HOG-MAPK(high osmolarity glycerol mitogen-activated protein kinase)信号途径是真菌MAPK途径中参与渗透压响应的一条重要通路,在植物病原菌生长发育及致病过程中发挥着重要的作用。Sho1(synthetic high osmolarity-sensitive protei...HOG-MAPK(high osmolarity glycerol mitogen-activated protein kinase)信号途径是真菌MAPK途径中参与渗透压响应的一条重要通路,在植物病原菌生长发育及致病过程中发挥着重要的作用。Sho1(synthetic high osmolarity-sensitive protein1)是HOG-M APK信号途径上游的一个重要感受器,在不同真菌中常具有不同的功能。本研究从胶孢炭疽菌中克隆了Sho1的同源基因,命名为Cg Sho1,该基因编码一个291个氨基酸的蛋白,含有4个跨膜结构域和一个SH3功能域。利用同源重组的方法获得了该基因的敲除突变体,与野生型相比,敲除突变体表现为营养生长缓慢,菌丝稀疏且疏水性增强,产孢量下降,对氧化压力和渗透压更加敏感,致病力明显减弱。上述结果表明,Cg Sho1参与调控胶胞炭疽菌的营养生长、分生孢子产量、氧化应激反应、渗透压响应及致病性。展开更多
Taijin-Kyofu-Sho (TKS) has long been considered as a Japanese culture-bound form of social anxiety disorder, although subsequent case-reports from countries outside Japan have dispelled this notion. There are subtle y...Taijin-Kyofu-Sho (TKS) has long been considered as a Japanese culture-bound form of social anxiety disorder, although subsequent case-reports from countries outside Japan have dispelled this notion. There are subtle yet distinct differences between TKS and DSM-defined social anxiety disorder (SAD). For instance, the TKS subject fears causing offence to others, whereas the SAD subject is more fearful of causing embarrassment to him/herself. Four sub-categories of TKS have been recognised of which the Jikoshu-kyofu variety resembles the olfactory reference syndrome (ORS) known to Western psychiatrists. There are two TKS subtypes, general (or simple) and offensive (delusional). The general subtype resembles social anxiety disorder, whereas the offensive subtype is characterised by delusions. True community-wide prevalence is unknown, although clinic studies estimate between 7.8% to 45.5% patients have a diagnosis of TKS, with a slight male preponderance. Cultural and societal norms engendering guilt, shame, and embarrassment are likely etiological factors. Treatment may consist of antidepressant and/or antipsychotic medications, while some patients may also benefit from cognitive behavior therapy.展开更多
The rising price of potash fertilizers has become a hot topic in China.The price of powder potassium chloride,the variety of potash fertilizers with the greatest consumption in the domestic market,surged from less tha...The rising price of potash fertilizers has become a hot topic in China.The price of powder potassium chloride,the variety of potash fertilizers with the greatest consumption in the domestic market,surged from less than RMB2000 per ton in December 2007 to more than RMB3 000 per ton at the end of February 2008 and reached around RMB4 000 per ton at the end of April.Imported展开更多
Due to the drastic price rise of raw materialsin late January,the production cost oflambda-cyhalothrin has increasedremarkably.The market price of 96%lambda-cyhalothrin technical has gone upsharply from RMB172 000 per...Due to the drastic price rise of raw materialsin late January,the production cost oflambda-cyhalothrin has increasedremarkably.The market price of 96%lambda-cyhalothrin technical has gone upsharply from RMB172 000 per ton in De-cember 2008 to RMB195 000 per ton with agrowth of 13%.Enterprises of single-com-ponent formulations and complex formula-tions are actively buying lambda-cyhalothrintechnical for processing.The remarkable price rise in early展开更多
文摘Taijin-Kyofu-Sho (TKS) has long been considered as a Japanese culture-bound form of social anxiety disorder, although subsequent case-reports from countries outside Japan have dispelled this notion. There are subtle yet distinct differences between TKS and DSM-defined social anxiety disorder (SAD). For instance, the TKS subject fears causing offence to others, whereas the SAD subject is more fearful of causing embarrassment to him/herself. Four sub-categories of TKS have been recognised of which the Jikoshu-kyofu variety resembles the olfactory reference syndrome (ORS) known to Western psychiatrists. There are two TKS subtypes, general (or simple) and offensive (delusional). The general subtype resembles social anxiety disorder, whereas the offensive subtype is characterised by delusions. True community-wide prevalence is unknown, although clinic studies estimate between 7.8% to 45.5% patients have a diagnosis of TKS, with a slight male preponderance. Cultural and societal norms engendering guilt, shame, and embarrassment are likely etiological factors. Treatment may consist of antidepressant and/or antipsychotic medications, while some patients may also benefit from cognitive behavior therapy.
文摘The rising price of potash fertilizers has become a hot topic in China.The price of powder potassium chloride,the variety of potash fertilizers with the greatest consumption in the domestic market,surged from less than RMB2000 per ton in December 2007 to more than RMB3 000 per ton at the end of February 2008 and reached around RMB4 000 per ton at the end of April.Imported
文摘Due to the drastic price rise of raw materialsin late January,the production cost oflambda-cyhalothrin has increasedremarkably.The market price of 96%lambda-cyhalothrin technical has gone upsharply from RMB172 000 per ton in De-cember 2008 to RMB195 000 per ton with agrowth of 13%.Enterprises of single-com-ponent formulations and complex formula-tions are actively buying lambda-cyhalothrintechnical for processing.The remarkable price rise in early
