Objective: To observe the clinical application of olopatadine eye drops alone or combination with pranoprofen eye drops in the treatment of allergic conjunctivitis (AC). The levels of serum immunoglobulin, histamine (...Objective: To observe the clinical application of olopatadine eye drops alone or combination with pranoprofen eye drops in the treatment of allergic conjunctivitis (AC). The levels of serum immunoglobulin, histamine (HA) and eosinophil cationic protein (ECP) were analyzed. Methods: A total of 90 AC patients were randomly divided into control group (n=45) and observation group (n=45) according to the lottery method. The control group was treated with olopatadine hydrochloride eye drops. On the basis of the control group, the observation group was treated with pranoprofen eye drops. The levels of serum immunoglobulin, HA and ECP were measured in all subjects. Results: There was no significant difference in serum immunoglobulin level between the observation group and the control group before treatment. After treatment, the levels of serum IgG, IgA and IgE in the observation group and the control group were significantly lower than those before treatment. And the observation group was significantly lower than the control group after treatment. There were no significant differences in serum HA and ECP levels between the observation group and the control group before treatment. After treatment, the levels of serum HA and ECP in the observation group and the control group were significantly lower than those before treatment. And the observation group was significantly lower than the control group after treatment. Conclusion: Compared with olopatadine eye drops, olopatadine eye drops combined with pranoprofen eye drops in the treatment of AC patients, can effectively reduce the serum immunoglobulin, HA and ECP levels, which may be the clinical treatment of AC patients Of the effective reference program.展开更多
Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus ...Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery.展开更多
目的系统评价普拉洛芬治疗白内障术后干眼的临床疗效。方法计算机检索中国知网、万方医学网、维普资讯中文期刊服务平台、Web of Science、中国生物医学文献服务系统(CBM)、PubMed、Cochrane Library数据库中有关普拉洛芬治疗白内障术...目的系统评价普拉洛芬治疗白内障术后干眼的临床疗效。方法计算机检索中国知网、万方医学网、维普资讯中文期刊服务平台、Web of Science、中国生物医学文献服务系统(CBM)、PubMed、Cochrane Library数据库中有关普拉洛芬治疗白内障术后干眼的随机对照试验。对照组使用玻璃酸钠滴眼液,试验组在使用玻璃酸钠滴眼液基础上使用普拉洛芬滴眼液,检索时限为2018年1月至2023年11月。由2名研究者独立筛选文献、提取相关资料并按照Cochrane系统评价员手册进行质量评价,采用Review Manager5.3软件及STATA12.0统计软件进行数据分析及异质性检验。结果共纳入文献18篇,2318例患者。试验组总有效率明显高于对照组[优势比(OR)=8.529,95%可信区间(95%CI)5.53~13.15,P<0.001];泪膜破裂时间明显长于对照组[加权均数差(WMD)=2.60,95%CI 2.09~3.11,P<0.001];泪液分泌量明显高于对照组(WMD=1.98,95%CI 1.66~2.30,P<0.01);角膜荧光素染色评分、干眼症状评分均明显低于对照组(WMD=-0.93、-1.55,95%CI-1.23~-0.63、-2.18~-0.92,P<0.001)。结论普拉洛芬治疗白内障术后干眼的疗效优于人工泪液,能提高临床有效率,延长患者泪膜破裂时间,增加泪液分泌量,降低角膜荧光素染色,改善干眼症状。展开更多
目的 观察普拉洛芬滴眼液对实施白内障超声乳化抽吸联合房角分离术的原发性闭角型青光眼合并白内障患者预后的影响。方法 选取2022年1月至2023年12月在合肥市第二人民医院眼科予以针对性治疗的原发性闭角型青光眼伴白内障患者共103例为...目的 观察普拉洛芬滴眼液对实施白内障超声乳化抽吸联合房角分离术的原发性闭角型青光眼合并白内障患者预后的影响。方法 选取2022年1月至2023年12月在合肥市第二人民医院眼科予以针对性治疗的原发性闭角型青光眼伴白内障患者共103例为此次试验的对象,通过随机数字表法分为两组,所有患者均予以白内障超声乳化抽吸联合房角分离术治疗,对照组52例患者术后予以重组牛碱性成纤维细胞生长因子眼用凝胶结合妥布霉素地塞米松滴眼液治疗,观察组51例患者术后加用普拉洛芬滴眼液治疗。比较两组并发症发生情况,手术后1个月的结膜充血和眼压、视功能相关生命质量量表(NEI-VFQ-25)评分和治疗满意度。结果 观察组术后并发症发生率[1.96%(1/51)]低于对照组[15.38%(8/52)],差异有统计学意义(χ^(2)=4.257,P=0.039);观察组术后NEI-VFQ-25得分、眼压和结膜充血评分[分别为(44.23±2.04)分、(15.22±1.89) mm Hg(1 mm Hg≈0.133 kPa)、(1.04±0.27)分]优于对照组[分别为(32.26±2.84)分、(18.45±2.00) mm Hg、(1.42±0.33)分],差异有统计学意义(t=24.526、8.421、6.389,均P<0.05)。在满意度方面,观察组(96.07%,49/51)相较于对照组(84.61%,44/52)更高(χ^(2)=3.859,P<0.05)。结论 原发性闭角型青光眼伴白内障患者实施白内障超声乳化抽吸联合房角分离术术后应用普拉洛芬滴眼液能够降低并发症出现概率,改善日常生活质量以及眼部压力。展开更多
