This work presents a systematic analysis of proton-induced total ionizing dose(TID)effects in 1.2 k V silicon carbide(SiC)power devices with various edge termination structures.Three edge terminations including ring-a...This work presents a systematic analysis of proton-induced total ionizing dose(TID)effects in 1.2 k V silicon carbide(SiC)power devices with various edge termination structures.Three edge terminations including ring-assisted junction termination extension(RA-JTE),multiple floating zone JTE(MFZ-JTE),and field limiting rings(FLR)were fabricated and irradiated with45 Me V protons at fluences ranging from 1×10^(12) to 1×10^(14) cm^(-2).Experimental results,supported by TCAD simulations,show that the RA-JTE structure maintained stable breakdown performance with less than 1%variation due to its effective electric field redistribution by multiple P+rings.In contrast,MFZ-JTE and FLR exhibit breakdown voltage shifts of 6.1%and 15.2%,respectively,under the highest fluence.These results demonstrate the superior radiation tolerance of the RA-JTE structure under TID conditions and provide practical design guidance for radiation-hardened Si C power devices in space and other highradiation environments.展开更多
This study investigates the distinct impacts of eastern Pacific(EP)and central Pacific(CP)El Niño events on winter shortwave solar radiation(SSR)in southern China,revealing different spatial distributions and und...This study investigates the distinct impacts of eastern Pacific(EP)and central Pacific(CP)El Niño events on winter shortwave solar radiation(SSR)in southern China,revealing different spatial distributions and underlying mechanisms.The results show that,during the developing winter of EP El Niño,significant SSR reductions occur in southwestern China and the east coast of southern China due to a strong,zonally extended Northwest Pacific anticyclone that transports moisture from the tropical Northwest Pacific and North Indian Ocean,while the northeast of southern China experiences a weak increase in SSR.In contrast,during the developing winter of CP El Niño,SSR decreases in the east of southern China with a significant decrease in the lower basin of the Yangtze River but an increase in the west of southern China with a remarkable increase in eastern Yunnan.The pronounced east-west dipole pattern in SSR anomalies is driven by a meridionally elongated Northwest Pacific anticyclone,which enhances northward moisture transport to the east of southern China while leaving western areas drier.Further research reveals that distinct moisture anomalies during the developing winter of EP and CP events result in divergent SSR distributions across southern China,primarily through modulating the total cloud cover.These findings highlight the critical need to differentiate between El Niño types when predicting medium and long-term variability of radiation in southern China.展开更多
During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of ra- diotherapy on the surrou...During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of ra- diotherapy on the surrounding nervous tissue. In the present study, we used three-dimensional, conformal, intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani. The focus of the hydatid disease on the left femur was subiected to radio- therapy （40 Gy） for 14 days, and the right femur received sham irradiation. Hematoxylin-eosin staining, electron microscopy, and terminal deoxynucleotidyl transferase-dUTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal, with no ob- vious apoptosis after radiation. Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized with Echinococcus granulosus disappeared in the left femur of the animals after treatment. The mortality of the protoscolex was higher in the left side than in the right side. The succinate dehydrogenase activity in the protoscolex in bone parasitized with Echi- nococcus granulosus was lower in the left femur than in the right femur. These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease in Meriones meridiani without damaging the morphology or function of the sciatic nerve.展开更多
Laser additive manufacturing(LAM)has been widely used in high-end manufacturing fields such as aerospace,nuclear power,and shipbuilding.However,it is a grand challenge for direct and continuous observation of complex ...Laser additive manufacturing(LAM)has been widely used in high-end manufacturing fields such as aerospace,nuclear power,and shipbuilding.However,it is a grand challenge for direct and continuous observation of complex laser-matter interaction,melt flow,and defect formation during LAM due to extremely large temperature gradient,fast cooling rate,and small time(millisecond)and space(micron)scales.The emergence of synchrotron radiation provides a feasible approach for in situ observation of the LAM process.This paper outlines the current development in real-time characterization of LAM by synchrotron radiation,including laser-matter interaction,molten pool evolution,solidification structure evolution,and defects formation and elimination.Furthermore,the future development direction and application-oriented research are also discussed.展开更多
The thermochemical non-equilibrium phenomena encountered by hypersonic vehicles present significant challenges in their design.To investigate the thermochemical reaction flow behind shock waves,the non-equilibrium rad...The thermochemical non-equilibrium phenomena encountered by hypersonic vehicles present significant challenges in their design.To investigate the thermochemical reaction flow behind shock waves,the non-equilibrium radiation in the visible range using a shock tube was studied.Experiments were conducted with a shock velocity of 4.7 km/s,using nitrogen at a pressure of 20 Pa.To address measurement difficulties associated with weak radiation,a special square section shock tube with a side length of 380 mm was utilized.A high-speed camera characterized the shock wave’s morphology,and a spectrograph and a monochromator captured the radiation.The spectra were analyzed,and the numerical spectra were compared with experimental results,showing a close match.Temperature changes behind the shock wave were obtained and compared with numerical predictions.The findings indicate that the vibrational temperatures are overestimated,while the vibrational relaxation time is likely underestimated,due to the oversimplified portrayals of the non-equilibrium relaxation process in the models.Additionally,both experimental and simulated time-resolved profiles of radiation intensity at specific wavelengths were analyzed.The gathered data aims to enhance computational fluid dynamics codes and radiation models,improving their predictive accuracy.展开更多
