目的探究二维剪切波弹性成像(2D-SWE)参数在评估乙型病毒性肝炎(简称乙肝)患者肝纤维化分期中的应用价值,获取其阈值点并进行探究。方法纳入乙肝患者100例为研究对象。患者均行2D-SWE检查,以Scheuer评分系统为依据进一步将乙肝患者肝纤...目的探究二维剪切波弹性成像(2D-SWE)参数在评估乙型病毒性肝炎(简称乙肝)患者肝纤维化分期中的应用价值,获取其阈值点并进行探究。方法纳入乙肝患者100例为研究对象。患者均行2D-SWE检查,以Scheuer评分系统为依据进一步将乙肝患者肝纤维化分为S0~S4期,并分为非显著纤维化组(S0~S1,41例)和显著纤维化组(S2~S4,59例)。收集患者的年龄、平均弹性模量值、肝弹性模量值及一致性、层粘连蛋白(LN)、血清透明质酸(HA)、肝纤维化-4因子指数(FIB-4)、谷草转氨酶/血小板比率指数(APRI)等指标水平。受试者操作特征(ROC)曲线评估2D-SWE的肝弹性模量值对患者肝纤维化分期预测的诊断效能,并获取其阈值点,按照阈值点对100例患者再次进行分层分析,探究与肝弹性模量值交互作用的影响因素。结果肝纤维化不同分期患者的年龄、平均弹性模量值比较差异有统计学意义(P<0.05);2位不同年资的医师对S0~S4期患者的肝弹性模量值和一致性进行评估,二者之间具有较高的一致性(P<0.05);2D-SWE对100例患者肝纤维化的预测效能(AUC=0.848,灵敏度92.7%,特异度79.5%),肝弹性模量值对S0-1,S2-4的诊断截断值为7.950 k Pa;分层分析发现,LN、HA、FIB-4、APRI指标与肝弹性模量值有交互作用(P<0.05)。结论2D-SWE在评估乙肝患者肝纤维化分期中具有很好的应用价值,肝纤维化不同分期患者的年龄和平均弹性模量值与纤维化程度密切相关,2D-SWE肝弹性模量值对肝纤维化的预测效能较高,且与LN、HA、FIB-4和APRI等关系密切。展开更多
脊柱疾病一直是医学界备受关注的领域,其中包括脊柱侧凸、骨折和椎间盘突出等多种疾病。传统影像技术在脊柱疾病的诊断和治疗中发挥着重要作用,然而其对于组织弹性特性的捕捉能力有限。近年来,剪切波超声弹性成像(Shear Wave Elastograp...脊柱疾病一直是医学界备受关注的领域,其中包括脊柱侧凸、骨折和椎间盘突出等多种疾病。传统影像技术在脊柱疾病的诊断和治疗中发挥着重要作用,然而其对于组织弹性特性的捕捉能力有限。近年来,剪切波超声弹性成像(Shear Wave Elastography, SWE)技术作为一种新兴的医学影像技术,因其能够提供组织弹性信息和对组织微观结构的敏感性而备受关注。在脊柱领域,这项技术可能为我们提供更加全面的诊断信息,并且对于指导手术和监测治疗效果也具有参考价值。因此,本综述旨在通过对剪切波弹性成像技术在脊柱疾病中的应用和进展进行综合分析,探讨其在脊柱疾病领域的作用。Spinal disorders have long been an area of concern in the medical community, including conditions as diverse as scoliosis, fractures, and disc herniations. Traditional imaging techniques play an important role in the diagnosis and treatment of spinal diseases, but their ability to capture tissue elastic features is limited. In recent years, shear wave elastography (SWE), as a new medical imaging technology, has attracted much attention because of its sensitivity to tissue elastic information and tissue microstructure. In the field of spinal diseases, this technology can provide us with more comprehensive diagnostic information and can also be useful for guiding surgery and monitoring outcomes. Therefore, this review aims to discuss the role of shear-wave elastography in the field of spinal diseases through a comprehensive analysis of its application and progress in spinal diseases.展开更多
