Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a...Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.展开更多
This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although ...This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.展开更多
The survival strategy of plants is to adjust their functional traits to adapt to the environment.However,these traits and survival strategies of evergreen broad-leaved forest species are not well understood.This study...The survival strategy of plants is to adjust their functional traits to adapt to the environment.However,these traits and survival strategies of evergreen broad-leaved forest species are not well understood.This study examined 10 leaf functional traits(LFTs)of 70 common plant species in an evergreen broad-leaved forest in Huangshan Mountain to decipher their adaptive strategies.The phylogenetic signals of these LFTs were assessed and phylogenetically independent contrasts(PIC)and correlation analyses were carried out.LFTs were analyzed to determine their CSR(C:competitor,S:stress-tolerator,R:ruderal)strategies.The results show that plant species exhibit different leaf functional traits and ecological strategies(nine strategies were identified;the most abundant were S/CS and S/CSR strategies).Some traits showed significant phylogenetic signals,indicating the effect of phylogeny on LFTs to an extent.Trait variations among species suggest distinct adaptation strategies to environmental changes.The study species were mainly clustered on the C-S strategy axis,with a high S component.Species leaning toward the C-strategy end(e.g.,deciduous species),favored a resource acquisition strategy characterized by higher specific leaf area(SLA),greater nutrient contents(N and P),lower leaf dry matter content(LDMC),and reduced nutrient utilization efficiency(C:N and C:P).Conversely,species closer to the S-strategy end(e.g.,evergreen species)usually adopted a resource conservative strategy with trait combinations contrary to those of C-strategy species.Overall,this study corroborated the applicability of the CSR strategy at a local scale and provides insights into the varied trait combinations and ecological strategies employed by plant species to adapt to their environment.These findings contribute to a better understanding of the mechanisms involved in biodiversity maintenance.展开更多
Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,thi...Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.展开更多
Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employe...Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employed to fabricate a multi-layer PENG based on a cellulose/polyvinylidene fluoride(PVDF)blend film matrix,incorporating multi-phase BCZT(0.1BaZr_(0.2)Ti_(0.8)O_(3)-0.9Ba_(0.7)Ca_(0.3)TiO_(3))ceramic fillers.Structural characterization via SEM and TEM revealed that an intricate hydrogen-bond network facilitated the uniform dispersion of ceramic fillers within the composite film’s sub-layers.In order to study the effect of filler distribution on piezoelectric performance,the single-and double-layer composite films with varying BCZT configurations were produced and evaluated.The results demonstrated that double-layer PENGs exhibit significantly enhanced electrical output compared to their single-layer counterparts,with the D-L_(3)H_(7) configuration achieving an open circuit voltage(V_(OC))of 23.13 V and a short circuit current(I_(SC))of 8.32μA.This enhancement is attributed to increased inter-layer interfaces,which effectively suppressed charge injection and migration,leading to improved charge density.Additionally,the presence of sharp tipped hexagonal tetragonal phase nanoparticles induced an electric field enhancement effect,further optimizing performance.展开更多
The disorderly mining activities and irrational layout in underground coal mines have left a large number of adjacent abandoned roadways.During the process of a working face passing through abandoned roadways,these st...The disorderly mining activities and irrational layout in underground coal mines have left a large number of adjacent abandoned roadways.During the process of a working face passing through abandoned roadways,these structures are prone to varying degrees of damage,with frequent occurrences of roof leakage and induced rock burst accidents,significantly impacting subsequent mining operations and safe production.To address these issues,this study investigates the surrounding rock deformation patterns during fully mechanized mining face passage through abandoned roadway clusters.Specific countermeasures were systematically summarized according to different occurrence characteristics of abandoned roadways.Through mechanical analysis,the critical unstable width of coal pillars was determined to be approximately 16.1~16.8 m.A three-dimensional numerical model was established based on 17 abandoned roadways with various shapes and occurrences in the working face.Simulation results indicate severe deformation and failure in roof rock layer roadways,while floor roadways exhibit relatively minor damage.Notably,when the distance between abandoned roadways and the coal seam exceeds 8 m,almost no damage occurs.Three technical measures for passing through abandoned roadway group was proposed according to their occurrence characteristics and implemented in engineering practice.Field applications demonstrate limited coal stress variations and weak strata pressure manifestations during the crossing process,ensuring safe passage through abandoned roadway clusters.This achievement enables efficient and safe crossing of abandoned roadway group in fully mechanized mining faces,enhances coal recovery rates,and provides practical engineering references for similar geological conditions.展开更多
Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practic...Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.展开更多
Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the...Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the transformation of the energy sector.Based on the achievements of high-quality energy cooperation within the Belt and Road Initiative,this paper systematically analyzes the current state of energy cooperation under the Belt and Road Initiative.In accordance with the intrinsic requirements for high-quality energy cooperation,and building upon the analysis and summary of prior research,this paper proposes strategies to promote high-quality energy cooperation within the Belt and Road Initiative:(1)Innovating cooperative concepts and optimizing the cooperative environment;(2)Innovating cooperation modes and expanding the scope of cooperation;(3)Improving the cooperation mechanism and building a multi-level cooperation platform;(4)Strengthening cultural exchanges and promoting dialogue.This paper offers insights and support for fostering high-quality collaboration within the Belt and Road Initiative and enhancing international energy cooperation.展开更多
