Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).Indi...Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).India(27%),China(14%),and the Russian Federation(8%)are the three countries with the highest share of the global burden.展开更多
There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that on...There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that only sufficient long hard segment (MDI/BD) domains could crystallize under certain conditions, while the shorter hard domains (hard segment in the SPEU with 1000 n PTMG and mole展开更多
Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data...Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data of 922 subjects with shorter statures.In each case,their information about height,weight,insulin-like growth factor-Ⅰ(IGF-Ⅰ),growth hormone peak,uric acid,and blood lipids were collected,and their BMI and BMI standard deviations score(SDS)were calculated.Smooth curve fitting and multiple piecewise linear regression were used to analyze the relationship between BMI SDS and uric acid.Results Univariate analysis found that serum uric acid was positively correlated with age,height standard deviation score,body weight standard deviation score,BMI SDS,IGF-Ⅰstandard deviation score,growth hormone peak,triglyceride,and creatinine(P<0.05),while negatively correlated with high-density lipoprotein-cholesterol(P<0.01).Female had significantly lower serum uric acid levels than male(P=0.003).The serum uric acid level was significantly increased after puberty(P<0.01).After adjusting for potential confounders,the smooth curve fitting revealed a U-shaped relationship between BMI SDS and uric acid,with a BMI SDS inflection point of-0.7.In the population of BMI SDS<-0.7,for every unit increase of BMI SDS,serum uric acid decreased by 11.78μmol/L(P=0.030).In the population of BMI SDS≥-0.7,uric acid increased by 11.79μmol/L(P<0.01)for every unit increase of BMI SDS.Conclusion Serum uric acid levels seem to be affected by BMI,and increased in population with thinness or obesity.We should pay attention to the measurement of serum uric acid in both thin and obese children.展开更多
China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust ...China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust rebound in growth in China has significant implications for the rest of the world.展开更多
这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is...这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is an indicator of childhood nutrition,which may have long-lasting effectson health,这个分析站得住脚吗?读者朋友,你信这个“邪”吗?】展开更多
The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses ...The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses and smaller families ; More conveniences, but less time; We have more degrees, but less sense;展开更多
Background The evidence regarding the association between leucocyte telomere length(LTL)and brain health is sparse and inconclusive.Aims To investigate the associations of LTL with brain structure and the risk of deme...Background The evidence regarding the association between leucocyte telomere length(LTL)and brain health is sparse and inconclusive.Aims To investigate the associations of LTL with brain structure and the risk of dementia based on a large-scale prospective study.Methods LTL in the peripheral blood was measured by the quantitative polymerase chain reaction(qPCR)assay from 439961 individuals in the UK Biobank recruited between 2006 and 2010 and followed up until 2020.Electronic health records were used to record the incidence of dementia,including Alzheimer’s disease(AD)and vascular dementia(VD).The brain structure,including total and regional brain volume,of 38740 participants was then assessed by magnetic resonance imaging(MRI).Results During a median follow-up of 11.6 years,a total of 5820(1.3%)dementia cases were documented.The restricted cubic spline model showed significant overall associations between LTL and the risk of dementia and AD(p for overall<0.05).The multivariable adjusted hazard ratios(HRs)for the lowest LTL tertile compared with the highest LTL tertile were 1.14(95%confidence interval(CI):1.06 to 1.21)for dementia,1.28(95%CI:1.12 to 1.46)for AD and 1.18(95%CI:0.98 to 1.42)for VD.Furthermore,we found that shorter LTL was associated with smaller total brain volume(β=−0.0128,p=0.003),white matter volume(β=−0.0224,p<0.001),hippocampus volume(β=−0.0172,p<0.001),thalamus volume(β=−0.0239,p<0.001)and accumbens(β=−0.0155,p=0.001).Conclusions Shorter LTL is associated with total and regional brain structure and a higher risk of incident dementia and AD,implying the potential of telomere length as a predictive biomarker of brain health.展开更多
目的探讨早产儿视网膜病变(retinopathy of prematurity,ROP)的发生率及危险因素。方法收集2007年12月2008年12月在四川省人民医院、成都市妇幼保健院、成都市妇产科医院住院的85例体重≤2000g或有严重疾病的早产儿,自出生后4～6周或矫...目的探讨早产儿视网膜病变(retinopathy of prematurity,ROP)的发生率及危险因素。方法收集2007年12月2008年12月在四川省人民医院、成都市妇幼保健院、成都市妇产科医院住院的85例体重≤2000g或有严重疾病的早产儿,自出生后4～6周或矫正胎龄32周开始筛查,至周边视网膜血管化。结果 85例早产儿中,有9例发生ROP,发病率10.58%。其中出生体重<1500g的早产儿ROP发病率为17.07%,孕周<30周的早产儿ROP发病率为40%。结论低体重、胎龄小、吸氧为早产儿发生ROP的重要危险因素;尽早进行眼底筛查是早期发现、诊断及治疗ROP的关键。展开更多
文摘Drug-resistant tuberculosis(DR-TB)continues to be a public health concern.In 2019,nearly half a million patients had rifampicin-resistant tuberculosis(RR-TB),with 78%of those having multidrug-resistant TB(MDR-TB).India(27%),China(14%),and the Russian Federation(8%)are the three countries with the highest share of the global burden.
