A unilateral self-locking mechanism(USM) was proposed to increase the tractive ability of the inchworm in-pipe robots for pipeline inspection.The USM was basically composed of a cam,a torsional spring and an axis.The ...A unilateral self-locking mechanism(USM) was proposed to increase the tractive ability of the inchworm in-pipe robots for pipeline inspection.The USM was basically composed of a cam,a torsional spring and an axis.The self-locking and virtual work principles were applied to studying the basic self-locking condition of the USM.In order to make the cooperation between the crutch and telescopic mechanism more harmonical,the unlocking time of the USM was calculated.A set of parameters were selected to build a virtual model and fabricate a prototype.Both the simulation and performance experiments were carried out in a pipe with a nominal inside diameter of 160 mm.The results show that USM enables the robot to move quickly in one way,and in the other way it helps the robot get self-locking with the pipe wall.The traction of the inchworm robot can rise to 1.2 kN,beyond the limitation of friction of 0.497 kN.展开更多
BACKGROUND Cervical degenerative disc(CDD)disease is a common type of spondylosis.Although anterior cervical discectomy and fusion(ACDF)is the preferred treatment for CDD disease,internal fixation with a titanium plat...BACKGROUND Cervical degenerative disc(CDD)disease is a common type of spondylosis.Although anterior cervical discectomy and fusion(ACDF)is the preferred treatment for CDD disease,internal fixation with a titanium plate may cause various complications.The invention of the ACDF with a self-locking fusion cage(ROI-C)has effectively decreased the incidence of postoperative complications.AIM To observe the outcomes of CDD disease treated by ACDF with a ROI-C.METHODS Ninety patients with CDD disease treated at our hospital from March 2019 to March 2021 were included.They were divided into two groups(control group and observation group,n=45 in each)using a random number table.Patients in the control group received ACDF plus internal fixation with a titanium plate.Those in the observation group received ACDF+ROI-C placement.The two groups of patients were compared in terms of surgical parameters,pain,cervical spine function,range of motion,and complications.RESULTS The two groups of patients showed no significant differences in surgical time,blood loss,drainage volume,and length of hospital stay(P>0.05).No significant differences in the visual analogue scale(VAS),Japanese Orthopedic Association(JOA),and neck disability index(NDI)scores were observed between the two groups before surgery(P>0.05).The VAS and NDI scores in the observation group were considerably lower than those in the control group after surgery;however,the JOA scores in the observation group were significantly higher than those in the control group(P<0.05).No significant differences were observed in cervical disc height and the range of motion of the superior or inferior adjacent vertebrae between the two groups before surgery(P>0.05).The disc height in the observation group was larger than that in the control group after surgery.The range of motion of both the superior and inferior adjacent vertebrae was significantly smaller in the observation group than in the control group(P<0.05).The incidence of complications was only 2.22% in the observation group compared to 15.56% in the control group,and the difference was statistically significant(P<0.05).CONCLUSION Cervical spine function restoration was better with ROI-C with internal fixation in ACDF than with conventional titanium plates in ACDF for CDD disease.展开更多