Metok,located in Nyingchi,the Xizang Autonomous Region,is known as the last county in China to be connected by road.Poor transportation and limited access to petroleum were two obstacles to its development.As soon as ...Metok,located in Nyingchi,the Xizang Autonomous Region,is known as the last county in China to be connected by road.Poor transportation and limited access to petroleum were two obstacles to its development.As soon as the highway connecting Metok and the outside world was completed in 2014,China National Petroleum Corporation’s(CNPC)first gas station in the county was put into operation,providing the momentum for this"secret land of Lotus"and helping it embark on a journey toward openness and prosperity.展开更多
Urban traffic generates massive and diverse data,yet most systems remain fragmented.Current approaches to congestion management suffer from weak data consistency and poor scalability.This study addresses this gap by p...Urban traffic generates massive and diverse data,yet most systems remain fragmented.Current approaches to congestion management suffer from weak data consistency and poor scalability.This study addresses this gap by proposing the Urban Traffic Congestion Unified Metadata Model(UTC-UMM).The goal is to provide a standardized and extensible framework for describing,extracting,and storing multisource traffic data in smart cities.The model defines a two-tier specification that organizes nine core traffic resource classes.It employs an eXtensible Markup Language(XML)Schema that connects general elements with resource-specific elements.This design ensures both syntactic and semantic interoperability across siloed datasets.Extension principles allow new elements or constraints to be introducedwithout breaking backward compatibility.Adistributed pipeline is implemented usingHadoop Distributed File System(HDFS)and HBase.It integrates computer vision for video and natural language processing for text to automate metadata extraction.Optimized row-key designs enable low-latency queries.Performance is tested with the Yahoo!Cloud Serving Benchmark(YCSB),which shows linear scalability and high throughput.The results demonstrate that UTC-UMM can unify heterogeneous traffic data while supporting real-time analytics.The discussion highlights its potential to improve data reuse,portability,and scalability in urban congestion studies.Future research will explore integration with association rulemining and advanced knowledge representation to capture richer spatiotemporal traffic patterns.展开更多
Aerodynamic research on road cars was reviewed in this work under the thread of reducing drag,with the awareness that this may succeed in effectively decreasing the carbon footprint of transportation.First,a selection...Aerodynamic research on road cars was reviewed in this work under the thread of reducing drag,with the awareness that this may succeed in effectively decreasing the carbon footprint of transportation.First,a selection of studies was presented to focus on the most important aerodynamic features of the flow around realistic car body shapes.Then,the discussion was organized around three pillars related to passive flow control,active flow control and active aerodynamics.Both experimental and numerical investigations were included to provide a comprehensive overview.A clear distinction was made between simplified and realistic car models,as well as production vehicles(within the limits of restricted access information).Moreover,a short essay was dedicated to electric vehicles,for which aerodynamics matters,especially at highway speeds.Last,the impact of aerodynamic principles on the design of current and future vehicle fleet was assessed,honestly admitting that recent market trends must be reversed to turn decarbonization goals into reality and damp the effects of global warming.展开更多
The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by the...The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by their interdisciplinary nature,regulatory constraints,and function-oriented definitions.Based on real-world translation examples,this paper analyzes the challenges in translating cosmetics ingredient terminology for international trade and proposes targeted translation strategies.The study aims to facilitate the global marketing of cosmetic products while ensuring consumers can accurately understand product ingredient information.展开更多
The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitroge...The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitrogenous and iso-lipidic diets were formulated.The control diet was made with 62%fish meal(FM).The other two experimental diets were formulated by replacing 45%FM with 22.5%mealworm(TM)and 22.5%cottonseed protein concentrate(CPC),or with 22.5%TM and 22.5%Clostridium autoethanogenum protein(CAP),respectively.The three kinds of diet were named as A1,A2 and A3,respectively.Five groups of large yellow croaker were fed with two different strategies:the first three groups were continuously fed with A1,A2 and A3 diets,respectively.The fourth group was alternately fed with A1 and A2 diet every 5 days.The fifth group was alternately fed with A1 and A3diet every 5 days.The five groups were named D1,D2,D3,D1-2 and D1-3,respectively.Results showed that D2 and D3 groups exhibited significantly lower weight gain rate(WGR)and higher feed conversion ratios(FCR)compared to the D1 group.The D1-2 and D1-3 groups exhibited improved WGR and significantly reduced FCR compared to the D2 and D3 groups.The A2 and A3 diets significantly suppressed digestive enzymes'activities compared to A1,whereas alternate-feeding groups significantly enhanced the enzyme activities.Compared to the D1 group,D2 and D3 groups significantly downregulated mRNA expression levels of intestinal antiinflammatory cytokines and upregulated the expression of pro-inflammatory mediators.The anti-inflammatory abilities in the D1-2and D1-3 groups were significantly higher than those in the D2 and D3 groups.Additionally,diets containing TM+CAP and TM+CPC protein sources enhanced ventral redness and yellowness indices.Considering the growth,digestion,immunity and organoleptic quality of large yellow croaker,it is recommended to replace up to 45%of FM with TM+CPC and use an alternate-feeding strategy.展开更多
