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Keyword Spotting Based on Dual-Branch Broadcast Residual and Time-Frequency Coordinate Attention
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作者 Zeyu Wang Jian-Hong Wang Kuo-Chun Hsu 《Computers, Materials & Continua》 2026年第4期333-352,共20页
In daily life,keyword spotting plays an important role in human-computer interaction.However,noise often interferes with the extraction of time-frequency information,and achieving both computational efficiency and rec... In daily life,keyword spotting plays an important role in human-computer interaction.However,noise often interferes with the extraction of time-frequency information,and achieving both computational efficiency and recognition accuracy on resource-constrained devices such as mobile terminals remains a major challenge.To address this,we propose a novel time-frequency dual-branch parallel residual network,which integrates a Dual-Branch Broadcast Residual module and a Time-Frequency Coordinate Attention module.The time-domain and frequency-domain branches are designed in parallel to independently extract temporal and spectral features,effectively avoiding the potential information loss caused by serial stacking,while enhancing information flow and multi-scale feature fusion.In terms of training strategy,a curriculum learning approach is introduced to progressively improve model robustness fromeasy to difficult tasks.Experimental results demonstrate that the proposed method consistently outperforms existing lightweight models under various signal-to-noise ratio(SNR)conditions,achieving superior far-field recognition performance on the Google Speech Commands V2 dataset.Notably,the model maintains stable performance even in low-SNR environments such as–10 dB,and generalizes well to unseen SNR conditions during training,validating its robustness to novel noise scenarios.Furthermore,the proposed model exhibits significantly fewer parameters,making it highly suitable for deployment on resource-limited devices.Overall,the model achieves a favorable balance between performance and parameter efficiency,demonstrating strong potential for practical applications. 展开更多
关键词 Keyword spotting convolutional neural network residual learning ATTENTION small footprint noisy far-field
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Adaptability Analysis of Dual Clearing Systems in Spot Electricity Markets Based on Fuzzy Evaluation Metrics:An Inner Mongolia Case Study
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作者 Kai Xie Shaoqing Yuan +4 位作者 Dayun Zou Jinran Wang Genjun Chen Ciwei Gao Yinghao Cao 《Energy Engineering》 2026年第2期348-368,共21页
The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt ... The construction of spot electricity markets plays a pivotal role in power system reforms,where market clearing systems profoundly influence market efficiency and security.Current clearing systems predominantly adopt a single-system architecture,with research focusing primarily on accelerating solution algorithms through techniques such as high-efficiency parallel solvers and staggered decomposition of mixed-integer programming models.Notably absent are systematic studies evaluating the adaptability of primary-backup clearing systems incontingency scenarios—a critical gap given redundant systems’expanding applications in operational environments.This paper proposes a comprehensive evaluation framework for analyzing dual-system adaptability,demonstrated through an in-depth case study of the Inner Mongolia power market.First,we establish the innovative“Dual-Active Heterogeneous”architecture that enables independent parallelized operation and fault-isolated redundancy.Subsequently,key performance indices are quantitatively evaluated across four critical dimensions:unit commitment decisions,generator output constraints,transmission section congestion patterns,and clearing price formation mechanisms.An integrated fuzzy evaluation methodology incorporating grey relational analysis is employed for objective indicator weighting,enabling systematic quantification of system superiority under specific grid operating states.Empirical results based on actual operational data from 200 generation units demonstrate the framework’s efficacy in guiding optimal system selection,with particularly strong performance observed during peak load periods.The proposed approach shows high generalization potential for other regional markets employing redundant clearing mechanisms—particularly those with increasing renewable penetration and associated uncertainty. 展开更多
