Photoacoustic computed tomography(PACT)is an innovative biomedical imaging technique that has gained significant application in the field of biomedicine due to its ability to visualize optical contrast with high resol...Photoacoustic computed tomography(PACT)is an innovative biomedical imaging technique that has gained significant application in the field of biomedicine due to its ability to visualize optical contrast with high resolution and deep tissue penetration.However,the inherent challenges associated with photoacoustic signal excitation,propagation and detection often result in suboptimal image quality.To overcome these limitations,researchers have developed various advanced algorithms that span the entire image reconstruction pipeline.This review paper aims to present a detailed analysis of the latest advancements in PACT algorithms and synthesize these algorithms into a coherent framework.We provide tripartite analysis—from signal processing to reconstruction solution to image processing,covering a spectrum of techniques.The principles and methodologies,as well as their applicability and limitations,are thoroughly discussed.The primary objective of this study is to provide a thorough review of advanced algorithms applicable to PACT,offering both theoretical foundations and practical guidance for enhancing the imaging effect of PACT.展开更多
源于量子内禀随机性的量子随机数发生器(quantum random number generator,QRNG)提供了安全性信息论可证的真随机数.本文提出一种融合实时相空间监测与熵评估的二重并行连续变量QRNG方案,通过动态阈值监测机制与自适应后处理矩阵规模调...源于量子内禀随机性的量子随机数发生器(quantum random number generator,QRNG)提供了安全性信息论可证的真随机数.本文提出一种融合实时相空间监测与熵评估的二重并行连续变量QRNG方案,通过动态阈值监测机制与自适应后处理矩阵规模调整技术,同步提升QRNG安全性与生成效率,该方案创新性地将熵源状态追踪与随机数提取优化相结合.实验上构建基于外差探测的真空态双边带模并行提取系统,为高精度、高速全息重构量子态和四路并行提取量子随机数提供了充足的原始数据;高动态范围、高分辨率、矩阵规模实时可调的硬件基Toeplitz-hash后处理协调了熵源状态追踪与随机数提取优化.在保持17 Gbit/s以上高产率的同时可有效抵御边信道攻击,通过了NIST SP 800-22,Diehard及Test U01标准测试.本工作为解决QRNG实时熵源可信评估难题提供了技术路径,且该方案集成度高、扩展性好,为量子随机数发生器走向应用提供了一种切实可行的方案.展开更多
Objective： To evaluate the role of spiral CT imaging postprocessing techniques in preoperative TNM staging of lung cancer. Methods： 106 patients with pathologically confirmed lung cancer received spiral CT examinati...Objective： To evaluate the role of spiral CT imaging postprocessing techniques in preoperative TNM staging of lung cancer. Methods： 106 patients with pathologically confirmed lung cancer received spiral CT examinations with a new revised TNM staging method of lung cancer which was taken as criterion of diagnosis. The images were reconstructed by using different postprocessing techniques such as MPR, MIP, SSD, VR, and their TNM staging capabilities were assessed by using postprocessing imaging and the results with axial CT images were compared. Results： In T staging, the accurate rates of axial CT images in T1-T4 staging were 77.3%, 60.6%, 60.7%, and 60.3% respectively; for postprocessing images, the accurate rates were 86.4%, 90.9%, 89.3%, and 87.0% respectively, In N staging, the accurate rates of axial CT images were 84.6%, 68.1%, 63.6%, and 64.2% in N0-N3 staging, respectively; but they were 92.3%, 90.9%, 90.9%, and 85.7% in postprocessing images, respectively. The postprocessing images were superior to axial CT images in T1-T3 and N1-N3 staging of lung cancer but there were no significant differences in T1 and NO staging. For metastasis, the postprocessing images may be helpful for the TNM staging of lung cancer. Conclusion： The postprocessing techniques of the spiral CT could improve the accurate rates of TNM staging of lung cancer, and represent a useful complement to the axial CT.展开更多