1文献来源FRENCH C A,KUTOK J L,FAQUIN W C,et al.Midline carcinoma of children and young adults with NUT rearrangement[J].J Clin Oncol,2004,22(20):4135-4139.doi:10.1200/JCO.2004.02.107.2研究背景既往病例报道描述了一种罕...1文献来源FRENCH C A,KUTOK J L,FAQUIN W C,et al.Midline carcinoma of children and young adults with NUT rearrangement[J].J Clin Oncol,2004,22(20):4135-4139.doi:10.1200/JCO.2004.02.107.2研究背景既往病例报道描述了一种罕见的癌症--NUT癌,它常发生在年轻人中并具有t(15;19)染色体易位的特征,该特征似乎与高致死性的临床进程相关。特殊的染色体易位是其独特标识,但大多数癌具有高度的同源性及多重核型,诊断性染色体平衡易位较缺乏。就细胞遗传学特征而言,NUT癌更类似于淋巴瘤及肉瘤。仅有的文献表明,该癌肿属于主要起源于胸腺或呼吸道上皮的实体瘤,对放化疗无明显效应,具有高度致命性,但这种疾病的临床病理特征仍不明确,需要进一步研究探索。展开更多
NUT癌是一种极为罕见的恶性肿瘤,与15q14号染色体上的NUT癌家族成员1(NUT midline carcinoma family member 1,NUTM1)基因重排密切相关,其中以BRD4::NUTM1融合基因多见[1]。NUT癌侵袭性高、分化程度低,往往具有较差的生存及预后。由于...NUT癌是一种极为罕见的恶性肿瘤,与15q14号染色体上的NUT癌家族成员1(NUT midline carcinoma family member 1,NUTM1)基因重排密切相关,其中以BRD4::NUTM1融合基因多见[1]。NUT癌侵袭性高、分化程度低,往往具有较差的生存及预后。由于其与鳞状细胞癌的同源相似性,存在较高的误诊率。诸多患者在诊断时已发现疾病处于晚期阶段[2]。目前,以免疫组化(immunohistochemistry,IHC)初筛为主,荧光原位杂交(fluorescence in situ hybridization,FISH)、二代测序(next-generation sequencing,NGS)等为辅的检测手段大大提高了NUT癌的检出率[3]。展开更多
1文献来源PIHA-PAUL S A,HANN C L,FRENCH C A,et al.Phase 1 study of molibresib(GSK525762),a bromodomain and extra-terminal domain protein inhibitor,in NUT carcinoma and other solid tumors[J].JNCI Cancer Spectr,2019,4(2)...1文献来源PIHA-PAUL S A,HANN C L,FRENCH C A,et al.Phase 1 study of molibresib(GSK525762),a bromodomain and extra-terminal domain protein inhibitor,in NUT carcinoma and other solid tumors[J].JNCI Cancer Spectr,2019,4(2):pkz093.doi:10.1093/jncics/pkz093.2研究背景溴结构域和超末端结构域(bromodomain and extraterminal domain,BET)家族是表观基因组的调节因子,也是肿瘤细胞生存所依赖的肿瘤相关基因表达的关键驱动因子,一些重要的原癌基因如MYC、BCL2、CDK6均受到BET蛋白的调控,BET蛋白的异常激活与包括癌症在内的各种人类疾病密切相关,包括罕见且具有高度侵袭性的NUT癌。展开更多
1文献来源LEWIN J,SORIA J C,STATHIS A,et al.PhaseⅠb trial with birabresib,a small-molecule inhibitor of bromodomain and extraterminal proteins,in patients with selected advanced solid tumors[J].J Clin Oncol,2018,36(30...1文献来源LEWIN J,SORIA J C,STATHIS A,et al.PhaseⅠb trial with birabresib,a small-molecule inhibitor of bromodomain and extraterminal proteins,in patients with selected advanced solid tumors[J].J Clin Oncol,2018,36(30):3007−3014.doi:10.1200/JCO.2018.78.2292.2证据水平1b。3研究背景伴睾丸核蛋白(nuclear protein in testis,NUT)基因重排的中线癌又称NUT癌,是一种罕见的具有高度侵袭性的鳞状癌。它的发病与位于15号染色体长臂的NUT中线癌家族成员1基因(NUT midline carcinoma family member 1,NUTM1)重排有关。展开更多
Activated carbons (ACs) calcined at 400˚C, 500˚C, and 600˚C (AC-400, AC-500, and AC-600) were prepared using palm nut shells from Gabon as raw material and zinc chloride (ZnCl2) as a chemical activating agent. Prepare...Activated carbons (ACs) calcined at 400˚C, 500˚C, and 600˚C (AC-400, AC-500, and AC-600) were prepared using palm nut shells from Gabon as raw material and zinc chloride (ZnCl2) as a chemical activating agent. Prepared ACs were characterized by physisorption of nitrogen (N2), determination of diode and methylene blue numbers for studies of porosity and by quantification and determination of surface functional groups and pH at point of zero charge (pHpzc) respectively, for studies of chemical properties of prepared ACs. Then, effects of calcination temperature (Tcal) on porosity and chemical properties of prepared ACs were studied. The results obtained showed that when the calcination temperature increases from 500˚C to 600˚C, the porosity and chemical properties of prepared ACs are modified. Indeed, the methylene blue and iodine numbers determined for activated carbons AC-400 (460 and 7.94 mg·g−1, respectively) and AC-500 (680 and 8.90 mg·g−1, respectively) are higher than those obtained for AC-600 (360 and 5.75 mg·g−1, respectively). Compared to the AC-500 adsorbent, specific surface areas (SBET) and microporous volume losses for AC-600 were estimated to 44.7% and 45.8%, respectively. Moreover, in our experimental conditions, the effect of Tcal on the quantities of acidic and basic functional groups on the surface of the ACs appears negligible. In addition, results of the pHpzc of prepared ACs showed that as Tcal increases, the pH of the adsorbents increases and tends towards neutrality. Indeed, a stronger acidity was determined on AC-400 (pHpzc = 5.60) compared to those on AC-500 and AC-600 (pHpzc = 6.85 and 6.70, respectively). Also according to the results of porosity and chemical characterizations, adsorption being a surface phenomenon, 500˚C appears to be the optimal calcination temperature for the preparation of activated carbons from palm nut shells in our experimental conditions.展开更多