关键词 spot electricity markets dual clearing systems fuzzy comprehensive evaluation system adaptability primary-backup switching
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Microstructure evolution and corrosion behavior of refill friction stir spot welding joint for dissimilar Al alloys
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作者 Fang-yuan JIANG Da ZHANG +3 位作者 Yan-kun MA Jiang-tao XIONG Wei GUO Jing-long LI 《Transactions of Nonferrous Metals Society of China》 2026年第1期80-95,共16页
The dissimilar 2B06 and 7B04 Al alloy joints were prepared by refill friction stir spot welding(RFSSW),and the microstructural evolution and corrosion behavior of the joints were investigated.Based on microstructural ... The dissimilar 2B06 and 7B04 Al alloy joints were prepared by refill friction stir spot welding(RFSSW),and the microstructural evolution and corrosion behavior of the joints were investigated.Based on microstructural analysis,the welded joints exhibit distinct microstructural zones,including the stir zone(SZ),thermomechanically affected zone(TMAZ),and heat-affected zone(HAZ).The grain size of each zone is in the order of HAZ>TMAZ>SZ.Notably,the TMAZ and HAZ contain significantly larger secondary-phase particles compared to the SZ,with particle size in the HAZ increasing at higher rotational speeds.Electrochemical tests indicate that corrosion susceptibility follows the sequence of HAZ>TMAZ>SZ>BM,with greater sensitivity observed at increased rotational speeds.Post-corrosion mechanical performance degradation primarily arises from crevice corrosion at joint overlaps,but not from the changes in the microstructure. 展开更多
关键词 refill friction stir spot welding high strength Al alloy dissimilar joint microstructure evolution corrosion behavior
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Time Delay Estimation of Target Echo Signal Based on Multi-bright Spot Echoes
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作者 Ge Yu Fan Du +1 位作者 Xiukun Li Yan Li 《哈尔滨工程大学学报(英文版)》 2026年第1期312-325,共14页
Accurate time delay estimation of target echo signals is a critical component of underwater target localization.In active sonar systems,echo signal processing is vulnerable to the effects of reverberation and noise in... Accurate time delay estimation of target echo signals is a critical component of underwater target localization.In active sonar systems,echo signal processing is vulnerable to the effects of reverberation and noise in the maritime environment.This paper proposes a novel method for estimating target time delay using multi-bright spot echoes,assuming the target’s size and depth are known.Aiming to effectively enhance the extraction of geometric features from the target echoes and mitigate the impact of reverberation and noise,the proposed approach employs the fractional order Fourier transform-frequency sliced wavelet transform to extract multi-bright spot echoes.Using the highlighting model theory and the target size information,an observation matrix is constructed to represent multi-angle incident signals and obtain the theoretical scattered echo signals from different angles.Aiming to accurately estimate the target’s time delay,waveform similarity coefficients and mean square error values between the theoretical return signals and received signals are computed across various incident angles and time delays.Simulation results show that,compared to the conventional matched filter,the proposed algorithm reduces the relative error by 65.9%-91.5%at a signal-to noise ratio of-25 dB,and by 66.7%-88.9%at a signal-to-reverberation ratio of−10 dB.This algorithm provides a new approach for the precise localization of submerged targets in shallow water environments. 展开更多