Objective:To evaluate the value of real-time two-dimensional shear wave elastography(SWE)in predicting liver parenchymal stiffness in non-alcoholic fatty liver disease(NAFLD).Methods:A total of 200 NAFLD patients(70 i...Objective:To evaluate the value of real-time two-dimensional shear wave elastography(SWE)in predicting liver parenchymal stiffness in non-alcoholic fatty liver disease(NAFLD).Methods:A total of 200 NAFLD patients(70 in the mild group,70 in the moderate group,and 60 in the severe group)and 60 healthy individuals(control group)who visited the hospital from December 2023 to December 2024 underwent real-time two-dimensional SWE examinations.Results:Except for high-density lipoprotein,comparisons of body mass index and biochemical indicators showed that the severe group>moderate group>mild group>control group,with P<0.05.Comparisons of liver stiffness values also showed that the severe group>moderate group>mild group>control group,with P<0.05.Pearson correlation analysis revealed a positive correlation between liver stiffness values and body mass index,triglycerides,total cholesterol,low-density lipoprotein,fasting blood glucose,and glycosylated hemoglobin.Analysis of the ROC curve indicated that the AUC,standard deviation,and P-value for liver stiffness values were 0.901,0.025,and 0.01,respectively,suggesting that liver stiffness values can predict the severity of NAFLD.Conclusion:The real-time two-dimensional shear wave elastography(SWE)technique for diagnosing NAFLD can differentiate between NAFLD patients and healthy individuals,as well as determine liver parenchymal stiffness,thereby assisting physicians in quantifying the degree of fatty liver.展开更多
SWE(Sensor Web Enablement)是基于OGC组织的web服务框架及信息模型提出的针对无线传感器网络资源的框架,通过提供统一的接口及编码实现了异构网络中资源的管理。为实现传感资源的有效整合,在应用SWE基础上扩展了基于ebRIM模型的OGC CS...SWE(Sensor Web Enablement)是基于OGC组织的web服务框架及信息模型提出的针对无线传感器网络资源的框架,通过提供统一的接口及编码实现了异构网络中资源的管理。为实现传感资源的有效整合,在应用SWE基础上扩展了基于ebRIM模型的OGC CSW规范,提出以OGC的SWE框架内SOS服务和CSW规范的融合的方法,并从系统实现角度,讨论了系统设计及数据格式以及实现验证等关键问题。未来的传感应用依赖于海量传感数据处理,对于传感资源的整合需求也应覆盖SWE的全部服务。这也是下一步的努力方向。展开更多
目的:观察姜黄素对β-淀粉样前体蛋白swe基因/早老蛋白1dE9基因(APPswe/PSEN1dE9)双转基因小鼠海马神经元B类Ⅰ型清道夫受体(scavenger receptor class B typeⅠ,SR-BⅠ)和三磷酸腺苷结合盒A1(ATP-binding cassette transporter,ABCA1)...目的:观察姜黄素对β-淀粉样前体蛋白swe基因/早老蛋白1dE9基因(APPswe/PSEN1dE9)双转基因小鼠海马神经元B类Ⅰ型清道夫受体(scavenger receptor class B typeⅠ,SR-BⅠ)和三磷酸腺苷结合盒A1(ATP-binding cassette transporter,ABCA1)表达的影响,探讨姜黄素在阿尔茨海默病(Alzheimer’s disease,AD)防治中的机制。方法:将10只6月龄的APPswe/PSEN1dE9双转基因小鼠随机分为对照组和姜黄素饲喂组,每组5只。姜黄素饲喂组每天饲喂500 ppm姜黄素,6个月后采用免疫组化法检测小鼠海马神经元SR-BⅠ和ABCA1表达的变化。结果:与对照组相比,姜黄素饲喂组小鼠海马神经元ABCA1表达明显增加(t=-10.805,P=0.000),但2组小鼠海马神经元中均未见SR-BⅠ表达。结论:姜黄素能提高APPswe/PSEN1dE9双转基因小鼠海马神经元ABCA1的表达,而SR-BⅠ在神经元中未见表达。展开更多