Global climate change is intensifying the impact of slope hazards,particularly rainfall-induced landslide hazards(RILH),on mountain road networks(MRNs).However,effective quantitative models for dynamically assessing M...Global climate change is intensifying the impact of slope hazards,particularly rainfall-induced landslide hazards(RILH),on mountain road networks(MRNs).However,effective quantitative models for dynamically assessing MRNs vulnerability under RILH disturbances are still lacking.To bridge this gap,this study develops a Cascading Failure Model for Rainfall-Induced Landslide Hazard(CFM-RILH).Validation via a case study of the GarzêTibetan Autonomous Prefecture Road Network(GTPRNs)reveals key characteristics of MRNs system vulnerability under RILH disturbances:(1)Under the disturbance effects of RILH,the vulnerability of the MRNs system follows a nonlinear phase transition law that intensifies with increasing disturbance intensity,exhibiting a distinct critical threshold.When the disturbance intensity exceeds this threshold,the system undergoes a global cascading failure phenomenon analogous to an“avalanche.”(2)Under RILH disturbances,the robustness of the MRNs system possesses a distinct safety boundary.Exceeding this boundary not only fails to improve hazard resistance but instead substantially elevates the risk of large-scale cascading failure.(3)Increasing network redundancy may be considered one of the primary engineering measures for enhancing MRNs resilience against such disturbances.Based on these findings,we propose a“Two-Stage Emergency Response and Hierarchical Fortification”strategy specifically to improve the resilience of GTPRNs impacted by RILH.The CFM-RILH model provides an effective tool for assessing road network vulnerability under such hazards.Furthermore,its modeling framework can also inform vulnerability assessment and resilience strategy development for road networks affected by other types of slope hazards.展开更多
Background:Self-esteem,life satisfaction,resilience,and coping strategies are closely linked to depression;however,their interrelationships and relative contributions to depressive outcomes remain insufficiently under...Background:Self-esteem,life satisfaction,resilience,and coping strategies are closely linked to depression;however,their interrelationships and relative contributions to depressive outcomes remain insufficiently understood.This study aimed to examine these associations in individuals with major depressive disorder(MDD)and healthy controls and to evaluate their predictive and mediating roles in depression.Methods:This analytical cross-sectional study included 311 participants(158 patients with MDD and 153 healthy controls)recruited from the Psychiatry Outpatient Clinics of Mugla Training and Research Hospital.Psychiatric diagnoses were confirmed using the Structured Clinical Interview for DSM-5(SCID-5).Groups were balanced for age,sex,and education using propensity score matching(PSM).Participants completed the Rosenberg Self-Esteem Scale,Satisfaction with Life Scale,Brief Resilience Scale,Brief COPE Inventory,and Beck Depression Inventory.Results:Compared with healthy controls,individuals with MDD reported significantly lower life satisfaction and resilience and higher depressive symptom severity,whereas self-esteem did not differ significantly between groups.Emotion-focused coping decreased with increasing depression severity,while avoidant coping showed a modest but significant increase in severe depression.Logistic regression analyses identified life satisfaction(OR=0.95,p=0.004)and resilience(OR=0.92,p=0.002)as significant protective predictors of depression.Mediation analyses demonstrated that life satisfaction partially mediated the relationship between self-esteem and depression,whereas resilience exerted a predominantly direct effect.Conclusion:Life satisfaction and resilience emerge as key protective factors against depression.Self-esteem appears to influence depressive outcomes indirectly through life satisfaction rather than through a direct effect.These findings underscore the importance of interventions that enhance resilience and promote positive evaluations of life in individuals at risk for depression.展开更多
With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitiv...With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitive impairment is characterized by chronicity,which not only seriously threatens the health of the elderly and reduces their quality of life,but also imposes a heavy burden on families and society due to its long course.Attaching importance to and strengthening the chronic disease management of elderly cognitive impairment has profound significance for delaying disease progression,improving patients’quality of life,and reducing the burden of family care.Therefore,this paper first comprehensively understands elderly cognitive impairment by briefly elaborating on its definition and characteristics;on this basis,it focuses on exploring effective strategies for the chronic disease management of elderly cognitive impairment,hoping to provide new ideas and methods for the management of this condition and offer useful references for relevant clinical research and practice.展开更多
Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomed...Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.展开更多
Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create...Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create a firefly campsite-a natural attraction where visitors can observe these glowing insects in a preserved habitat.The site quickly drew waves of tourists,who shared their experience online,recouping its initial investment in just two years.展开更多
