The Cd puzzle implies that the phonon excitation of a spherical nucleus should be questioned and refuted.To understand the newly and experimentally discovered spherical-like γ-soft mode,the SU3-IBM was recently propo...The Cd puzzle implies that the phonon excitation of a spherical nucleus should be questioned and refuted.To understand the newly and experimentally discovered spherical-like γ-soft mode,the SU3-IBM was recently proposed In this study,the evolutions ofthe normal states in ^(108-120)Cd are investigated and compared with the experimental results.To better explain the nearly zero B(E2)values between the O_(2)^(+) and 2_(1)^(+) states,SU(3)higherorder interactions except for the SU(3)second-order and third-order Casimir operators are also considered in detail.We find that the results of theoretical fitting and experimental data agree well with simple parameter selection,and the spherical-like spectra truly exist.The deficiency may arise from the lack of configuration mixing.The realistic spectra characteristicsof thespherical-like spectrare found for ^(118,120)Cd,and the electricquadrupole moments of the 2_(1)^(+) state are predicted.The Q2_(1)^(+)anomaly in ^(108-116)Cd is also discussed.展开更多
Recently,studies have argued that a spherical-like spectrum emerges in the SU3-IBM,thus creating new approaches to understanding y-softness in realistic nuclei.In a previous study,γ-softness with degeneracy of the gr...Recently,studies have argued that a spherical-like spectrum emerges in the SU3-IBM,thus creating new approaches to understanding y-softness in realistic nuclei.In a previous study,γ-softness with degeneracy of the ground and quasi-y bands was observed.In this paper,another special point connected to the middle degenerate point is discussed.It is found to be related to the properties of^(196)Pt.This emergentγ-softness is also shown to be important for understanding the prolate-oblate asymmetric shape phase transition.The low-lying spectra,B(E2)values,and quadrupole moments in^(196)Pt are discussed,and we show that the new model can account for several observed features.This is the first part of the discussion on theγ-soft-like spectrum of^(196)Pt.展开更多
Glioma stem cells are considered responsible for drug resistance and glioma relapse resulting in poor prognosis in glioblastoma multiforme. SU3 glioma cell is a highly invasive glioma stem cell line from the patients ...Glioma stem cells are considered responsible for drug resistance and glioma relapse resulting in poor prognosis in glioblastoma multiforme. SU3 glioma cell is a highly invasive glioma stem cell line from the patients with glioblastoma multifrome. It is of great significance to study the efficacy and molecular mechanism for anticancer drug effects on SU3 glioma cells. In this work, we develop a liquid chromatography–mass spectrometry（LC–MS） method for direct analysis of the role of drugs（paclitaxel）on SU3 glioma cells at the molecular level. We use the specific fluorescence dyes to evaluate cell viability,the levels of ROS and GSH when the cells were treated with drugs. In addition, the LC–MS platform was successfully employed to detect the amount of 6-O-methylguanine, demonstrating that it is effective to induce cell apoptosis and enhance the cytotoxic response of SU3 glioma cells. The analytical linear equals are Y = 9.49 ？ 105 X ＋ 2.42 ？ 104 for 6-O-methylguanine（R2= 0.9998） and Y = 4.72 ？ 104 X ＋ 2.21 ？ 103（R2= 0.9996） for 7-methylguanine. Thus, the combination of cell-specific fluorescence dyes and LC–MS method enables us to reveal the molecular mechanism of paclitaxel-inhibited growth and enhanced therapeutic response in the chemotherapy for glioma multiforme.展开更多
基金Supported by the Educational Department of Jilin Province,China(JJKH20210526KJ)supported by the National Natural Science Foundation of China(11875158)。
文摘The Cd puzzle implies that the phonon excitation of a spherical nucleus should be questioned and refuted.To understand the newly and experimentally discovered spherical-like γ-soft mode,the SU3-IBM was recently proposed In this study,the evolutions ofthe normal states in ^(108-120)Cd are investigated and compared with the experimental results.To better explain the nearly zero B(E2)values between the O_(2)^(+) and 2_(1)^(+) states,SU(3)higherorder interactions except for the SU(3)second-order and third-order Casimir operators are also considered in detail.We find that the results of theoretical fitting and experimental data agree well with simple parameter selection,and the spherical-like spectra truly exist.The deficiency may arise from the lack of configuration mixing.The realistic spectra characteristicsof thespherical-like spectrare found for ^(118,120)Cd,and the electricquadrupole moments of the 2_(1)^(+) state are predicted.The Q2_(1)^(+)anomaly in ^(108-116)Cd is also discussed.
基金supported by the Educational Department of Jilin Province,China(JJKH20210526KJ)support from the Project Supported by Scientific Research Fund of Hunan University of Art and Science(23ZZ04)。
文摘Recently,studies have argued that a spherical-like spectrum emerges in the SU3-IBM,thus creating new approaches to understanding y-softness in realistic nuclei.In a previous study,γ-softness with degeneracy of the ground and quasi-y bands was observed.In this paper,another special point connected to the middle degenerate point is discussed.It is found to be related to the properties of^(196)Pt.This emergentγ-softness is also shown to be important for understanding the prolate-oblate asymmetric shape phase transition.The low-lying spectra,B(E2)values,and quadrupole moments in^(196)Pt are discussed,and we show that the new model can account for several observed features.This is the first part of the discussion on theγ-soft-like spectrum of^(196)Pt.
基金supported by National Nature Science Foundation of China(Nos.214350002,81373373)CERS-China Equipment and Education Resources System(No.CERS-1-75)
文摘Glioma stem cells are considered responsible for drug resistance and glioma relapse resulting in poor prognosis in glioblastoma multiforme. SU3 glioma cell is a highly invasive glioma stem cell line from the patients with glioblastoma multifrome. It is of great significance to study the efficacy and molecular mechanism for anticancer drug effects on SU3 glioma cells. In this work, we develop a liquid chromatography–mass spectrometry（LC–MS） method for direct analysis of the role of drugs（paclitaxel）on SU3 glioma cells at the molecular level. We use the specific fluorescence dyes to evaluate cell viability,the levels of ROS and GSH when the cells were treated with drugs. In addition, the LC–MS platform was successfully employed to detect the amount of 6-O-methylguanine, demonstrating that it is effective to induce cell apoptosis and enhance the cytotoxic response of SU3 glioma cells. The analytical linear equals are Y = 9.49 ？ 105 X ＋ 2.42 ？ 104 for 6-O-methylguanine（R2= 0.9998） and Y = 4.72 ？ 104 X ＋ 2.21 ？ 103（R2= 0.9996） for 7-methylguanine. Thus, the combination of cell-specific fluorescence dyes and LC–MS method enables us to reveal the molecular mechanism of paclitaxel-inhibited growth and enhanced therapeutic response in the chemotherapy for glioma multiforme.