Because of restriction of workspace of parallel kinematics Machine (PKM), 6 DOF PKM can’t finish machining of workpiece with complicated surfaces under only once locating. It is necessary to fit workpiece beyond twic...Because of restriction of workspace of parallel kinematics Machine (PKM), 6 DOF PKM can’t finish machining of workpiece with complicated surfaces under only once locating. It is necessary to fit workpiece beyond twice and to lead to low machining precision. Therefore the seven-axis linkage PKM is implemented by fixing a turntable on the worktable of the six-axis linkage PKM. However, the turntable angle decomposing problem from the CL file should be well considered. If the traditional decomposing methods are adopted, the nutation angle usually goes beyond the workspace of the machine. Therefore, according to the relation of the machine coordinate system and the workpiece coordinate system, the turntable angle decomposition algorithmic of the consistent coordinate system and the turntable angle decomposition algorithmic of the non-consistent coordinate system are developed to resolve the problem mentioned above. The turntable angle decomposition of the non-consistent coordinate system processes the decomposition which is based on the consistent coordinate system again. It calculates the initial angle of the locating workpiece, and the decomposed angle of the turntable at the machine coordinate system results in the nutation angle not going beyond workspace of the machine, thereby the decomposition process can be simplified.展开更多
Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily necessities.The traceability measurements along supply chain or logistic circulation have become...Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily necessities.The traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on site.In an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and enrofloxacin.The key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold carriers.The“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the analytes.On the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive brightness.Enlightened by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection performance.Thus,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and selectivity.Further field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.展开更多
基金supported by Beijing Natural Science Foundation(7232146)National Natural Science Foundation of China(NSFC)Grant(62475277,62105355,82122034,82327805,81927807,62275062)+4 种基金Strategic Priority Research Program of the Chinese Academy of Sciences(XDB0930000)Shenzhen Science and Technology Innovation Grant(JCYJ20220531100409023,JCYJ20210324101403010,JCYJ20220818101403008)Project of Shandong Innovation and Startup Community of High-end Medical Apparatus and Instruments Grant(2021-SGTTXM005)Shandong Province Technology Innovation Guidance Plan(Central Leading Local Science and Technology Development Fund,YDZX2023115)Taishan Scholar Special Funding Project of Shandong Province.
文摘Photoacoustic computed tomography(PACT)is an innovative biomedical imaging technique that has gained significant application in the field of biomedicine due to its ability to visualize optical contrast with high resolution and deep tissue penetration.However,the inherent challenges associated with photoacoustic signal excitation,propagation and detection often result in suboptimal image quality.To overcome these limitations,researchers have developed various advanced algorithms that span the entire image reconstruction pipeline.This review paper aims to present a detailed analysis of the latest advancements in PACT algorithms and synthesize these algorithms into a coherent framework.We provide tripartite analysis—from signal processing to reconstruction solution to image processing,covering a spectrum of techniques.The principles and methodologies,as well as their applicability and limitations,are thoroughly discussed.The primary objective of this study is to provide a thorough review of advanced algorithms applicable to PACT,offering both theoretical foundations and practical guidance for enhancing the imaging effect of PACT.
文摘源于量子内禀随机性的量子随机数发生器(quantum random number generator,QRNG)提供了安全性信息论可证的真随机数.本文提出一种融合实时相空间监测与熵评估的二重并行连续变量QRNG方案,通过动态阈值监测机制与自适应后处理矩阵规模调整技术,同步提升QRNG安全性与生成效率,该方案创新性地将熵源状态追踪与随机数提取优化相结合.实验上构建基于外差探测的真空态双边带模并行提取系统,为高精度、高速全息重构量子态和四路并行提取量子随机数提供了充足的原始数据;高动态范围、高分辨率、矩阵规模实时可调的硬件基Toeplitz-hash后处理协调了熵源状态追踪与随机数提取优化.在保持17 Gbit/s以上高产率的同时可有效抵御边信道攻击,通过了NIST SP 800-22,Diehard及Test U01标准测试.本工作为解决QRNG实时熵源可信评估难题提供了技术路径,且该方案集成度高、扩展性好,为量子随机数发生器走向应用提供了一种切实可行的方案.