With the escalating demand for safe,sustainable,and high-performance energy storage systems,hydrogel electrolytes have emerged as promising alternatives to conventional liquid electrolytes in zinc-ion batteries.By int...With the escalating demand for safe,sustainable,and high-performance energy storage systems,hydrogel electrolytes have emerged as promising alternatives to conventional liquid electrolytes in zinc-ion batteries.By integrating the high ionic conductivity of liquid electrolytes with the mechanical robustness of solid frameworks,hydrogel electrolytes offer distinct advantages in suppressing zinc dendrite formation,enhancing interfacial stability,and enabling reliable operation under extreme environmental conditions.This review systematically summarizes the fundamental characteristics and design criteria of hydrogel electrolytes,including mechanical flexibility,ionic transport capabilities,and environmental adaptability.It further explores various compositional design strategies involving natural polymers,synthetic polymers,and composite systems,as well as the incorporation of electrolyte salts and functional additives.In addition,recent advances in functional optimization,such as anti-freezing properties,self-healing abilities,thermal responsiveness,and biocompatibility,are comprehensively discussed.Finally,the review outlines the current challenges and proposes potential directions for future research.展开更多
The rapid development of artificial intelligence(AI)has placed significant pressure on universities to rethink how they train software engineering students.Tools like GitHub Copilot can now generate basic code in seco...The rapid development of artificial intelligence(AI)has placed significant pressure on universities to rethink how they train software engineering students.Tools like GitHub Copilot can now generate basic code in seconds.This raises important questions:What is the value of traditional programming education?What role should instructors play when AI becomes a powerful teaching assistant?How should the goals of software engineering programs change as companies increasingly use AI to handle coding tasks?This paper explores the key challenges AI brings to software engineering education and proposes practical strategies for updating talent development models to meet these changes.展开更多
基金supported by the National Natural Science Foundation of China,82471345(to LC)the Key Research and Development Program for Social Development by the Jiangsu Provincial Department of Science and Technology.No.BE2022668(to LC).
文摘Ischemic stroke is a major cause of neurological deficits and high disability rate.As the primary immune cells of the central nervous system,microglia play dual roles in neuroinflammation and tissue repair following a stroke.Their dynamic activation and polarization states are key factors that influence the disease process and treatment outcomes.This review article investigates the role of microglia in ischemic stroke and explores potential intervention strategies.Microglia exhibit a dynamic functional state,transitioning between pro-inflammatory(M1)and anti-inflammatory(M2)phenotypes.This duality is crucial in ischemic stroke,as it maintains a balance between neuroinflammation and tissue repair.Activated microglia contribute to neuroinflammation through cytokine release and disruption of the blood-brain barrier,while simultaneously promoting tissue repair through anti-inflammatory responses and regeneration.Key pathways influencing microglial activation include Toll-like receptor 4/nuclear factor kappa B,mitogen-activated protein kinases,Janus kinase/signal transducer and activator of transcription,and phosphoinositide 3-kinase/protein kinase B/mammalian target of rapamycin pathways.These pathways are targets for various experimental therapies aimed at promoting M2 polarization and mitigating damage.Potential therapeutic agents include natural compounds found in drugs such as minocycline,as well as traditional Chinese medicines.Drugs that target these regulatory mechanisms,such as small molecule inhibitors and components of traditional Chinese medicines,along with emerging technologies such as single-cell RNA sequencing and spatial transcriptomics,offer new therapeutic strategies and clinical translational potential for ischemic stroke.
文摘This article focuses on the challenges of rural economic development under the strategy of rural revitalization,and deeply analyzes the current situation of rural economic development.Research has found that although the rural revitalization strategy has achieved significant results in improving residents’quality of life,promoting agricultural modernization,it still faces challenges such as severe loss of human resources,insufficient agricultural technological innovation,and backward infrastructure construction.In response to these challenges,this paper proposes optimization strategies from three aspects:strengthening rural education and talent team construction,promoting agricultural technology innovation and achievement transformation,and increasing investment in rural infrastructure construction.
基金supported by the Special Foundation for National Science and Technology Basic Resources Investigation of China(2019FY202300)the Biodiversity Survey,Observation and Assessment Project of the Ministry of Ecology and Environment(2110404).
文摘The survival strategy of plants is to adjust their functional traits to adapt to the environment.However,these traits and survival strategies of evergreen broad-leaved forest species are not well understood.This study examined 10 leaf functional traits(LFTs)of 70 common plant species in an evergreen broad-leaved forest in Huangshan Mountain to decipher their adaptive strategies.The phylogenetic signals of these LFTs were assessed and phylogenetically independent contrasts(PIC)and correlation analyses were carried out.LFTs were analyzed to determine their CSR(C:competitor,S:stress-tolerator,R:ruderal)strategies.The results show that plant species exhibit different leaf functional traits and ecological strategies(nine strategies were identified;the most abundant were S/CS and S/CSR strategies).Some traits showed significant phylogenetic signals,indicating the effect of phylogeny on LFTs to an extent.Trait variations among species suggest distinct adaptation strategies to environmental changes.The study species were mainly clustered on the C-S strategy axis,with a high S component.Species leaning toward the C-strategy end(e.g.,deciduous species),favored a resource acquisition strategy characterized by higher specific leaf area(SLA),greater nutrient contents(N and P),lower leaf dry matter content(LDMC),and reduced nutrient utilization efficiency(C:N and C:P).Conversely,species closer to the S-strategy end(e.g.,evergreen species)usually adopted a resource conservative strategy with trait combinations contrary to those of C-strategy species.Overall,this study corroborated the applicability of the CSR strategy at a local scale and provides insights into the varied trait combinations and ecological strategies employed by plant species to adapt to their environment.These findings contribute to a better understanding of the mechanisms involved in biodiversity maintenance.