关键词 Multi-bright spot echoes Time-delay estimation Target echo signal Frequency sliced wavelet transform Fractional order fourier transform
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外周血T-SPOT和TB-Ab联合呼吸道标本TB-DNA对艾滋病合并肺结核诊断中的应用研究
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作者 钟希 漆阳红 李根 《临床医药实践》 2026年第2期123-127,共5页
目的:探讨外周血结核感染T细胞斑点试验(T-SPOT)、结核抗体(TB-Ab)联合呼吸道标本结核分歧杆菌核酸(TB-DNA)对艾滋病合并肺结核的诊断价值。方法:选取2021年7月-2024年7月萍乡市第二人民医院收治的40例艾滋病合并肺结核患者为观察1组,... 目的:探讨外周血结核感染T细胞斑点试验(T-SPOT)、结核抗体(TB-Ab)联合呼吸道标本结核分歧杆菌核酸(TB-DNA)对艾滋病合并肺结核的诊断价值。方法:选取2021年7月-2024年7月萍乡市第二人民医院收治的40例艾滋病合并肺结核患者为观察1组,同期接收的40例单纯肺结核患者为观察2组,同时选取40例健康体检者为对照组。分别采集血液标本和呼吸道标本,检测T-SPOT,TB-Ab和TB-DNA,采用受试者工作特征(ROC)曲线分析T-SPOT,TB-Ab和TB-DNA单项检测及联合检测对艾滋病合并肺结核的诊断价值。结果:观察1组与观察2组患者的T-SPOT,TB-Ab和TB-DNA阳性检出率均高于对照组,差异有统计学意义(P<0.05)。观察2组患者的T-SPOT,TB-Ab和TB-DNA阳性检出率均略高于观察1组,但差异无统计学意义(P>0.05)。联合检测对艾滋病合并肺结核患者的阳性检出率均高于3项指标单项检测,差异有统计学意义(P<0.05)。联合检测对健康体检者的阳性检出率低于TB-Ab单项检测,差异有统计学意义(P<0.05)。联合检测诊断艾滋病合并肺结核的曲线下面积(AUC)均高于3项指标单项检测(P<0.05)。结论:T-SOPT,TB-Ab和TB-DNA对艾滋病合并肺结核有良好的诊断作用,联合检测可进一步提高阳性检出率及诊断效能。 展开更多
关键词 艾滋病 肺结核 结核感染T细胞斑点试验 结核抗体 结核分歧杆菌核酸
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天津地区684例学龄前儿童视力和Spot筛查仪屈光筛查结果调查分析 被引量:1
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作者 刘晖 《黑龙江医学》 2025年第1期83-85,共3页
目的:调查天津地区684例学龄前儿童的视力状况并分析其Spot筛查仪屈光筛查结果。方法:选取2022年1—12月在天津市妇女儿童保健中心眼科门诊进行裸眼视力检查及Spot屈光筛查的684例学龄前儿童作为研究对象。使用常规视力检查调查684例学... 目的:调查天津地区684例学龄前儿童的视力状况并分析其Spot筛查仪屈光筛查结果。方法:选取2022年1—12月在天津市妇女儿童保健中心眼科门诊进行裸眼视力检查及Spot屈光筛查的684例学龄前儿童作为研究对象。使用常规视力检查调查684例学龄前儿童的视力状况,使用Spot筛查仪进行屈光筛查并分析Spot筛查仪屈光筛查结果。结果:本研究最终纳入680例学龄前儿童,检查结果显示,680例学龄前儿童中有48例视力低常,检出率7.06%;不同年龄段学龄前儿童检出率比较,差异有统计学意义(χ^(2)=7.686,P<0.05);不同年龄段学龄前儿童间柱镜度比较,差异有统计学意义(H=17.964,P<0.05)。结论:Spot筛查仪操作简单,屈光检查数值获取率高,在大规模学龄前儿童筛查中具有较高应用价值,可以帮助了解学龄前儿童屈光状态,尽早发现屈光异常。 展开更多
关键词 学龄前儿童 视力状况 spot筛查仪 屈光筛查
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Diagnosis of focal spots at relativistic intensity utilizing coherent radiation from laser-driven flying electron sheets
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作者 Shirui Xu Zhuo Pan +22 位作者 Ying Gao Jiarui Zhao Shiyou Chen Zhusong Mei Xun Chen Ziyang Peng Xuan Liu Yulan Liang Tianqi Xu Tan Song Qingfan Wu Yujia Zhang Zhipeng Liu Zihao Zhang Haoran Chen Qihang Han Jundong Shen Chenghao Hua Kun Zhu Yanying Zhao Chen Lin Xueqing Yan Wenjun Ma 《Matter and Radiation at Extremes》 2025年第2期16-23,共8页
Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challe... Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity. 展开更多
关键词 diagnosis focal spot peak intensity laser foil interactions laser fi coherent radiation farfiel patterns laser driven electron sheets experimental validation laser intensity focal spot coherent radiation
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Spot视力筛查仪和自动电脑验光仪测量学龄前儿童屈光结果比较 被引量:1
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作者 章敏 徐武平 +1 位作者 蔡苏博 徐学东 《国际眼科杂志》 2025年第9期1537-1540,共4页
目的:比较自然瞳孔状态下Spot视力筛查仪和自动电脑验光仪测量学龄前儿童屈光结果的差异和相关性。方法:横断面研究。采用随机方法于2021年10月至2021年11月抽取江阴市某幼儿园大班儿童311名,分别用Spot视力筛查仪与自动电脑验光进行验... 目的:比较自然瞳孔状态下Spot视力筛查仪和自动电脑验光仪测量学龄前儿童屈光结果的差异和相关性。方法:横断面研究。采用随机方法于2021年10月至2021年11月抽取江阴市某幼儿园大班儿童311名,分别用Spot视力筛查仪与自动电脑验光进行验光检查。通过Thibos矢量分析法将散光分解为J_(0)和J_(45),两种仪器测量等效球镜度数、球镜度数、柱镜度数、J_(0)和J_(45)的差异,采用Spearman行相关分析。结果:纳入311名儿童中有1名儿童因球镜度数<-7.50 D,超出Spot视力筛查仪检测范围(-7.50-+7.50 D)而予数据剔除,最终共纳入310名儿童,均取右眼数据进行分析。Spot视力筛查仪与自动电脑验光测量等效球镜度数比较无差异(P=0.598),两种设备测量球镜度数、柱镜度数、J_(0)、J_(45)比较均有差异(均P<0.001);两组仪器所测结果均呈正相关[等效球镜度数(r_(s)=0.350,P<0.001),球镜度数(r_(s)=0.403,P<0.001),柱镜度数(r_(s)=0.545,P<0.001),J_(0)(r_(s)=0.672,P<0.001),J_(45)(r_(s)=0.439,P<0.001)]。结论:Spot视力筛查仪和自动电脑验光仪的检查结果不能相互替代,两种设备在视力筛查中应设置不同转诊指标。 展开更多
关键词 spot视力筛查仪 自动电脑验光仪 差异 相关性
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SPOT和Bayes递推估计融合的运载火箭样本量设计
