The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted wor...The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted worldwide.The same recommendation,initially made during the coronavirus disease 2019(COVID-19)pandemic,was subsequently proven incorrect.In this clinical report,we present evidence,for the first time globally,from a real-life practice that NSAIDs may actually be lifesaving in the early management of DVD as they have proved to be in COVID-19.Moreover,we propose that the personalized immunemodulatory Kelleni’s protocol,which includes nitazoxanide as a key component,can be safely and effectively used to manage various separate or concomitant viral infections and co-infections,including DVD.Importantly,this article contributes to the current medical knowledge in the global pursuit of a safe and effective broad-spectrum antiviral protocol that can be used to early manage multiple highly infectious viruses.However,it’s crucial that sufficiently powered controlled randomized clinical trials be conducted to thoroughly assess and evaluate the safety of NSAIDs in the early management of DVD as well as the efficacy of nitazoxanide with or without NSAIDs in its management.展开更多
The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded versio...The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded version of the protocol was written for professional health care providers with a consumer version tailored for family caregivers. The underlying mid-range theory is presented along with a seminal study that was followed by further research in the United States, Canada, Great Britain, France, Sweden, Norway, Japan and Taiwan. Key studies are summarized. Given its efficacy when implemented by research staff, studies have advanced to testing the intervention under real-life conditions when implemented and evaluated by trained nursing assistants in long-term care facilities and visiting family members. In addition, one study evaluated the implementation of music by family members in the home setting. Initial research focused on agitation as the dependent variable with subsequent research indicating a more holistic response such as positive affect, expressed satisfaction, and meaningful interaction with others. The article advances by describing on-line programs designed to train health care professionals in the assessment, implementation and evaluation of individualized music. In addition, Gerdner has written a story for apicture book intended for children and their families(in press). The story models principles of individualized music to elicit positive memories, reduce anxiety and agitation, and promote communication. The article concludes with implications for future research.展开更多
FIDO(Fast IDentity Online) Alliance proposed a set of standard in 2014 for change the nature of online authentication. By now, it has drawn attention from many companies, including Google, VISA, Intel etc. In this pap...FIDO(Fast IDentity Online) Alliance proposed a set of standard in 2014 for change the nature of online authentication. By now, it has drawn attention from many companies, including Google, VISA, Intel etc. In this paper, we analyze the FIDO UAF(Universal Authentication Framework) Protocol, one of the two sets of specifications in the standard. We first present protocols' cryptographic abstractions for the registration and authentication protocols of the FIDO UAF. According to the abstractions, we discuss on selected security goals presented in the standard to study UAF security properties. We also propose three attacks, which the first two are based on an assumption that an attacker can corrupt the software installed on the user device, and the third is based on two users sharing a FIDO roaming authenticator. The results of the attacks are to impersonate the legitimate user to pass the online authentication.展开更多
AIMTo investigate the benefits of the Seattle protocol in the diagnosis of Chinese individuals with Barrett’s esophagus.METHODSSubjects enrolled were patients from one center with endoscopically-suspected esophageal ...AIMTo investigate the benefits of the Seattle protocol in the diagnosis of Chinese individuals with Barrett’s esophagus.METHODSSubjects enrolled were patients from one center with endoscopically-suspected esophageal metaplasia. These patients first received narrow-band imaging-targeted biopsy, and later, the Seattle protocol-guided biopsy, within a period from October 2012 to December 2014. Those cases without initial pathologic patterns of intestinal metaplasia （IM） and then appearance or loss of IM tissue were designated as Group A or B, respectively. Those with initial pathologic patterns ofIM, which then persisted or were lost were designated as Group C or D, respectively.RESULTSThe number of cases for each group was as follows： A： 20, B： 78, C： 31 and D： 14. The distribution of the Prague criteria M levels of Group A was significantly higher than Group B （ P = 0.174）. Among these groups, Group C had the highest proportions of hiatus hernia （54.8%）, long segment Barrett’s esophagus （29%）, and also the highest Prague criteria M levels. The sensitivity of IM detection was 69.2% for the narrow-band imaging-targeted biopsy and 78.5% for the Lee SW et al . Seattle protocol for Barrett’s esophagusSeattle protocol-guided biopsy. The difference was not signifcant （P = 0.231）. The number of detectable dysplasias increased from one case via the NBI-target biopsy to five cases via the Seattle protocol-guided biopsy, including one case of adenocarcinoma.CONCLUSIONThe Seattle protocol improved the IM detection in our subjects with higher Prague criteria M levels and disclosed more cases with dysplastic tissues.展开更多
