A 16‐year‐old male teenager with no prior medical history suddenly experienced right upper limb weakness.The weakness persisted for 2 weeks,followed by a headache and unstable walking.On physical examination,the pat...A 16‐year‐old male teenager with no prior medical history suddenly experienced right upper limb weakness.The weakness persisted for 2 weeks,followed by a headache and unstable walking.On physical examination,the patient exhibited decreased verbal fluency,a shallow right nasolabial fold,and tongue movement to the right side.Reduced muscle strength with normal muscle tension was observed in the right limb.On laboratory examination,lymphocytes were decreased,and neutrophils were slightly increased.The patient underwent brain CT,MRI,and whole‐body ^(18)F‐fluorodeoxyglucose PET/CT.Intra-cranial biopsy was performed to confirm the pathology(Figure 1).The final pathological diagnosis was the Rosai-Dorfman disease,characterized by abnormal hyperplasia of the sinuses combined with an accumulation of histiocytes in the lymph nodes.Although extranodal involvement has been reported,primary infiltration of the central nervous system is extremely rare,particularly in the brain parenchyma.展开更多
文摘A 16‐year‐old male teenager with no prior medical history suddenly experienced right upper limb weakness.The weakness persisted for 2 weeks,followed by a headache and unstable walking.On physical examination,the patient exhibited decreased verbal fluency,a shallow right nasolabial fold,and tongue movement to the right side.Reduced muscle strength with normal muscle tension was observed in the right limb.On laboratory examination,lymphocytes were decreased,and neutrophils were slightly increased.The patient underwent brain CT,MRI,and whole‐body ^(18)F‐fluorodeoxyglucose PET/CT.Intra-cranial biopsy was performed to confirm the pathology(Figure 1).The final pathological diagnosis was the Rosai-Dorfman disease,characterized by abnormal hyperplasia of the sinuses combined with an accumulation of histiocytes in the lymph nodes.Although extranodal involvement has been reported,primary infiltration of the central nervous system is extremely rare,particularly in the brain parenchyma.
