咏叹调《Giunto sul passo estremo》又名《濒临生命的尽头》,是1866—1867年由博伊托创作的歌剧作品《梅菲斯托费勒斯》中的咏叹调。《梅菲斯托费勒斯》是一部五幕歌剧,取材自文学作品《浮士德》,以魔鬼梅菲斯托费勒斯为主线展开剧情,...咏叹调《Giunto sul passo estremo》又名《濒临生命的尽头》,是1866—1867年由博伊托创作的歌剧作品《梅菲斯托费勒斯》中的咏叹调。《梅菲斯托费勒斯》是一部五幕歌剧,取材自文学作品《浮士德》,以魔鬼梅菲斯托费勒斯为主线展开剧情,而其中的咏叹调《Giunto sul passo estremo》则是整部歌剧中较为经典的曲目。文章选取咏叹调作为审美、情感两方面分析的对象,意在透过这一咏叹调将音乐演唱中的情感传达及技巧表现做较为深入的研究。展开更多
Carbonic acid produced by the dissolution of atmospheric and soil CO_(2)in water is usually the most dominant catalyst for chemical weathering,but a sulfuric aciddriven phenomenon,different from usual,was found in the...Carbonic acid produced by the dissolution of atmospheric and soil CO_(2)in water is usually the most dominant catalyst for chemical weathering,but a sulfuric aciddriven phenomenon,different from usual,was found in the orogenic belt watersheds dominated by silicate bedrock.This study,rooted in comprehensive field investigations in the Manas River Basin(MRB)north of the Tianshan Mountains,delves into the mechanisms and impacts of sulfuric and carbonic acid as catalysts driving diff erent types of chemical weathering in the Central Asian Orogenic Belt.Quantitative analyses elucidate that carbonate weathering constitutes 52.4%of the total chemical weathering,while silicate and evaporite account for 18.6%and 25.3%,respectively,with anthropogenic activities and atmospheric precipitation having little eff ect.The estimated total chemical weathering rate in MRB is approximately 0.075×10^(6)mol/km^(2)/year.Quantitative findings further suggest that,preceding carbonate precipitation(<10^(4)year),chemical weathering can absorb CO_(2).Subsequently,and following carbonate precipitation(10^(4)-10^(7)year),it will release CO_(2).The release significantly surpasses the global average CO_(2)consumption,contributing to a noteworthy climate impact.This study underscores the distinctive weathering mechanisms,wherein sulfuric acid emerges as the predominant catalyst.The quantity of sulfuric acid as a catalyst is approximately three times that of carbonic acid.Sulfuric acid-driven carbonate rock weathering(SCW)is identified as the sole chemical weathering type with a net CO_(2)release eff ect.SCW CO_(2)release flux(5176 mol/km^(2)/year)is roughly 2.5 times the CO_(2)absorption by Ca-Mg silicate weathering,highlighting the pivotal role of chemical weathering in sourcing atmospheric CO_(2)over the timescales of carbonate precipitation and sulfate reduction.Lastly,this study posits that catalyst and transport limitations are the most plausible critical factors in MRB.The interplay between sulfuric acid and dissolved CO_(2)competitively shapes the types and rates of chemical weathering reactions.展开更多
Antibiotic resistance genes(ARGs)can be easily promoted by antibiotics,however,the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in,especially,acti...Antibiotic resistance genes(ARGs)can be easily promoted by antibiotics,however,the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in,especially,activated sludge sequencing batch reactors.In the present study,the effects of 9 sulfonamides(SAs)with different structures on the proliferation dynamic of sulfonamide resistance genes(Suls)in the activated sludge sequencing batch reactors and the corresponding mechanisms were determined(30 days),and the results showed that the largest proliferation value(ΔA^(R))of Suls dynamic for SAs(sulfachloropyridazine)was approximately 2.9 times than that of the smallest one(sulfadiazine).The proliferation of Suls was significantly related to the structural features(minHBint6,SssNH,SHBd and SpMax2_Bhm)that represent the biological activity of SAs.To interpret the phenomenon,a mechanistic model was developed and the results indicated that the biodegradation of SAs(T_(1/2))rather than conjugative transfer frequency or mutation frequency tends to be the key process for affecting Suls proliferation.T_(1/2)was proved to be dependent on the interactions between SAs and receptors(E_(binding)),the cleavage mode(bond dissociation energy),and the site of nucleophilic assault.Besides,the metagenomic analysis showed that SAs posed significant effect on antibiotic resistome and Tnp31 played a vital role in the proliferation of Suls.Overall,our findings provide important insight into a theoretical basis for understanding the structural effects of SAs on the proliferation of ARGs in SBR systems.展开更多
Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TM...Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TMLR) (PDB ID: 5EDQ) to identify new drug candidates for treating cancer. Binding free energy was calculated by Molegro virtual docker (MVD) to select the most promising hits. The corresponding docking score values into EGFR (TMLR) of 4b gave the best energy docking -147.213 Kcal/mol. And some of the designed sulfonamide derivatives have been synthesized by conventional method in addition to a microwave-assisted method of synthesis. The reaction of an amino group-containing drug;sulfamethoxazole and sulfanilamide with carbonyl group in benzoyl chloride and phthalic acid in basic media, generated a series of sulfonamide derivatives. The structures of all the synthesized compounds were well characterized by Mass spectrometry (MS), Infrared spectroscopy (IR), <sup><span style="font-family:Verdana;">1</sup><span style="font-family:Verdana;">H nuclear magnetic resonance (<sup><span style="font-family:Verdana;">1</sup><span style="font-family:Verdana;">H NMR), <sup><span style="font-family:Verdana;">13</sup><span style="font-family:Verdana;">C nuclear magnetic resonance (<sup><span style="font-family:Verdana;">13</sup><span style="font-family:Verdana;">C NMR) and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the approaches, conventional and microwave-assisted method, it was shown that the microwave-assisted method gave higher yield with shorter time and higher temperature compared to conventional heating methods.展开更多
By orthodox experiment, the main influence factors of desulfurization by sulfolobas of pH value, temperature, coal slurry concentration and coal granularity are studied in detail and the optimal experimental condition...By orthodox experiment, the main influence factors of desulfurization by sulfolobas of pH value, temperature, coal slurry concentration and coal granularity are studied in detail and the optimal experimental conditions were also obtained. The experimental results demonstrate that sulfolobas being kind of linking-heat, acidophilic and self-supported bacterium with double characters can effectively remove inorganic and organic sulfur in coal. The superlatively desulfurization rate is up to 48.57% total sulfur and 41.71% inorganic sulfur within 10 d and its desulfurization rate can be greatly affected by the four factors above mentioned. Therefore, the optimum conditions of desulfurization are obtained by comprehensive experiment and they are as following: pH value 3, temperature 70℃, coal slurry concentration 10% and coal granularity 150 μm, respectively. Moreover, the repetition experimental results confirm that the desulfurization by sulfolobas is steady.展开更多
安哥拉Benguela Sul 220 kV变电站综合自动化系统按照“无人值班”(少人值守)的原则进行设计,计算机监控系统由站控层和间隔层组成,采用全开放分层分布式网络结构。站控层是整个变电站的一、二次设备管理、控制、监视、测量的中心,监控...安哥拉Benguela Sul 220 kV变电站综合自动化系统按照“无人值班”(少人值守)的原则进行设计,计算机监控系统由站控层和间隔层组成,采用全开放分层分布式网络结构。站控层是整个变电站的一、二次设备管理、控制、监视、测量的中心,监控系统采用双环形光纤以太网计算机局域网连接方式,间隔层通过100Mbps光纤交换式快速以太网或RS485总线与站控层设备通信。本站采用光纤通信+载波通信方式,计算机监控系统通过远动通信设备与调度中心通信。展开更多
文摘咏叹调《Giunto sul passo estremo》又名《濒临生命的尽头》,是1866—1867年由博伊托创作的歌剧作品《梅菲斯托费勒斯》中的咏叹调。《梅菲斯托费勒斯》是一部五幕歌剧,取材自文学作品《浮士德》,以魔鬼梅菲斯托费勒斯为主线展开剧情,而其中的咏叹调《Giunto sul passo estremo》则是整部歌剧中较为经典的曲目。文章选取咏叹调作为审美、情感两方面分析的对象,意在透过这一咏叹调将音乐演唱中的情感传达及技巧表现做较为深入的研究。
基金support from the Third Xinjiang Scientific Expedition Program(2021XJKK0803)the National Natural Science Foundation of China(No.41930640)the Project of the Second Comprehensive Scientific Investigation on the Qinghai-Tibetan Plateau(2019QZKK1003)。
文摘Carbonic acid produced by the dissolution of atmospheric and soil CO_(2)in water is usually the most dominant catalyst for chemical weathering,but a sulfuric aciddriven phenomenon,different from usual,was found in the orogenic belt watersheds dominated by silicate bedrock.This study,rooted in comprehensive field investigations in the Manas River Basin(MRB)north of the Tianshan Mountains,delves into the mechanisms and impacts of sulfuric and carbonic acid as catalysts driving diff erent types of chemical weathering in the Central Asian Orogenic Belt.Quantitative analyses elucidate that carbonate weathering constitutes 52.4%of the total chemical weathering,while silicate and evaporite account for 18.6%and 25.3%,respectively,with anthropogenic activities and atmospheric precipitation having little eff ect.The estimated total chemical weathering rate in MRB is approximately 0.075×10^(6)mol/km^(2)/year.Quantitative findings further suggest that,preceding carbonate precipitation(<10^(4)year),chemical weathering can absorb CO_(2).Subsequently,and following carbonate precipitation(10^(4)-10^(7)year),it will release CO_(2).The release significantly surpasses the global average CO_(2)consumption,contributing to a noteworthy climate impact.This study underscores the distinctive weathering mechanisms,wherein sulfuric acid emerges as the predominant catalyst.The quantity of sulfuric acid as a catalyst is approximately three times that of carbonic acid.Sulfuric acid-driven carbonate rock weathering(SCW)is identified as the sole chemical weathering type with a net CO_(2)release eff ect.SCW CO_(2)release flux(5176 mol/km^(2)/year)is roughly 2.5 times the CO_(2)absorption by Ca-Mg silicate weathering,highlighting the pivotal role of chemical weathering in sourcing atmospheric CO_(2)over the timescales of carbonate precipitation and sulfate reduction.Lastly,this study posits that catalyst and transport limitations are the most plausible critical factors in MRB.The interplay between sulfuric acid and dissolved CO_(2)competitively shapes the types and rates of chemical weathering reactions.
