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Research Progress on Process Optimization and Performance Control of Additive Manufacturing for Refractory Metals
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作者 Lu Durui Song Suocheng Lu Bingheng 《稀有金属材料与工程》 北大核心 2026年第2期345-364,共20页
Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durabili... Refractory metals,including tungsten(W),tantalum(Ta),molybdenum(Mo),and niobium(Nb),play a vital role in industries,such as nuclear energy and aerospace,owing to their exceptional melting temperatures,thermal durability,and corrosion resistance.These metals have body-centered cubic crystal structure,characterized by limited slip systems and impeded dislocation motion,resulting in significant low-temperature brittleness,which poses challenges for the conventional processing.Additive manufacturing technique provides an innovative approach,enabling the production of intricate parts without molds,which significantly improves the efficiency of material usage.This review provides a comprehensive overview of the advancements in additive manufacturing techniques for the production of refractory metals,such as W,Ta,Mo,and Nb,particularly the laser powder bed fusion.In this review,the influence mechanisms of key process parameters(laser power,scan strategy,and powder characteristics)on the evolution of material microstructure,the formation of metallurgical defects,and mechanical properties were discussed.Generally,optimizing powder characteristics,such as sphericity,implementing substrate preheating,and formulating alloying strategies can significantly improve the densification and crack resistance of manufactured parts.Meanwhile,strictly controlling the oxygen impurity content and optimizing the energy density input are also the key factors to achieve the simultaneous improvement in strength and ductility of refractory metals.Although additive manufacturing technique provides an innovative solution for processing refractory metals,critical issues,such as residual stress control,microstructure and performance anisotropy,and process stability,still need to be addressed.This review not only provides a theoretical basis for the additive manufacturing of high-performance refractory metals,but also proposes forward-looking directions for their industrial application. 展开更多
关键词 refractory metals additive manufacturing mechanical properties microstructure evolution optimization of printing process
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Optimization of Reaming Process and Design of Winding Motion Control for Type IV Composite Hydrogen Storage Cylinder
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作者 SONG Junze LÜHongzhan 《Journal of Donghua University(English Edition)》 2026年第1期152-161,共10页
In order to optimize the reaming process of the type IV composite hydrogen storage cylinder,the netting theory was employed for the design of stacking sequences,and the thickness in the head section was predicted.A fi... In order to optimize the reaming process of the type IV composite hydrogen storage cylinder,the netting theory was employed for the design of stacking sequences,and the thickness in the head section was predicted.A finite element model of the plastic-lined composite hydrogen storage cylinder,designed to withstand a working pressure of 70.0 MPa,was established by using the wound composite modeler(WCM)in the Abaqus software to analyze the forces acting on the winding layer.The Hashin failure criterion was utilized as the standard for assessing composite failure,and a progressive failure analysis of the cylinder was conducted to predict both the bursting pressure and the failure location of the composite hydrogen storage cylinder.The results indicate that the reaming process can effectively reduce the maximum filament winding thickness in the head section and promote a more uniform transition.At the bursting pressure,the stress within the head liner decreases,thereby enhancing the ultimate bearing capacity of the cylinder.A control system for a four-axis winding machine was designed by utilizing an industrial computer and a programmable multi-axis controller(PMAC).The winding line pattern is designed and the G-code trajectory is generated by the industrial computer.The numerical control system,composed of the PMAC and servo motor,executes the four-axis interpolation motion. 展开更多
关键词 filament winding reaming process motion control progressive failure thickness prediction
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Simulation and Optimization of Urban Small-Scale Centralized Bio-Gas Purification Process Based on Methyl Diethanolamine Absorbent
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作者 Luling Li Minghui Li +9 位作者 Zhengxiang Xu Haofeng Lin Xuemei Lang Peiming Li Hengrong Zhang Dongxu Ji Jian Liu Jianhui Liu Guang Yang Shuanshi Fan 《Frontiers in Heat and Mass Transfer》 2026年第1期170-186,共17页
