the active constituents include： anti-tumor, anti- virus, antibiosis, antiphlogosis, hypotensive action, and etc. This paper summarizes the methods for determining the contents of chemical constituents in Thalictrum plants and new chemical constituents discovered in this genus in recent ten years.展开更多
Two new compounds, 5-hydro-N-methylcorydalidine (1) and 1-(4-methoxybenzyl)-2-N-methyl-6-hydroxyl-5, 7-dimethoxy-isoquinoline (2), together with seven known ones (3-9) were isolated from the chloroform extract of the ...Two new compounds, 5-hydro-N-methylcorydalidine (1) and 1-(4-methoxybenzyl)-2-N-methyl-6-hydroxyl-5, 7-dimethoxy-isoquinoline (2), together with seven known ones (3-9) were isolated from the chloroform extract of the herb Thalictrum delavayi Franch., among which compound 7 was firstly obtained from the genus Thalictrum. Their structures were elucidated on the basis of spectroscopic evidence including HMQC and HMBC experiments.展开更多
A new triterpene glycoside, 24S-cycloartane-3 beta, 16 beta, 24, 25, 30-pentaol 3-O-(2-O-beta-D-xylosyl)-beta-D-xyloside was isolated from Thalictrum smithii. Its structure was determined by spectroscopic and chemical...A new triterpene glycoside, 24S-cycloartane-3 beta, 16 beta, 24, 25, 30-pentaol 3-O-(2-O-beta-D-xylosyl)-beta-D-xyloside was isolated from Thalictrum smithii. Its structure was determined by spectroscopic and chemical methods.展开更多
[Objective] The aim was to make pharmacognostic research of Thalictrum foeniculaceum to lay foundation for development of the plant and formulation of re- lated medicinal quality standard. [Method] Based on Thalictrum...[Objective] The aim was to make pharmacognostic research of Thalictrum foeniculaceum to lay foundation for development of the plant and formulation of re- lated medicinal quality standard. [Method] Based on Thalictrum foeniculaceum plants, morphological characters of the plants, and the paraffin sections and powders of dif- ferent organs were observed with an optical microscope. [Result] Cross-section of roots of Thalictrum foeniculaceum is typical secondary structure of dicotyledon and anticlinal wall of endodermis is curve. What＇s more, vessel type is diversified, in- cluding reticulate vessel, spiral vessel, and bordered pit vessel. In addition, the leaf can be classified into basal leaf and stem leaf, of which the former is ternate vein and bifacial leaf, and the latter is isolateral leaf. The cells in palisade tissue are 2-3 lists and small granules can be found in surface of leaf epidermal cells; pollen grain is round and scattered. [Conclusion] The research laid foundation for development of plant resources and formulation of quality standard for Thalictrum foeniculaceum.展开更多
A new flavonoid glycoside, 5, 7-dihydroxy-4'-methoxyflavonoid 7-Q-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside was isolated from Thalictrum przewalskii. Its structure was de...A new flavonoid glycoside, 5, 7-dihydroxy-4'-methoxyflavonoid 7-Q-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside was isolated from Thalictrum przewalskii. Its structure was determined on basis of spectroscopic evidences.展开更多
Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxo...Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxohernandalin(3),(–)-9-(2’-methoxycarbonyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(4),(–)-2’-methoxycarbonyl thaliadin(5),(–)-9-(2’-methoxyethyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(6),(–)-3-methoxy hydroxyhernandalinol(7),together with six known isoquinoline alkaloids(8–13)were isolated from the roots of Thalictrum foetidum.Their structures were elucidated by extensive spectroscopic measurements.Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells(GSC-3#and GSC-18#)with IC50 values ranging from 2.36 to 5.37μg·mL^–1.展开更多
为了更全面了解我国药用植物高原唐松草(Thalictrum cultratum Wall.)的化学成分,首次研究了其非生物碱类成分。利用色谱分离技术从中分离得到了10个化合物,根据核磁共振波谱数据,其结构分别鉴定为催吐萝芙木醇(1)、blumenol C glucosid...为了更全面了解我国药用植物高原唐松草(Thalictrum cultratum Wall.)的化学成分,首次研究了其非生物碱类成分。利用色谱分离技术从中分离得到了10个化合物,根据核磁共振波谱数据,其结构分别鉴定为催吐萝芙木醇(1)、blumenol C glucoside(2)、酪醇(3)、4-羟基-3-甲氧基-苯乙醇(4)、β-D-果糖(5)、甲基-α-D-呋喃果糖苷(6)、乙基-β-D-吡喃果糖苷(7)、1-O-β-D-吡喃果糖-α-D-吡喃阿洛糖苷(8)、β-谷甾醇(9)和sitost-5-en-3β-ol acetate(10)。所有化合物均首次从该植物中分离。展开更多
Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analog...Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense Turcz.ex Ledeb.The structures were determined by extensive spectroscopic methods and ECD calculations.Thaliberberine A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at C-6.Plausible biosynthetic routes of 1 are proposed.展开更多
唐松草属Thalictrum隶属毛茛科Ranunculaceae,包含约200个原生种或变种,在园艺生产和传统医药中具有重要地位。本研究从Web of Science(WOS)核心数据库和中国知网(CNKI)期刊论文数据库,检索获得与唐松草属植物研究相关的中英文文献,利用...唐松草属Thalictrum隶属毛茛科Ranunculaceae,包含约200个原生种或变种,在园艺生产和传统医药中具有重要地位。本研究从Web of Science(WOS)核心数据库和中国知网(CNKI)期刊论文数据库,检索获得与唐松草属植物研究相关的中英文文献,利用VOSviewer等软件进行文献计量分析。结果表明,国内外对唐松草属植物的研究主要集中在资源分类、系统进化、植物化学(尤其是苄基异喹啉类生物碱)和民族药理学等方面,但总体上并不深入。中国是唐松草属植物研究的重要参与者之一,英文文献发文量占世界总量的39.9%,在相关研究中处于领先地位。结合基因组学解析唐松草属植物系统发育关系,利用多组学分析方法解析苄基异喹啉生物碱多样性生物合成机制,综合现代药理学和分子生物学方法探究其生理功能机制都是比较有前景的研究方向。此外,充分发挥我国资源优势,着力推进资源利用与资源保护并行,对推动我国唐松草属植物研究与利用具有重要意义。展开更多
基金Supported by the State Key Development Program for Basic Research of ChinaScientific and Technological Development Project of Shandong Province(2008GG2NS02022)~~
文摘Thalictrum plants are perennial herbs in the family Ranuneulaceae, many of which are of important medicinal values. Alkaloids are major active constituents in Thalictrum plants in addition to a small amount of triterpene and flavonoids. The major pharmacological functions of the active constituents include： anti-tumor, anti- virus, antibiosis, antiphlogosis, hypotensive action, and etc. This paper summarizes the methods for determining the contents of chemical constituents in Thalictrum plants and new chemical constituents discovered in this genus in recent ten years.