基金Project(2007AA04Z256) supported by the National High-Tech Research and Development Program of China
文摘A unilateral self-locking mechanism(USM) was proposed to increase the tractive ability of the inchworm in-pipe robots for pipeline inspection.The USM was basically composed of a cam,a torsional spring and an axis.The self-locking and virtual work principles were applied to studying the basic self-locking condition of the USM.In order to make the cooperation between the crutch and telescopic mechanism more harmonical,the unlocking time of the USM was calculated.A set of parameters were selected to build a virtual model and fabricate a prototype.Both the simulation and performance experiments were carried out in a pipe with a nominal inside diameter of 160 mm.The results show that USM enables the robot to move quickly in one way,and in the other way it helps the robot get self-locking with the pipe wall.The traction of the inchworm robot can rise to 1.2 kN,beyond the limitation of friction of 0.497 kN.
文摘BACKGROUND Cervical degenerative disc(CDD)disease is a common type of spondylosis.Although anterior cervical discectomy and fusion(ACDF)is the preferred treatment for CDD disease,internal fixation with a titanium plate may cause various complications.The invention of the ACDF with a self-locking fusion cage(ROI-C)has effectively decreased the incidence of postoperative complications.AIM To observe the outcomes of CDD disease treated by ACDF with a ROI-C.METHODS Ninety patients with CDD disease treated at our hospital from March 2019 to March 2021 were included.They were divided into two groups(control group and observation group,n=45 in each)using a random number table.Patients in the control group received ACDF plus internal fixation with a titanium plate.Those in the observation group received ACDF+ROI-C placement.The two groups of patients were compared in terms of surgical parameters,pain,cervical spine function,range of motion,and complications.RESULTS The two groups of patients showed no significant differences in surgical time,blood loss,drainage volume,and length of hospital stay(P>0.05).No significant differences in the visual analogue scale(VAS),Japanese Orthopedic Association(JOA),and neck disability index(NDI)scores were observed between the two groups before surgery(P>0.05).The VAS and NDI scores in the observation group were considerably lower than those in the control group after surgery;however,the JOA scores in the observation group were significantly higher than those in the control group(P<0.05).No significant differences were observed in cervical disc height and the range of motion of the superior or inferior adjacent vertebrae between the two groups before surgery(P>0.05).The disc height in the observation group was larger than that in the control group after surgery.The range of motion of both the superior and inferior adjacent vertebrae was significantly smaller in the observation group than in the control group(P<0.05).The incidence of complications was only 2.22% in the observation group compared to 15.56% in the control group,and the difference was statistically significant(P<0.05).CONCLUSION Cervical spine function restoration was better with ROI-C with internal fixation in ACDF than with conventional titanium plates in ACDF for CDD disease.
