The effects of enteral nutrition containing long chain triglycerides （LCT） and medium chain triglycerides （MCT） or L-arginine （Arg） on fat absorbability, serum free fatty acid profiles and intestinal morphology ...The effects of enteral nutrition containing long chain triglycerides （LCT） and medium chain triglycerides （MCT） or L-arginine （Arg） on fat absorbability, serum free fatty acid profiles and intestinal morphology in rats with short-bowel syndrome （SBS） were studied using gas chromatography. Twenty-eight Sprague-Dawley rats were randomly assigned to 4 groups： sham operation fed with LCT as control; 85% small bowel resection fed with LCT, MCT/LCT, and Arg/LCT, respectively. SBS rats showed a decrease of fat absorptivity. Enteral nutrition supplemented with MCT could increase fat absorptivity. L-Arginine enhanced enteral nutrition was associated with the elevation of fat absorptivity, possibly due to its enterotrophic effect on remnant small bowel mucosa. LCT group showed a significant deficiency of total free fatty acid and the decreased essential fatty acid content, which was improved in other two SBS groups.展开更多
目的系统回顾与分析替度格鲁肽致不良反应的临床特征、时间规律、累及器官/系统及转归情况等,探讨其潜在机制及风险防范策略,为临床安全用药提供循证依据。方法通过系统检索PubMed、Web of Science、CNKI、维普及万方数据库,筛选2025年...目的系统回顾与分析替度格鲁肽致不良反应的临床特征、时间规律、累及器官/系统及转归情况等,探讨其潜在机制及风险防范策略,为临床安全用药提供循证依据。方法通过系统检索PubMed、Web of Science、CNKI、维普及万方数据库,筛选2025年5月前公开发表的中英文个案报告与病例系列研究,纳入33例经Naranjo量表判定为与替度格鲁肽相关的不良反应病例,进行回顾性描述分析。结果33例病例中,女性占60.61%,60岁及以上老年人占51.52%;不良反应多发生于治疗初期,尤以用药后3个月内(39.13%)最为集中。药物不良反应累及器官/系统主要包括消化系统(72.46%)、皮肤及其附件(14.49%)、心血管系统(5.80%)等,临床表现以腹痛、胆囊炎、血清脂肪酶和淀粉酶升高为主。干预后,84.85%的患者预后良好,个别合并基础疾病者预后不佳。结论替度格鲁肽所致不良反应具有一定的性别、年龄特征,累及器官/系统较为广泛,但多数为可逆性反应。临床应注重高危人群识别、早期风险预警及个体化治疗策略的实施,以实现疗效与安全性的协同优化。展开更多
基金Project supported by the National Science Fundation for Distinguished Young Scholars （No. 20325518） and Creative Research Groups （No. 20521503）, the Key （No. 20535010） and General Programs （No. 20275017） from the National Natural Science Foundation of China.
文摘The effects of enteral nutrition containing long chain triglycerides （LCT） and medium chain triglycerides （MCT） or L-arginine （Arg） on fat absorbability, serum free fatty acid profiles and intestinal morphology in rats with short-bowel syndrome （SBS） were studied using gas chromatography. Twenty-eight Sprague-Dawley rats were randomly assigned to 4 groups： sham operation fed with LCT as control; 85% small bowel resection fed with LCT, MCT/LCT, and Arg/LCT, respectively. SBS rats showed a decrease of fat absorptivity. Enteral nutrition supplemented with MCT could increase fat absorptivity. L-Arginine enhanced enteral nutrition was associated with the elevation of fat absorptivity, possibly due to its enterotrophic effect on remnant small bowel mucosa. LCT group showed a significant deficiency of total free fatty acid and the decreased essential fatty acid content, which was improved in other two SBS groups.
文摘目的系统回顾与分析替度格鲁肽致不良反应的临床特征、时间规律、累及器官/系统及转归情况等,探讨其潜在机制及风险防范策略,为临床安全用药提供循证依据。方法通过系统检索PubMed、Web of Science、CNKI、维普及万方数据库,筛选2025年5月前公开发表的中英文个案报告与病例系列研究,纳入33例经Naranjo量表判定为与替度格鲁肽相关的不良反应病例,进行回顾性描述分析。结果33例病例中,女性占60.61%,60岁及以上老年人占51.52%;不良反应多发生于治疗初期,尤以用药后3个月内(39.13%)最为集中。药物不良反应累及器官/系统主要包括消化系统(72.46%)、皮肤及其附件(14.49%)、心血管系统(5.80%)等,临床表现以腹痛、胆囊炎、血清脂肪酶和淀粉酶升高为主。干预后,84.85%的患者预后良好,个别合并基础疾病者预后不佳。结论替度格鲁肽所致不良反应具有一定的性别、年龄特征,累及器官/系统较为广泛,但多数为可逆性反应。临床应注重高危人群识别、早期风险预警及个体化治疗策略的实施,以实现疗效与安全性的协同优化。
