目的:评估初诊2型糖尿病患者中性粒细胞/高密度脂蛋白胆固醇比值(neutrophil-to-high density lipoprotein cholesterol ratio,NHR)、淋巴细胞/高密度脂蛋白胆固醇比值(lymphocyte-to-high density lipoprotein cholesterol ratio,LHR)...目的:评估初诊2型糖尿病患者中性粒细胞/高密度脂蛋白胆固醇比值(neutrophil-to-high density lipoprotein cholesterol ratio,NHR)、淋巴细胞/高密度脂蛋白胆固醇比值(lymphocyte-to-high density lipoprotein cholesterol ratio,LHR)、单核细胞/高密度脂蛋白胆固醇比值(monocyte to high density lipoprotein-cholesterol ratio,MHR)与早期糖尿病肾病的相关性及预测价值。方法:2021年4月至2022年8月湖北医药学院附属太和医院内分泌科住院初诊2型糖尿病患者386例,分为单纯糖尿病组(SDM组154例):UACR<30 mg/g、早期糖尿病肾病组(EDKD组232例):30 mg/g≤UACR≤300 mg/g;选取同期门诊体检健康者110例为正常对照组(NC组)。比较各组间的一般临床资料,利用Spearman相关性分析和Logistic回归分析评估NHR、LHR、MHR与2型糖尿病的相关性,并绘制ROC曲线。结果:EDKD组的NHR高于NC组和SDM组,EDKD组LHR高于NC组,MHR在NC组、SDM组、EDKD组依次递增,组间差异均有统计学意义(P<0.05);NHR、MHR与UACR均呈正相关(P<0.05),LHR与UACR无相关性(P>0.05);多因素Logistic回归分析发现,NHR、MHR是早期DKD的独立预测因素;ROC曲线分析显示,NHR、MHR及NHR、MHR联合检测的曲线下面积(AUC)分别为0.735、0.654、0.764,敏感度分别为0.668、0.638、0.849,特异度分别为0.688、0.597、0.526;二者联合检测敏感度高于单独检测。结论:NHR、MHR是早期糖尿病肾病的独立预测因子;NHR、MHR水平越高,2型糖尿病患者合并早期糖尿病肾病的风险越高。展开更多
探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的...探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的180例T2DM患者为观察组,根据是否发生并发症分为非并发症组(50例)和并发症组(130例)。同时选取同期体检的180例健康人群为对照组。对比C肽、HbA1c、GLU水平,并经Spearman相关性分析C肽、HbA1c、GLU水平与T2DM患者并发症发生风险的相关性。结果显示,观察组血清C肽水平低于对照组,HbA1c水平、GLU高于对照组(P<0.05)。并发症组血清C肽水平低于非并发症组,HbA1c水平、GLU高于非并发症组(P<0.05)。HbA1c、GLU水平与T2DM患者并发症的发生风险呈正相关,C肽水平与T2DM患者并发症的发生风险呈负相关(P<0.05)。研究发现,通过监测血清C肽、HbA1c以及GLU水平,可评估T2DM患者的并发症发生风险。展开更多
<div style="text-align:justify;"> <span style="font-family:Verdana;">Type 2 diabetes mellitus is a growing health problem, characterized by insulin resistance progressing to beta cell d...<div style="text-align:justify;"> <span style="font-family:Verdana;">Type 2 diabetes mellitus is a growing health problem, characterized by insulin resistance progressing to beta cell dysfunction and insulin deficiency, most of these patients will need intensification of treatment and initiation of insulin to delay or prevent diabetic complications. Glycemic control is the most important aspect of management, and in reducing morbidity and mortality of the diseases. Control of plasma glucose in patients with diabetes can be assessed by HbA1c, FPG, PPG, but still HbA1c% remains the gold standard for assessment of glycemic control and follow up of diabetic patients. The aim of this study is to assess HbA1c% in patients on oral anti-diabetic drugs, with poor glycemic control before and after adding basal insulin, with titration of the dose of insulin depending on fasting blood sugar. 82 patients with uncontrolled type 2 diabetes (43.9% male, 56.1% female), with HbA1c more than 9%, on two types of oral diabetic medication or more, were started on basal insulin (glargine, lantus) and followed for three to six months. Overall 82 patients with type 2 diabetes mellitus were included in the study. The mean age of the study population was 58.4 years, the mean duration of the disease range was 13.4 years. All patients with HbA1c more than 9%, without organ failure, were included in the study. The mean HbA1c overall had decreased from mean of 11.15% before starting basal insulin to the mean of 8.43% within 3 to 6 month, after initiating basal insulin, this difference was significant at p < 0.001. There was no adverse effect on this medication in any of the study group. The addition of basal insulin to oral anti-diabetic medication in uncontrolled insulin-na<span style="color:#4F4F4F;font-family:"font-size:14px;white-space:normal;background-color:#F7F7F7;">ï</span>ve type 2 diabetic patients resulted in significant improvement of glycemic control, with improved HbA1c level, without adverse effects.</span> </div>展开更多