The coronavirus disease 2019(COVID-19)mortality rate in 55 African countries is almost 4.5 times lower than in the coronavirus disease 2019(COVID-19)despite Africa having over 4.2 times more people.This mortality para...The coronavirus disease 2019(COVID-19)mortality rate in 55 African countries is almost 4.5 times lower than in the coronavirus disease 2019(COVID-19)despite Africa having over 4.2 times more people.This mortality paradox is also evident when comparing Nigeria,a heavily populated,poorly vaccinated and weakly mandated country to Israel,a small,highly vaccinated and strictly mandated country.Nigeria has almost 4 times lower COVID mortality than Israel.In this Field of Vision perspective,I explain how this paradox has evolved drawing upon my academic,clinical and social experience.Since April 2020,I’ve developed and been using the Egyptian immune-modulatory Kelleni’s protocol to manage COVID-19 patients including pediatric,geriatric,pregnant,immune-compromised and other individuals suffering from multiple comorbidities.It’s unfortunate that severe acute respiratory syndrome coronavirus 2 is still evolving accompanied by more deaths.However in Africa,we’ve been able to live without anxiety or mandates throughout the pandemic because we trust science and adopted early treatment using safe,and effective repurposed drugs that have saved the majority of COVID-19 patients.This article represents an African and Egyptian tale of honor.展开更多
根据传感器节点的生存时间取决于节点能量消耗的特点,设计了节能的MAC协议.提出了一种基于节点流量的低能耗无线传感器网络MAC协议TBEE-MAC(traffic-based energy efficient MAC).在TBEE-MAC中,节点采用周期性休眠机制来节省能量,提出...根据传感器节点的生存时间取决于节点能量消耗的特点,设计了节能的MAC协议.提出了一种基于节点流量的低能耗无线传感器网络MAC协议TBEE-MAC(traffic-based energy efficient MAC).在TBEE-MAC中,节点采用周期性休眠机制来节省能量,提出了活动时间结构和基于节点流量的同步调度方式,在时间误差允许的范围内,调整了同步调度周期,减少了能量消耗.仿真显示,TBEE-MAC在提供低延时性能的基础上,能量有效性相对于S-MAC协议有很大提高.展开更多
文摘The current recommendation to avoid non-steroidal anti-inflammatory drugs(NSAIDs)in the management of dengue virus disease(DVD)is scientifically considered of very low to low certainty,despite being widely adopted worldwide.The same recommendation,initially made during the coronavirus disease 2019(COVID-19)pandemic,was subsequently proven incorrect.In this clinical report,we present evidence,for the first time globally,from a real-life practice that NSAIDs may actually be lifesaving in the early management of DVD as they have proved to be in COVID-19.Moreover,we propose that the personalized immunemodulatory Kelleni’s protocol,which includes nitazoxanide as a key component,can be safely and effectively used to manage various separate or concomitant viral infections and co-infections,including DVD.Importantly,this article contributes to the current medical knowledge in the global pursuit of a safe and effective broad-spectrum antiviral protocol that can be used to early manage multiple highly infectious viruses.However,it’s crucial that sufficiently powered controlled randomized clinical trials be conducted to thoroughly assess and evaluate the safety of NSAIDs in the early management of DVD as well as the efficacy of nitazoxanide with or without NSAIDs in its management.
文摘The theory-based intervention of individualized music has been evaluated clinically and empirically leading to advancement and refinement of an evidence-based protocol, currently in its 5th edition. An expanded version of the protocol was written for professional health care providers with a consumer version tailored for family caregivers. The underlying mid-range theory is presented along with a seminal study that was followed by further research in the United States, Canada, Great Britain, France, Sweden, Norway, Japan and Taiwan. Key studies are summarized. Given its efficacy when implemented by research staff, studies have advanced to testing the intervention under real-life conditions when implemented and evaluated by trained nursing assistants in long-term care facilities and visiting family members. In addition, one study evaluated the implementation of music by family members in the home setting. Initial research focused on agitation as the dependent variable with subsequent research indicating a more holistic response such as positive affect, expressed satisfaction, and meaningful interaction with others. The article advances by describing on-line programs designed to train health care professionals in the assessment, implementation and evaluation of individualized music. In addition, Gerdner has written a story for apicture book intended for children and their families(in press). The story models principles of individualized music to elicit positive memories, reduce anxiety and agitation, and promote communication. The article concludes with implications for future research.