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作者 黄彭奇子 段晓君 张银辉 《国防科技大学学报》 北大核心 2025年第1期207-213,共7页
针对运载火箭小子样条件,结合序贯验后加权检验(sequential posterior odd test, SPOT)和Bayes递推估计法,分别从假设检验和参数估计两方面,对传统试验样本量评估方法进行改进。在对运载火箭服从正态分布的性能指标进行评估时,引入复合... 针对运载火箭小子样条件,结合序贯验后加权检验(sequential posterior odd test, SPOT)和Bayes递推估计法,分别从假设检验和参数估计两方面,对传统试验样本量评估方法进行改进。在对运载火箭服从正态分布的性能指标进行评估时,引入复合等效系数来有效融合多源数据,弥补真实试验数据或现场数据的不足。综合考虑两类风险和置信度要求,制定合理的评估方案,有效减少所需试验样本数量,从而控制试验成本。通过算例分析发现,提出样本量评估方法结果真实可信,能够有效降低样本量需求,可较好用于小子样条件下的运载火箭样本量试验设计。 展开更多
关键词 样本量评估 spot BAYES估计
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A model for predicting marine shale gas sweet spots based on relative sea-level changes and its application 被引量:1
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作者 Hongyan Wang Zhensheng Shi +2 位作者 Xi Yang Qun Zhao Changmin Guo 《Energy Geoscience》 2025年第2期142-154,共13页
Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sw... Gas-bearing shales have become a major source of future natural gas production worldwide.It has become increasingly urgent to develop a reliable prediction model and corresponding workflow for identifying shale gas sweet spots.The formation of gas-bearing shales is closely linked to relative sealevel changes,providing an important approach to predicting sweet spots in the Wufeng-Longmaxi shale in the southern Sichuan Basin,China.Three types of marine shale gas sweet spots are identified in the shale based on their formation stages combined with relative sea-level changes:early,middle,and late transgression types.This study develops a prediction model and workflow for identifying shale gas sweet spots by analyzing relative sea-level changes and facies sequences.Predicting shale gas sweet spots in an explored block using this model and workflow can provide a valuable guide for well design and hydraulic fracturing,significantly enhancing the efficiency of shale gas exploration and development.Notably,the new prediction model and workflow can be utilized for the rapid evaluation of the potential for shale gas development in new shale gas blocks or those with low exploratory maturity. 展开更多
关键词 Shale gas Sweet spot Relative sea-level change Wufeng-longmaxi shale Southern sichuan basin
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Analysis of Renewable Energy Absorption and Economic Feasibility in Multi-Energy Complementary Systems under Spot Market Conditions 被引量:1
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作者 Xiuyun Wang Zipeng Zhang +1 位作者 Chuang Liu Guoliang Bian 《Energy Engineering》 2025年第2期577-619,共43页
As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy o... As the power system transitions to a new green and low-carbon paradigm,the penetration of renewable energy in China’s power system is gradually increasing.However,the variability and uncertainty of renewable energy output limit its profitability in the electricity market and hinder its market-based integration.This paper first constructs a wind-solar-thermalmulti-energy complementary system,analyzes its external game relationships,and develops a bi-level market optimization model.Then,it considers the contribution levels of internal participants to establish a comprehensive internal distribution evaluation index system.Finally,simulation studies using the IEEE 30-bus system demonstrate that the multi-energy complementary system stabilizes nodal outputs,enhances the profitability of market participants,and promotes the market-based integration of renewable energy. 展开更多
关键词 Multi-energy complementary systems spot market two-layer optimization new energy consumption
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Fatigue and deformation mechanisms of ultrasonic spot-welded dissimilar joints of a magnesium alloy to a clad aluminum alloy 被引量:1
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作者 Soumya Sobhan Dash Rylan Christopher Fernandes +7 位作者 Xiao Shang Yu Zou He Peng Xianquan Jiang Xiangfan Fang Ninshu Ma Dongyang Li Daolun Chen 《Journal of Magnesium and Alloys》 2025年第5期1939-1952,共14页