Radioactive microspheres have demonstrated excellent therapeutic effects and good tolerance in the treatment of unresectable primary and secondary liver malignancies.This is attributed to precise embolization and pote...Radioactive microspheres have demonstrated excellent therapeutic effects and good tolerance in the treatment of unresectable primary and secondary liver malignancies.This is attributed to precise embolization and potent anti-tumor effect.However,certain limitations such as unstable loading,perfusion stasis,heterogeneous distribution,ectopic distribution,and insufficient dosage,restrict their clinical application.Herein,a novel personalized Y-90 carbon microsphere with high uniformity,high specific activity and high availability(^(90)Y-HUACM)is presented.It is synthesized through planar molecular complex adsorption and chemical deposition solidification.^(90)Y-HUACM exhibited controllable size,excellent biocompatibility,outstanding in vitro and in vivo stability.The radiolabeling efficiency of Y-90 exceeded 99%and the leaching rate of Y-90 is far below 0.1%.Furthermore,the excellent anti-tumor effect,nuclide loading stability,anti-reflux characteristics,precise embolization,and biosafety of^(90)Y-HUACM were validated in a rabbit VX2liver tumor model.In summary,this new,high-performance,and customizable radioactive microsphere provides a superior choice for selective internal radiation treatment of advanced liver cancer is expected to be rapidly applied in clinical practice.展开更多
A sp^(2) carbon-conjugated covalent organic framework (BDATN) was modified through γ-ray radiation reduction and subsequent acidification with hydrochloric acid to yield a novel functional COF (named rBDATN-HCl) for ...A sp^(2) carbon-conjugated covalent organic framework (BDATN) was modified through γ-ray radiation reduction and subsequent acidification with hydrochloric acid to yield a novel functional COF (named rBDATN-HCl) for Cr(Ⅵ) removal.The morphology and structure of rBDATN-HCl were analyzed and identified by SEM,FTIR,XRD and solid-state13C NMR.It is found that the active functional groups,such as hydroxyl and amide,were introduced into BDATN after radiation reduction and acidification.The prepared rBDATN-HCl demonstrates a photocatalytic reduction removal rate of Cr(Ⅵ) above 99%after 60min of illumination with a solid-liquid ratio of 0.5 mg/mL,showing outstanding performance,which is attributed to the increase of dispersibility and adsorption sites of r BDATN-HCl.In comparison to the cBDATN-HCl synthesized with chemical reduction,rBDATN-HCl exhibits a better photoreduction performance for Cr(Ⅵ),demonstrating the advantages of radiation preparation of rBDATN-HCl.It is expected that more functionalized sp^(2) carbon-conjugated COFs could be obtained by this radiation-induced reduction strategy.展开更多
Auroral Kilometric Radiation (AKR) is a common radio emission,which can contribute to the magnetosphere-ionosphereatmosphere co u pling.Similar emissions have been observed in all magnetic planet magnetospheres of the...Auroral Kilometric Radiation (AKR) is a common radio emission,which can contribute to the magnetosphere-ionosphereatmosphere co u pling.Similar emissions have been observed in all magnetic planet magnetospheres of the solar system.In this study,using observations from the FAST satellite from 30 August 1996 to 9 September 2001,the distribution of AKR in altitude=500-4500 km and invariant latitude (|ILAT|)=60°-80°has been analyzed.63045 AKR samples have been identified with~48%(52%) samples on the dayside (nightside).Of considerable interest,there is a distinct MLT asymmetry with the high occurrence rate in MLT=05-08 and 18-22(02-05 and 12-17) in the northern (southern) hemisphere.The distinct MLT asymmetry is associated with the direction of Bxof the interplaneta ry magnetic field.In addition,the occurrence rate on the nightside clearly increases as the AE^(*) index increases.This study further enriches the information and understanding of AKR in the magnetosphere as well as other similar radio emissions.展开更多
In this work,we present a parallel implementation of radiation hydrodynamics coupled with particle transport,utilizing software infrastructure JASMIN(J Adaptive Structured Meshes applications INfrastructure)which enca...In this work,we present a parallel implementation of radiation hydrodynamics coupled with particle transport,utilizing software infrastructure JASMIN(J Adaptive Structured Meshes applications INfrastructure)which encapsulates high-performance technology for the numerical simulation of complex applications.Two serial codes,radiation hydrodynamics RH2D and particle transport Sn2D,have been integrated into RHSn2D on JASMIN infrastructure,which can efficiently use thousands of processors to simulate the complex multi-physics phenomena.Moreover,the non-conforming processors strategy has ensured RHSn2D against the serious load imbalance between radiation hydrodynamics and particle transport for large scale parallel simulations.Numerical results show that RHSn2D achieves a parallel efficiency of 17.1%using 90720 cells on 8192 processors compared with 256 processors in the same problem.展开更多
The response and performance of radiation detectors for accurate measurements and effective use for radiological safety in medical, industrial, and nuclear sectors are based on the optimal use, maintenance, repair and...The response and performance of radiation detectors for accurate measurements and effective use for radiological safety in medical, industrial, and nuclear sectors are based on the optimal use, maintenance, repair and calibration of radiation monitoring instruments in a secondary standard dosimetry laboratory. In Nigeria, the suboptimal performances of these instruments are attributed to inadequate maintenance practices, insufficient calibration, and limited awareness of proper equipment handling for optimal use. This study assesses the current practices related to the optimal use, maintenance, repair, and calibration of radiation detection equipment across Nigeria’s six geopolitical zones. Using a cross-sectional survey approach, data were collected from Ninety (90) radiation monitoring equipment operators, Radiation Safety Officers, and frontline responders to evaluate their knowledge, awareness, and practices concerning equipment usage, operation, storage, handling, and calibration. The findings reveal significant gaps in knowledge of usage (trained is 43.2%, not trained is 56.8%) and inconsistencies in maintenance practices (as indicated by the regression analysis (β = 0.51, p < 0.01), particularly regarding specialized instruments such as the PackEye, Mobile Detection System (MDS), Radionuclide Identifinder (RID), and Personal Radiation Detectors (PRD). While there is high awareness of the need for regular calibration and handling training, the lack of standardized protocols and training alignment poses challenges to the effective use of these instruments. This study underscores the importance of comprehensive training programs, standardized maintenance protocols, and enhanced awareness initiatives to optimize the usage, performance and safety of radiation monitoring instruments in Nigeria.展开更多
