Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).Indi...Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).India(27%),China(14%),and the Russian Federation(8%)are the three countries with the highest share of the global burden.展开更多
China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust ...China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust rebound in growth in China has significant implications for the rest of the world.展开更多
There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that on...There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that only sufficient long hard segment (MDI/BD) domains could crystallize under certain conditions, while the shorter hard domains (hard segment in the SPEU with 1000 n PTMG and mole展开更多
Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data...Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data of 922 subjects with shorter statures.In each case,their information about height,weight,insulin-like growth factor-Ⅰ(IGF-Ⅰ),growth hormone peak,uric acid,and blood lipids were collected,and their BMI and BMI standard deviations score(SDS)were calculated.Smooth curve fitting and multiple piecewise linear regression were used to analyze the relationship between BMI SDS and uric acid.Results Univariate analysis found that serum uric acid was positively correlated with age,height standard deviation score,body weight standard deviation score,BMI SDS,IGF-Ⅰstandard deviation score,growth hormone peak,triglyceride,and creatinine(P<0.05),while negatively correlated with high-density lipoprotein-cholesterol(P<0.01).Female had significantly lower serum uric acid levels than male(P=0.003).The serum uric acid level was significantly increased after puberty(P<0.01).After adjusting for potential confounders,the smooth curve fitting revealed a U-shaped relationship between BMI SDS and uric acid,with a BMI SDS inflection point of-0.7.In the population of BMI SDS<-0.7,for every unit increase of BMI SDS,serum uric acid decreased by 11.78μmol/L(P=0.030).In the population of BMI SDS≥-0.7,uric acid increased by 11.79μmol/L(P<0.01)for every unit increase of BMI SDS.Conclusion Serum uric acid levels seem to be affected by BMI,and increased in population with thinness or obesity.We should pay attention to the measurement of serum uric acid in both thin and obese children.展开更多
这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is...这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is an indicator of childhood nutrition,which may have long-lasting effectson health,这个分析站得住脚吗?读者朋友,你信这个“邪”吗?】展开更多
Background: From the two facts reported by previous research: 1) frequent co-occurrence of more than one addictive behavior, 2) childhood adversities identified as origins of different types of addictive behaviors, it...Background: From the two facts reported by previous research: 1) frequent co-occurrence of more than one addictive behavior, 2) childhood adversities identified as origins of different types of addictive behaviors, it is assumed that all types of addictive behaviors, regardless of substance, behavioral, or relationship, share common factors which have not yet been proven by epidemiological research. The Shorter PROMIS Questionnaire (SPQ) was previously developed to assess 16 types of addictive behaviors. Its factor structure, however, has not been fully investigated. Confirming the factor structure will enable us to hypothesize the common factor(s) shared by all, or if not all, most types of addictive behaviors. Aims: This study aimed at 1) examining the factor structure of the SPQ, 2) confirming the reliability of the questionnaire, and 3) examining the impacts of gender and age on each addictive behavior. Methods: Data obtained from 232 Japanese adults who completed all items of the SPQ were used for the analyses. After confirming the one-factor structure model for each of the 16 subscales, the validity of the one-factor structure of the SPQ was evaluated using Confirmatory Factor Analysis (CFA), by adapting 16 subscale scores as observed variables. If its validity was not confirmed, another model which showed better compatibility to the data was explored. The reliability of the SPQ as well as that of all 16 subscales was evaluated. Also, the impacts of gender and age on each subscale score were examined. Results: The one-factor structure for each of the 16 subscales was confirmed. The compatibility of the SPQ one-factor model was not acceptable. The best fit model was a bi-factor model in which one main factor was shared by all 16 subscales, and three factors were shared by some specific addictive behaviors. Male respondents were more likely than female respondents to show high scores in Alcohol, Tobacco, Gambling, Sex, and Recreational Drugs, and low scores only in Shopping. Respondents’ age did not impact any of the 16 subscale scores. Conclusion: It was demonstrated that there are common factors shared by all different types, as well as selected types of addictive behaviors, by conducting CFAs of the SPQ. Reliability was proven for the SPQ and for all 16 subscales. Male respondents were more likely to show physically hedonic addictive behaviors.展开更多
针对现有的研究大多将短序列时间序列预测和长序列时间序列预测分开研究而导致模型在较短的长序列时序预测时精度较低的问题,提出一种较短的长序列时间序列预测模型(SLTSFM)。首先,利用卷积神经网络(CNN)和PBUSM(Probsparse Based on Un...针对现有的研究大多将短序列时间序列预测和长序列时间序列预测分开研究而导致模型在较短的长序列时序预测时精度较低的问题,提出一种较短的长序列时间序列预测模型(SLTSFM)。首先,利用卷积神经网络(CNN)和PBUSM(Probsparse Based on Uniform Selection Mechanism)自注意力机制搭建一个序列到序列(Seq2Seq)结构,用于提取长序列输入的特征;其次,设计“远轻近重”策略将多个短序列输入特征提取能力较强的长短时记忆(LSTM)模块提取的各时段数据特征进行重分配;最后,用重分配的特征增强提取的长序列输入特征,提高预测精度并实现时序预测。利用4个公开的时间序列数据集验证模型的有效性。实验结果表明,与综合表现次优的对比模型循环门单元(GRU)相比,SLTSFM的平均绝对误差(MAE)指标在4个数据集上的单变量时序预测分别减小了61.54%、13.48%、0.92%和19.58%,多变量时序预测分别减小了17.01%、18.13%、3.24%和6.73%。由此可见SLTSFM在提升较短的长序列时序预测精度方面的有效性。展开更多
The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses ...The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses and smaller families ; More conveniences, but less time; We have more degrees, but less sense;展开更多
文摘Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).India(27%),China(14%),and the Russian Federation(8%)are the three countries with the highest share of the global burden.