文摘Dove’s 2017 advertising incident,which sparked widespread debate regarding perceived cultural insensitivity,highlighted a disconnect between the brand’s“Real Beauty”positioning and public reception.In response,this study proposes a strategic digital recovery framework,including revised campaign content,transparent communication through social media,and data-driven customer segmentation based on diverse skincare needs and cultural backgrounds.A PESTLE analysis underscores the importance of digital transformation and rising social consciousness in brand management.Findings suggest that inclusive messaging,precision targeting,and omnichannel digital engagement are key to restoring brand trust and reputation in the digital landscape.
基金National Natural Science Foundation of China(52472132)Opening Project of Engineering Research Center of Eco-friendly Polymeric Materials,Ministry of Education(EFP-KF2403)Innovation Service Capability Support Plan of Xianyang(Science and Technology Innovation Talents)。
文摘Development of high performance,flexible piezoelectric nanogenerators(PENGs)is critical for advancing self-powered sensing and microelectronic applications.In this study,a hydrogen-bond substitute strategy was employed to fabricate a multi-layer PENG based on a cellulose/polyvinylidene fluoride(PVDF)blend film matrix,incorporating multi-phase BCZT(0.1BaZr_(0.2)Ti_(0.8)O_(3)-0.9Ba_(0.7)Ca_(0.3)TiO_(3))ceramic fillers.Structural characterization via SEM and TEM revealed that an intricate hydrogen-bond network facilitated the uniform dispersion of ceramic fillers within the composite film’s sub-layers.In order to study the effect of filler distribution on piezoelectric performance,the single-and double-layer composite films with varying BCZT configurations were produced and evaluated.The results demonstrated that double-layer PENGs exhibit significantly enhanced electrical output compared to their single-layer counterparts,with the D-L_(3)H_(7) configuration achieving an open circuit voltage(V_(OC))of 23.13 V and a short circuit current(I_(SC))of 8.32μA.This enhancement is attributed to increased inter-layer interfaces,which effectively suppressed charge injection and migration,leading to improved charge density.Additionally,the presence of sharp tipped hexagonal tetragonal phase nanoparticles induced an electric field enhancement effect,further optimizing performance.
基金supported by the National Key R&D Program of China(2023YFC3904300)the Taichuangyuan Thick Coal Seam Water Conservation Mining"Scientists+Engineers"Team(2024QCY-KXJ-055)the 111 Project(B21016).
文摘The disorderly mining activities and irrational layout in underground coal mines have left a large number of adjacent abandoned roadways.During the process of a working face passing through abandoned roadways,these structures are prone to varying degrees of damage,with frequent occurrences of roof leakage and induced rock burst accidents,significantly impacting subsequent mining operations and safe production.To address these issues,this study investigates the surrounding rock deformation patterns during fully mechanized mining face passage through abandoned roadway clusters.Specific countermeasures were systematically summarized according to different occurrence characteristics of abandoned roadways.Through mechanical analysis,the critical unstable width of coal pillars was determined to be approximately 16.1~16.8 m.A three-dimensional numerical model was established based on 17 abandoned roadways with various shapes and occurrences in the working face.Simulation results indicate severe deformation and failure in roof rock layer roadways,while floor roadways exhibit relatively minor damage.Notably,when the distance between abandoned roadways and the coal seam exceeds 8 m,almost no damage occurs.Three technical measures for passing through abandoned roadway group was proposed according to their occurrence characteristics and implemented in engineering practice.Field applications demonstrate limited coal stress variations and weak strata pressure manifestations during the crossing process,ensuring safe passage through abandoned roadway clusters.This achievement enables efficient and safe crossing of abandoned roadway group in fully mechanized mining faces,enhances coal recovery rates,and provides practical engineering references for similar geological conditions.
基金the support from Base for Interdisciplinary Innovative Talent Training,Shanghai Jiao Tong UniversityYouth Science and Technology Innovation Studio of Shanghai Jiao Tong University School of Medicine。
文摘Neural injuries can cause considerable functional impairments,and both central and peripheral nervous systems have limited regenerative capacity.The existing conventional pharmacological treatments in clinical practice show poor targeting,rapid drug clearance from the circulatory system,and low therapeutic efficiency.Therefore,in this review,we have first described the mechanisms underlying nerve regeneration,characterized the biomaterials used for drug delivery to facilitate nerve regeneration,and highlighted the functionalization strategies used for such drug-delivery systems.These systems mainly use natural and synthetic polymers,inorganic materials,and hybrid systems with advanced drug-delivery abilities,including nanoparticles,hydrogels,and scaffoldbased systems.Then,we focused on comparing the types of drug-delivery systems for neural regeneration as well as the mechanisms and challenges associated with targeted delivery of drugs to facilitate neural regeneration.Finally,we have summarized the clinical application research and limitations of targeted delivery of these drugs.These biomaterials and drug-delivery systems can provide mechanical support,sustained release of bioactive molecules,and enhanced intercellular contact,ultimately reducing cell apoptosis and enhancing functional recovery.Nevertheless,immune reactions,degradation regulation,and clinical translations remain major unresolved challenges.Future studies should focus on optimizing biomaterial properties,refining delivery precision,and overcoming translational barriers to advance these technologies toward clinical applications.