A low rare-earth containing ZEK100-O magnesium alloy was welded to AA1230-clad high-strength AA2024-T3 aluminum alloy via solidstate ultrasonic spot welding(USW)to evaluate the microstructure,tensile lap shear strengt... A low rare-earth containing ZEK100-O magnesium alloy was welded to AA1230-clad high-strength AA2024-T3 aluminum alloy via solidstate ultrasonic spot welding(USW)to evaluate the microstructure,tensile lap shear strength,and fatigue properties.The tensile strength increased with increasing welding energy,peaked at a welding energy of 1000 J,and then decreased due to the formation of an increasingly thick diffusion layer mainly containing Al12Mg17intermetallic compound at higher energy levels.The peak tensile lap shear strength attained at 1000 J was attributed to the optimal inter-diffusion between the magnesium alloy and softer AA1230-clad Al layer along with the presence of‘fishhook'-like mechanical interlocks at the weld interface and the formation of an indistinguishable intermetallic layer.The dissimilar joints welded at 1000 J also exhibited a longer fatigue life than other Mg-Al dissimilar joints,suggesting the beneficial role of the softer clad layer with a better intermingling capacity during USW.While the transverse-through-thickness(TTT)failure mode prevailed at lower cyclic loading levels,interfacial failure was the predominant mode of fatigue failure at higher cyclic loads,where distinctive fatigue striations were also observed on the fracture surface of the softer clad Al layer.This was associated with the presence of opening stress and bending moment near the nugget edge despite the tension-tension lap shear cyclic loading applied. 展开更多
关键词 Ultrasonic spot welding Magnesium alloy Clad aluminum alloy Tensile lap shear strength Fatigue life
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High-precision spot centroid positioning of high-frame-rate short-wave infrared images for satellite laser communication
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作者 FU Peng HE Dao-Gang +1 位作者 LIU Jun WANG Yue-Ming 《红外与毫米波学报》 北大核心 2025年第1期66-77,共12页
The accuracy of spot centroid positioning has a significant impact on the tracking accuracy of the system and the stability of the laser link construction.In satellite laser communication systems,the use of short-wave... The accuracy of spot centroid positioning has a significant impact on the tracking accuracy of the system and the stability of the laser link construction.In satellite laser communication systems,the use of short-wave infrared wavelengths as beacon light can reduce atmospheric absorption and signal attenuation.However,there are strong non-uniformity and blind pixels in the short-wave infrared image,which makes the image distorted and leads to the decrease of spot centroid positioning accuracy.Therefore,the high-precision localization of the spot centroid of the short-wave infrared images is of great research significance.A high-precision spot centroid positioning model for short-wave infrared is proposed to correct for non-uniformity and blind pixels in short-wave infrared images and quantify the localization errors caused by the two,further model-based localization error simulations are performed,and a novel spot centroid positioning payload for satellite laser communications has been designed using the latest 640×512 planar array InGaAs shortwave infrared detector.The experimental results show that the non-uniformity of the corrected image is reduced from 7%to 0.6%,the blind pixels rejection rate reaches 100%,the frame rate can be up to 2000 Hz,and the spot centroid localization accuracy is as high as 0.1 pixel point,which realizes high-precision spot centroid localization of high-frame-frequency short-wave infrared images. 展开更多
关键词 satellite laser communication spot centroid positioning short-wave infrared high frame rate NONUNIFORMITY
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Research Progress and Challenges of Tobacco Brown Spot
