The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individua...The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individualized treatment.Tong xiao-lin proposed the state-target strategy to build a bridge for the integration of Chinese and Western medicine.It is a model based on modern medical disease concepts and using the method of TCM to balance the pathological states and adopting the achievements of pharmacology of Chinese medicine to focus on the disease targets,symptom targets,and biochemical indicator targets.The reconstruction of TCM diagnosis and treatment system for diabetes is a good example to demonstrate this theory.It could improve the clinical efficacy,support the scientific research,and reinforce the standardization of TCM.展开更多
Insomnia has become an urgent clinical problem in modern society.Current research has found that the gut flora-gut-brain axis plays an important role in regulating insomnia.The state-target theory is a product of the ...Insomnia has become an urgent clinical problem in modern society.Current research has found that the gut flora-gut-brain axis plays an important role in regulating insomnia.The state-target theory is a product of the combination of traditional Chinese medicine and modern molecular biology technology.This paper clarifies the correlation between the state-target theory,the intestinal flora-gut-brain axis,and liver-depression-spleen-deficiency insomnia.The use of traditional Chinese medicine to regulate the structure and abundance of intestinal flora was also explored,aiming to integrate traditional Chinese medicine with Western medicine for the prevention and treatment of liver-depression-spleen-deficiency insomnia.展开更多
Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies(HMs).Targeted therapy,aiming for DNA methylation,is an effective mainstay of modem medicine;however,many issues rema...Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies(HMs).Targeted therapy,aiming for DNA methylation,is an effective mainstay of modem medicine;however,many issues remain to be addressed.The progress of epigenetic studies and the proposed theory of"state-target medicine"have provided conditions to form a new treatment paradigm that combines the"body state adjustment"of CM with targeted therapy.We discussed the correlation between Chinese medicine(CM)syndromes/states and DNA methylation in this paper.Additionally,the latest research findings on the intervention and regulation of DNA methylation in HMs,including the core targets,therapy status,CM compounds and active components of the Chinese materia medica were concisely summarized to establish a theoretical foundation of"state-target synchronous conditioning"pattern of integrative medicine for HMs,simultaneously leading a new perspective in clinical diagnosis and therapy.展开更多
风电大规模并网导致系统惯量严重降低,恶化了系统的频率稳定性。针对上述问题,该文结合非线性预测理论以及扩张状态观测理论(extended state observer,ESO)提出双馈风机参与电网频率调节的短期频率支撑方法。首先,建立与系统频率偏差和...风电大规模并网导致系统惯量严重降低,恶化了系统的频率稳定性。针对上述问题,该文结合非线性预测理论以及扩张状态观测理论(extended state observer,ESO)提出双馈风机参与电网频率调节的短期频率支撑方法。首先,建立与系统频率偏差和风机转速相关的目标状态方程,并计算不同控制目标量对应的预测阶;其次,根据非线性预测理论计算预测矩阵,对未来时刻状态跟踪误差进行预测,并求得非线性控制律;最后,引入扩张状态观测器对非线性控制律中的复杂李导数运算进行观测,减轻控制律所需的计算负担。通过MATLAB/SIMULINK搭建含风电系统进行仿真验证,结果表明,所提方法有效地改善了电网的频率响应,并且无需单独设计转速恢复环节,能够实现风机转速的自恢复。展开更多
文摘The methods of Traditional Chinese Medicine(TCM)’s diagnosis and treatment have undergone several changes.It is crucial to build a proper model which is capable to modernize TCM into a both standardized and individualized treatment.Tong xiao-lin proposed the state-target strategy to build a bridge for the integration of Chinese and Western medicine.It is a model based on modern medical disease concepts and using the method of TCM to balance the pathological states and adopting the achievements of pharmacology of Chinese medicine to focus on the disease targets,symptom targets,and biochemical indicator targets.The reconstruction of TCM diagnosis and treatment system for diabetes is a good example to demonstrate this theory.It could improve the clinical efficacy,support the scientific research,and reinforce the standardization of TCM.
文摘Insomnia has become an urgent clinical problem in modern society.Current research has found that the gut flora-gut-brain axis plays an important role in regulating insomnia.The state-target theory is a product of the combination of traditional Chinese medicine and modern molecular biology technology.This paper clarifies the correlation between the state-target theory,the intestinal flora-gut-brain axis,and liver-depression-spleen-deficiency insomnia.The use of traditional Chinese medicine to regulate the structure and abundance of intestinal flora was also explored,aiming to integrate traditional Chinese medicine with Western medicine for the prevention and treatment of liver-depression-spleen-deficiency insomnia.
基金Supported by the National Natural Science Foundation of China(No.81774068)the Natural Science Foundation of Zhejiang Province(No.LY20H290004)Youth Project of the Natural Science Foundation of Zhejiang Province(No.LQ19H290002)。
文摘Aberrant regulation of DNA methylation plays a crucial causative role in haematological malignancies(HMs).Targeted therapy,aiming for DNA methylation,is an effective mainstay of modem medicine;however,many issues remain to be addressed.The progress of epigenetic studies and the proposed theory of"state-target medicine"have provided conditions to form a new treatment paradigm that combines the"body state adjustment"of CM with targeted therapy.We discussed the correlation between Chinese medicine(CM)syndromes/states and DNA methylation in this paper.Additionally,the latest research findings on the intervention and regulation of DNA methylation in HMs,including the core targets,therapy status,CM compounds and active components of the Chinese materia medica were concisely summarized to establish a theoretical foundation of"state-target synchronous conditioning"pattern of integrative medicine for HMs,simultaneously leading a new perspective in clinical diagnosis and therapy.
文摘风电大规模并网导致系统惯量严重降低,恶化了系统的频率稳定性。针对上述问题,该文结合非线性预测理论以及扩张状态观测理论(extended state observer,ESO)提出双馈风机参与电网频率调节的短期频率支撑方法。首先,建立与系统频率偏差和风机转速相关的目标状态方程,并计算不同控制目标量对应的预测阶;其次,根据非线性预测理论计算预测矩阵,对未来时刻状态跟踪误差进行预测,并求得非线性控制律;最后,引入扩张状态观测器对非线性控制律中的复杂李导数运算进行观测,减轻控制律所需的计算负担。通过MATLAB/SIMULINK搭建含风电系统进行仿真验证,结果表明,所提方法有效地改善了电网的频率响应,并且无需单独设计转速恢复环节,能够实现风机转速的自恢复。
