Antibacterial nanoagents with broad-spectrum antibacterial activities have emerged as an evolution of antibiotics.However,their bacteria-capturing capability and bacteria-killing efficiency remain insufficient for com...Antibacterial nanoagents with broad-spectrum antibacterial activities have emerged as an evolution of antibiotics.However,their bacteria-capturing capability and bacteria-killing efficiency remain insufficient for commercial implementation.Inspired by the hunting behavior of spiders,here,a novel spiderweb-like nanoagent based on silver-adenine nanowires is designed to achieve high-efficiency capture and killing of bacteria.By virtue of the initiative bacteriacapturing functionality,this spiderweb-like nanoagent could effectively attract and trap bacteria through electrostatic interaction and its reticular morphology feature.Furthermore,its synergetic antibacterial mechanism combining physical membranolysis with reactive oxygen species(ROS)release allows such nanoagent to harvest a promoted bactericidal activity.Importantly,the woundplast employing the spiderweblike nanoagent exhibits a superior antibacterial efficacy against drug-resistant Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus compared with commercially available woundplasts.This work may pave a new way for rational design of new generation bactericidal agents facing the future super-bacteria booming.展开更多
A novel distributed packet routing algorithm for Low Earth Orbit (LEO) satellite networks based on spiderweb topology is presented. The algorithm gives the shortest path with very low computational complexity and with...A novel distributed packet routing algorithm for Low Earth Orbit (LEO) satellite networks based on spiderweb topology is presented. The algorithm gives the shortest path with very low computational complexity and without on-board routing tables, which is suitable and practical for on-board processing. Simulation results show its practicability and feasibility.展开更多
目的观察蛛网型个性化钛网暴露后的骨增量效果,并探究对钛网进行聚氨酯涂层是否可降低感染率。方法实验选取6只比格犬,对犬下颌双侧第二、三前臼齿虚拟拔除,构建骨缺损模型,设计、打印截骨导板及蛛网结构个性化钛网,分别对钛网进行酸蚀...目的观察蛛网型个性化钛网暴露后的骨增量效果,并探究对钛网进行聚氨酯涂层是否可降低感染率。方法实验选取6只比格犬,对犬下颌双侧第二、三前臼齿虚拟拔除,构建骨缺损模型,设计、打印截骨导板及蛛网结构个性化钛网,分别对钛网进行酸蚀及聚氨酯涂层处理。对比格犬双侧下颌骨行牙槽骨骨缺损引导骨再生(guided bone regeneration,GBR),术后2周在术区滴食诱食剂建立钛网暴露模型,3个月处死6只比格犬,通过观察、CBCT分析、体视显微镜观察分析各组钛网暴露后牙槽骨骨增量效果。结果12个钛网暴露位点的3种结果:(1)钛网脱落,软组织愈合;(2)钛网在位,暴露持续存在;(3)钛网在位,软组织愈合。其中2个酸蚀位点及1个聚氨酯涂层位点出现不同程度感染症状。CBCT、体积比计算及体视显微镜观察得出:钛网脱落组成骨35%±13%;钛网暴露愈合组48%±8%的成骨明显高于暴露持续存在组的27%±10%(P<0.05)。钛网暴露后愈合组高于钛网暴露后脱落组(P>0.05)。结论个性化钛网早期暴露后依旧可以形成新生骨,暴露后愈合的成骨效果最佳。经聚氨酯涂层后感染率稍低于酸蚀组,两组的差异为16.6%。展开更多
基金supported by the National Natural Science Foundation of China(21703230,21635007 and 21721003)K.C.Wong Education Foundation。
文摘Antibacterial nanoagents with broad-spectrum antibacterial activities have emerged as an evolution of antibiotics.However,their bacteria-capturing capability and bacteria-killing efficiency remain insufficient for commercial implementation.Inspired by the hunting behavior of spiders,here,a novel spiderweb-like nanoagent based on silver-adenine nanowires is designed to achieve high-efficiency capture and killing of bacteria.By virtue of the initiative bacteriacapturing functionality,this spiderweb-like nanoagent could effectively attract and trap bacteria through electrostatic interaction and its reticular morphology feature.Furthermore,its synergetic antibacterial mechanism combining physical membranolysis with reactive oxygen species(ROS)release allows such nanoagent to harvest a promoted bactericidal activity.Importantly,the woundplast employing the spiderweblike nanoagent exhibits a superior antibacterial efficacy against drug-resistant Gram-negative Escherichia coli and Gram-positive methicillin-resistant Staphylococcus aureus compared with commercially available woundplasts.This work may pave a new way for rational design of new generation bactericidal agents facing the future super-bacteria booming.
文摘A novel distributed packet routing algorithm for Low Earth Orbit (LEO) satellite networks based on spiderweb topology is presented. The algorithm gives the shortest path with very low computational complexity and without on-board routing tables, which is suitable and practical for on-board processing. Simulation results show its practicability and feasibility.
文摘目的观察蛛网型个性化钛网暴露后的骨增量效果,并探究对钛网进行聚氨酯涂层是否可降低感染率。方法实验选取6只比格犬,对犬下颌双侧第二、三前臼齿虚拟拔除,构建骨缺损模型,设计、打印截骨导板及蛛网结构个性化钛网,分别对钛网进行酸蚀及聚氨酯涂层处理。对比格犬双侧下颌骨行牙槽骨骨缺损引导骨再生(guided bone regeneration,GBR),术后2周在术区滴食诱食剂建立钛网暴露模型,3个月处死6只比格犬,通过观察、CBCT分析、体视显微镜观察分析各组钛网暴露后牙槽骨骨增量效果。结果12个钛网暴露位点的3种结果:(1)钛网脱落,软组织愈合;(2)钛网在位,暴露持续存在;(3)钛网在位,软组织愈合。其中2个酸蚀位点及1个聚氨酯涂层位点出现不同程度感染症状。CBCT、体积比计算及体视显微镜观察得出:钛网脱落组成骨35%±13%;钛网暴露愈合组48%±8%的成骨明显高于暴露持续存在组的27%±10%(P<0.05)。钛网暴露后愈合组高于钛网暴露后脱落组(P>0.05)。结论个性化钛网早期暴露后依旧可以形成新生骨,暴露后愈合的成骨效果最佳。经聚氨酯涂层后感染率稍低于酸蚀组,两组的差异为16.6%。