文摘1文献来源FRENCH C A,KUTOK J L,FAQUIN W C,et al.Midline carcinoma of children and young adults with NUT rearrangement[J].J Clin Oncol,2004,22(20):4135-4139.doi:10.1200/JCO.2004.02.107.2研究背景既往病例报道描述了一种罕见的癌症--NUT癌,它常发生在年轻人中并具有t(15;19)染色体易位的特征,该特征似乎与高致死性的临床进程相关。特殊的染色体易位是其独特标识,但大多数癌具有高度的同源性及多重核型,诊断性染色体平衡易位较缺乏。就细胞遗传学特征而言,NUT癌更类似于淋巴瘤及肉瘤。仅有的文献表明,该癌肿属于主要起源于胸腺或呼吸道上皮的实体瘤,对放化疗无明显效应,具有高度致命性,但这种疾病的临床病理特征仍不明确,需要进一步研究探索。
文摘NUT癌是一种极为罕见的恶性肿瘤,与15q14号染色体上的NUT癌家族成员1(NUT midline carcinoma family member 1,NUTM1)基因重排密切相关,其中以BRD4::NUTM1融合基因多见[1]。NUT癌侵袭性高、分化程度低,往往具有较差的生存及预后。由于其与鳞状细胞癌的同源相似性,存在较高的误诊率。诸多患者在诊断时已发现疾病处于晚期阶段[2]。目前,以免疫组化(immunohistochemistry,IHC)初筛为主,荧光原位杂交(fluorescence in situ hybridization,FISH)、二代测序(next-generation sequencing,NGS)等为辅的检测手段大大提高了NUT癌的检出率[3]。
文摘1文献来源PIHA-PAUL S A,HANN C L,FRENCH C A,et al.Phase 1 study of molibresib(GSK525762),a bromodomain and extra-terminal domain protein inhibitor,in NUT carcinoma and other solid tumors[J].JNCI Cancer Spectr,2019,4(2):pkz093.doi:10.1093/jncics/pkz093.2研究背景溴结构域和超末端结构域(bromodomain and extraterminal domain,BET)家族是表观基因组的调节因子,也是肿瘤细胞生存所依赖的肿瘤相关基因表达的关键驱动因子,一些重要的原癌基因如MYC、BCL2、CDK6均受到BET蛋白的调控,BET蛋白的异常激活与包括癌症在内的各种人类疾病密切相关,包括罕见且具有高度侵袭性的NUT癌。
文摘1文献来源LEWIN J,SORIA J C,STATHIS A,et al.PhaseⅠb trial with birabresib,a small-molecule inhibitor of bromodomain and extraterminal proteins,in patients with selected advanced solid tumors[J].J Clin Oncol,2018,36(30):3007−3014.doi:10.1200/JCO.2018.78.2292.2证据水平1b。3研究背景伴睾丸核蛋白(nuclear protein in testis,NUT)基因重排的中线癌又称NUT癌,是一种罕见的具有高度侵袭性的鳞状癌。它的发病与位于15号染色体长臂的NUT中线癌家族成员1基因(NUT midline carcinoma family member 1,NUTM1)重排有关。
文摘Activated carbons (ACs) calcined at 400˚C, 500˚C, and 600˚C (AC-400, AC-500, and AC-600) were prepared using palm nut shells from Gabon as raw material and zinc chloride (ZnCl2) as a chemical activating agent. Prepared ACs were characterized by physisorption of nitrogen (N2), determination of diode and methylene blue numbers for studies of porosity and by quantification and determination of surface functional groups and pH at point of zero charge (pHpzc) respectively, for studies of chemical properties of prepared ACs. Then, effects of calcination temperature (Tcal) on porosity and chemical properties of prepared ACs were studied. The results obtained showed that when the calcination temperature increases from 500˚C to 600˚C, the porosity and chemical properties of prepared ACs are modified. Indeed, the methylene blue and iodine numbers determined for activated carbons AC-400 (460 and 7.94 mg·g−1, respectively) and AC-500 (680 and 8.90 mg·g−1, respectively) are higher than those obtained for AC-600 (360 and 5.75 mg·g−1, respectively). Compared to the AC-500 adsorbent, specific surface areas (SBET) and microporous volume losses for AC-600 were estimated to 44.7% and 45.8%, respectively. Moreover, in our experimental conditions, the effect of Tcal on the quantities of acidic and basic functional groups on the surface of the ACs appears negligible. In addition, results of the pHpzc of prepared ACs showed that as Tcal increases, the pH of the adsorbents increases and tends towards neutrality. Indeed, a stronger acidity was determined on AC-400 (pHpzc = 5.60) compared to those on AC-500 and AC-600 (pHpzc = 6.85 and 6.70, respectively). Also according to the results of porosity and chemical characterizations, adsorption being a surface phenomenon, 500˚C appears to be the optimal calcination temperature for the preparation of activated carbons from palm nut shells in our experimental conditions.
