[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by con...[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by conducting interspecific crosses among the major wild species subsect.Delavayanae(Paeonia delavayi,Paeonia lutea,Paeonia potaninii,and Paeonia ludlowii)as well as reciprocal crosses between these species and cultivated varieties from the subsect.Vaginatae.[Results]Crosses among P.delavayi,P.lutea,and P.potaninii generally exhibited good seed set,with the resulting seeds showing a high emergence rate.In contrast,crosses involving P.ludlowii as a parent produced only a limited number of seeds,none of which germinated.In crosses with cultivated varieties where the wild species served as the maternal parent,the average seed set ranked as follows:P.lutea>P.delavayi>P.ludlowii>P.potaninii.When wild species were used as paternal parent,the average seed set ranked as follows:P.potaninii>P.lutea>P.delavayi>P.ludlowii.On the whole,most crosses between wild species of subsect.Delavayanae and cultivated varieties achieved normal seed set,demonstrating a certain degree of cross-compatibility.However,when the wild species served as the maternal parent,both the seed set and seedling emergence rate were superior to those in the reciprocal crosses(with wild species as the paternal parent).[Conclusions]Significant differences in cross-compatibility were observed among species within Paeonia subsect.Delavayanae.In addition,a significant maternal effect was identified in crosses between wild species of this subsection and cultivated varieties.These findings suggest that by selecting highly compatible combinations,there remains considerable potential for utilizing these wild species in peony breeding.展开更多
Editor's Note:As a unique system of succession in Tibetan Buddhism,the reincarnation of Living Buddhas is governed by standardized religious rituals,historical conventions,and established principles.Since the Karm...Editor's Note:As a unique system of succession in Tibetan Buddhism,the reincarnation of Living Buddhas is governed by standardized religious rituals,historical conventions,and established principles.Since the Karma Kagyu sect pioneered the reincarnation system of Living Buddhas in the 13th century,this tradition has continued for more than 700 years.Since the Gelug sect adopted the reincarnation practice in the 16th century,resulting in major lineages such as the Dalai Lama and Panchen Erdeni reincarnations,the system has now held a history of over 400 years.Since the Yuan Dynasty(1271-1368),successive central governments of China have,without exception,strengthened administration over reincarnation matters.In the 57th year of the reign of Emperor Qianlong(1792)of the Qing Dynasty,the Golden Urn Lot-Drawing System was formally established.This system has remained in place up to the present day.Demonstrating national sovereignty,governmental authority,as well as the sacredness and impartiality of Buddhism,it has effectively prevented corruption and malpractice during the reincarnation process.展开更多
目的评价白芍总苷(TGP)制剂治疗系统性红斑狼疮(SLE)的有效性及安全性。方法检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、维普网、万方数据和中国生物医学文献数据库,收集TGP制剂联合西药对比单用西药的随机对照...目的评价白芍总苷(TGP)制剂治疗系统性红斑狼疮(SLE)的有效性及安全性。方法检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、维普网、万方数据和中国生物医学文献数据库,收集TGP制剂联合西药对比单用西药的随机对照研究(RCT)。检索时间为建库起至2025年6月1日。筛选文献、提取资料、评价文献质量后,采用RevMan 5.4软件进行Meta分析。结果共纳入15项RCT,包括1318例患者。Meta分析结果显示,与单用西药比较,TGP制剂联合西药能提高患者的临床有效率[OR=4.96,95%CI(3.41,7.23),P<0.00001]、补体3[MD=0.18,95%CI(0.13,0.23),P<0.00001]、补体4水平[MD=0.08,95%CI(0.04,0.11),P<0.00001],降低免疫球蛋白G(IgG)[MD=-3.10,95%CI(-3.59,-2.62),P<0.00001]、IgA[MD=-0.68,95%CI(-0.78,-0.58),P<0.00001]、IgM[MD=-0.43,95%CI(-0.53,-0.34),P<0.00001]、系统性红斑狼疮疾病活动性指数[MD=-1.59,95%CI(-2.20,-0.99),P<0.00001]、复发率[OR=0.23,95%CI(0.13,0.42),P<0.00001]及不良反应发生率[OR=0.54,95%CI(0.36,0.82),P=0.004]。结论TGP制剂能提高SLE患者的疗效,促进免疫球蛋白及补体恢复,降低系统性红斑狼疮疾病活动性指数和复发率,且安全性较好。展开更多