基金National Social Science Fund Western Project,“Promoting strategies and realization paths for high-quality energy cooperation under the Belt and Road Initiative”(Grant No.24XGJ002)。
文摘Energy is the bedrock of national economic development and a vital pillar for achieving sustainable growth.High-quality energy cooperation is critical to ensuring sustained,stable national economic development and the transformation of the energy sector.Based on the achievements of high-quality energy cooperation within the Belt and Road Initiative,this paper systematically analyzes the current state of energy cooperation under the Belt and Road Initiative.In accordance with the intrinsic requirements for high-quality energy cooperation,and building upon the analysis and summary of prior research,this paper proposes strategies to promote high-quality energy cooperation within the Belt and Road Initiative:(1)Innovating cooperative concepts and optimizing the cooperative environment;(2)Innovating cooperation modes and expanding the scope of cooperation;(3)Improving the cooperation mechanism and building a multi-level cooperation platform;(4)Strengthening cultural exchanges and promoting dialogue.This paper offers insights and support for fostering high-quality collaboration within the Belt and Road Initiative and enhancing international energy cooperation.
文摘Metok,located in Nyingchi,the Xizang Autonomous Region,is known as the last county in China to be connected by road.Poor transportation and limited access to petroleum were two obstacles to its development.As soon as the highway connecting Metok and the outside world was completed in 2014,China National Petroleum Corporation’s(CNPC)first gas station in the county was put into operation,providing the momentum for this"secret land of Lotus"and helping it embark on a journey toward openness and prosperity.
基金supported by the National Natural Science Foundation of China(Grant No.62172033).
文摘Urban traffic generates massive and diverse data,yet most systems remain fragmented.Current approaches to congestion management suffer from weak data consistency and poor scalability.This study addresses this gap by proposing the Urban Traffic Congestion Unified Metadata Model(UTC-UMM).The goal is to provide a standardized and extensible framework for describing,extracting,and storing multisource traffic data in smart cities.The model defines a two-tier specification that organizes nine core traffic resource classes.It employs an eXtensible Markup Language(XML)Schema that connects general elements with resource-specific elements.This design ensures both syntactic and semantic interoperability across siloed datasets.Extension principles allow new elements or constraints to be introducedwithout breaking backward compatibility.Adistributed pipeline is implemented usingHadoop Distributed File System(HDFS)and HBase.It integrates computer vision for video and natural language processing for text to automate metadata extraction.Optimized row-key designs enable low-latency queries.Performance is tested with the Yahoo!Cloud Serving Benchmark(YCSB),which shows linear scalability and high throughput.The results demonstrate that UTC-UMM can unify heterogeneous traffic data while supporting real-time analytics.The discussion highlights its potential to improve data reuse,portability,and scalability in urban congestion studies.Future research will explore integration with association rulemining and advanced knowledge representation to capture richer spatiotemporal traffic patterns.
文摘Aerodynamic research on road cars was reviewed in this work under the thread of reducing drag,with the awareness that this may succeed in effectively decreasing the carbon footprint of transportation.First,a selection of studies was presented to focus on the most important aerodynamic features of the flow around realistic car body shapes.Then,the discussion was organized around three pillars related to passive flow control,active flow control and active aerodynamics.Both experimental and numerical investigations were included to provide a comprehensive overview.A clear distinction was made between simplified and realistic car models,as well as production vehicles(within the limits of restricted access information).Moreover,a short essay was dedicated to electric vehicles,for which aerodynamics matters,especially at highway speeds.Last,the impact of aerodynamic principles on the design of current and future vehicle fleet was assessed,honestly admitting that recent market trends must be reversed to turn decarbonization goals into reality and damp the effects of global warming.
基金funded by 2025 Graduate Teaching Construction Project of USST.
文摘The cosmetics industry operates on a global scale,making the accurate translation of ingredient terminology crucial for international trade and consumer comprehension.Cosmetic ingredient terms are characterized by their interdisciplinary nature,regulatory constraints,and function-oriented definitions.Based on real-world translation examples,this paper analyzes the challenges in translating cosmetics ingredient terminology for international trade and proposes targeted translation strategies.The study aims to facilitate the global marketing of cosmetic products while ensuring consumers can accurately understand product ingredient information.