文摘Objective： To evaluate the role of spiral CT imaging postprocessing techniques in preoperative TNM staging of lung cancer. Methods： 106 patients with pathologically confirmed lung cancer received spiral CT examinations with a new revised TNM staging method of lung cancer which was taken as criterion of diagnosis. The images were reconstructed by using different postprocessing techniques such as MPR, MIP, SSD, VR, and their TNM staging capabilities were assessed by using postprocessing imaging and the results with axial CT images were compared. Results： In T staging, the accurate rates of axial CT images in T1-T4 staging were 77.3%, 60.6%, 60.7%, and 60.3% respectively; for postprocessing images, the accurate rates were 86.4%, 90.9%, 89.3%, and 87.0% respectively, In N staging, the accurate rates of axial CT images were 84.6%, 68.1%, 63.6%, and 64.2% in N0-N3 staging, respectively; but they were 92.3%, 90.9%, 90.9%, and 85.7% in postprocessing images, respectively. The postprocessing images were superior to axial CT images in T1-T3 and N1-N3 staging of lung cancer but there were no significant differences in T1 and NO staging. For metastasis, the postprocessing images may be helpful for the TNM staging of lung cancer. Conclusion： The postprocessing techniques of the spiral CT could improve the accurate rates of TNM staging of lung cancer, and represent a useful complement to the axial CT.
文摘Because of restriction of workspace of parallel kinematics Machine (PKM), 6 DOF PKM can’t finish machining of workpiece with complicated surfaces under only once locating. It is necessary to fit workpiece beyond twice and to lead to low machining precision. Therefore the seven-axis linkage PKM is implemented by fixing a turntable on the worktable of the six-axis linkage PKM. However, the turntable angle decomposing problem from the CL file should be well considered. If the traditional decomposing methods are adopted, the nutation angle usually goes beyond the workspace of the machine. Therefore, according to the relation of the machine coordinate system and the workpiece coordinate system, the turntable angle decomposition algorithmic of the consistent coordinate system and the turntable angle decomposition algorithmic of the non-consistent coordinate system are developed to resolve the problem mentioned above. The turntable angle decomposition of the non-consistent coordinate system processes the decomposition which is based on the consistent coordinate system again. It calculates the initial angle of the locating workpiece, and the decomposed angle of the turntable at the machine coordinate system results in the nutation angle not going beyond workspace of the machine, thereby the decomposition process can be simplified.
基金supported by National Natural Science Foundation of China(Nos.21874071 and 22204077)China Postdoctoral Science Foundation(No.2021M701722)Fundamental Research Funds for the Central Universities(Nos.30921013112 and 30922010501)。
文摘Antibiotic abuse now poses a grave threat to global ecology and bestirs public concerns about the residue issue in daily necessities.The traceability measurements along supply chain or logistic circulation have become increasingly essential given the labile nature of diverse synthetic residuals on site.In an attempt to answer this urgency,here a miniaturized fluorometric aptasensor prototype was contrived that catered to the point-of-care screening norm for two typical additives:chloramphenicol and enrofloxacin.The key target-indicating module worked in vitro based on the competitive binding-induced fluorescence recovery of fluorescein-labeled aptamers,which were photobleached beforehand in the format of double helix on burlike nanogold carriers.The“prickly”geometry of the latter not just enriched the capture probes at preferentially substrate-accessible spires;but also contributed to a tip-enhanced surface plasmon effect,sensitizing the signal-on during the duplex dissociation even at nanomolar threshold of the analytes.On the other hand,to encompass a full portable,a set of optical devices were mounted within a 3D-printed cartridge(adaptor)to converge the light beam and route it towards the detector,for which the smartphone camera came up in handy with a home-developed App for calibrating the emissive brightness.Enlightened by the high-dynamic-range compression,an imaging diagnostic algorithm was built in to grid and digitize each slide in the album for augmented detection performance.Thus,a novel bio-to-silico integration was invented that capable of in situ rapid reporting on the antibiotic presence with high sensitivity and selectivity.Further field practices in spiked milk on sales proved the precision and rudimentary feasibility of the well-assembled model of appliance,thus holding nice prospects in nonexpert(e.g.,family and local community)utilities for foodborne antibiotic identification.