Bone marrow serves as the life-long home for hemato-poietic stem cells(HSCs)and is the most radio-sensitive organ^([1]).Acute ionizing radiation exceeding 1 Gray(Gy)causes severe damage in bone marrow while no effecti...Bone marrow serves as the life-long home for hemato-poietic stem cells(HSCs)and is the most radio-sensitive organ^([1]).Acute ionizing radiation exceeding 1 Gray(Gy)causes severe damage in bone marrow while no effective drug has been approved in clinical.In a recent work pub-lished in MedComm,Gao and her team reported,for the first time,cannabidiol(CBD)as an outstanding radioprotection agent targeting acute radiation-induced hematopoietic injury^([2]).Within two weeks post radiation,CBD can pro-mote the stemness of hematopoietic stem cells to a regular level.Using single-cell RNA sequencing(scRNA-seq)and functional assay,the authors decoded molecular changes underlying radiation-induced damage and CBD-induced recovery in HSCs.展开更多
Radiation detectors, such as survey meters, are essential for ensuring radiation safety in various sectors, including healthcare, industrial processing, emergency response, etc. However, regular calibration and proper...Radiation detectors, such as survey meters, are essential for ensuring radiation safety in various sectors, including healthcare, industrial processing, emergency response, etc. However, regular calibration and proper maintenance of survey meters are important in order to ascertain their accuracy and reliability. This study provides a comprehensive retrospective assessment of the calibration behaviour, durability, and fault trends of 160 survey meters, spanning ten different models. They were calibrated at the Secondary Standard Dosimetry Laboratory (SSDL) in Nigeria over a decade (2012-2023) using an X-Ray Beam Irradiator Model X80-225K and Cs-137 irradiator (OB6) with a PTW reference spherical chamber traceable to the IAEA SSDL in Seibersdorf, Austria. The calibration stability of each model was evaluated, revealing that models like Instrument A and Instrument B demonstrated high reliability with calibration factors close to the ideal value of 1, while models like Instrument C exhibited higher variability, suggesting less consistent performance for dose rate monitoring. Fault analysis showed that the most common issues were related to the battery compartment, indicating a need for improved handling practices. Correlation analysis reveals no statistically significant correlation between calibration factor and age of survey meter across the analysed models. The study concludes that regular calibration, proper handling, and user training are crucial for maintaining the accuracy and longevity of radiation detectors.展开更多
Prostate cancer is the most common non-cutaneous cancers occurring in American men,and whilemost men with early-stage prostate cancers are cured,up to a third might manifest with biochemical recurrence(BCR)of prostate...Prostate cancer is the most common non-cutaneous cancers occurring in American men,and whilemost men with early-stage prostate cancers are cured,up to a third might manifest with biochemical recurrence(BCR)of prostate cancer.BCR is a disease entitywhich is characterized by a rising prostate-specific antigen(PSA)in the setting of a previously treated localized prostate cancerwith either surgery or radiation therapywith curativeintent.展开更多
We present a study of magnetic transport and radiation properties during compression of a magnetized laboratory plasma.A theta pinch is used to produce a magnetized plasma column undergoing radial implosion,with plasm...We present a study of magnetic transport and radiation properties during compression of a magnetized laboratory plasma.A theta pinch is used to produce a magnetized plasma column undergoing radial implosion,with plasma parameters comprehensively measured through diverse diagnostic techniques.High-resolution observations show the implosion progressing through three stages:compression,expansion,and recompression.An anomalous demagnetization phenomenon is observed during the first compression stage,wherein the magnetic field at the plasma center is depleted as the density increases.We reveal the demagnetization mechanism and formulate a straightforward criterion for determining its occurrence,through analysis based on extended-magnetohydrodynamics theory and a generalized Ohm’s law.Additionally,we quantitatively evaluate the radiation losses and magnetic field variations during the two compression stages,providing experimental evidence that magnetic transport can influence the radiation properties by altering the plasma hydrodynamics.Furthermore,extrapolated results using our findings reveal direct relevance to magnetized inertial confinement fusion,space,and astrophysical plasma scenarios.展开更多
This review evaluates the role of stereotactic body radiation therapy(SBRT)in advanced/metastatic intrahepatic cholangiocarcinoma(iCCA),highlighting its efficacy,integration with systemic therapy,and potential for res...This review evaluates the role of stereotactic body radiation therapy(SBRT)in advanced/metastatic intrahepatic cholangiocarcinoma(iCCA),highlighting its efficacy,integration with systemic therapy,and potential for resection or transplantation.SBRT is emerging as a transformative,non-invasive treatment for iCCA,extending beyond palliation.SBRT with a biologically effective dose>75 Gy improves survival in unresectable iCCA,with median overall survival(mOS)of 15-24 months,significantly surpassing lower-dose regimens.Advanced motion management techniques like fiducial tracking and gating achieve>70%local control at 1 year.In metastatic iCCA,hypo-fractionated SBRT provides symptom relief with mOS of 6-9 months and reduced toxicity.Neoadjuvant SBRT increases R0 resection rates to 60%-75%in borderline resectable cases,compared to 30%-40%with chemotherapy alone.SBRT combined with systemic therapy expands eligibility for liver transplantation,achieving 3-year post-transplant survival>65%.SBRT is a transformative therapy for iCCA,improving control,survival,and eligibility for curative treatments.Further research is needed to optimize protocols and patient selection.展开更多