文摘China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust rebound in growth in China has significant implications for the rest of the world.
文摘There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that only sufficient long hard segment (MDI/BD) domains could crystallize under certain conditions, while the shorter hard domains (hard segment in the SPEU with 1000 n PTMG and mole
文摘Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data of 922 subjects with shorter statures.In each case,their information about height,weight,insulin-like growth factor-Ⅰ(IGF-Ⅰ),growth hormone peak,uric acid,and blood lipids were collected,and their BMI and BMI standard deviations score(SDS)were calculated.Smooth curve fitting and multiple piecewise linear regression were used to analyze the relationship between BMI SDS and uric acid.Results Univariate analysis found that serum uric acid was positively correlated with age,height standard deviation score,body weight standard deviation score,BMI SDS,IGF-Ⅰstandard deviation score,growth hormone peak,triglyceride,and creatinine(P<0.05),while negatively correlated with high-density lipoprotein-cholesterol(P<0.01).Female had significantly lower serum uric acid levels than male(P=0.003).The serum uric acid level was significantly increased after puberty(P<0.01).After adjusting for potential confounders,the smooth curve fitting revealed a U-shaped relationship between BMI SDS and uric acid,with a BMI SDS inflection point of-0.7.In the population of BMI SDS<-0.7,for every unit increase of BMI SDS,serum uric acid decreased by 11.78μmol/L(P=0.030).In the population of BMI SDS≥-0.7,uric acid increased by 11.79μmol/L(P<0.01)for every unit increase of BMI SDS.Conclusion Serum uric acid levels seem to be affected by BMI,and increased in population with thinness or obesity.We should pay attention to the measurement of serum uric acid in both thin and obese children.
文摘这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is an indicator of childhood nutrition,which may have long-lasting effectson health,这个分析站得住脚吗?读者朋友,你信这个“邪”吗?】
文摘Background: From the two facts reported by previous research: 1) frequent co-occurrence of more than one addictive behavior, 2) childhood adversities identified as origins of different types of addictive behaviors, it is assumed that all types of addictive behaviors, regardless of substance, behavioral, or relationship, share common factors which have not yet been proven by epidemiological research. The Shorter PROMIS Questionnaire (SPQ) was previously developed to assess 16 types of addictive behaviors. Its factor structure, however, has not been fully investigated. Confirming the factor structure will enable us to hypothesize the common factor(s) shared by all, or if not all, most types of addictive behaviors. Aims: This study aimed at 1) examining the factor structure of the SPQ, 2) confirming the reliability of the questionnaire, and 3) examining the impacts of gender and age on each addictive behavior. Methods: Data obtained from 232 Japanese adults who completed all items of the SPQ were used for the analyses. After confirming the one-factor structure model for each of the 16 subscales, the validity of the one-factor structure of the SPQ was evaluated using Confirmatory Factor Analysis (CFA), by adapting 16 subscale scores as observed variables. If its validity was not confirmed, another model which showed better compatibility to the data was explored. The reliability of the SPQ as well as that of all 16 subscales was evaluated. Also, the impacts of gender and age on each subscale score were examined. Results: The one-factor structure for each of the 16 subscales was confirmed. The compatibility of the SPQ one-factor model was not acceptable. The best fit model was a bi-factor model in which one main factor was shared by all 16 subscales, and three factors were shared by some specific addictive behaviors. Male respondents were more likely than female respondents to show high scores in Alcohol, Tobacco, Gambling, Sex, and Recreational Drugs, and low scores only in Shopping. Respondents’ age did not impact any of the 16 subscale scores. Conclusion: It was demonstrated that there are common factors shared by all different types, as well as selected types of addictive behaviors, by conducting CFAs of the SPQ. Reliability was proven for the SPQ and for all 16 subscales. Male respondents were more likely to show physically hedonic addictive behaviors.
文摘针对现有的研究大多将短序列时间序列预测和长序列时间序列预测分开研究而导致模型在较短的长序列时序预测时精度较低的问题,提出一种较短的长序列时间序列预测模型(SLTSFM)。首先,利用卷积神经网络(CNN)和PBUSM(Probsparse Based on Uniform Selection Mechanism)自注意力机制搭建一个序列到序列(Seq2Seq)结构,用于提取长序列输入的特征;其次,设计“远轻近重”策略将多个短序列输入特征提取能力较强的长短时记忆(LSTM)模块提取的各时段数据特征进行重分配;最后,用重分配的特征增强提取的长序列输入特征,提高预测精度并实现时序预测。利用4个公开的时间序列数据集验证模型的有效性。实验结果表明,与综合表现次优的对比模型循环门单元(GRU)相比,SLTSFM的平均绝对误差(MAE)指标在4个数据集上的单变量时序预测分别减小了61.54%、13.48%、0.92%和19.58%,多变量时序预测分别减小了17.01%、18.13%、3.24%和6.73%。由此可见SLTSFM在提升较短的长序列时序预测精度方面的有效性。
文摘The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses and smaller families ; More conveniences, but less time; We have more degrees, but less sense;