空天协同对地观测是对地观测领域的新趋势。为解决现有空天资源规划调度系统相对独立、协同困难的问题,分析总结了SWE(Sensor Web Enablement)标准,并在此基础上提出了空天资源对地观测协同任务规划服务模型。在此模型中,为实现观测资...空天协同对地观测是对地观测领域的新趋势。为解决现有空天资源规划调度系统相对独立、协同困难的问题,分析总结了SWE(Sensor Web Enablement)标准,并在此基础上提出了空天资源对地观测协同任务规划服务模型。在此模型中,为实现观测资源共享,建立了空天观测资源传感器描述模型,能够描述典型空天资源的载荷平台、观测机理、定位信息、使用约束和工作特性等信息;为简化观测请求交互流程,基于SOA技术对SWE标准操作进行封装及简化,用户可以在不了解观测平台细节信息的情况下提交观测数据请求。为验证模型有效性,构建了空天资源对地观测协同任务规划实验平台,结果表明该模型具有较强的可实现性和适应性。展开更多
文摘目的探究二维剪切波弹性成像(2D-SWE)参数在评估乙型病毒性肝炎(简称乙肝)患者肝纤维化分期中的应用价值,获取其阈值点并进行探究。方法纳入乙肝患者100例为研究对象。患者均行2D-SWE检查,以Scheuer评分系统为依据进一步将乙肝患者肝纤维化分为S0~S4期,并分为非显著纤维化组(S0~S1,41例)和显著纤维化组(S2~S4,59例)。收集患者的年龄、平均弹性模量值、肝弹性模量值及一致性、层粘连蛋白(LN)、血清透明质酸(HA)、肝纤维化-4因子指数(FIB-4)、谷草转氨酶/血小板比率指数(APRI)等指标水平。受试者操作特征(ROC)曲线评估2D-SWE的肝弹性模量值对患者肝纤维化分期预测的诊断效能,并获取其阈值点,按照阈值点对100例患者再次进行分层分析,探究与肝弹性模量值交互作用的影响因素。结果肝纤维化不同分期患者的年龄、平均弹性模量值比较差异有统计学意义(P<0.05);2位不同年资的医师对S0~S4期患者的肝弹性模量值和一致性进行评估,二者之间具有较高的一致性(P<0.05);2D-SWE对100例患者肝纤维化的预测效能(AUC=0.848,灵敏度92.7%,特异度79.5%),肝弹性模量值对S0-1,S2-4的诊断截断值为7.950 k Pa;分层分析发现,LN、HA、FIB-4、APRI指标与肝弹性模量值有交互作用(P<0.05)。结论2D-SWE在评估乙肝患者肝纤维化分期中具有很好的应用价值,肝纤维化不同分期患者的年龄和平均弹性模量值与纤维化程度密切相关,2D-SWE肝弹性模量值对肝纤维化的预测效能较高,且与LN、HA、FIB-4和APRI等关系密切。
文摘脊柱疾病一直是医学界备受关注的领域,其中包括脊柱侧凸、骨折和椎间盘突出等多种疾病。传统影像技术在脊柱疾病的诊断和治疗中发挥着重要作用,然而其对于组织弹性特性的捕捉能力有限。近年来,剪切波超声弹性成像(Shear Wave Elastography, SWE)技术作为一种新兴的医学影像技术,因其能够提供组织弹性信息和对组织微观结构的敏感性而备受关注。在脊柱领域,这项技术可能为我们提供更加全面的诊断信息,并且对于指导手术和监测治疗效果也具有参考价值。因此,本综述旨在通过对剪切波弹性成像技术在脊柱疾病中的应用和进展进行综合分析,探讨其在脊柱疾病领域的作用。Spinal disorders have long been an area of concern in the medical community, including conditions as diverse as scoliosis, fractures, and disc herniations. Traditional imaging techniques play an important role in the diagnosis and treatment of spinal diseases, but their ability to capture tissue elastic features is limited. In recent years, shear wave elastography (SWE), as a new medical imaging technology, has attracted much attention because of its sensitivity to tissue elastic information and tissue microstructure. In the field of spinal diseases, this technology can provide us with more comprehensive diagnostic information and can also be useful for guiding surgery and monitoring outcomes. Therefore, this review aims to discuss the role of shear-wave elastography in the field of spinal diseases through a comprehensive analysis of its application and progress in spinal diseases.