This study addresses the energy-intensive challenge of small-scale biogas upgrading by optimizing a chemical absorption process employing methyl diethanolamine(MDEA).Focusing on a typical distributed application of 30... This study addresses the energy-intensive challenge of small-scale biogas upgrading by optimizing a chemical absorption process employing methyl diethanolamine(MDEA).Focusing on a typical distributed application of 300 Nm^(3)/d,we developed an integrated simulation-optimization framework using Aspen HYSYS 14.0 to systematically evaluate the effects of critical operating parameters—absorption pressure,MDEA concentration,flow rate,temperature,number of trays,and reboiler duty—on methane purity and energy consumption.The key finding is the identification of an optimal parameter set:absorption pressure of 1200 kPa,MDEA concentration of 20mol%,lean flow rate of 2.5 kmol/h,temperature of 298.15 K,20 absorber trays,10 regenerator trays,and a reboiler duty of 4 kW,which enabled the product gas to achieve a high CH4 concentration of 97mol%,compliant with pipeline standards.A detailed energy consumption analysis revealed that the reboiler is the most energy-intensive unit,accounting for 75.40%of the total 5.29 kW energy consumption,followed by the gas compressor(23.38%).The specific energy consumption for CH4 recovery and the Energy Consumption Index(ECI)were quantified at 0.8852 kWh/kg CH_(4)and 6.82,respectively.This work provides a validated optimization strategy and critical energy breakdown,offering practical guidance for enhancing the technical and economic viability of small-scale,centralized biogas purification systems. 展开更多
关键词 Chemical absorption process CO_(2)capture bio-gas optimization MDEA
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郭为与他的AI for Process
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作者 姜奇平 端利涛 《互联网周刊》 2026年第2期8-12,共5页
一、作为哲学的AI for Process(一)郭为的哲学思想1.郭为是谁郭为是谁?他是一位哲学家。顺便说,他同时还领导着神州数码。为什么说郭为是哲学家呢?因为他在著作中谈到高深的哲学,如“数据如水,奔流不息,无界融合”。他引述古希腊哲学家... 一、作为哲学的AI for Process(一)郭为的哲学思想1.郭为是谁郭为是谁?他是一位哲学家。顺便说,他同时还领导着神州数码。为什么说郭为是哲学家呢?因为他在著作中谈到高深的哲学,如“数据如水,奔流不息,无界融合”。他引述古希腊哲学家赫拉克利特所说的“万物流转”,又说“你不能两次踏进同一条河流,因为新的水不断地流过你的身旁”,他所表达的意思是“世界上唯一不变的就是变化”。 展开更多
关键词 AI for process 郭为
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Prediction and optimization of flue pressure in sintering process based on SHAP 被引量:4
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作者 Mingyu Wang Jue Tang +2 位作者 Mansheng Chu Quan Shi Zhen Zhang 《International Journal of Minerals,Metallurgy and Materials》 SCIE EI CAS 2025年第2期346-359,共14页
Sinter is the core raw material for blast furnaces.Flue pressure,which is an important state parameter,affects sinter quality.In this paper,flue pressure prediction and optimization were studied based on the shapley a... Sinter is the core raw material for blast furnaces.Flue pressure,which is an important state parameter,affects sinter quality.In this paper,flue pressure prediction and optimization were studied based on the shapley additive explanation(SHAP)to predict the flue pressure and take targeted adjustment measures.First,the sintering process data were collected and processed.A flue pressure prediction model was then constructed after comparing different feature selection methods and model algorithms using SHAP+extremely random-ized trees(ET).The prediction accuracy of the model within the error range of±0.25 kPa was 92.63%.SHAP analysis was employed to improve the interpretability of the prediction model.The effects of various sintering operation parameters on flue pressure,the relation-ship between the numerical range of key operation parameters and flue pressure,the effect of operation parameter combinations on flue pressure,and the prediction process of the flue pressure prediction model on a single sample were analyzed.A flue pressure optimization module was also constructed and analyzed when the prediction satisfied the judgment conditions.The operating parameter combination was then pushed.The flue pressure was increased by 5.87%during the verification process,achieving a good optimization effect. 展开更多
关键词 sintering process flue pressure shapley additive explanation PREDICTION optimizatioN
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Buoyancy characteristic analysis and optimization of precast concrete slab track during casting process of self-compacting concrete 被引量:1
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作者 Pengsong Wang Tao Xin +2 位作者 Peng Chen Sen Wang Di Cheng 《Railway Sciences》 2025年第2期159-173,共15页
