Aging is considered the main risk factor for the development of several diseases,including the leading neurodegenerative disorders.While the cellular features of aging are complex and multifaceted,neuronal senescence ...Aging is considered the main risk factor for the development of several diseases,including the leading neurodegenerative disorders.While the cellular features of aging are complex and multifaceted,neuronal senescence has emerged as a major contributor and driver of this process in the mammalian cell.Cellular senescence is a programmed response to stress and irreparable damage,which drives the cell into an apoptosis-resistant,non-proliferative state.Senescent cells can also deleteriously affect neighboring,non-senescent cells.Senescence is a complex and multifaceted process associated with a wide range of cellular events,including the secretion of pro-inflammatory molecules and the arrest of the cell cycle.展开更多
Machining-features of the workplace are described by using of the object-oriented （O-O） technology. Geometrical machining-features are recognized in the given cut region by using the maximum membership priciple abou...Machining-features of the workplace are described by using of the object-oriented （O-O） technology. Geometrical machining-features are recognized in the given cut region by using the maximum membership priciple about the fuzzy set. Depending on the IF-THEN rule and the fuzzy matching method, the rough information of the machining-process for high-speed milling （HSM） is extracted based on the database of machining-process for HSM. The optimization model of machining-process scheme is established to obtain shorter cut time, lower cost or higher surface quality. It is helpful to form successful cases for HSM. NC programming for HSM is realized according to optimized machining-process data from HSM cases selected by the optimization model and the extracted information of machining-process.展开更多
文摘Aging is considered the main risk factor for the development of several diseases,including the leading neurodegenerative disorders.While the cellular features of aging are complex and multifaceted,neuronal senescence has emerged as a major contributor and driver of this process in the mammalian cell.Cellular senescence is a programmed response to stress and irreparable damage,which drives the cell into an apoptosis-resistant,non-proliferative state.Senescent cells can also deleteriously affect neighboring,non-senescent cells.Senescence is a complex and multifaceted process associated with a wide range of cellular events,including the secretion of pro-inflammatory molecules and the arrest of the cell cycle.
文摘Machining-features of the workplace are described by using of the object-oriented （O-O） technology. Geometrical machining-features are recognized in the given cut region by using the maximum membership priciple about the fuzzy set. Depending on the IF-THEN rule and the fuzzy matching method, the rough information of the machining-process for high-speed milling （HSM） is extracted based on the database of machining-process for HSM. The optimization model of machining-process scheme is established to obtain shorter cut time, lower cost or higher surface quality. It is helpful to form successful cases for HSM. NC programming for HSM is realized according to optimized machining-process data from HSM cases selected by the optimization model and the extracted information of machining-process.