基金financially supported by the Key Research and Development Program of Shandong,China(No.2021SFGC0701)。
文摘The present study investigated the effects of varying protein source combinations and feeding strategies on the growth,health and organoleptic quality of the large yellow croaker(Larimichthys crocea).Three iso-nitrogenous and iso-lipidic diets were formulated.The control diet was made with 62%fish meal(FM).The other two experimental diets were formulated by replacing 45%FM with 22.5%mealworm(TM)and 22.5%cottonseed protein concentrate(CPC),or with 22.5%TM and 22.5%Clostridium autoethanogenum protein(CAP),respectively.The three kinds of diet were named as A1,A2 and A3,respectively.Five groups of large yellow croaker were fed with two different strategies:the first three groups were continuously fed with A1,A2 and A3 diets,respectively.The fourth group was alternately fed with A1 and A2 diet every 5 days.The fifth group was alternately fed with A1 and A3diet every 5 days.The five groups were named D1,D2,D3,D1-2 and D1-3,respectively.Results showed that D2 and D3 groups exhibited significantly lower weight gain rate(WGR)and higher feed conversion ratios(FCR)compared to the D1 group.The D1-2 and D1-3 groups exhibited improved WGR and significantly reduced FCR compared to the D2 and D3 groups.The A2 and A3 diets significantly suppressed digestive enzymes'activities compared to A1,whereas alternate-feeding groups significantly enhanced the enzyme activities.Compared to the D1 group,D2 and D3 groups significantly downregulated mRNA expression levels of intestinal antiinflammatory cytokines and upregulated the expression of pro-inflammatory mediators.The anti-inflammatory abilities in the D1-2and D1-3 groups were significantly higher than those in the D2 and D3 groups.Additionally,diets containing TM+CAP and TM+CPC protein sources enhanced ventral redness and yellowness indices.Considering the growth,digestion,immunity and organoleptic quality of large yellow croaker,it is recommended to replace up to 45%of FM with TM+CPC and use an alternate-feeding strategy.
基金financially supported by the National Key R&D Program of China(2024YFE0111900)The National Natural Science Foundation of China(U2468214,52378370,52278372)+1 种基金The National Ten Thousand Talent Program for Young Top-notch Talents(2022QB04978)The Science and Technology Program of Hebei Province(2023HBQZYCSB004)。
文摘Global climate change is intensifying the impact of slope hazards,particularly rainfall-induced landslide hazards(RILH),on mountain road networks(MRNs).However,effective quantitative models for dynamically assessing MRNs vulnerability under RILH disturbances are still lacking.To bridge this gap,this study develops a Cascading Failure Model for Rainfall-Induced Landslide Hazard(CFM-RILH).Validation via a case study of the GarzêTibetan Autonomous Prefecture Road Network(GTPRNs)reveals key characteristics of MRNs system vulnerability under RILH disturbances:(1)Under the disturbance effects of RILH,the vulnerability of the MRNs system follows a nonlinear phase transition law that intensifies with increasing disturbance intensity,exhibiting a distinct critical threshold.When the disturbance intensity exceeds this threshold,the system undergoes a global cascading failure phenomenon analogous to an“avalanche.”(2)Under RILH disturbances,the robustness of the MRNs system possesses a distinct safety boundary.Exceeding this boundary not only fails to improve hazard resistance but instead substantially elevates the risk of large-scale cascading failure.(3)Increasing network redundancy may be considered one of the primary engineering measures for enhancing MRNs resilience against such disturbances.Based on these findings,we propose a“Two-Stage Emergency Response and Hierarchical Fortification”strategy specifically to improve the resilience of GTPRNs impacted by RILH.The CFM-RILH model provides an effective tool for assessing road network vulnerability under such hazards.Furthermore,its modeling framework can also inform vulnerability assessment and resilience strategy development for road networks affected by other types of slope hazards.
文摘Background:Self-esteem,life satisfaction,resilience,and coping strategies are closely linked to depression;however,their interrelationships and relative contributions to depressive outcomes remain insufficiently understood.This study aimed to examine these associations in individuals with major depressive disorder(MDD)and healthy controls and to evaluate their predictive and mediating roles in depression.Methods:This analytical cross-sectional study included 311 participants(158 patients with MDD and 153 healthy controls)recruited from the Psychiatry Outpatient Clinics of Mugla Training and Research Hospital.Psychiatric diagnoses were confirmed using the Structured Clinical Interview for DSM-5(SCID-5).Groups were balanced for age,sex,and education using propensity score matching(PSM).Participants completed the Rosenberg Self-Esteem Scale,Satisfaction with Life Scale,Brief Resilience Scale,Brief COPE Inventory,and Beck Depression Inventory.Results:Compared with healthy controls,individuals with MDD reported significantly lower life satisfaction and resilience and higher depressive symptom severity,whereas self-esteem did not differ significantly between groups.Emotion-focused coping decreased with increasing depression severity,while avoidant coping showed a modest but significant increase in severe depression.Logistic regression analyses identified life satisfaction(OR=0.95,p=0.004)and resilience(OR=0.92,p=0.002)as significant protective predictors of depression.Mediation analyses demonstrated that life satisfaction partially mediated the relationship between self-esteem and depression,whereas resilience exerted a predominantly direct effect.Conclusion:Life satisfaction and resilience emerge as key protective factors against depression.Self-esteem appears to influence depressive outcomes indirectly through life satisfaction rather than through a direct effect.These findings underscore the importance of interventions that enhance resilience and promote positive evaluations of life in individuals at risk for depression.