Purpose–The precast concrete slab track(PST)has advantages of fewer maintenance frequencies,better smooth rides and structural stability,which has been widely applied in urban rail transit.Precise positioning of prec... Purpose–The precast concrete slab track(PST)has advantages of fewer maintenance frequencies,better smooth rides and structural stability,which has been widely applied in urban rail transit.Precise positioning of precast concrete slab(PCS)is vital for keeping the initial track regularity.However,the cast-in-place process of the self-compacting concrete(SCC)filling layer generally causes a large deformation of PCS due to the water-hammer effect of flowing SCC,even cracking of PCS.Currently,the buoyancy characteristic and influencing factors of PCS during the SCC casting process have not been thoroughly studied in urban rail transit.Design/methodology/approach–In this work,a Computational Fluid Dynamics(CFD)model is established to calculate the buoyancy of PCS caused by the flowing SCC.The main influencing factors,including the inlet speed and flowability of SCC,have been analyzed and discussed.A new structural optimization scheme has been proposed for PST to reduce the buoyancy caused by the flowing SCC.Findings–The simulation and field test results showed that the buoyancy and deformation of PCS decreased obviously after adopting the new scheme.Originality/value–The findings of this study can provide guidance for the control of the deformation of PCS during the SCC construction process. 展开更多
关键词 Casting process Buoyancy characteristics Precast concrete slab track SIMULATION Field test optimizatioN
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Optimization of Surface Layer Properties of Mg-9Li-1Zn Alloy by Ultrasonic Surface Rolling Process and its Impact on Corrosion Behavior 被引量:1
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作者 Huimin Yang Kun Yang +1 位作者 Guobing Wei Rongguang Li 《Acta Metallurgica Sinica(English Letters)》 2025年第8期1421-1435,共15页
The Mg-9Li-1Zn(LZ91)alloy was subjected to an ultrasonic surface rolling process(USRP)with varying passes for the purpose of modifying its surface state.The USRP transformed surface residual stress from initial tensil... The Mg-9Li-1Zn(LZ91)alloy was subjected to an ultrasonic surface rolling process(USRP)with varying passes for the purpose of modifying its surface state.The USRP transformed surface residual stress from initial tensile stress to compressive stress,decreasing the surface roughness and increasing the ratio of the β-Li phase.The USRPed LZ91 sample(3 passes)showed superior corrosion resistance,with the corrosion current density changing from 57.11 to 24.70μA cm^(-2),and the polarization resistance increasing from 576.3 to 1146.1Ωcm^(2).According to the corrosion procedure evaluations,in situ observation revealed that the LZ91 alloy initially experiences pitting,which subsequently develops into cracking.The substantial area coverage of the β-Li phase facilitates the formation of a protective film on the surface,effectively delaying localized corrosion. 展开更多
关键词 Dual-phase Mg-Li alloy Ultrasonic surface rolling process Oxide film Local corrosion Compressive residual stress
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Multi-objective optimization of grinding process parameters for improving gear machining precision 被引量:1
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作者 YOU Tong-fei HAN Jiang +4 位作者 TIAN Xiao-qing TANG Jian-ping LU Yi-guo LI Guang-hui XIA Lian 《Journal of Central South University》 2025年第2期538-551,共14页
The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can caus... The gears of new energy vehicles are required to withstand higher rotational speeds and greater loads,which puts forward higher precision essentials for gear manufacturing.However,machining process parameters can cause changes in cutting force/heat,resulting in affecting gear machining precision.Therefore,this paper studies the effect of different process parameters on gear machining precision.A multi-objective optimization model is established for the relationship between process parameters and tooth surface deviations,tooth profile deviations,and tooth lead deviations through the cutting speed,feed rate,and cutting depth of the worm wheel gear grinding machine.The response surface method(RSM)is used for experimental design,and the corresponding experimental results and optimal process parameters are obtained.Subsequently,gray relational analysis-principal component analysis(GRA-PCA),particle swarm optimization(PSO),and genetic algorithm-particle swarm optimization(GA-PSO)methods are used to analyze the experimental results and obtain different optimal process parameters.The results show that optimal process parameters obtained by the GRA-PCA,PSO,and GA-PSO methods improve the gear machining precision.Moreover,the gear machining precision obtained by GA-PSO is superior to other methods. 展开更多
关键词 worm wheel gear grinding machine gear machining precision machining process parameters multi objective optimization
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Application Effect of Intelligent Guidance Optimization in Physical Examination Process Management
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作者 Fan Li 《Journal of Clinical and Nursing Research》 2025年第8期183-188,共6页
