目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每...目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每组例数均为55例,分组方法为随机数字表法。对照组给予盐酸米诺环素片,在对照组患者治疗的基础上,采用低能量Pixel调Q像束激光对观察组患者进行治疗。两组治疗时间均为6周。比较两组临床疗效(治疗6周后),玫瑰痤疮情况、整体病情、p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)通路蛋白、生活质量、红斑情况、面部功能、炎性因子(治疗前、治疗6周后),不良反应(治疗期间)。结果:治疗6周后,观察组总有效率高于对照组(76.36%vs.54.55%,P<0.05)。与治疗前比较,两组治疗6周后的玫瑰痤疮医师全球评分(Patient's global assessment,PGA)、整体病情评估(Investigator global assessment,IGA)、皮肤病生活质量量表(Dermatology life quality index,DLQI)评分、红斑评估量表(Clinician′s erythema assessment,CEA)评分、皮损区红斑指数(Erythema index,EI)、经皮水分丢失(Trans epidermal water loss,TEWL)、皮肤酸碱度(Pondus Hydrogenii,pH)值、炎性因子及p38MAPK通路蛋白相关因子水平均降低,且相比于对照组,观察组更低;两组角质层含水量均升高,且相比于对照组,观察组更高(P<0.05)。观察组和对照组治疗期间的不良反应发生率比较差异无统计学意义(P>0.05)。结论:玫瑰痤疮患者经低能量Pixel调Q像束激光联合米诺环素治疗后,其相关临床症状可得到有效缓解,炎症反应得以减轻,并可调节p38MAPK信号通路蛋白的表达,进一步可促进患者红斑情况及面部功能的改善,进而促使患者生活质量及临床疗效得以提高,且具有良好的安全性。展开更多
目的:观察低能量Pixel调Q像束激光联合盐酸米诺环素治疗玫瑰痤疮安全性和疗效。方法:选取某三甲医院门诊收治的玫瑰痤疮患者100例,按照随机数字法分为药物治疗组(32例)、激光治疗组(34例)与联合组(34例),药物治疗组采用单独盐酸米诺环...目的:观察低能量Pixel调Q像束激光联合盐酸米诺环素治疗玫瑰痤疮安全性和疗效。方法:选取某三甲医院门诊收治的玫瑰痤疮患者100例,按照随机数字法分为药物治疗组(32例)、激光治疗组(34例)与联合组(34例),药物治疗组采用单独盐酸米诺环素治疗,每晚1次,100 mg口服,连续治疗6周;激光治疗组采用低能量Pixel调Q像束激光治疗,2周1次,连续6周;联合组采用低能量Pixel调Q像束激光联合盐酸米诺环素100 mg口服每晚1次,连续6周治疗。治疗结束后比较3组患者整体病情的评估(investigator’s global assessment,IGA)。结果:治疗前3组患者IGA评分差异无统计学意义,治疗结束后,联合组患者整体病情评估IGA评分、症状积分均较2个对照组改善明显(P<0.01)。结论:低能量Pixel调Q像束激光联合米诺环素治疗玫瑰痤疮效果良好,不良反应少。展开更多
The detection range of underwater laser imaging technology achieves 4—6 times of detection range of conventional camera in intervening water medium, which makes it very promising in oceanic research, deep sea explora...The detection range of underwater laser imaging technology achieves 4—6 times of detection range of conventional camera in intervening water medium, which makes it very promising in oceanic research, deep sea exploration and robotic works. However, the special features in underwater laser images, such as speckle noise and non-uniform illumination, bring great difficulty for image segmentation. In this paper, a novel saliency motivated pulse coupled neural network(SM-PCNN) is proposed for underwater laser image segmentation. The pixel saliency is used as external stimulus of neurons. For improvement of convergence speed to optimal segmentation, a gradient descent method based on maximum two-dimensional Renyi entropy criterion is utilized to determine the dynamic threshold. On the basis of region contrast in