Background:Disorders of metabolism can affect the food intake,weight changes,and behavioral alterations of the body.Metabolic disorders are usually accompanied by the occurrence of diseases.We aimed to study the effec...Background:Disorders of metabolism can affect the food intake,weight changes,and behavioral alterations of the body.Metabolic disorders are usually accompanied by the occurrence of diseases.We aimed to study the effects of the compatibility of Paeoniae Radix Rubra(PRR)and Angelicae Sinensis Radix(ASR)on the metabolic level of rats,and observe the changes in body weight and behavior.Discover the mechanism of preventing the occurrence of diseases by using PRR and ASR.Methods:Two animal models were induced by levothyroxine and low-temperature stimulation,followed by 21 days of edible traditional Chinese medicine administration.The changes in the rats’water intake,food intake,body temperature,and thermotactic behavior were recorded.Results:The results showed that PRR could cause an increase in the body weight of rats,a decrease in body temperature,and a stronger preference for warm environments.PRR inhibited thyroid function,the excitability of the nervous system,and energy metabolism.PRR upregulated the expressions of mTOR and TRPM8 while downregulating the expressions of AMPK and TRPV1.Conclusion:Our research findings suggest that the cold-natured PRR can inhibit the material and energy metabolism of the body and lower the body temperature,increasing the thermophilic behavior of rats.In contrast,ASR exhibited an antagonistic effect against PRR.展开更多
文摘[Objectives]To provide a reference for the efficient use of wild Paeonia suffruticosa germplasm resources and the scientific selection of parents.[Methods]This study systematically evaluated cross-compatibility by conducting interspecific crosses among the major wild species subsect.Delavayanae(Paeonia delavayi,Paeonia lutea,Paeonia potaninii,and Paeonia ludlowii)as well as reciprocal crosses between these species and cultivated varieties from the subsect.Vaginatae.[Results]Crosses among P.delavayi,P.lutea,and P.potaninii generally exhibited good seed set,with the resulting seeds showing a high emergence rate.In contrast,crosses involving P.ludlowii as a parent produced only a limited number of seeds,none of which germinated.In crosses with cultivated varieties where the wild species served as the maternal parent,the average seed set ranked as follows:P.lutea>P.delavayi>P.ludlowii>P.potaninii.When wild species were used as paternal parent,the average seed set ranked as follows:P.potaninii>P.lutea>P.delavayi>P.ludlowii.On the whole,most crosses between wild species of subsect.Delavayanae and cultivated varieties achieved normal seed set,demonstrating a certain degree of cross-compatibility.However,when the wild species served as the maternal parent,both the seed set and seedling emergence rate were superior to those in the reciprocal crosses(with wild species as the paternal parent).[Conclusions]Significant differences in cross-compatibility were observed among species within Paeonia subsect.Delavayanae.In addition,a significant maternal effect was identified in crosses between wild species of this subsection and cultivated varieties.These findings suggest that by selecting highly compatible combinations,there remains considerable potential for utilizing these wild species in peony breeding.