Objective:To investigate the application effects of intelligent guidance systems in optimizing health check-up process management.Methods:A total of 400 examinees who underwent physical examinations at the hospital’s... Objective:To investigate the application effects of intelligent guidance systems in optimizing health check-up process management.Methods:A total of 400 examinees who underwent physical examinations at the hospital’s Health Management Center from January to December 2024 were randomly divided into a control group(200 cases)and an observation group(200 cases).The control group used traditional manual guidance methods,while the observation group employed the intelligent guidance system.The study compared two groups in terms of completion time,waiting time for each procedure,check-up efficiency scores,examinee satisfaction,and report issuance time.Results:The overall examination time in the observation group(85.3±12.7 minutes)was significantly shorter than that in the control group(142.6±18.5 minutes)(P<0.01);average waiting time per procedure decreased by 62.4%;check-up efficiency scores(8.9±0.8 points)were significantly higher than those in the control group(5.2±1.1 points)(P<0.01);satisfaction reached 96.5%,significantly higher than the control group’s 78.0%(P<0.01);and report issuance time was advanced by 1.5 days.Conclusion:Intelligent guidance systems can significantly optimize check-up processes,improve work efficiency,and examinee satisfaction,demonstrating significant clinical application value. 展开更多
关键词 Intelligent guidance Check-up process Health management process optimization SATISFACTION
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Rapid optimization of laser powder bed fusion process:a high-throughput integrated multi-task robust modeling approach
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作者 Han Zhang Bingke Song +6 位作者 Keyu Shi Yusheng Chen Biqi Yang Miao Chang Longhai Hu Jinming Xing Dongdong Gu 《International Journal of Extreme Manufacturing》 2025年第4期312-332,共21页
Transpiration cooling is crucial for the performance of aerospace engine components,relying heavily on the processing quality and accuracy of microchannels.Laser powder bed fusion(LPBF)offers the potential for integra... Transpiration cooling is crucial for the performance of aerospace engine components,relying heavily on the processing quality and accuracy of microchannels.Laser powder bed fusion(LPBF)offers the potential for integrated manufacturing of complex parts and precise microchannel fabrication,essential for engine cooling applications.However,optimizing LPBF’s extensive process parameters to control processing quality and microchannel accuracy effectively remains a significant challenge,especially given the time-consuming and labor-intensive nature of handling numerous variables and the need for thorough data analysis and correlation discovery.This study introduced a combined methodology of high-throughput experiments and Gaussian process algorithms to optimize the processing quality and accuracy of nickel-based high-temperature alloy with microchannel structures.250 parameter combinations,including laser power,scanning speed,channel diameter,and spot compensation,were designed across ten high-throughput specimens.This setup allowed for rapid and efficient evaluation of processing quality and microchannel accuracy.Employing Bayesian optimization,the Gaussian process model accurately predicted processing outcomes over a broad parameter range.The correlation between various processing parameters,processing quality and accuracy was revealed,and various optimized process combinations were summarized.Verification through computed Tomography testing of the specimens confirmed the effectiveness and precision of this approach.The approach introduced in this research provides a way for quickly and efficiently optimizing the process parameters and establishing process-property relationships for LPBF,which has broad application value. 展开更多
关键词 laser powder bed fusion process parameter HIGH-THROUGHPUT Gaussian process microchannel accuracy
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Optimization of the Crystallization Process for Ceftriaxone Sodium, a Third-Generation Cephalosporin, Utilizing Response Surface Methodology
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作者 Yanxi LAI Furong ZHANG +4 位作者 Jingyue ZHU Hao LIU Yizhang WANG Jing LI Shengjiu GU 《Medicinal Plant》 2025年第2期14-18,共5页
[Objectives] To optimize the crystallization process of ceftriaxone sodium using response surface methodology (RSM) for enhancing both the crystallization rate and the quality of the final product. [Methods] Four key ... [Objectives] To optimize the crystallization process of ceftriaxone sodium using response surface methodology (RSM) for enhancing both the crystallization rate and the quality of the final product. [Methods] Four key factors, including crystallization temperature, stirring speed, solvent drop rate, and seed crystal content, were employed as independent variables, while the crystallization rate served as the response variable. The Box-Behnken response surface method was utilized for the optimization design. [Results] The optimal parameters for the crystallization process, determined through optimization, were as follows: a temperature of 10.6 ℃, a stirring rate of 150 rpm, a solvent drop rate of 1.50 mL/min, and a seed crystal content of 0.12 g. Validation tests conducted under these conditions yielded an average crystallization rate of 94.38% for the refined product. [Conclusions] The crystallization efficiency of ceftriaxone sodium is markedly enhanced, thereby offering substantial support for its industrial production and clinical application. 展开更多