In order to meet the growing global energy demand and fulfill energy conservation and emission reduction goals, the efficient utilization of solar energy is becoming increasingly critical. However, the effects of high...In order to meet the growing global energy demand and fulfill energy conservation and emission reduction goals, the efficient utilization of solar energy is becoming increasingly critical. However, the effects of high temperatures on solar absorption are rarely considered in practical research. Therefore, this study presents a porous zinc and silver sulfide solar absorber with high-temperature radiative cooling capabilities. The solar absorption rate and radiative cooling efficiency in the high-temperature range(636 K–1060 K) are computed using the finite-difference time-domain method. Furthermore, the impact of parameters such as characteristic length, porosity, incident angle, and pore shape factor on both the absorption rate and efficiency of the solar absorber is analyzed. The mechanism is further examined from the perspective of microscopic thermal radiation. The results show that, in the high-temperature range, the solar absorption rate increases with higher porosity and incident angles, reaching its peak when the characteristic length is 1 μm. These findings highlight the significant potential of the solar absorber for efficient solar energy harvesting in photo-thermal conversion applications within a specific high-temperature range.展开更多
Radiological or nuclear accidents can lead to serious outcomes for individuals exposed to ionizing radiation,with health effects that are either acute or delayed,deterministic or stochastic,depending on the effective ...Radiological or nuclear accidents can lead to serious outcomes for individuals exposed to ionizing radiation,with health effects that are either acute or delayed,deterministic or stochastic,depending on the effective dose of exposure.Mechanistically,ionizing radiation can inflict damage either directly on DNA or through oxidative stress,which may trigger a cascade of damages to tissues and organs.The development of effective radiation medical countermeasures is an unmet need and should be a top priority in preparing for radiation emergencies.This paper aims to address the critical questions of whether current countermeasures are available,what additional measures are needed,and what actions can be taken to enhance the development of radiation medical countermeasures from a systematic perspective.展开更多
Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challe...Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity.展开更多
Fluoroscopic imaging is widely utilised for diagnostic and therapeutic procedures and is fundamental to the establishment and maintenance of dialysis vascular access.To optimise outcomes and avoid injury to patients a...Fluoroscopic imaging is widely utilised for diagnostic and therapeutic procedures and is fundamental to the establishment and maintenance of dialysis vascular access.To optimise outcomes and avoid injury to patients and healthcare pro-viders,radiation technology must be applied effectively and safely in clinical practice.Radiation safety may be overlooked by nephrology training curricula.This narrative review discusses the theoretical and practical principles of radiation management in fluoroscopy-guided procedures and is intended as a primer for trainees and nephrologists working in interventional settings.展开更多
Aggregation-induced emission(AIE)is a unique phenomenon where certain organic materials exhibit enhanced luminescence in their aggregated states,overcoming the typical quenching observed in conventional organic materi...Aggregation-induced emission(AIE)is a unique phenomenon where certain organic materials exhibit enhanced luminescence in their aggregated states,overcoming the typical quenching observed in conventional organic materials.Since its discovery in 2001,AIE has driven significant advances in fields like OLEDs and biological imaging,earning recognition in fundamental research.However,its application in high-energy radiation detection remains underexplored.Organic scintillators,though widely used,face challenges such as low light yield and poor radiation attenuation.AIE materials offer promising solutions by improving light yield,response speed,and radiation attenuation.This review summarizes the design strategies behind AIE scintillators and their very recent applications in X-ray,γ-ray,and fast neutron detection.We highlight their advantages in enhancing detection sensitivity,reducing background noise,and achieving high-resolution imaging.By addressing the current challenges,we believe AIE materials will play a pivotal role in advancing future radiation detection and imaging technologies.展开更多
基金supported by the IITP(Institute for Information&Communications Technology Planning&Evaluation)under the ITRC(Information Technology Research Center)support program(IITP-2025-RS-2024-00438288)grant funded by the Korea government(MSIT)+1 种基金National Research Council of Science&Technology(NST)grant by the MSIT(Aerospace Semiconductor Strategy Research Project No.GTL25051-000)supported by the IC Design Education Center(IDEC),Korea。
文摘This work presents a systematic analysis of proton-induced total ionizing dose(TID)effects in 1.2 k V silicon carbide(SiC)power devices with various edge termination structures.Three edge terminations including ring-assisted junction termination extension(RA-JTE),multiple floating zone JTE(MFZ-JTE),and field limiting rings(FLR)were fabricated and irradiated with45 Me V protons at fluences ranging from 1×10^(12) to 1×10^(14) cm^(-2).Experimental results,supported by TCAD simulations,show that the RA-JTE structure maintained stable breakdown performance with less than 1%variation due to its effective electric field redistribution by multiple P+rings.In contrast,MFZ-JTE and FLR exhibit breakdown voltage shifts of 6.1%and 15.2%,respectively,under the highest fluence.These results demonstrate the superior radiation tolerance of the RA-JTE structure under TID conditions and provide practical design guidance for radiation-hardened Si C power devices in space and other highradiation environments.