目的探讨预后营养指数(PNI)在2型糖尿病(T2DM)合并视网膜病变(DR)中的临床意义。方法本研究纳入了2017年3月-2020年3月在温州医科大学附属第一医院住院的445例正常体重T2DM患者,根据有无DR分为无DR组(218例)和DR组(227例),分析两组之间...目的探讨预后营养指数(PNI)在2型糖尿病(T2DM)合并视网膜病变(DR)中的临床意义。方法本研究纳入了2017年3月-2020年3月在温州医科大学附属第一医院住院的445例正常体重T2DM患者,根据有无DR分为无DR组(218例)和DR组(227例),分析两组之间PNI、体重指数、腰围及糖脂代谢指标等临床资料。将PNI按四分位数进行分层,采用Logistic回归分析PNI对DR的发生率的影响。多因素分析方法分析DR与年龄、性别、PNI、糖尿病病程、血红蛋白及代谢指标的相关性。结果与非DR组比较,DR组年龄大,糖尿病病程长,餐后2h血糖、收缩压、血肌酐、尿酸较高,而血白蛋白、总淋巴细胞计数、PNI、血红蛋白、红细胞显著较低。随着PNI水平的下降,DR的发生率显著上升(Q4 vs Q1:OR=3.148,95%CI:1.474-6.722,P=0.003)。多元线性回归分析发现PNI是T2DM患者并发DR的独立危险因素。结论T2DM患者PNI与DR的发生率密切相关,PNI可作为评估T2DM并发DR和改善预后的一项重要指标。展开更多
Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus （T2DM） patients and healthy subjects using DNA microarray analysis, Methods T2DM...Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus （T2DM） patients and healthy subjects using DNA microarray analysis, Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to anaIyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was ≥2 folds, These differentially expressed genes were classified into 15 categories according to their functions. Conclusion New genes are found and T2DM can be prevented or cured.展开更多
文摘目的:评估初诊2型糖尿病患者中性粒细胞/高密度脂蛋白胆固醇比值(neutrophil-to-high density lipoprotein cholesterol ratio,NHR)、淋巴细胞/高密度脂蛋白胆固醇比值(lymphocyte-to-high density lipoprotein cholesterol ratio,LHR)、单核细胞/高密度脂蛋白胆固醇比值(monocyte to high density lipoprotein-cholesterol ratio,MHR)与早期糖尿病肾病的相关性及预测价值。方法:2021年4月至2022年8月湖北医药学院附属太和医院内分泌科住院初诊2型糖尿病患者386例,分为单纯糖尿病组(SDM组154例):UACR<30 mg/g、早期糖尿病肾病组(EDKD组232例):30 mg/g≤UACR≤300 mg/g;选取同期门诊体检健康者110例为正常对照组(NC组)。比较各组间的一般临床资料,利用Spearman相关性分析和Logistic回归分析评估NHR、LHR、MHR与2型糖尿病的相关性,并绘制ROC曲线。结果:EDKD组的NHR高于NC组和SDM组,EDKD组LHR高于NC组,MHR在NC组、SDM组、EDKD组依次递增,组间差异均有统计学意义(P<0.05);NHR、MHR与UACR均呈正相关(P<0.05),LHR与UACR无相关性(P>0.05);多因素Logistic回归分析发现,NHR、MHR是早期DKD的独立预测因素;ROC曲线分析显示,NHR、MHR及NHR、MHR联合检测的曲线下面积(AUC)分别为0.735、0.654、0.764,敏感度分别为0.668、0.638、0.849,特异度分别为0.688、0.597、0.526;二者联合检测敏感度高于单独检测。结论:NHR、MHR是早期糖尿病肾病的独立预测因子;NHR、MHR水平越高,2型糖尿病患者合并早期糖尿病肾病的风险越高。
文摘探究2型糖尿病(diabetes mellitus type 2,T2DM)患者血清C肽、糖化血红蛋白(glycosylated hemoglobin,HbA1c)以及葡萄糖(glucose,GLU)水平表达及其同并发症发生风险的相关性。选取甘肃省陇南市第一人民医院(2024年1月—2025年4月)收治的180例T2DM患者为观察组,根据是否发生并发症分为非并发症组(50例)和并发症组(130例)。同时选取同期体检的180例健康人群为对照组。对比C肽、HbA1c、GLU水平,并经Spearman相关性分析C肽、HbA1c、GLU水平与T2DM患者并发症发生风险的相关性。结果显示,观察组血清C肽水平低于对照组,HbA1c水平、GLU高于对照组(P<0.05)。并发症组血清C肽水平低于非并发症组,HbA1c水平、GLU高于非并发症组(P<0.05)。HbA1c、GLU水平与T2DM患者并发症的发生风险呈正相关,C肽水平与T2DM患者并发症的发生风险呈负相关(P<0.05)。研究发现,通过监测血清C肽、HbA1c以及GLU水平,可评估T2DM患者的并发症发生风险。
