It is important to search for the ingredients with SOD—like activity present in Chinese traditional drugs.Four classes of constituents including fifteen compounds isolated from Chinese rhubarb were studied for their ...It is important to search for the ingredients with SOD—like activity present in Chinese traditional drugs.Four classes of constituents including fifteen compounds isolated from Chinese rhubarb were studied for their SOD-like activity by determining the percentage of scavenging effect of the superoxide radical anion (O2),(S％),The results showed that the SOD-like activities of four tanninoid compounds were stronger among which(—)-epi- catechin has the strongest SOD-like activity at lower concentrations:the activity of five stil- bene compounds is weaker:while chrysophanol-8-glucoside and desoxyrhaponticin have no SOD-like activity and,on the contrary.may promote the production of O_2^-展开更多
Three complexes of Mn（Ⅱ）with L-amino acid[L-Isoleucine（L-Ile）,L-Methionine（L-Met）,L-Tryptophan（L-Trp）]were synthesized and characterized by elemental analysis,infrared spectra and gravithem metrical analyses....Three complexes of Mn（Ⅱ）with L-amino acid[L-Isoleucine（L-Ile）,L-Methionine（L-Met）,L-Tryptophan（L-Trp）]were synthesized and characterized by elemental analysis,infrared spectra and gravithem metrical analyses.The catalytic activity of the three complexes for disproportionation of O2-was determined by NBT method.The result shows that the complexes have a high SOD-like activity,and the KQ values of complexes 1,2 and 3 are 0.78×107mol-1·L·s-1,1.28×107mol-1,and 1.50×107mol-1L·s-1,respectively.展开更多
Two novel complexes [Cu（TATP）（L-Leu）（H2O）]NO3·H2O and [Cu（TATP）L-Met)（H2O）]NO3·0.5H2O（TATP=1,4,8,9-tetraazatriphenylene,L-Leu=L-Leucinate,L-Met=L-Methioninate）were synthesized and characterized b...Two novel complexes [Cu（TATP）（L-Leu）（H2O）]NO3·H2O and [Cu（TATP）L-Met)（H2O）]NO3·0.5H2O（TATP=1,4,8,9-tetraazatriphenylene,L-Leu=L-Leucinate,L-Met=L-Methioninate）were synthesized and characterized by elemental analysis,molar conductivity,infrared absorption spectrum,electronic absorption spectrum and DTA-TGA.The results showed that both of the complexes had a distorted square-pyramidal geometry with two nitrogen atoms of TATP and one amino nitrogen and one carboxylate oxygen atoms of L-Leu/L-Met at the equatorial positions,and one water oxygen at the axial position.The SOD-Like activity of the complexes was determined by NBT-illumination method.The result indicated that the complexes possessed excellent SOD-like activity and showed 50% inhibition ration in the concentration of 0.355 μmol·L-1 and 0.185 μmol·L-1,respectively.The greater SOD-like activity of the complex[Cu（TATP）（L-Leu）（H2O）]NO3·H2O may be attributed to the smaller spatial hindrance of the side-chain group of L-Met.展开更多
基金This project was supported by the National Natural Science Foundation of ChinaA preliminary report of this work has heen presented at the First International Symposium OH Rhubarb.Chengde China.May 30.1990
文摘It is important to search for the ingredients with SOD—like activity present in Chinese traditional drugs.Four classes of constituents including fifteen compounds isolated from Chinese rhubarb were studied for their SOD-like activity by determining the percentage of scavenging effect of the superoxide radical anion (O2),(S％),The results showed that the SOD-like activities of four tanninoid compounds were stronger among which(—)-epi- catechin has the strongest SOD-like activity at lower concentrations:the activity of five stil- bene compounds is weaker:while chrysophanol-8-glucoside and desoxyrhaponticin have no SOD-like activity and,on the contrary.may promote the production of O_2^-
文摘Three complexes of Mn（Ⅱ）with L-amino acid[L-Isoleucine（L-Ile）,L-Methionine（L-Met）,L-Tryptophan（L-Trp）]were synthesized and characterized by elemental analysis,infrared spectra and gravithem metrical analyses.The catalytic activity of the three complexes for disproportionation of O2-was determined by NBT method.The result shows that the complexes have a high SOD-like activity,and the KQ values of complexes 1,2 and 3 are 0.78×107mol-1·L·s-1,1.28×107mol-1,and 1.50×107mol-1L·s-1,respectively.
文摘Two novel complexes [Cu（TATP）（L-Leu）（H2O）]NO3·H2O and [Cu（TATP）L-Met)（H2O）]NO3·0.5H2O（TATP=1,4,8,9-tetraazatriphenylene,L-Leu=L-Leucinate,L-Met=L-Methioninate）were synthesized and characterized by elemental analysis,molar conductivity,infrared absorption spectrum,electronic absorption spectrum and DTA-TGA.The results showed that both of the complexes had a distorted square-pyramidal geometry with two nitrogen atoms of TATP and one amino nitrogen and one carboxylate oxygen atoms of L-Leu/L-Met at the equatorial positions,and one water oxygen at the axial position.The SOD-Like activity of the complexes was determined by NBT-illumination method.The result indicated that the complexes possessed excellent SOD-like activity and showed 50% inhibition ration in the concentration of 0.355 μmol·L-1 and 0.185 μmol·L-1,respectively.The greater SOD-like activity of the complex[Cu（TATP）（L-Leu）（H2O）]NO3·H2O may be attributed to the smaller spatial hindrance of the side-chain group of L-Met.
