目的分析合成生物学领域的主路径。方法以“合成生物学”为主题词在Web of Science平台德温特专利数据库(DII)进行精准检索,得到专利数据集;构建专利引文网络,采用搜索路径连接数(SPLC)算法计算遍历权重,选择5种路径搜索方式,提取主路径...目的分析合成生物学领域的主路径。方法以“合成生物学”为主题词在Web of Science平台德温特专利数据库(DII)进行精准检索,得到专利数据集;构建专利引文网络,采用搜索路径连接数(SPLC)算法计算遍历权重,选择5种路径搜索方式,提取主路径,识别合成生物学技术创新热点。结果截至2023年6月5日,合成生物学领域共有专利申请432项,包含专利引文4987件。1992年至2021年,专利申请数量呈增长趋势,预计2025年和2030年专利申请数量将分别达到113项和216项;技术创新聚焦于基因合成及基因编辑相关研究。合成生物学领域局部后向主路径与全局主路径一致,识别出的专利数量最多,有14件,包含6条技术路线;局部前向主路径与全局关键路径主路径上的专利完全相同,仅技术轨迹有差异,识别出13件专利;局部前向主路径的技术路线最多,有12条。基于主路径分析,合成生物学领域技术创新主要聚焦于脂质体、样本处理方法、水凝胶、液滴网络等技术,高价值专利技术聚焦于生物打印、液滴封装、水凝胶网络等技术。结论主路径分析可识别技术发展轨迹及高价值专利,从情报学角度为合成生物学研究提供了信息支撑。展开更多
Background: Single port laparoscopic cholecystectomy (SPLC) is a widely performed advanced technique in laparoscopic surgery which has many benefits compare to conventional three port laparoscopic cholecystectomy (TPL...Background: Single port laparoscopic cholecystectomy (SPLC) is a widely performed advanced technique in laparoscopic surgery which has many benefits compare to conventional three port laparoscopic cholecystectomy (TPLC). The purpose of this study was to compare the patients’ satisfaction of SPLC and TPLC after one year of operation by using questionnaire which not only objective factors such as results of operation and hospital days but also subjective factor such as social and cosmetic quality of life. Materials and Methods: This study analyzed the data of 74 patients (SPLC = 42, TPLC = 32) who underwent the laparoscopic cholecystectomy between March and July 2013. The patients were asked to complete a patient-assessment questionnaire measuring the postoperative social and cosmetic quality-of-life values at the 12-month mark. Results: Statistically significant differences in the age, sex distribution, and body mass index are absent between the two groups. All the average scores of the different parameters of the social-activity aspect—satisfaction with physical condition, limitation of nutrition, stamina, postoperative pain level, returning to social life, impairment of social life, degree of complications, and cost-effectiveness of the surgery—are not statistically significant in both groups. Alternatively, all the results of the cosmetic aspect—scar influence on charms (p p = 0.015), and patient’s score of scars (p < 0.001)—show statistically significant differences. Conclusion: The SPLC is a safe and an attractive approach regarding the patients of this study. It offers a more effective cosmetic result that may be conveyed by a greater patient satisfaction.展开更多
文摘目的分析合成生物学领域的主路径。方法以“合成生物学”为主题词在Web of Science平台德温特专利数据库(DII)进行精准检索,得到专利数据集;构建专利引文网络,采用搜索路径连接数(SPLC)算法计算遍历权重,选择5种路径搜索方式,提取主路径,识别合成生物学技术创新热点。结果截至2023年6月5日,合成生物学领域共有专利申请432项,包含专利引文4987件。1992年至2021年,专利申请数量呈增长趋势,预计2025年和2030年专利申请数量将分别达到113项和216项;技术创新聚焦于基因合成及基因编辑相关研究。合成生物学领域局部后向主路径与全局主路径一致,识别出的专利数量最多,有14件,包含6条技术路线;局部前向主路径与全局关键路径主路径上的专利完全相同,仅技术轨迹有差异,识别出13件专利;局部前向主路径的技术路线最多,有12条。基于主路径分析,合成生物学领域技术创新主要聚焦于脂质体、样本处理方法、水凝胶、液滴网络等技术,高价值专利技术聚焦于生物打印、液滴封装、水凝胶网络等技术。结论主路径分析可识别技术发展轨迹及高价值专利,从情报学角度为合成生物学研究提供了信息支撑。
文摘Background: Single port laparoscopic cholecystectomy (SPLC) is a widely performed advanced technique in laparoscopic surgery which has many benefits compare to conventional three port laparoscopic cholecystectomy (TPLC). The purpose of this study was to compare the patients’ satisfaction of SPLC and TPLC after one year of operation by using questionnaire which not only objective factors such as results of operation and hospital days but also subjective factor such as social and cosmetic quality of life. Materials and Methods: This study analyzed the data of 74 patients (SPLC = 42, TPLC = 32) who underwent the laparoscopic cholecystectomy between March and July 2013. The patients were asked to complete a patient-assessment questionnaire measuring the postoperative social and cosmetic quality-of-life values at the 12-month mark. Results: Statistically significant differences in the age, sex distribution, and body mass index are absent between the two groups. All the average scores of the different parameters of the social-activity aspect—satisfaction with physical condition, limitation of nutrition, stamina, postoperative pain level, returning to social life, impairment of social life, degree of complications, and cost-effectiveness of the surgery—are not statistically significant in both groups. Alternatively, all the results of the cosmetic aspect—scar influence on charms (p p = 0.015), and patient’s score of scars (p < 0.001)—show statistically significant differences. Conclusion: The SPLC is a safe and an attractive approach regarding the patients of this study. It offers a more effective cosmetic result that may be conveyed by a greater patient satisfaction.