文摘With the intensification of population aging in China,the problem of cognitive impairment in the elderly has become increasingly prominent,attracting widespread attention from all sectors of society.Geriatric cognitive impairment is characterized by chronicity,which not only seriously threatens the health of the elderly and reduces their quality of life,but also imposes a heavy burden on families and society due to its long course.Attaching importance to and strengthening the chronic disease management of elderly cognitive impairment has profound significance for delaying disease progression,improving patients’quality of life,and reducing the burden of family care.Therefore,this paper first comprehensively understands elderly cognitive impairment by briefly elaborating on its definition and characteristics;on this basis,it focuses on exploring effective strategies for the chronic disease management of elderly cognitive impairment,hoping to provide new ideas and methods for the management of this condition and offer useful references for relevant clinical research and practice.
基金supported by the National Natural Science Foundation of China[82003956]the National Key Research and Development Program of China[No.2022YFA1205802]+2 种基金financially supported by Henan Province Health Science and Technology Innovation Youth Talent Project(YQRC2023013 and YQRC2024013)the Key Project of Medical Science and Technology of Henan Province(SBGJ202302072)the Science and Technology Research Project of Henan Province(252102311236).
文摘Single-atom nanozymes(SAzymes)exhibit exceptional catalytic efficiency due to their maximized atom utilization and precisely modulated metalcarrier interactions,which have attracted significant attention in the biomedical field.However,stability issues may impede the clinical translation of SAzymes.This review provides a comprehensive overview of the applications of SAzymes in various biomedical fields,including disease diagnosis(e.g.,biosensors and diagnostic imaging),antitumor therapy(e.g.,photothermal therapy,photodynamic therapy,sonodynamic therapy,and immunotherapy),antimicrobial therapy,and anti-oxidative stress therapy.More importantly,the existing challenges of SAzymes are discussed,such as metal atom clustering and active site loss,ligand bond breakage at high temperature,insufficient environment tolerance,biosecurity risks,and limited catalytic long-term stability.Finally,several innovative strategies to address these stability concerns are proposed—synthesis process optimization(space-limited strategy,coordination site design,bimetallic synergistic strategy,defect engineering strategy,atom stripping-capture),surface modification,and dynamic responsive design—that collectively pave the way for robust,clinically viable SAzymes.
文摘Fifty-five-year-old Shi Yizhong never imagined fireflies could become the foundation of a serious business.In 2022,Longshan Village in Huzhou’s Wuxing District collaborated with a young entrepreneurial team to create a firefly campsite-a natural attraction where visitors can observe these glowing insects in a preserved habitat.The site quickly drew waves of tourists,who shared their experience online,recouping its initial investment in just two years.
基金financially supported by the Guangdong Major Project of Basic Research(No.2023B0303000002)Shenzhen Science and Technology Plan Project(No.SGDX20230116091644003)+3 种基金Shenzhen Key Laboratory of Advanced Energy Storage(No.ZDSYS20220401141000001)high-level special funds(No.G03034K001)the Guangxi Key Technologies R&D Program(AB23075171,AB25069180)National Natural Science Foundation of China(22265007,52263016)。
文摘With the escalating demand for safe,sustainable,and high-performance energy storage systems,hydrogel electrolytes have emerged as promising alternatives to conventional liquid electrolytes in zinc-ion batteries.By integrating the high ionic conductivity of liquid electrolytes with the mechanical robustness of solid frameworks,hydrogel electrolytes offer distinct advantages in suppressing zinc dendrite formation,enhancing interfacial stability,and enabling reliable operation under extreme environmental conditions.This review systematically summarizes the fundamental characteristics and design criteria of hydrogel electrolytes,including mechanical flexibility,ionic transport capabilities,and environmental adaptability.It further explores various compositional design strategies involving natural polymers,synthetic polymers,and composite systems,as well as the incorporation of electrolyte salts and functional additives.In addition,recent advances in functional optimization,such as anti-freezing properties,self-healing abilities,thermal responsiveness,and biocompatibility,are comprehensively discussed.Finally,the review outlines the current challenges and proposes potential directions for future research.
基金supported in part by the Northeastern University’s 2024 Undergraduate Education and Teaching Reform Research Project:Innovation and Practice of Professional Course Teaching Paradigms in the Context of Digital Education.
文摘The rapid development of artificial intelligence(AI)has placed significant pressure on universities to rethink how they train software engineering students.Tools like GitHub Copilot can now generate basic code in seconds.This raises important questions:What is the value of traditional programming education?What role should instructors play when AI becomes a powerful teaching assistant?How should the goals of software engineering programs change as companies increasingly use AI to handle coding tasks?This paper explores the key challenges AI brings to software engineering education and proposes practical strategies for updating talent development models to meet these changes.