文摘Two new compounds, 5-hydro-N-methylcorydalidine (1) and 1-(4-methoxybenzyl)-2-N-methyl-6-hydroxyl-5, 7-dimethoxy-isoquinoline (2), together with seven known ones (3-9) were isolated from the chloroform extract of the herb Thalictrum delavayi Franch., among which compound 7 was firstly obtained from the genus Thalictrum. Their structures were elucidated on the basis of spectroscopic evidence including HMQC and HMBC experiments.
文摘A new triterpene glycoside, 24S-cycloartane-3 beta, 16 beta, 24, 25, 30-pentaol 3-O-(2-O-beta-D-xylosyl)-beta-D-xyloside was isolated from Thalictrum smithii. Its structure was determined by spectroscopic and chemical methods.
基金Supported by National Program on Key Basic Research Project of China(973 Program) (2007CB512601)Shandong Science and Technology Development Program (2008GG2NS02022)~~
文摘[Objective] The aim was to make pharmacognostic research of Thalictrum foeniculaceum to lay foundation for development of the plant and formulation of re- lated medicinal quality standard. [Method] Based on Thalictrum foeniculaceum plants, morphological characters of the plants, and the paraffin sections and powders of dif- ferent organs were observed with an optical microscope. [Result] Cross-section of roots of Thalictrum foeniculaceum is typical secondary structure of dicotyledon and anticlinal wall of endodermis is curve. What＇s more, vessel type is diversified, in- cluding reticulate vessel, spiral vessel, and bordered pit vessel. In addition, the leaf can be classified into basal leaf and stem leaf, of which the former is ternate vein and bifacial leaf, and the latter is isolateral leaf. The cells in palisade tissue are 2-3 lists and small granules can be found in surface of leaf epidermal cells; pollen grain is round and scattered. [Conclusion] The research laid foundation for development of plant resources and formulation of quality standard for Thalictrum foeniculaceum.
文摘A new flavonoid glycoside, 5, 7-dihydroxy-4'-methoxyflavonoid 7-Q-[6-O-(4-O-acetyl-alpha-L-rhamnosyl)-3-O-beta-D-glucosyl]-6-O-acetyl-beta-D-glucoside was isolated from Thalictrum przewalskii. Its structure was determined on basis of spectroscopic evidences.
基金supported by the Natural Science Foundation of China(U1802281,31770388)
文摘Seven new isoquinoline alkaloids,9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy dehydroaporphine(1),9-(2’-formyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy oxoaporphine(2),3-methoxy-2’-formyl oxohernandalin(3),(–)-9-(2’-methoxycarbonyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(4),(–)-2’-methoxycarbonyl thaliadin(5),(–)-9-(2’-methoxyethyl-5’,6’-dimethoxyphenoxy)-1,2,3,10-tetramethoxy aporphine(6),(–)-3-methoxy hydroxyhernandalinol(7),together with six known isoquinoline alkaloids(8–13)were isolated from the roots of Thalictrum foetidum.Their structures were elucidated by extensive spectroscopic measurements.Compounds 1 and 2 showed significant selective cytotoxicity against glioma stem cells(GSC-3#and GSC-18#)with IC50 values ranging from 2.36 to 5.37μg·mL^–1.
基金This work was supported by the National Natural Science Foundationof China(No.82173715).
文摘Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense Turcz.ex Ledeb.The structures were determined by extensive spectroscopic methods and ECD calculations.Thaliberberine A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at C-6.Plausible biosynthetic routes of 1 are proposed.
文摘唐松草属Thalictrum隶属毛茛科Ranunculaceae,包含约200个原生种或变种,在园艺生产和传统医药中具有重要地位。本研究从Web of Science(WOS)核心数据库和中国知网(CNKI)期刊论文数据库,检索获得与唐松草属植物研究相关的中英文文献,利用VOSviewer等软件进行文献计量分析。结果表明,国内外对唐松草属植物的研究主要集中在资源分类、系统进化、植物化学(尤其是苄基异喹啉类生物碱)和民族药理学等方面,但总体上并不深入。中国是唐松草属植物研究的重要参与者之一,英文文献发文量占世界总量的39.9%,在相关研究中处于领先地位。结合基因组学解析唐松草属植物系统发育关系,利用多组学分析方法解析苄基异喹啉生物碱多样性生物合成机制,综合现代药理学和分子生物学方法探究其生理功能机制都是比较有前景的研究方向。此外,充分发挥我国资源优势,着力推进资源利用与资源保护并行,对推动我国唐松草属植物研究与利用具有重要意义。