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作者 Dongkun WANG Ping LYU +12 位作者 Bin WANG Jijun NIU Guohua ZONG Yongqing XU Hairong XU Xiaojie BAI Weina ZHANG Yushan ZHANG Hanyu WU Songwei LIU Xianzhi ZHU Feng LI Lei TIAN 《Plant Diseases and Pests》 2025年第2期1-7,共7页
This paper provide a comprehensive overview of research findings regarding the pathogen responsible for tobacco brown spot,its occurrence regularity,and integrated control strategies.Additionally,this study provide a ... This paper provide a comprehensive overview of research findings regarding the pathogen responsible for tobacco brown spot,its occurrence regularity,and integrated control strategies.Additionally,this study provide a brief analysis of the challenges encountered in the study of tobacco brown spot,which include the study of pathogenesis and virulence,the breeding of disease-resistant varieties,the screening of low-toxicity and high-efficiency agents,the development of biological control methods with more stable efficacy,and the necessity for accurate prediction and forecasting techniques. 展开更多
关键词 TOBACCO BROWN spot INTEGRATED control CHALLENGE
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T-SPOT.TB在肺结节病与肺结核鉴别诊断中的应用价值 被引量:17
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作者 叶秋月 许文兵 +1 位作者 刘晓清 张丽帆 《基础医学与临床》 CSCD 北大核心 2014年第4期527-530,共4页
目的通过T-SPOT-TB检测,探讨其在肺结节病和肺结核鉴别诊断中的应用价值。方法检测2008年1月至2011年3月在北京协和医院确诊的44例肺结节病和30例肺结核患者并进行对比。结果44例肺结节病患者T-SPOT.3B阳性12例(27.3%),30例肺结... 目的通过T-SPOT-TB检测,探讨其在肺结节病和肺结核鉴别诊断中的应用价值。方法检测2008年1月至2011年3月在北京协和医院确诊的44例肺结节病和30例肺结核患者并进行对比。结果44例肺结节病患者T-SPOT.3B阳性12例(27.3%),30例肺结核患者阳性27例(90%);肺结节病患者ESAT-6和CFP.10肽段合并的分泌IFN-7细胞频数是46 SFCs/106 PBMC(IQR28~204),显著低于肺结核患者565SFCs/106 PBMC(IQR170~2340)。结论T-SPOT-TB检测有助于鉴别诊断肺结节病与肺结核。 展开更多
关键词 肺结节病 肺结核 鉴别诊断 ELIspot T-spot-TB
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Pigmented skin spots:Morphological characteristics,common causes,and treatment with cosmetic ingredients
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作者 Xin Nie Sen Hou Anzhang Li 《Journal of Dermatologic Science and Cosmetic Technology》 2025年第4期11-18,共8页
Pigmented skin spots,a visible sign of aging,can significantly affect the appearance of facial skin.To elucidate their pathogenesis and support the development of novel cosmetic ingredients,this review summarizes the ... Pigmented skin spots,a visible sign of aging,can significantly affect the appearance of facial skin.To elucidate their pathogenesis and support the development of novel cosmetic ingredients,this review summarizes the morphological characteristics of pigmented skin spots and the extrinsic and intrinsic factors contributing to their development.Additionally,it highlights the common cosmetic ingredients currently used for reducing hyperpigmentation.The relevant literature was collected by searching PubMed and Wanfang Data for studies focusing on pigmented spots and facial spots.Overall,the literature indicates that pigmented spots display distinct morphological characteristics,including specialized melanocyte dendrites,altered vascular architecture,abnormal keratinization,and immune cell infiltration.Mechanistically,their formation is driven by both extrinsic factors(e.g.,sun exposure,skin microbiota,and particulate matter)as well as intrinsic factors(e.g.,vascular abnormalities,chronic inflammation,and hormonal fluctuations).Thus,pigmented skin spots represent a complex biological system encompassing multiple types of cells and molecular mediators,regulated by diverse environmental and physiological factors.Given their intricate microenvironment conditions and multifactorial etiology,a systematic and comprehensive investigation of pigmented spots is warranted.Such research could inform the development of cosmetic ingredients with targeted and multitargeted actions,enabling the more effective reduction of pigmented skin spots. 展开更多
关键词 Pigmented spots Skin hyperpigmentation Cosmetic ingredients Pathogenesis