文摘Objective:To evaluate the value of real-time two-dimensional shear wave elastography(SWE)in predicting liver parenchymal stiffness in non-alcoholic fatty liver disease(NAFLD).Methods:A total of 200 NAFLD patients(70 in the mild group,70 in the moderate group,and 60 in the severe group)and 60 healthy individuals(control group)who visited the hospital from December 2023 to December 2024 underwent real-time two-dimensional SWE examinations.Results:Except for high-density lipoprotein,comparisons of body mass index and biochemical indicators showed that the severe group>moderate group>mild group>control group,with P<0.05.Comparisons of liver stiffness values also showed that the severe group>moderate group>mild group>control group,with P<0.05.Pearson correlation analysis revealed a positive correlation between liver stiffness values and body mass index,triglycerides,total cholesterol,low-density lipoprotein,fasting blood glucose,and glycosylated hemoglobin.Analysis of the ROC curve indicated that the AUC,standard deviation,and P-value for liver stiffness values were 0.901,0.025,and 0.01,respectively,suggesting that liver stiffness values can predict the severity of NAFLD.Conclusion:The real-time two-dimensional shear wave elastography(SWE)technique for diagnosing NAFLD can differentiate between NAFLD patients and healthy individuals,as well as determine liver parenchymal stiffness,thereby assisting physicians in quantifying the degree of fatty liver.
文摘SWE(Sensor Web Enablement)是基于OGC组织的web服务框架及信息模型提出的针对无线传感器网络资源的框架,通过提供统一的接口及编码实现了异构网络中资源的管理。为实现传感资源的有效整合,在应用SWE基础上扩展了基于ebRIM模型的OGC CSW规范,提出以OGC的SWE框架内SOS服务和CSW规范的融合的方法,并从系统实现角度,讨论了系统设计及数据格式以及实现验证等关键问题。未来的传感应用依赖于海量传感数据处理,对于传感资源的整合需求也应覆盖SWE的全部服务。这也是下一步的努力方向。
文摘目的:观察姜黄素对β-淀粉样前体蛋白swe基因/早老蛋白1dE9基因(APPswe/PSEN1dE9)双转基因小鼠海马神经元B类Ⅰ型清道夫受体(scavenger receptor class B typeⅠ,SR-BⅠ)和三磷酸腺苷结合盒A1(ATP-binding cassette transporter,ABCA1)表达的影响,探讨姜黄素在阿尔茨海默病(Alzheimer’s disease,AD)防治中的机制。方法:将10只6月龄的APPswe/PSEN1dE9双转基因小鼠随机分为对照组和姜黄素饲喂组,每组5只。姜黄素饲喂组每天饲喂500 ppm姜黄素,6个月后采用免疫组化法检测小鼠海马神经元SR-BⅠ和ABCA1表达的变化。结果:与对照组相比,姜黄素饲喂组小鼠海马神经元ABCA1表达明显增加(t=-10.805,P=0.000),但2组小鼠海马神经元中均未见SR-BⅠ表达。结论:姜黄素能提高APPswe/PSEN1dE9双转基因小鼠海马神经元ABCA1的表达,而SR-BⅠ在神经元中未见表达。
文摘空天协同对地观测是对地观测领域的新趋势。为解决现有空天资源规划调度系统相对独立、协同困难的问题,分析总结了SWE(Sensor Web Enablement)标准,并在此基础上提出了空天资源对地观测协同任务规划服务模型。在此模型中,为实现观测资源共享,建立了空天观测资源传感器描述模型,能够描述典型空天资源的载荷平台、观测机理、定位信息、使用约束和工作特性等信息;为简化观测请求交互流程,基于SOA技术对SWE标准操作进行封装及简化,用户可以在不了解观测平台细节信息的情况下提交观测数据请求。为验证模型有效性,构建了空天资源对地观测协同任务规划实验平台,结果表明该模型具有较强的可实现性和适应性。
