Background:Hyperlipidemia(HLP)is a disorder in which lipids in the blood are disturbed due to abnormal lipid metabolism.Statins and fibrates lipid-regulating drugs prevent the generation of lipids and improves HLP,the...Background:Hyperlipidemia(HLP)is a disorder in which lipids in the blood are disturbed due to abnormal lipid metabolism.Statins and fibrates lipid-regulating drugs prevent the generation of lipids and improves HLP,thereby reducing the likelihood of developing cardiovascular and cerebrovascular diseases.However,their adverse reactions and side effects limit a wide range of clinical applications.Tibetan medicine compound preparation Siwei Yuganzi decoction(SYD)is an adaptation of a classical prescription of the Tibetan medicine Sanguo decoction,that has been proved to have the effect of improving lipid metabolism;however,its possible mechanism remains unknown.Methods:Sixty specific-pathogen free grade Sprague Dawley rats were randomly divided into the blank control group,the HLP group,the Chinese patent medicine Xuezhikang positive control group,and the treatment groups with Tibetan SYD high-,middle-,and low-dosages respectively.Ten rats were assigned to each group.Every rat in these groups was fed with a high-fat emulsion to establish the hyperlipidemic animal model,except for those in the blank control group.Then the rats in the blank control and HLP groups were fed with 0.9%normal saline,those in Xuezhikang group were fed with Xuezhikang suspension at the dose of 0.11 g/kg/d,and those in SYD groups were fed with the SYD suspension at the dosage of 16.2 g/kg/d(high dosage),10.8 g/kg/d(middle dosage),and 5.4 g/kg/d(low dosage),respectively.After 8 weeks,the levels of serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)were detected by the ELISA.The mRNA and protein expression levels of liver X receptorα(LXRα)and cholesterol 7α-hydroxylase 1(CYP7A1)were detected using RT-PCR,western blotting,and immunohistochemistry.Results:The serum levels of TC,TG,and LDL-C in the HLP group were higher than those in the blank control group(P<0.05),whereas the serum levels of HDL-C and the expression levels of both LXRαand CYP7A1 mRNA and proteins in the liver in the HLP group were lower than those in the control group(P<0.05).After the treatment of the Xuezhikang and SYD,the serum levels of TG,TC,and LDL-C significantly decreased(P<0.05),whereas the serum levels of HDL-C and the expression levels of both LXRαand CYP7A1 mRNA and proteins in the liver significantly increased compared with those in the HLP group(P<0.05).Furthermore,The serum levels of TC,TG,and LDL-C in the SYD group at high dosage were lower(P<0.05),the serum level of HDL-C was higher,and the expression levels of both LXRαand CYP7A1 mRNA and proteins in the liver tissue were higher than those in the Xuezhikang group(P<0.05).Conclusion:SYD can improve the serum levels of TC,TG,and LDL-C in the hyperlipidemic animal model via increasing the expression of both LXRαand CYP7A1 mRNA and proteins in the liver tissue.展开更多
Objective: to explore the curative effect of Mongolian medicine Siwei Guangming Salt Decoction Powder and Hadunhai Lumule Jiuwei Pills on chronic gastroenteritis. Methods: 100 college students with chronic gastroenter...Objective: to explore the curative effect of Mongolian medicine Siwei Guangming Salt Decoction Powder and Hadunhai Lumule Jiuwei Pills on chronic gastroenteritis. Methods: 100 college students with chronic gastroenteritis admitted from October 2019 to April 2021 were selected and the clinical data were analyzed retrospectively. Thirty-nine patients receiving conventional domperidone plus reductive changyanning as the control group, and 61 patients receiving Mongolian medicine Siwei Guangming Salt Decoction Powder combined with Hadunhai Lumule Jiuwei Pills as the observation group. The changes of inflammatory factors, gastrointestinal hormones and clinical symptoms of the two groups were compared before and after treatment for one month. Results: after one month of treatment, the levels of tumor necrosis factor, interleukin -6, neutrophil colony-stimulating factor, macrophage colony-stimulating factor and vasoactive peptide in serum of the two groups of patients were significantly lower than before treatment, and the degree of decrease in the observation group was better than before treatment. Compared with the control group, there was a statistically significant difference (P < 0.05). After one month of treatment, the variables and duration of diarrhea in both patient groups were significantly improved, and the improvement in the observation group was better than that in the control group. There was a statistical difference between the two groups (P < 0.05). No serious side effects occurred during the treatment of the two groups. Conclusion: In the treatment of chronic gastroenteritis patients, the combination of Mongolian medicine Siwei Guangming Salt Decoction Powder and Hadunhai Lumule Jiuwei Pills has significant curative effect. It can effectively reduce the inflammatory reaction and gastrointestinal hormone levels, improve clinical symptoms, and have high safety and high application significance.展开更多