文摘Objective: To observe the clinical application of olopatadine eye drops alone or combination with pranoprofen eye drops in the treatment of allergic conjunctivitis (AC). The levels of serum immunoglobulin, histamine (HA) and eosinophil cationic protein (ECP) were analyzed. Methods: A total of 90 AC patients were randomly divided into control group (n=45) and observation group (n=45) according to the lottery method. The control group was treated with olopatadine hydrochloride eye drops. On the basis of the control group, the observation group was treated with pranoprofen eye drops. The levels of serum immunoglobulin, HA and ECP were measured in all subjects. Results: There was no significant difference in serum immunoglobulin level between the observation group and the control group before treatment. After treatment, the levels of serum IgG, IgA and IgE in the observation group and the control group were significantly lower than those before treatment. And the observation group was significantly lower than the control group after treatment. There were no significant differences in serum HA and ECP levels between the observation group and the control group before treatment. After treatment, the levels of serum HA and ECP in the observation group and the control group were significantly lower than those before treatment. And the observation group was significantly lower than the control group after treatment. Conclusion: Compared with olopatadine eye drops, olopatadine eye drops combined with pranoprofen eye drops in the treatment of AC patients, can effectively reduce the serum immunoglobulin, HA and ECP levels, which may be the clinical treatment of AC patients Of the effective reference program.
文摘Purpose:To evaluate the efficacy and safety of pranoprofen eye drops for reducing postoperative ocular pain and inflammation after corneal cross-linking (CXL). Methods:Twenty-seven patients (38 eyes) with keratoconus undergoing CXL were examined and randomly divided into control (12 cases; 18 eyes) and experimental groups (15 cases;20 eyes).The patients in the control group were given fluorometholone eye drops,and those in the experimental group were administered with fluorometholone combined with pranoprofen eye drops.Corneal irritation and haze were compared between the two groups at 1 month postoperatively. Results:At 1 to 3 days after surgery,the corneal irritation in the experimental group was significantly reduced compared with that in the control group (P<0.05), but there was no significant difference on 5 to 7 days postoperatively (P>0.05). The average degree of haze in the experimental group was significantly lower than that in the control group 1 month after surgery (P<0.05), but there was no significant difference in the best-corrected vision acuity and intraocular pressure between the two groups. There were 2 cases with >20 mmHg intraocular pressure in the control group. Conclusion:The combined use of fluorometholone and pranoprofen can significantly reduce inflammatory response,alleviate corneal irritation at early stage after CXL,effectively prevent and control the average of haze,and reduce the incidence of steroid-induced ocular hypertension after surgery.
文摘目的 观察普拉洛芬滴眼液对实施白内障超声乳化抽吸联合房角分离术的原发性闭角型青光眼合并白内障患者预后的影响。方法 选取2022年1月至2023年12月在合肥市第二人民医院眼科予以针对性治疗的原发性闭角型青光眼伴白内障患者共103例为此次试验的对象,通过随机数字表法分为两组,所有患者均予以白内障超声乳化抽吸联合房角分离术治疗,对照组52例患者术后予以重组牛碱性成纤维细胞生长因子眼用凝胶结合妥布霉素地塞米松滴眼液治疗,观察组51例患者术后加用普拉洛芬滴眼液治疗。比较两组并发症发生情况,手术后1个月的结膜充血和眼压、视功能相关生命质量量表(NEI-VFQ-25)评分和治疗满意度。结果 观察组术后并发症发生率[1.96%(1/51)]低于对照组[15.38%(8/52)],差异有统计学意义(χ^(2)=4.257,P=0.039);观察组术后NEI-VFQ-25得分、眼压和结膜充血评分[分别为(44.23±2.04)分、(15.22±1.89) mm Hg(1 mm Hg≈0.133 kPa)、(1.04±0.27)分]优于对照组[分别为(32.26±2.84)分、(18.45±2.00) mm Hg、(1.42±0.33)分],差异有统计学意义(t=24.526、8.421、6.389,均P<0.05)。在满意度方面,观察组(96.07%,49/51)相较于对照组(84.61%,44/52)更高(χ^(2)=3.859,P<0.05)。结论 原发性闭角型青光眼伴白内障患者实施白内障超声乳化抽吸联合房角分离术术后应用普拉洛芬滴眼液能够降低并发症出现概率,改善日常生活质量以及眼部压力。