文摘FIDO(Fast IDentity Online) Alliance proposed a set of standard in 2014 for change the nature of online authentication. By now, it has drawn attention from many companies, including Google, VISA, Intel etc. In this paper, we analyze the FIDO UAF(Universal Authentication Framework) Protocol, one of the two sets of specifications in the standard. We first present protocols' cryptographic abstractions for the registration and authentication protocols of the FIDO UAF. According to the abstractions, we discuss on selected security goals presented in the standard to study UAF security properties. We also propose three attacks, which the first two are based on an assumption that an attacker can corrupt the software installed on the user device, and the third is based on two users sharing a FIDO roaming authenticator. The results of the attacks are to impersonate the legitimate user to pass the online authentication.
文摘AIMTo investigate the benefits of the Seattle protocol in the diagnosis of Chinese individuals with Barrett’s esophagus.METHODSSubjects enrolled were patients from one center with endoscopically-suspected esophageal metaplasia. These patients first received narrow-band imaging-targeted biopsy, and later, the Seattle protocol-guided biopsy, within a period from October 2012 to December 2014. Those cases without initial pathologic patterns of intestinal metaplasia （IM） and then appearance or loss of IM tissue were designated as Group A or B, respectively. Those with initial pathologic patterns ofIM, which then persisted or were lost were designated as Group C or D, respectively.RESULTSThe number of cases for each group was as follows： A： 20, B： 78, C： 31 and D： 14. The distribution of the Prague criteria M levels of Group A was significantly higher than Group B （ P = 0.174）. Among these groups, Group C had the highest proportions of hiatus hernia （54.8%）, long segment Barrett’s esophagus （29%）, and also the highest Prague criteria M levels. The sensitivity of IM detection was 69.2% for the narrow-band imaging-targeted biopsy and 78.5% for the Lee SW et al . Seattle protocol for Barrett’s esophagusSeattle protocol-guided biopsy. The difference was not signifcant （P = 0.231）. The number of detectable dysplasias increased from one case via the NBI-target biopsy to five cases via the Seattle protocol-guided biopsy, including one case of adenocarcinoma.CONCLUSIONThe Seattle protocol improved the IM detection in our subjects with higher Prague criteria M levels and disclosed more cases with dysplastic tissues.
文摘The coronavirus disease 2019(COVID-19)mortality rate in 55 African countries is almost 4.5 times lower than in the coronavirus disease 2019(COVID-19)despite Africa having over 4.2 times more people.This mortality paradox is also evident when comparing Nigeria,a heavily populated,poorly vaccinated and weakly mandated country to Israel,a small,highly vaccinated and strictly mandated country.Nigeria has almost 4 times lower COVID mortality than Israel.In this Field of Vision perspective,I explain how this paradox has evolved drawing upon my academic,clinical and social experience.Since April 2020,I’ve developed and been using the Egyptian immune-modulatory Kelleni’s protocol to manage COVID-19 patients including pediatric,geriatric,pregnant,immune-compromised and other individuals suffering from multiple comorbidities.It’s unfortunate that severe acute respiratory syndrome coronavirus 2 is still evolving accompanied by more deaths.However in Africa,we’ve been able to live without anxiety or mandates throughout the pandemic because we trust science and adopted early treatment using safe,and effective repurposed drugs that have saved the majority of COVID-19 patients.This article represents an African and Egyptian tale of honor.
文摘根据传感器节点的生存时间取决于节点能量消耗的特点,设计了节能的MAC协议.提出了一种基于节点流量的低能耗无线传感器网络MAC协议TBEE-MAC(traffic-based energy efficient MAC).在TBEE-MAC中,节点采用周期性休眠机制来节省能量,提出了活动时间结构和基于节点流量的同步调度方式,在时间误差允许的范围内,调整了同步调度周期,减少了能量消耗.仿真显示,TBEE-MAC在提供低延时性能的基础上,能量有效性相对于S-MAC协议有很大提高.