基金funded by a Project from China Southern Power Grid Company Ltd.(Nos.ZBKJXM20232481 and ZBKJXM20232482)。
文摘This study investigates the distinct impacts of eastern Pacific(EP)and central Pacific(CP)El Niño events on winter shortwave solar radiation(SSR)in southern China,revealing different spatial distributions and underlying mechanisms.The results show that,during the developing winter of EP El Niño,significant SSR reductions occur in southwestern China and the east coast of southern China due to a strong,zonally extended Northwest Pacific anticyclone that transports moisture from the tropical Northwest Pacific and North Indian Ocean,while the northeast of southern China experiences a weak increase in SSR.In contrast,during the developing winter of CP El Niño,SSR decreases in the east of southern China with a significant decrease in the lower basin of the Yangtze River but an increase in the west of southern China with a remarkable increase in eastern Yunnan.The pronounced east-west dipole pattern in SSR anomalies is driven by a meridionally elongated Northwest Pacific anticyclone,which enhances northward moisture transport to the east of southern China while leaving western areas drier.Further research reveals that distinct moisture anomalies during the developing winter of EP and CP events result in divergent SSR distributions across southern China,primarily through modulating the total cloud cover.These findings highlight the critical need to differentiate between El Niño types when predicting medium and long-term variability of radiation in southern China.
基金supported by the National Natural Science Foundation of China,No.81360276a grant from the Science and Technology Project of Xinjiang Uygur Autonomous Region in China,No.2013911129+2 种基金a grant from the Youth Science and Technology Innovation Talents Project of Xinjiang Uygur Autonomous Region-Young Doctor Talents Training Project,No.2013731013the Natural Science Foundation of Xinjiang Uygur Autonomous Region,No.2012211B34the China Postdoctoral Science Foundation,No.2014M552566XB
文摘During radiotherapy to kill femoral hydatid tapeworms, the sciatic nerve surrounding the focus can be easily damaged by the treatment. Thus, it is very important to evaluate the effects of ra- diotherapy on the surrounding nervous tissue. In the present study, we used three-dimensional, conformal, intensity-modulated radiation therapy to treat bilateral femoral hydatid disease in Meriones meridiani. The focus of the hydatid disease on the left femur was subiected to radio- therapy （40 Gy） for 14 days, and the right femur received sham irradiation. Hematoxylin-eosin staining, electron microscopy, and terminal deoxynucleotidyl transferase-dUTP nick end labeling assays on the left femurs showed that the left sciatic nerve cell structure was normal, with no ob- vious apoptosis after radiation. Trypan blue staining demonstrated that the overall protoscolex structure in bone parasitized with Echinococcus granulosus disappeared in the left femur of the animals after treatment. The mortality of the protoscolex was higher in the left side than in the right side. The succinate dehydrogenase activity in the protoscolex in bone parasitized with Echi- nococcus granulosus was lower in the left femur than in the right femur. These results suggest that three-dimensional conformal intensity-modulated radiation therapy achieves good therapeutic effects on the secondary bone in hydatid disease in Meriones meridiani without damaging the morphology or function of the sciatic nerve.
基金supported by the National Natural Science Foundation of China-Distinguished Young Scholars(No.52325407)the National Natural Science Foundation of China-Key Program(No.52234010)the Open Research Fund of the State Key Laboratory of Rolling and Automation,Northeastern University(No.2022RALKFKT004).
文摘Laser additive manufacturing(LAM)has been widely used in high-end manufacturing fields such as aerospace,nuclear power,and shipbuilding.However,it is a grand challenge for direct and continuous observation of complex laser-matter interaction,melt flow,and defect formation during LAM due to extremely large temperature gradient,fast cooling rate,and small time(millisecond)and space(micron)scales.The emergence of synchrotron radiation provides a feasible approach for in situ observation of the LAM process.This paper outlines the current development in real-time characterization of LAM by synchrotron radiation,including laser-matter interaction,molten pool evolution,solidification structure evolution,and defects formation and elimination.Furthermore,the future development direction and application-oriented research are also discussed.
基金supported by the Key-Area Research and Development Program of Guangdong Province(Grant No.2021B0909060004)the National Natural Science Foundation of China(Grant Nos.12072355 and 92271117)the Strategic Priority Research Program of the Chinese Academy of Sciences(Grant No.XDB0620202).