关键词 Ceftriaxone sodium Response surface methodology(RSM) Crystallization process process optimization
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Microstructure and mechanical properties of digital light processing printed AISI 316L stainless steel:Optimization of slurry and sintering process
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作者 Junnai Wang Jie Guo +5 位作者 Zhibo Liu Xinjian Cao Da Bian Jun Cheng Shanhua Qian Jun Yang 《Additive Manufacturing Frontiers》 2025年第4期236-247,共12页
Digital light processing(DLP)is widely used in ceramic additive manufacturing.However,it remains unexplored for metals.In this study,the regulatory mechanisms of the microstructure and mechanical properties of AISI 31... Digital light processing(DLP)is widely used in ceramic additive manufacturing.However,it remains unexplored for metals.In this study,the regulatory mechanisms of the microstructure and mechanical properties of AISI 316L stainless steel were investigated by optimizing a DLP-compatible metal slurry formulation and sintering process.A photosensitive resin system(mass ratio of 5:1:2:2 for U600,LA,ACMO,and HDDA,respectively)with 88 wt%solid content is designed to achieve a slurry with balanced rheology,photocurability,and low pyrolysis residue.Compared to vacuum sintering,which leads to brittle fracture of material,the Ar/H2 mixed gas(5%H2)effectively reduces carbon and oxygen impurities via reduction,mitigating carbide and oxide segregation at grain boundaries and within grains,thereby enhancing strength-ductility.In addition,the prolonged high-temperature sintering inducesδ-ferrite precipitation at grain boundaries,which fills residual pores to improve densification obviously.Under optimized sintering conditions(Ar/H2,1380°C,6 h),the material achieves 96.2%relative density with tensile strength and fracture elongation of 543.5 MPa and 58.7%,respectively,exhibiting uniform dimple-dominated fracture morphology.This synergistic optimization of the slurry formulation and sintering parameters improves the strength-ductility balance in DLP-fabricated metal materials,offering theoretical and technical insights for the additive manufacturing of complex high-performance metal components. 展开更多
关键词 Digital light processing 316L stainless steel Mechanical properties Sintering process Metal slurry
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Optimization of Technical Briefing Management Process in Construction Projects
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作者 Zhiwei Zhuang 《Journal of World Architecture》 2025年第4期89-95,共7页
This paper examines the challenges in the technical briefing process for construction projects,including a three-level system and issues related to formalization.An optimization approaches was introduced based on the ... This paper examines the challenges in the technical briefing process for construction projects,including a three-level system and issues related to formalization.An optimization approaches was introduced based on the PDCA cycle,alongside the application of BIM and AR technologies.The key preparatory measures were outlined in this study and the functions of the management system was mentioned.Through case comparisons,this paper demonstrated that these optimizations can significantly improve efficiency and quality,support the development of an evaluation system to verify results,and highlight the critical role of organizational support. 展开更多
关键词 Construction project Technical briefing process optimization
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Optimization of Extraction Process of Qingdu Jianpi Mixture by Orthogonal Experimental Design
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作者 Jiangcun WEI Bing QING +4 位作者 Jinqing PENG Xiaofen FENG Weiwei CHEN Wen ZHONG Zujie QIN 《Medicinal Plant》 2025年第3期10-14,共5页
[Objectives]To optimize the optimal extraction process of Qingdu Jianpi Mixture.[Methods]Taking water addition ratio,extraction time and extraction times as process investigation factors,psoralen content,astilbin cont... [Objectives]To optimize the optimal extraction process of Qingdu Jianpi Mixture.[Methods]Taking water addition ratio,extraction time and extraction times as process investigation factors,psoralen content,astilbin content and dry extract yield as evaluation indicators,the main influencing factors and level range of the extraction process of Qingdu Jianpi Mixture were determined on the basis of single factor test method,and the optimal weight coefficient was screened by AHP-entropy method mixed with weighting method.Combined with L_(9)(3^(4))orthogonal experiment,the best extraction process was obtained.At the same time,thin-layer chromatographic identification was used to identify Ficus simplicissima Lour.and Smilax glabra Roxb.in the medicinal liquid.[Results]The best extraction process:add 1:12 water to the prescription decoction pieces,extract under reflux for 2 times,1.5 h per time,and combine the filtrate to 250 mL.Thin layer chromatography analysis showed that the spots of Ficus simplicissima Lour.and Smilax glabra Roxb.in the medicinal solution were the same as those of reference substances at the corresponding positions,and the negative control had no interference.[Conclusions]The experimental method is reasonable and feasible,and the process is reliable,which can provide experimental reference for the subsequent application of in-hospital preparations and research and development of Qingdu Jianpi Mixture. 展开更多