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Differences of Morphology and Muscle Transcriptomes Reveal the Individual Difference of Swimming Performance in Juvenile Spotted Sea Bass(Lateolabrax maculatus)
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作者 LI Haoyang LI Hao +7 位作者 LI Chengtian JIN Xi LI Weiwei WEN Haishen LI Yun LAI Qianyan NIU Chunxiang QI Xin 《Journal of Ocean University of China》 2025年第3期707-720,共14页
Deep-sea aquaculture is an emerging trend due to the contamination and overexploitation of nearshore mariculture areas.However,the complex water conditions in the deep sea impose higher demands on the swimming perform... Deep-sea aquaculture is an emerging trend due to the contamination and overexploitation of nearshore mariculture areas.However,the complex water conditions in the deep sea impose higher demands on the swimming performance of farmed animals.Spotted sea bass(Lateolabrax maculatus)is one of the most economically important fish species in China.To investigate the mechanisms underlying the individual variations in swimming performance among spotted sea bass,we measured their critical swimming speed(U_(crit))and morphological phenotypes.Total length,body length,body weight,caudal region length,and condition factor showed significant positive correlations with absolute Ucrit.In contrast,caudal fin length and pectoral fin length tended to hinder the swimming performance of individual spotted sea bass.Additionally,white muscle tissues from fish exhibiting good swimming performance(relative U_(crit)>8.20 BL/s)and poor swimming performance(relative U_(crit)<7.31 BL/s)were sampled for RNA-seq.A total of 694 differential expression genes(DEGs)were identified through gene expression analysis,with significant enrichment in GO terms such as mitochondrial protein complex,ribosomal subunit,structural constituent of ribosome,and oxidative phosphorylation,as well as genes in KEGG pathways including ribosome and metabolic pathways.In conclusion,our study for the first time comprehensively elucidated the impact of morphology of spotted sea bass on its individual differences in swimming ability,and analyzed the genetic basis underlying swimming ability using transcriptomic methods.This study provides a theoretical basis for the potential breeding varieties of spotted sea bass suitable for deep-sea aquaculture. 展开更多
关键词 spotted sea bass critical swimming speed MORPHOLOGY RNA-seq
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Genome-Wide Analysis of Urea Transporter(ut)Gene Family in Spotted Sea Bass(Lateolabrax maculatus):Evolution and Differential Expression After Salinity Adaptation
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作者 YANG Rutao HUANG Zurui +8 位作者 LI Jinku WEN Haishen QI Xin ZHANG Kaiqiang ZHANG Jingru LIU Mengqun LI Jifang ZHANG Meizhao LI Yun 《Journal of Ocean University of China》 2025年第2期427-438,共12页
Urea is a major end product of nitrogen catabolism,serving as an osmolyte to regulate osmotic stress in fish exposed to varying water environments.It has been well known that urea transporters(UTs)facilitate the rapid... Urea is a major end product of nitrogen catabolism,serving as an osmolyte to regulate osmotic stress in fish exposed to varying water environments.It has been well known that urea transporters(UTs)facilitate the rapid movement of urea across cell membranes.However,researches on ut genes were predominantly focused on elasmobranchs and early developmental stages of fish.In this investigation,a total of three ut genes were identified in spotted sea bass.Phylogenetic,homology,and syntenic analyses were conducted to validate the annotation and assess the evolutionary relationships among ut genes.Both ut-a and ut-b genes have retained their evolutionary stability,demonstrating a significant level of homology between them.To gain deeper insights into the evolution of ut genes in spotted sea bass,we performed selective pressure analysis using site,branch,and branch-site models.The results suggested that positive selection likely played a significant role in shaping the