文摘The thermochemical non-equilibrium phenomena encountered by hypersonic vehicles present significant challenges in their design.To investigate the thermochemical reaction flow behind shock waves,the non-equilibrium radiation in the visible range using a shock tube was studied.Experiments were conducted with a shock velocity of 4.7 km/s,using nitrogen at a pressure of 20 Pa.To address measurement difficulties associated with weak radiation,a special square section shock tube with a side length of 380 mm was utilized.A high-speed camera characterized the shock wave’s morphology,and a spectrograph and a monochromator captured the radiation.The spectra were analyzed,and the numerical spectra were compared with experimental results,showing a close match.Temperature changes behind the shock wave were obtained and compared with numerical predictions.The findings indicate that the vibrational temperatures are overestimated,while the vibrational relaxation time is likely underestimated,due to the oversimplified portrayals of the non-equilibrium relaxation process in the models.Additionally,both experimental and simulated time-resolved profiles of radiation intensity at specific wavelengths were analyzed.The gathered data aims to enhance computational fluid dynamics codes and radiation models,improving their predictive accuracy.
基金supported by the National Major Scientific and Technological Special Project for“Significant New Drugs Development”(No.2018ZX09201018–028)the nuclear energy development projects of China during the 13thFive Year Plan periodthe key research and development project of the Sichuan Provincial Department of Science and Technology(No.18ZDYF1466)。
文摘Radioactive microspheres have demonstrated excellent therapeutic effects and good tolerance in the treatment of unresectable primary and secondary liver malignancies.This is attributed to precise embolization and potent anti-tumor effect.However,certain limitations such as unstable loading,perfusion stasis,heterogeneous distribution,ectopic distribution,and insufficient dosage,restrict their clinical application.Herein,a novel personalized Y-90 carbon microsphere with high uniformity,high specific activity and high availability(^(90)Y-HUACM)is presented.It is synthesized through planar molecular complex adsorption and chemical deposition solidification.^(90)Y-HUACM exhibited controllable size,excellent biocompatibility,outstanding in vitro and in vivo stability.The radiolabeling efficiency of Y-90 exceeded 99%and the leaching rate of Y-90 is far below 0.1%.Furthermore,the excellent anti-tumor effect,nuclide loading stability,anti-reflux characteristics,precise embolization,and biosafety of^(90)Y-HUACM were validated in a rabbit VX2liver tumor model.In summary,this new,high-performance,and customizable radioactive microsphere provides a superior choice for selective internal radiation treatment of advanced liver cancer is expected to be rapidly applied in clinical practice.
基金supported by the National Natural Science Foundation of China(No.U2067212)the National Science Fund for Distinguished Young Scholars(No.21925603).
文摘A sp^(2) carbon-conjugated covalent organic framework (BDATN) was modified through γ-ray radiation reduction and subsequent acidification with hydrochloric acid to yield a novel functional COF (named rBDATN-HCl) for Cr(Ⅵ) removal.The morphology and structure of rBDATN-HCl were analyzed and identified by SEM,FTIR,XRD and solid-state13C NMR.It is found that the active functional groups,such as hydroxyl and amide,were introduced into BDATN after radiation reduction and acidification.The prepared rBDATN-HCl demonstrates a photocatalytic reduction removal rate of Cr(Ⅵ) above 99%after 60min of illumination with a solid-liquid ratio of 0.5 mg/mL,showing outstanding performance,which is attributed to the increase of dispersibility and adsorption sites of r BDATN-HCl.In comparison to the cBDATN-HCl synthesized with chemical reduction,rBDATN-HCl exhibits a better photoreduction performance for Cr(Ⅵ),demonstrating the advantages of radiation preparation of rBDATN-HCl.It is expected that more functionalized sp^(2) carbon-conjugated COFs could be obtained by this radiation-induced reduction strategy.
基金supported by the National Natural Science Foundation of China grants 42230209,42374215,42304183,72342001,71931003 and 72061147004the Scientific Research Fund of Hunan Provincial Education Department grants 21A0212the Science and Technology Innovation Program of Hunan Province under Grants 2022RC4025,2023JJ50312,2023JJ50010.
文摘Auroral Kilometric Radiation (AKR) is a common radio emission,which can contribute to the magnetosphere-ionosphereatmosphere co u pling.Similar emissions have been observed in all magnetic planet magnetospheres of the solar system.In this study,using observations from the FAST satellite from 30 August 1996 to 9 September 2001,the distribution of AKR in altitude=500-4500 km and invariant latitude (|ILAT|)=60°-80°has been analyzed.63045 AKR samples have been identified with~48%(52%) samples on the dayside (nightside).Of considerable interest,there is a distinct MLT asymmetry with the high occurrence rate in MLT=05-08 and 18-22(02-05 and 12-17) in the northern (southern) hemisphere.The distinct MLT asymmetry is associated with the direction of Bxof the interplaneta ry magnetic field.In addition,the occurrence rate on the nightside clearly increases as the AE^(*) index increases.This study further enriches the information and understanding of AKR in the magnetosphere as well as other similar radio emissions.
基金National Natural Science Foundation of China(12471367)。
文摘In this work,we present a parallel implementation of radiation hydrodynamics coupled with particle transport,utilizing software infrastructure JASMIN(J Adaptive Structured Meshes applications INfrastructure)which encapsulates high-performance technology for the numerical simulation of complex applications.Two serial codes,radiation hydrodynamics RH2D and particle transport Sn2D,have been integrated into RHSn2D on JASMIN infrastructure,which can efficiently use thousands of processors to simulate the complex multi-physics phenomena.Moreover,the non-conforming processors strategy has ensured RHSn2D against the serious load imbalance between radiation hydrodynamics and particle transport for large scale parallel simulations.Numerical results show that RHSn2D achieves a parallel efficiency of 17.1%using 90720 cells on 8192 processors compared with 256 processors in the same problem.
