胃型胃癌中的印戒细胞癌(Signet ring cell carcinoma,SRCC),具有分化程度低、侵袭性高以及预后差等特点。本研究利用大样本的胃印戒细胞癌患者的临床数据,采用机器学习算法建立生存预测模型,从分类和回归的角度,预测胃印戒细胞癌患者...胃型胃癌中的印戒细胞癌(Signet ring cell carcinoma,SRCC),具有分化程度低、侵袭性高以及预后差等特点。本研究利用大样本的胃印戒细胞癌患者的临床数据,采用机器学习算法建立生存预测模型,从分类和回归的角度,预测胃印戒细胞癌患者的治愈情况和生存周期。分别使用决策树、随机森林、支持向量机算法和反向传播(Backpropagation,BP)神经网络模型建立分类模型,通过对比各模型在测试集上的预测结果发现,BP神经网络模型的预测准确率达到了82%,召回率为80%,泛化能力最好,模型的预测效果最优。同时,使用加速失效时间(Accelerated failuretime,AFT)与COX回归(COX regression,COX)模型,指标一致性指数(Concordance index,C-index)和赤池信息量准则(Akaike information criterion,AIC)值的评估结果显示,COX回归模型的预测能力较好。最后,使用Kaplan-Meier生存分析算法绘制生存曲线,探究患者生存期概率的影响因素。结果显示,年龄、肿瘤淋巴结转移(Tumor node metastasis,TNM)分期以及手术等因素对患者生存期的概率影响较为明显。展开更多
Signet-ring cell carcinoma(SRCC) of ampulla of Vater is extremely uncommon,and less than 15 cases have been reported so far in literature.It mainly occurs in elderly people(median age 57 years).We report a rare case o...Signet-ring cell carcinoma(SRCC) of ampulla of Vater is extremely uncommon,and less than 15 cases have been reported so far in literature.It mainly occurs in elderly people(median age 57 years).We report a rare case of SRCC of the ampulla of Vater in a 38-year-old woman who presented with a small tumor at the Vater,discovered by the contrast-enhanced ultrasound(CEUS).Histopathological examination showed prominent signet-ring features.We also describe the imaging features of SRCC of ampulla of Vater in CEUS.展开更多
基金Supported by The Educational Fund of Liaoning Province,No.2008795
文摘Signet-ring cell carcinoma(SRCC) of ampulla of Vater is extremely uncommon,and less than 15 cases have been reported so far in literature.It mainly occurs in elderly people(median age 57 years).We report a rare case of SRCC of the ampulla of Vater in a 38-year-old woman who presented with a small tumor at the Vater,discovered by the contrast-enhanced ultrasound(CEUS).Histopathological examination showed prominent signet-ring features.We also describe the imaging features of SRCC of ampulla of Vater in CEUS.