文摘<div style="text-align:justify;"> <span style="font-family:Verdana;">Type 2 diabetes mellitus is a growing health problem, characterized by insulin resistance progressing to beta cell dysfunction and insulin deficiency, most of these patients will need intensification of treatment and initiation of insulin to delay or prevent diabetic complications. Glycemic control is the most important aspect of management, and in reducing morbidity and mortality of the diseases. Control of plasma glucose in patients with diabetes can be assessed by HbA1c, FPG, PPG, but still HbA1c% remains the gold standard for assessment of glycemic control and follow up of diabetic patients. The aim of this study is to assess HbA1c% in patients on oral anti-diabetic drugs, with poor glycemic control before and after adding basal insulin, with titration of the dose of insulin depending on fasting blood sugar. 82 patients with uncontrolled type 2 diabetes (43.9% male, 56.1% female), with HbA1c more than 9%, on two types of oral diabetic medication or more, were started on basal insulin (glargine, lantus) and followed for three to six months. Overall 82 patients with type 2 diabetes mellitus were included in the study. The mean age of the study population was 58.4 years, the mean duration of the disease range was 13.4 years. All patients with HbA1c more than 9%, without organ failure, were included in the study. The mean HbA1c overall had decreased from mean of 11.15% before starting basal insulin to the mean of 8.43% within 3 to 6 month, after initiating basal insulin, this difference was significant at p < 0.001. There was no adverse effect on this medication in any of the study group. The addition of basal insulin to oral anti-diabetic medication in uncontrolled insulin-na<span style="color:#4F4F4F;font-family:"font-size:14px;white-space:normal;background-color:#F7F7F7;">ï</span>ve type 2 diabetic patients resulted in significant improvement of glycemic control, with improved HbA1c level, without adverse effects.</span> </div>
文摘目的探讨预后营养指数(PNI)在2型糖尿病(T2DM)合并视网膜病变(DR)中的临床意义。方法本研究纳入了2017年3月-2020年3月在温州医科大学附属第一医院住院的445例正常体重T2DM患者,根据有无DR分为无DR组(218例)和DR组(227例),分析两组之间PNI、体重指数、腰围及糖脂代谢指标等临床资料。将PNI按四分位数进行分层,采用Logistic回归分析PNI对DR的发生率的影响。多因素分析方法分析DR与年龄、性别、PNI、糖尿病病程、血红蛋白及代谢指标的相关性。结果与非DR组比较,DR组年龄大,糖尿病病程长,餐后2h血糖、收缩压、血肌酐、尿酸较高,而血白蛋白、总淋巴细胞计数、PNI、血红蛋白、红细胞显著较低。随着PNI水平的下降,DR的发生率显著上升(Q4 vs Q1:OR=3.148,95%CI:1.474-6.722,P=0.003)。多元线性回归分析发现PNI是T2DM患者并发DR的独立危险因素。结论T2DM患者PNI与DR的发生率密切相关,PNI可作为评估T2DM并发DR和改善预后的一项重要指标。
基金supported by the National High Technology Research and Development Program of China (863 Program No. 2001AA221161)the National Key Technologies R & D Program of China (No. 2002BA711A05)
文摘Objective To study the differential patterns of gene expression in skeletal muscle and adipose tissue between type 2 diabetes mellitus （T2DM） patients and healthy subjects using DNA microarray analysis, Methods T2DM patiens were divided into female group, young male group and old male group. DNA microarray analysis and quantitative real-time PCR were carried out to anaIyze the relation between gene expressions and T2DM. Results The mRNA expression of 298, 578, and 350 genes was changed in the skeletal muscle of diabetes mellitus patients compared with control subjects. The 1320, 1143, and 2847 genes were modified in adipose tissue of the three groups. Among the genes surveyed, the change of 25 and 39 gene transcripts in skeletal muscle and adipose tissue was ≥2 folds, These differentially expressed genes were classified into 15 categories according to their functions. Conclusion New genes are found and T2DM can be prevented or cured.