文摘The response and performance of radiation detectors for accurate measurements and effective use for radiological safety in medical, industrial, and nuclear sectors are based on the optimal use, maintenance, repair and calibration of radiation monitoring instruments in a secondary standard dosimetry laboratory. In Nigeria, the suboptimal performances of these instruments are attributed to inadequate maintenance practices, insufficient calibration, and limited awareness of proper equipment handling for optimal use. This study assesses the current practices related to the optimal use, maintenance, repair, and calibration of radiation detection equipment across Nigeria’s six geopolitical zones. Using a cross-sectional survey approach, data were collected from Ninety (90) radiation monitoring equipment operators, Radiation Safety Officers, and frontline responders to evaluate their knowledge, awareness, and practices concerning equipment usage, operation, storage, handling, and calibration. The findings reveal significant gaps in knowledge of usage (trained is 43.2%, not trained is 56.8%) and inconsistencies in maintenance practices (as indicated by the regression analysis (β = 0.51, p < 0.01), particularly regarding specialized instruments such as the PackEye, Mobile Detection System (MDS), Radionuclide Identifinder (RID), and Personal Radiation Detectors (PRD). While there is high awareness of the need for regular calibration and handling training, the lack of standardized protocols and training alignment poses challenges to the effective use of these instruments. This study underscores the importance of comprehensive training programs, standardized maintenance protocols, and enhanced awareness initiatives to optimize the usage, performance and safety of radiation monitoring instruments in Nigeria.
文摘Bone marrow serves as the life-long home for hemato-poietic stem cells(HSCs)and is the most radio-sensitive organ^([1]).Acute ionizing radiation exceeding 1 Gray(Gy)causes severe damage in bone marrow while no effective drug has been approved in clinical.In a recent work pub-lished in MedComm,Gao and her team reported,for the first time,cannabidiol(CBD)as an outstanding radioprotection agent targeting acute radiation-induced hematopoietic injury^([2]).Within two weeks post radiation,CBD can pro-mote the stemness of hematopoietic stem cells to a regular level.Using single-cell RNA sequencing(scRNA-seq)and functional assay,the authors decoded molecular changes underlying radiation-induced damage and CBD-induced recovery in HSCs.
文摘Radiation detectors, such as survey meters, are essential for ensuring radiation safety in various sectors, including healthcare, industrial processing, emergency response, etc. However, regular calibration and proper maintenance of survey meters are important in order to ascertain their accuracy and reliability. This study provides a comprehensive retrospective assessment of the calibration behaviour, durability, and fault trends of 160 survey meters, spanning ten different models. They were calibrated at the Secondary Standard Dosimetry Laboratory (SSDL) in Nigeria over a decade (2012-2023) using an X-Ray Beam Irradiator Model X80-225K and Cs-137 irradiator (OB6) with a PTW reference spherical chamber traceable to the IAEA SSDL in Seibersdorf, Austria. The calibration stability of each model was evaluated, revealing that models like Instrument A and Instrument B demonstrated high reliability with calibration factors close to the ideal value of 1, while models like Instrument C exhibited higher variability, suggesting less consistent performance for dose rate monitoring. Fault analysis showed that the most common issues were related to the battery compartment, indicating a need for improved handling practices. Correlation analysis reveals no statistically significant correlation between calibration factor and age of survey meter across the analysed models. The study concludes that regular calibration, proper handling, and user training are crucial for maintaining the accuracy and longevity of radiation detectors.
文摘Prostate cancer is the most common non-cutaneous cancers occurring in American men,and whilemost men with early-stage prostate cancers are cured,up to a third might manifest with biochemical recurrence(BCR)of prostate cancer.BCR is a disease entitywhich is characterized by a rising prostate-specific antigen(PSA)in the setting of a previously treated localized prostate cancerwith either surgery or radiation therapywith curativeintent.
基金the State Key Development Program for Basic Research of China(Grant No.2022YFA1602503)the National Natural Science Foundation of China(Grant Nos.12120101005 and 12205247)
文摘We present a study of magnetic transport and radiation properties during compression of a magnetized laboratory plasma.A theta pinch is used to produce a magnetized plasma column undergoing radial implosion,with plasma parameters comprehensively measured through diverse diagnostic techniques.High-resolution observations show the implosion progressing through three stages:compression,expansion,and recompression.An anomalous demagnetization phenomenon is observed during the first compression stage,wherein the magnetic field at the plasma center is depleted as the density increases.We reveal the demagnetization mechanism and formulate a straightforward criterion for determining its occurrence,through analysis based on extended-magnetohydrodynamics theory and a generalized Ohm’s law.Additionally,we quantitatively evaluate the radiation losses and magnetic field variations during the two compression stages,providing experimental evidence that magnetic transport can influence the radiation properties by altering the plasma hydrodynamics.Furthermore,extrapolated results using our findings reveal direct relevance to magnetized inertial confinement fusion,space,and astrophysical plasma scenarios.