evolution of the ut gene family.Furthermore,tissue-specific expression analyses revealed high expression levels of ut genes in osmoregulatory tissues such as the gill and kidney.Additionally,all three ut genes exhibited salinity-related expression patterns in gill and kidney tissues during both seawater-to-freshwater(SF)and freshwater-to-seawater(FS)adaptation.In situ hybridization results demonstrated the localization of both ut-a and ut-c mRNAs on the gill lamellae and adjacent gill filament epithelium.In summary,our study establishes a solid foundation for future research elucidating the evolutionary relationships and functional significance of ut genes during salinity acclimation in spotted sea bass and other teleost species. 展开更多
关键词 spotted sea bass urea transporter salinity transfer gene expression OSMOREGULATION
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Soft reduction control investigation of spot segregation in continuous casting bloom for 42CrMoA crankshaft steel
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作者 Hai-jie Wang Ze Zhang +4 位作者 De-guo Fan Chuan-hui Jiang Bin-bin Zhang Pu Wang Jia-quan Zhang 《Journal of Iron and Steel Research International》 2025年第3期695-706,共12页
The crankshaft is subjected to complex rotational centrifugal force,periodic gas inertia force,and reciprocating inertia force during its working process.Consequently,the homogeneity requirement for crankshaft steel i... The crankshaft is subjected to complex rotational centrifugal force,periodic gas inertia force,and reciprocating inertia force during its working process.Consequently,the homogeneity requirement for crankshaft steel is exceptionally high.The distribution characteristics of center segregation and spot segregation of continuous casting bloom 42CrMoA crankshaft steel were analyzed by experiments,and the control mechanism of spot segregation by soft reduction zone and reduction amount was discussed.When the center solid fraction is between 0.61 and 1.00,an 8-mm soft reduction has a negligible impact on the flow of liquid steel at the end of solidification.Although it effectively improves center segregation,the improvement of spot segregation is limited.On the other hand,when the center solid fraction is between 0.31 and 1.00,a reduction of 10–12 mm,along with an expanded reduction zone and increased reduction amount,significantly promotes the flow of liquid steel at the end of solidification,reduces the size of equiaxed grains,mitigates the center negative segregation,and decreases the maximum size of spot segregation from 2954.29 to 1354.07μm.The number of spot segregations and the solutes enrichment degree of C,Cr,and Mn have also been significantly improved.An appropriate soft reduction zone and reduction amount can markedly ameliorate the semi-macro spot segregation of crankshaft steel blooms,thereby providing high-quality raw materials for subsequent products and enhancing the competitiveness of crankshaft products. 展开更多
关键词 Continuous casting Soft reduction spot segregation Solute distribution Improvement mechanism
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Scenic Spots Get a Makeover
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作者 YUAN YUAN 《ChinAfrica》 2025年第12期48-50,共3页
As NPC performances surge in popularity,destinations are recruiting actors and building story-driven scenes to reinvent traditional tourism Eight days,seven cities-a whirlwind tour that defined actor Zheng Guolin’s w... As NPC performances surge in popularity,destinations are recruiting actors and building story-driven scenes to reinvent traditional tourism Eight days,seven cities-a whirlwind tour that defined actor Zheng Guolin’s work schedule during the National Day holiday a month ago.From 1 to 8 October,he maintained a relentless pace,not just logging miles but also switching between roles. 展开更多
关键词 national day holiday switching roles npc performances TOURISM ACTORS scenic spots story driven scenes
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