文摘There have been studies on the structure and properties of segmented polyetherurethane (SPEU)based on polytetramethylene glycol (PTMG)/4, 4′-diphenylmethane diisoeyanate (MDI)/1,4-butandiol (BD). It was shown that only sufficient long hard segment (MDI/BD) domains could crystallize under certain conditions, while the shorter hard domains (hard segment in the SPEU with 1000 n PTMG and mole
文摘Objective To investigate the independent association of the body mass index(BMI)with serum uric acid among shorter children and adolescent.Methods A cross-sectional study was conducted to collect general clinical data of 922 subjects with shorter statures.In each case,their information about height,weight,insulin-like growth factor-Ⅰ(IGF-Ⅰ),growth hormone peak,uric acid,and blood lipids were collected,and their BMI and BMI standard deviations score(SDS)were calculated.Smooth curve fitting and multiple piecewise linear regression were used to analyze the relationship between BMI SDS and uric acid.Results Univariate analysis found that serum uric acid was positively correlated with age,height standard deviation score,body weight standard deviation score,BMI SDS,IGF-Ⅰstandard deviation score,growth hormone peak,triglyceride,and creatinine(P<0.05),while negatively correlated with high-density lipoprotein-cholesterol(P<0.01).Female had significantly lower serum uric acid levels than male(P=0.003).The serum uric acid level was significantly increased after puberty(P<0.01).After adjusting for potential confounders,the smooth curve fitting revealed a U-shaped relationship between BMI SDS and uric acid,with a BMI SDS inflection point of-0.7.In the population of BMI SDS<-0.7,for every unit increase of BMI SDS,serum uric acid decreased by 11.78μmol/L(P=0.030).In the population of BMI SDS≥-0.7,uric acid increased by 11.79μmol/L(P<0.01)for every unit increase of BMI SDS.Conclusion Serum uric acid levels seem to be affected by BMI,and increased in population with thinness or obesity.We should pay attention to the measurement of serum uric acid in both thin and obese children.
文摘China's annual Central Economic Work Conference was held in Beijing on December 11 and 12.Serving to set the priorities for economic policy in the next year,this year's session was closely watched,as a robust rebound in growth in China has significant implications for the rest of the world.
文摘这个标题非常触目,标题中的Stature就是“身材”的意思。标题可以四字直译:矮人命短。这并非是对现代人的研究结果,而是一种考古的发现:Therisk of death before age 30 declined as bone length increased。本文的观点之一是:Height is an indicator of childhood nutrition,which may have long-lasting effectson health,这个分析站得住脚吗?读者朋友,你信这个“邪”吗?】
文摘The paradox of our time in history is that: We have taller buildings, but shorter tempers; Wider freeways, but narrower viewpoints ; We spend more, but have less; We buy more, but enjoy it less; We have bigger houses and smaller families ; More conveniences, but less time; We have more degrees, but less sense;
基金This work was supported by the National Natural Science Foundation of China(grant number 72204071)Zhejiang Provincial Natural Science Foundation of China(grant number LY23G030005)Scientific Research Foundation for Scholars of HZNU(grant number 4265C50221204119)。
文摘Background The evidence regarding the association between leucocyte telomere length(LTL)and brain health is sparse and inconclusive.Aims To investigate the associations of LTL with brain structure and the risk of dementia based on a large-scale prospective study.Methods LTL in the peripheral blood was measured by the quantitative polymerase chain reaction(qPCR)assay from 439961 individuals in the UK Biobank recruited between 2006 and 2010 and followed up until 2020.Electronic health records were used to record the incidence of dementia,including Alzheimer’s disease(AD)and vascular dementia(VD).The brain structure,including total and regional brain volume,of 38740 participants was then assessed by magnetic resonance imaging(MRI).Results During a median follow-up of 11.6 years,a total of 5820(1.3%)dementia cases were documented.The restricted cubic spline model showed significant overall associations between LTL and the risk of dementia and AD(p for overall<0.05).The multivariable adjusted hazard ratios(HRs)for the lowest LTL tertile compared with the highest LTL tertile were 1.14(95%confidence interval(CI):1.06 to 1.21)for dementia,1.28(95%CI:1.12 to 1.46)for AD and 1.18(95%CI:0.98 to 1.42)for VD.Furthermore,we found that shorter LTL was associated with smaller total brain volume(β=−0.0128,p=0.003),white matter volume(β=−0.0224,p<0.001),hippocampus volume(β=−0.0172,p<0.001),thalamus volume(β=−0.0239,p<0.001)and accumbens(β=−0.0155,p=0.001).Conclusions Shorter LTL is associated with total and regional brain structure and a higher risk of incident dementia and AD,implying the potential of telomere length as a predictive biomarker of brain health.
文摘目的探讨早产儿视网膜病变(retinopathy of prematurity,ROP)的发生率及危险因素。方法收集2007年12月2008年12月在四川省人民医院、成都市妇幼保健院、成都市妇产科医院住院的85例体重≤2000g或有严重疾病的早产儿,自出生后4～6周或矫正胎龄32周开始筛查,至周边视网膜血管化。结果 85例早产儿中,有9例发生ROP,发病率10.58%。其中出生体重<1500g的早产儿ROP发病率为17.07%,孕周<30周的早产儿ROP发病率为40%。结论低体重、胎龄小、吸氧为早产儿发生ROP的重要危险因素;尽早进行眼底筛查是早期发现、诊断及治疗ROP的关键。