文摘This review evaluates the role of stereotactic body radiation therapy(SBRT)in advanced/metastatic intrahepatic cholangiocarcinoma(iCCA),highlighting its efficacy,integration with systemic therapy,and potential for resection or transplantation.SBRT is emerging as a transformative,non-invasive treatment for iCCA,extending beyond palliation.SBRT with a biologically effective dose>75 Gy improves survival in unresectable iCCA,with median overall survival(mOS)of 15-24 months,significantly surpassing lower-dose regimens.Advanced motion management techniques like fiducial tracking and gating achieve>70%local control at 1 year.In metastatic iCCA,hypo-fractionated SBRT provides symptom relief with mOS of 6-9 months and reduced toxicity.Neoadjuvant SBRT increases R0 resection rates to 60%-75%in borderline resectable cases,compared to 30%-40%with chemotherapy alone.SBRT combined with systemic therapy expands eligibility for liver transplantation,achieving 3-year post-transplant survival>65%.SBRT is a transformative therapy for iCCA,improving control,survival,and eligibility for curative treatments.Further research is needed to optimize protocols and patient selection.
基金Project supported by the National Natural Science Foundation of China (Grant No. 52406102)Shandong Provincial Natural Science Foundation (Grant No. ZR2023QE258)。
文摘In order to meet the growing global energy demand and fulfill energy conservation and emission reduction goals, the efficient utilization of solar energy is becoming increasingly critical. However, the effects of high temperatures on solar absorption are rarely considered in practical research. Therefore, this study presents a porous zinc and silver sulfide solar absorber with high-temperature radiative cooling capabilities. The solar absorption rate and radiative cooling efficiency in the high-temperature range(636 K–1060 K) are computed using the finite-difference time-domain method. Furthermore, the impact of parameters such as characteristic length, porosity, incident angle, and pore shape factor on both the absorption rate and efficiency of the solar absorber is analyzed. The mechanism is further examined from the perspective of microscopic thermal radiation. The results show that, in the high-temperature range, the solar absorption rate increases with higher porosity and incident angles, reaching its peak when the characteristic length is 1 μm. These findings highlight the significant potential of the solar absorber for efficient solar energy harvesting in photo-thermal conversion applications within a specific high-temperature range.
基金Beijing Nova Program,Grant/Award Number:20220484086。
文摘Radiological or nuclear accidents can lead to serious outcomes for individuals exposed to ionizing radiation,with health effects that are either acute or delayed,deterministic or stochastic,depending on the effective dose of exposure.Mechanistically,ionizing radiation can inflict damage either directly on DNA or through oxidative stress,which may trigger a cascade of damages to tissues and organs.The development of effective radiation medical countermeasures is an unmet need and should be a top priority in preparing for radiation emergencies.This paper aims to address the critical questions of whether current countermeasures are available,what additional measures are needed,and what actions can be taken to enhance the development of radiation medical countermeasures from a systematic perspective.
基金supported by the Guangdong High Level Innovation Research Institute(Grant No.2021B0909050006)the National Grand Instrument Project(Grant No.2019YFF01014402)+1 种基金the National Natural Science Foundation of China(Grant No.12205008)support from the National Science Fund for Distinguished Young Scholars(Grant No.12225501)。
文摘Experimental validation of laser intensity is particularly important for the study of fundamental physics at extremely high intensities.However,reliable diagnosis of the focal spot and peak intensity faces huge challenges.In this work,we demonstrate for the firs time that the coherent radiation farfiel patterns from laser–foil interactions can serve as an in situ,real-time,and easy-to-implement diagnostic for an ultraintense laser focus.The laser-driven electron sheets,curved by the spatially varying laser fiel and leaving the targets at nearly the speed of light,produce doughnut-shaped patterns depending on the shapes of the focal spot and the absolute laser intensities.Assisted by particle-in-cell simulations,we can achieve measurements of the intensity and the focal spot,and provide immediate feedback to optimize the focal spots for extremely high intensity.
文摘Fluoroscopic imaging is widely utilised for diagnostic and therapeutic procedures and is fundamental to the establishment and maintenance of dialysis vascular access.To optimise outcomes and avoid injury to patients and healthcare pro-viders,radiation technology must be applied effectively and safely in clinical practice.Radiation safety may be overlooked by nephrology training curricula.This narrative review discusses the theoretical and practical principles of radiation management in fluoroscopy-guided procedures and is intended as a primer for trainees and nephrologists working in interventional settings.
基金financial support from National Natural Science Foundation of China(No.22175156)the Fundamental Research Funds for the Central Universities,China University of Geosciences(Wuhan)(No.162301202692).
文摘Aggregation-induced emission(AIE)is a unique phenomenon where certain organic materials exhibit enhanced luminescence in their aggregated states,overcoming the typical quenching observed in conventional organic materials.Since its discovery in 2001,AIE has driven significant advances in fields like OLEDs and biological imaging,earning recognition in fundamental research.However,its application in high-energy radiation detection remains underexplored.Organic scintillators,though widely used,face challenges such as low light yield and poor radiation attenuation.AIE materials offer promising solutions by improving light yield,response speed,and radiation attenuation.This review summarizes the design strategies behind AIE scintillators and their very recent applications in X-ray,γ-ray,and fast neutron detection.We highlight their advantages in enhancing detection sensitivity,reducing background noise,and achieving high-resolution imaging.By addressing the current challenges,we believe AIE materials will play a pivotal role in advancing future radiation detection and imaging technologies.