关键词 Qingdu Jianpi MIXTURE AHP-entropy method ORTHOGONAL design EXTRACTION process
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Optimization Design of Workshop Painting Parameter Process
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作者 Lei Sun Zhongyuan Shen 《Journal of Electronic Research and Application》 2025年第3期159-164,共6页
Through the analysis of the actual situation and process of painting industrial steel components in Hechang Company,we have modified the mixing ratio of paint,thinner,and curing agent.Additionally,we have effectively ... Through the analysis of the actual situation and process of painting industrial steel components in Hechang Company,we have modified the mixing ratio of paint,thinner,and curing agent.Additionally,we have effectively adjusted the drying time of various paint types under different seasons and temperatures.Eventually,a painting solution suitable for our company has been developed.According to this process,the painting quality has been significantly improved,costs have been saved,the labor intensity has been reduced,and production efficiency has been remarkably enhanced. 展开更多
关键词 Painting process Mixing ratio Adjustment Production efficiency
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Research on Optimization of Project Procurement Management Process in Telecommunication Enterprises
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作者 Xiang Chen 《Proceedings of Business and Economic Studies》 2025年第4期7-13,共7页
In the project procurement management process of telecommunication enterprises,due to the complexity of technology,the professional procurement project manager is responsible for the whole process of professional proc... In the project procurement management process of telecommunication enterprises,due to the complexity of technology,the professional procurement project manager is responsible for the whole process of professional procurement in a one-stop way.The integration of this management process superficially improves labor productivity,but in essence lacks effective checks and balances and supervision.In order to supervise the project procurement management process and ensure the legal compliance of procurement management,this paper studies the project procurement management process of telecommunication enterprises,proposes the optimization process of project procurement management in the segmentation of purchasing manager-business manager,and constructs a matrix project procurement management model,which will contribute to the overall improvement of the telecommunication enterprises’procurement performance. 展开更多
关键词 Telecommunication enterprises Project procurement management process optimization
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Optimization and Research on the Synthesis Process of Hymenidin
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作者 Ai WANG 《Medicinal Plant》 2025年第4期29-32,共4页
In response to the challenges associated with the traditional synthesis process of hymenidin,such as complex reaction steps,low yields,high costs,and environmental concerns,the synthesis process has been significantly... In response to the challenges associated with the traditional synthesis process of hymenidin,such as complex reaction steps,low yields,high costs,and environmental concerns,the synthesis process has been significantly enhanced by optimizing reaction conditions,screening for efficient catalysts,and incorporating the concepts of green chemistry.The optimized process has significantly improved the synthesis efficiency and product quality of hymenidin,reduced production costs,and minimized environmental pollution,thereby providing robust support for its industrial production and broad application. 展开更多
关键词 Hymenidin optimizatioN Synthesis process Reaction conditions Green chemistry CATALYST
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Research Progress on the Process Optimization and Stability Improvement of Third-generation Cephalosporins
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作者 Hao LIU Yanxi LAI +1 位作者 Shengjiu GU Kaimei ZHU 《Medicinal Plant》 2025年第1期23-26,共4页