文摘Editor's Note:As a unique system of succession in Tibetan Buddhism,the reincarnation of Living Buddhas is governed by standardized religious rituals,historical conventions,and established principles.Since the Karma Kagyu sect pioneered the reincarnation system of Living Buddhas in the 13th century,this tradition has continued for more than 700 years.Since the Gelug sect adopted the reincarnation practice in the 16th century,resulting in major lineages such as the Dalai Lama and Panchen Erdeni reincarnations,the system has now held a history of over 400 years.Since the Yuan Dynasty(1271-1368),successive central governments of China have,without exception,strengthened administration over reincarnation matters.In the 57th year of the reign of Emperor Qianlong(1792)of the Qing Dynasty,the Golden Urn Lot-Drawing System was formally established.This system has remained in place up to the present day.Demonstrating national sovereignty,governmental authority,as well as the sacredness and impartiality of Buddhism,it has effectively prevented corruption and malpractice during the reincarnation process.
文摘目的评价白芍总苷(TGP)制剂治疗系统性红斑狼疮(SLE)的有效性及安全性。方法检索PubMed、Embase、Cochrane Library、Web of Science、中国知网、维普网、万方数据和中国生物医学文献数据库,收集TGP制剂联合西药对比单用西药的随机对照研究(RCT)。检索时间为建库起至2025年6月1日。筛选文献、提取资料、评价文献质量后,采用RevMan 5.4软件进行Meta分析。结果共纳入15项RCT,包括1318例患者。Meta分析结果显示,与单用西药比较,TGP制剂联合西药能提高患者的临床有效率[OR=4.96,95%CI(3.41,7.23),P<0.00001]、补体3[MD=0.18,95%CI(0.13,0.23),P<0.00001]、补体4水平[MD=0.08,95%CI(0.04,0.11),P<0.00001],降低免疫球蛋白G(IgG)[MD=-3.10,95%CI(-3.59,-2.62),P<0.00001]、IgA[MD=-0.68,95%CI(-0.78,-0.58),P<0.00001]、IgM[MD=-0.43,95%CI(-0.53,-0.34),P<0.00001]、系统性红斑狼疮疾病活动性指数[MD=-1.59,95%CI(-2.20,-0.99),P<0.00001]、复发率[OR=0.23,95%CI(0.13,0.42),P<0.00001]及不良反应发生率[OR=0.54,95%CI(0.36,0.82),P=0.004]。结论TGP制剂能提高SLE患者的疗效,促进免疫球蛋白及补体恢复,降低系统性红斑狼疮疾病活动性指数和复发率,且安全性较好。
基金the preparation of this manuscript.This study was supported by the General Projects-Youth project(2022JQ-817)the Shaanxi University of Traditional Chinese Medicine Shaanxi Provincial Key Laboratory of Basic and New Drug Research Open Project(KF202303)+1 种基金the Research on process optimization and quality standard enhancement of five large varieties,including Four Seasons Antiviral Combination(2024CY-JJQ-36)the Shaanxi provincial science and technology department project(2025JC-YBMS-1033).
文摘Background:Disorders of metabolism can affect the food intake,weight changes,and behavioral alterations of the body.Metabolic disorders are usually accompanied by the occurrence of diseases.We aimed to study the effects of the compatibility of Paeoniae Radix Rubra(PRR)and Angelicae Sinensis Radix(ASR)on the metabolic level of rats,and observe the changes in body weight and behavior.Discover the mechanism of preventing the occurrence of diseases by using PRR and ASR.Methods:Two animal models were induced by levothyroxine and low-temperature stimulation,followed by 21 days of edible traditional Chinese medicine administration.The changes in the rats’water intake,food intake,body temperature,and thermotactic behavior were recorded.Results:The results showed that PRR could cause an increase in the body weight of rats,a decrease in body temperature,and a stronger preference for warm environments.PRR inhibited thyroid function,the excitability of the nervous system,and energy metabolism.PRR upregulated the expressions of mTOR and TRPM8 while downregulating the expressions of AMPK and TRPV1.Conclusion:Our research findings suggest that the cold-natured PRR can inhibit the material and energy metabolism of the body and lower the body temperature,increasing the thermophilic behavior of rats.In contrast,ASR exhibited an antagonistic effect against PRR.
