Objective:Explicating the property and action of traditional Chinese medicine(TCM)in the perspectives of modern science deepens the insight into the property of TCM,and provides the basis for new drug discovery and cl...Objective:Explicating the property and action of traditional Chinese medicine(TCM)in the perspectives of modern science deepens the insight into the property of TCM,and provides the basis for new drug discovery and clinical therapy.In this study,we investigated the relationship between transient receptor potential melastatin 8(TRPM8)and pungent flavor using three-dimensional pharmacophores based on virtual screening methods.Methods:Firstly,an inhouse database was established to identify the related pharmacological action according to the traditional Chinese herbs expressing an action of promoting blood circulation.Then,several therapeutic targets,3-hydroxy-3-methylglutaryl-coenzyme A reductase(HMG-CoAR),cholesteryl ester transfer protein(CETP),Niemann-Pick C1-Like 1(NPC1L1)and platelet-activating factor receptor(PAFR),were selected to screen traditional Chinese herbs,and the common virtual screening hits with various hit scores providing data to reveal the correlation among TRPM8 and therapeutic targets.Results:According to the screening results,TRPM8 agonists were able to identify the effective components of pungent herbs and TRPM8,which shares the common virtual screening hits with the therapeutic targets,was considered to be related to the action of pungent taste.Conclusion:The novel ideas and methods in this study are beneficial to unveil the scientific relationship between a TCM property and its action.展开更多
The angina pectoris in coronary heart disease belongs to the category of"chest impediment"in traditional Chinese medicine,and belongs to the syndrome of root deficiency with tip excess.Its main pathogenesis ...The angina pectoris in coronary heart disease belongs to the category of"chest impediment"in traditional Chinese medicine,and belongs to the syndrome of root deficiency with tip excess.Its main pathogenesis is obstruction of the heart collaterals,and treatment mainly adopts dredging collaterals and relieving pain.Based on the treatment principles of dredging collaterals with pungent,aiming at the etiology,pathogenesis and disease characteristics of angina pectoris in coronary heart disease,this article systematically analyzes the Method of Dredging Collaterals with Pungent including the methods of dredging collaterals with pungent moisture,dredging collaterals with pungent warm,dredging collaterals with pungent aroma,and dredging collaterals with insect type drugs,to provide ideas for the treatment of angina pectoris in coronary heart disease.展开更多
In ancient times,the application of Xuming Decoction was popular in the treatment of stroke.Sun Simiao was a famous physician in treating stroke disease in his times.He inherited the theme of Xuming Decoction for trea...In ancient times,the application of Xuming Decoction was popular in the treatment of stroke.Sun Simiao was a famous physician in treating stroke disease in his times.He inherited the theme of Xuming Decoction for treating wind with pungent herbs.This paper focuses on reviewing Sun Simiao's application of Xuming Decoction in^Qianjin Yaofang^,we re-apprehend the mechanism of Sun Simiao's treatment of stroke from the perspective of the divergence of pungent medicine.展开更多
In ancient times,the application of Xuming Decoction was popular in the treatment of stroke.Sun Simiao was a famous physician in treating stroke disease in his times.He inherited the theme of Xuming Decoction for trea...In ancient times,the application of Xuming Decoction was popular in the treatment of stroke.Sun Simiao was a famous physician in treating stroke disease in his times.He inherited the theme of Xuming Decoction for treating wind with pungent herbs.This paper focuses on reviewing Sun Simiao’s application of Xuming Decoction in“Qianjin Yaofang”,we re-apprehend the mechanism of Sun Simiao's treatment of stroke from the perspective of the divergence of pungent medicine.展开更多
基金National Science Foundation of China(Project No.81430094 and No.81603311)Beijing Municipal Natural Science Foundation(No.7164239).
文摘Objective:Explicating the property and action of traditional Chinese medicine(TCM)in the perspectives of modern science deepens the insight into the property of TCM,and provides the basis for new drug discovery and clinical therapy.In this study,we investigated the relationship between transient receptor potential melastatin 8(TRPM8)and pungent flavor using three-dimensional pharmacophores based on virtual screening methods.Methods:Firstly,an inhouse database was established to identify the related pharmacological action according to the traditional Chinese herbs expressing an action of promoting blood circulation.Then,several therapeutic targets,3-hydroxy-3-methylglutaryl-coenzyme A reductase(HMG-CoAR),cholesteryl ester transfer protein(CETP),Niemann-Pick C1-Like 1(NPC1L1)and platelet-activating factor receptor(PAFR),were selected to screen traditional Chinese herbs,and the common virtual screening hits with various hit scores providing data to reveal the correlation among TRPM8 and therapeutic targets.Results:According to the screening results,TRPM8 agonists were able to identify the effective components of pungent herbs and TRPM8,which shares the common virtual screening hits with the therapeutic targets,was considered to be related to the action of pungent taste.Conclusion:The novel ideas and methods in this study are beneficial to unveil the scientific relationship between a TCM property and its action.
基金Supported by the Youth Science Fund Project of the National Natural Science Foundation of China(30304117474)Scientific Research Project of Shanghai Municipal Health Commission(202040308)。
文摘The angina pectoris in coronary heart disease belongs to the category of"chest impediment"in traditional Chinese medicine,and belongs to the syndrome of root deficiency with tip excess.Its main pathogenesis is obstruction of the heart collaterals,and treatment mainly adopts dredging collaterals and relieving pain.Based on the treatment principles of dredging collaterals with pungent,aiming at the etiology,pathogenesis and disease characteristics of angina pectoris in coronary heart disease,this article systematically analyzes the Method of Dredging Collaterals with Pungent including the methods of dredging collaterals with pungent moisture,dredging collaterals with pungent warm,dredging collaterals with pungent aroma,and dredging collaterals with insect type drugs,to provide ideas for the treatment of angina pectoris in coronary heart disease.
文摘In ancient times,the application of Xuming Decoction was popular in the treatment of stroke.Sun Simiao was a famous physician in treating stroke disease in his times.He inherited the theme of Xuming Decoction for treating wind with pungent herbs.This paper focuses on reviewing Sun Simiao's application of Xuming Decoction in^Qianjin Yaofang^,we re-apprehend the mechanism of Sun Simiao's treatment of stroke from the perspective of the divergence of pungent medicine.
文摘In ancient times,the application of Xuming Decoction was popular in the treatment of stroke.Sun Simiao was a famous physician in treating stroke disease in his times.He inherited the theme of Xuming Decoction for treating wind with pungent herbs.This paper focuses on reviewing Sun Simiao’s application of Xuming Decoction in“Qianjin Yaofang”,we re-apprehend the mechanism of Sun Simiao's treatment of stroke from the perspective of the divergence of pungent medicine.