The latest progress in the process optimization and stability improvement of third-generation cephalosporins in recent years was reviewed.The introduction of green chemistry,enzyme catalysis,nanotechnology,lyophilizat... The latest progress in the process optimization and stability improvement of third-generation cephalosporins in recent years was reviewed.The introduction of green chemistry,enzyme catalysis,nanotechnology,lyophilization,and nitrogen-filled packaging technologies can only improve production efficiency and reduce the generation of by-products,but also significantly extend the shelf life of drugs.In the future,process automation and intelligent technology will further optimize the large-scale production process,and the combination of nanotechnology and precision drug delivery will promote the improvement of effect in clinical applications. 展开更多
关键词 Third-generation cephalosporins process optimization NANOTECHNOLOGY Green chemistry Drug stability
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A novel wire arc additive and subtractive hybrid manufacturing process optimization method
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作者 GUO Yiming ZHANG Wanyuan +2 位作者 XIAO Mingkun SONG Shida ZHANG Xiaoyong 《Journal of Southeast University(English Edition)》 2025年第1期109-117,共9页
A reasonable process plan is an important basis for implementing wire arc additive and subtractive hybrid manufacturing(ASHM),and a new optimization method is proposed.Firstly,the target parts and machining tools are ... A reasonable process plan is an important basis for implementing wire arc additive and subtractive hybrid manufacturing(ASHM),and a new optimization method is proposed.Firstly,the target parts and machining tools are modeled by level set functions.Secondly,the mathematical model of the additive direction optimization problem is established,and an improved particle swarm optimization algorithm is designed to decide the best additive direction.Then,the two-step strategy is used to plan the hybrid manufacturing alternating sequence.The target parts are directly divided into various processing regions;each processing region is optimized based on manufacturability and manufacturing efficiency,and the optimal hybrid manufacturing alternating sequence is obtained by merging some processing regions.Finally,the method is used to outline the process plan of the designed example model and applied to the actual hybrid manufacturing process of the model.The manufacturing result shows that the method can meet the main considerations in hybrid manufacturing.In addition,the degree of automation of process planning is high,and the dependence on manual intervention is low. 展开更多
关键词 wire arc additive manufacturing hybrid manufacturing process optimization MANUFACTURABILITY
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Study on Optimization of Ultrasonic Extraction Process for Benzoic Acid as a Harmful Component in Paeonia Iactiflora Pall
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作者 Shangyue Chen Guiming Guo +5 位作者 Gang Chen Yanxin Zhai Jingliang Xie Xu Zhao Mingxue Cai Xuegang Zhou 《Chinese Medicine and Natural Products》 2025年第3期193-198,共6页
Objective To optimize the ultrasonic extraction process for benzoic acid as a harmful substance in Paeonia lactiflora Pall.(P.lactiflora Pall.).Methods Methanol and ethanol solutions at different concentration gradien... Objective To optimize the ultrasonic extraction process for benzoic acid as a harmful substance in Paeonia lactiflora Pall.(P.lactiflora Pall.).Methods Methanol and ethanol solutions at different concentration gradients(25,50,75%)were prepared to investigate the effects of extraction solvents on the extraction efficiency of benzoic acid.The influences of ultrasonic frequency(35,50 Hz),ultrasonic power(40,60,80,100 W),ultrasonic time(10,20,30,40,50,60 minutes),and ultrasonic temperature(20,30,40,50℃)on the extraction efficiency were examined.Orthogonal experiments were conducted to analyze the effects of temperature,time,and ultrasonic power on the extraction efficiency and to screen the optimal ultrasonic extraction process.Results Various influencing factors had certain effects on the extraction efficiency of benzoic acid from P.lactiflora Pall.Single-factor analysis revealed that 25%methanol,ultrasonic frequency of 50 Hz,ultrasonic power of 40 W,ultrasonic time of 10minutes,and ultrasonic temperature of 30℃yielded the highest extraction efficiency for benzoic acid.The order of influence of different factors on the extraction efficiency was temperature>time>power.The optimal conditions obtained from orthogonal experiments were:extraction solvent of 25%methanol,ultrasonic frequency of 50 Hz,ultrasonic time of 20 minutes,ultrasonic power of 40 W,and ultrasonic temperature of 30℃.Conclusion Under the conditions of 25%methanol as the extraction solvent,ultrasonic frequency of 50 Hz,ultrasonic time of 20 minutes,ultrasonic power of 40 W,and ultrasonic temperature of 30℃,the extraction efficiency of benzoic acid from P.lactiflora Pall.was the highest.This method offers advantages such as simple operation,small sample size requirement,and low solvent consumption,providing a reliable analytical approach for quality control and safety evaluation of P.lactiflora Pall. 展开更多
关键词 Paeonia lactiflora Pall. benzoic acid ultrasonic extraction process optimization
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