基金supported by the National Natural Science Foundation of China (Nos.32160303 and 31760165)the Education Department of Jiangxi Province (No.GJJ211001)+1 种基金the Scientific and Technological Project of Ji’an City (No.20211–025333)the Key Project of Natural Science Foundation of Jiangxi Province (2022)。
文摘Antibiotic resistance genes(ARGs)can be easily promoted by antibiotics,however,the structural effects of antibiotics on the proliferation of ARGs dynamic and the associated mechanisms remain obscure in,especially,activated sludge sequencing batch reactors.In the present study,the effects of 9 sulfonamides(SAs)with different structures on the proliferation dynamic of sulfonamide resistance genes(Suls)in the activated sludge sequencing batch reactors and the corresponding mechanisms were determined(30 days),and the results showed that the largest proliferation value(ΔA^(R))of Suls dynamic for SAs(sulfachloropyridazine)was approximately 2.9 times than that of the smallest one(sulfadiazine).The proliferation of Suls was significantly related to the structural features(minHBint6,SssNH,SHBd and SpMax2_Bhm)that represent the biological activity of SAs.To interpret the phenomenon,a mechanistic model was developed and the results indicated that the biodegradation of SAs(T_(1/2))rather than conjugative transfer frequency or mutation frequency tends to be the key process for affecting Suls proliferation.T_(1/2)was proved to be dependent on the interactions between SAs and receptors(E_(binding)),the cleavage mode(bond dissociation energy),and the site of nucleophilic assault.Besides,the metagenomic analysis showed that SAs posed significant effect on antibiotic resistome and Tnp31 played a vital role in the proliferation of Suls.Overall,our findings provide important insight into a theoretical basis for understanding the structural effects of SAs on the proliferation of ARGs in SBR systems.
文摘Some novel sulfonamide-derivatives were designed to develop novel kinase inhibitors. The molecular docking study was performed for the designed compounds against epidermal growth factor kinase receptor T790M/L858R (TMLR) (PDB ID: 5EDQ) to identify new drug candidates for treating cancer. Binding free energy was calculated by Molegro virtual docker (MVD) to select the most promising hits. The corresponding docking score values into EGFR (TMLR) of 4b gave the best energy docking -147.213 Kcal/mol. And some of the designed sulfonamide derivatives have been synthesized by conventional method in addition to a microwave-assisted method of synthesis. The reaction of an amino group-containing drug;sulfamethoxazole and sulfanilamide with carbonyl group in benzoyl chloride and phthalic acid in basic media, generated a series of sulfonamide derivatives. The structures of all the synthesized compounds were well characterized by Mass spectrometry (MS), Infrared spectroscopy (IR), <sup><span style="font-family:Verdana;">1</sup><span style="font-family:Verdana;">H nuclear magnetic resonance (<sup><span style="font-family:Verdana;">1</sup><span style="font-family:Verdana;">H NMR), <sup><span style="font-family:Verdana;">13</sup><span style="font-family:Verdana;">C nuclear magnetic resonance (<sup><span style="font-family:Verdana;">13</sup><span style="font-family:Verdana;">C NMR) and elemental analysis. After obtaining experimental data regarding the yield and the time taken for the synthesis by both the approaches, conventional and microwave-assisted method, it was shown that the microwave-assisted method gave higher yield with shorter time and higher temperature compared to conventional heating methods.
文摘By orthodox experiment, the main influence factors of desulfurization by sulfolobas of pH value, temperature, coal slurry concentration and coal granularity are studied in detail and the optimal experimental conditions were also obtained. The experimental results demonstrate that sulfolobas being kind of linking-heat, acidophilic and self-supported bacterium with double characters can effectively remove inorganic and organic sulfur in coal. The superlatively desulfurization rate is up to 48.57% total sulfur and 41.71% inorganic sulfur within 10 d and its desulfurization rate can be greatly affected by the four factors above mentioned. Therefore, the optimum conditions of desulfurization are obtained by comprehensive experiment and they are as following: pH value 3, temperature 70℃, coal slurry concentration 10% and coal granularity 150 μm, respectively. Moreover, the repetition experimental results confirm that the desulfurization by sulfolobas is steady.
文摘安哥拉Benguela Sul 220 kV变电站综合自动化系统按照“无人值班”(少人值守)的原则进行设计,计算机监控系统由站控层和间隔层组成,采用全开放分层分布式网络结构。站控层是整个变电站的一、二次设备管理、控制、监视、测量的中心,监控系统采用双环形光纤以太网计算机局域网连接方式,间隔层通过100Mbps光纤交换式快速以太网或RS485总线与站控层设备通信。本站采用光纤通信+载波通信方式,计算机监控系统通过远动通信设备与调度中心通信。