文摘Background:Hyperlipidemia(HLP)is a disorder in which lipids in the blood are disturbed due to abnormal lipid metabolism.Statins and fibrates lipid-regulating drugs prevent the generation of lipids and improves HLP,thereby reducing the likelihood of developing cardiovascular and cerebrovascular diseases.However,their adverse reactions and side effects limit a wide range of clinical applications.Tibetan medicine compound preparation Siwei Yuganzi decoction(SYD)is an adaptation of a classical prescription of the Tibetan medicine Sanguo decoction,that has been proved to have the effect of improving lipid metabolism;however,its possible mechanism remains unknown.Methods:Sixty specific-pathogen free grade Sprague Dawley rats were randomly divided into the blank control group,the HLP group,the Chinese patent medicine Xuezhikang positive control group,and the treatment groups with Tibetan SYD high-,middle-,and low-dosages respectively.Ten rats were assigned to each group.Every rat in these groups was fed with a high-fat emulsion to establish the hyperlipidemic animal model,except for those in the blank control group.Then the rats in the blank control and HLP groups were fed with 0.9%normal saline,those in Xuezhikang group were fed with Xuezhikang suspension at the dose of 0.11 g/kg/d,and those in SYD groups were fed with the SYD suspension at the dosage of 16.2 g/kg/d(high dosage),10.8 g/kg/d(middle dosage),and 5.4 g/kg/d(low dosage),respectively.After 8 weeks,the levels of serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)were detected by the ELISA.The mRNA and protein expression levels of liver X receptorα(LXRα)and cholesterol 7α-hydroxylase 1(CYP7A1)were detected using RT-PCR,western blotting,and immunohistochemistry.Results:The serum levels of TC,TG,and LDL-C in the HLP group were higher than those in the blank control group(P<0.05),whereas the serum levels of HDL-C and the expression levels of both LXRαand CYP7A1 mRNA and proteins in the liver in the HLP group were lower than those in the control group(P<0.05).After the treatment of the Xuezhikang and SYD,the serum levels of TG,TC,and LDL-C significantly decreased(P<0.05),whereas the serum levels of HDL-C and the expression levels of both LXRαand CYP7A1 mRNA and proteins in the liver significantly increased compared with those in the HLP group(P<0.05).Furthermore,The serum levels of TC,TG,and LDL-C in the SYD group at high dosage were lower(P<0.05),the serum level of HDL-C was higher,and the expression levels of both LXRαand CYP7A1 mRNA and proteins in the liver tissue were higher than those in the Xuezhikang group(P<0.05).Conclusion:SYD can improve the serum levels of TC,TG,and LDL-C in the hyperlipidemic animal model via increasing the expression of both LXRαand CYP7A1 mRNA and proteins in the liver tissue.
文摘Objective: to explore the curative effect of Mongolian medicine Siwei Guangming Salt Decoction Powder and Hadunhai Lumule Jiuwei Pills on chronic gastroenteritis. Methods: 100 college students with chronic gastroenteritis admitted from October 2019 to April 2021 were selected and the clinical data were analyzed retrospectively. Thirty-nine patients receiving conventional domperidone plus reductive changyanning as the control group, and 61 patients receiving Mongolian medicine Siwei Guangming Salt Decoction Powder combined with Hadunhai Lumule Jiuwei Pills as the observation group. The changes of inflammatory factors, gastrointestinal hormones and clinical symptoms of the two groups were compared before and after treatment for one month. Results: after one month of treatment, the levels of tumor necrosis factor, interleukin -6, neutrophil colony-stimulating factor, macrophage colony-stimulating factor and vasoactive peptide in serum of the two groups of patients were significantly lower than before treatment, and the degree of decrease in the observation group was better than before treatment. Compared with the control group, there was a statistically significant difference (P < 0.05). After one month of treatment, the variables and duration of diarrhea in both patient groups were significantly improved, and the improvement in the observation group was better than that in the control group. There was a statistical difference between the two groups (P < 0.05). No serious side effects occurred during the treatment of the two groups. Conclusion: In the treatment of chronic gastroenteritis patients, the combination of Mongolian medicine Siwei Guangming Salt Decoction Powder and Hadunhai Lumule Jiuwei Pills has significant curative effect. It can effectively reduce the inflammatory reaction and gastrointestinal hormone levels, improve clinical symptoms, and have high safety and high application significance.