each iteration step, the real object regions are effectively distinguished,and the robustness against speckle noise and non-uniform illumination is improved by region selection. The proposed method is compared with four other state-of-the-art methods which are watershed, fuzzy C-means, meanshift and normalized cut methods. Experimental results demonstrate the superiority of our proposed method to allow more accurate segmentation and higher robustness.展开更多
文摘目的:探讨玫瑰痤疮患者采用低能量Pixel调Q像束激光与米诺环素联合治疗后红斑情况及面部功能改善情况。方法:研究对象选自于2020年3月-2023年7月在上海交通大学医学院苏州九龙医院接受治疗的玫瑰痤疮患者110例,并分为对照组和观察组,每组例数均为55例,分组方法为随机数字表法。对照组给予盐酸米诺环素片,在对照组患者治疗的基础上,采用低能量Pixel调Q像束激光对观察组患者进行治疗。两组治疗时间均为6周。比较两组临床疗效(治疗6周后),玫瑰痤疮情况、整体病情、p38丝裂原活化蛋白激酶(p38 mitogen activated protein kinase,p38MAPK)通路蛋白、生活质量、红斑情况、面部功能、炎性因子(治疗前、治疗6周后),不良反应(治疗期间)。结果:治疗6周后,观察组总有效率高于对照组(76.36%vs.54.55%,P<0.05)。与治疗前比较,两组治疗6周后的玫瑰痤疮医师全球评分(Patient's global assessment,PGA)、整体病情评估(Investigator global assessment,IGA)、皮肤病生活质量量表(Dermatology life quality index,DLQI)评分、红斑评估量表(Clinician′s erythema assessment,CEA)评分、皮损区红斑指数(Erythema index,EI)、经皮水分丢失(Trans epidermal water loss,TEWL)、皮肤酸碱度(Pondus Hydrogenii,pH)值、炎性因子及p38MAPK通路蛋白相关因子水平均降低,且相比于对照组,观察组更低;两组角质层含水量均升高,且相比于对照组,观察组更高(P<0.05)。观察组和对照组治疗期间的不良反应发生率比较差异无统计学意义(P>0.05)。结论:玫瑰痤疮患者经低能量Pixel调Q像束激光联合米诺环素治疗后,其相关临床症状可得到有效缓解,炎症反应得以减轻,并可调节p38MAPK信号通路蛋白的表达,进一步可促进患者红斑情况及面部功能的改善,进而促使患者生活质量及临床疗效得以提高,且具有良好的安全性。
文摘目的:观察低能量Pixel调Q像束激光联合盐酸米诺环素治疗玫瑰痤疮安全性和疗效。方法:选取某三甲医院门诊收治的玫瑰痤疮患者100例,按照随机数字法分为药物治疗组(32例)、激光治疗组(34例)与联合组(34例),药物治疗组采用单独盐酸米诺环素治疗,每晚1次,100 mg口服,连续治疗6周;激光治疗组采用低能量Pixel调Q像束激光治疗,2周1次,连续6周;联合组采用低能量Pixel调Q像束激光联合盐酸米诺环素100 mg口服每晚1次,连续6周治疗。治疗结束后比较3组患者整体病情的评估(investigator’s global assessment,IGA)。结果:治疗前3组患者IGA评分差异无统计学意义,治疗结束后,联合组患者整体病情评估IGA评分、症状积分均较2个对照组改善明显(P<0.01)。结论:低能量Pixel调Q像束激光联合米诺环素治疗玫瑰痤疮效果良好,不良反应少。
基金the National High Technology Research and Development Program(863)of China(No.2011AA09A106)the National Natural Science Foundation of China(No.51009040)and the Fundamental Research Funds for Central Universities of China(No.HEUCF140113)
文摘The detection range of underwater laser imaging technology achieves 4—6 times of detection range of conventional camera in intervening water medium, which makes it very promising in oceanic research, deep sea exploration and robotic works. However, the special features in underwater laser images, such as speckle noise and non-uniform illumination, bring great difficulty for image segmentation. In this paper, a novel saliency motivated pulse coupled neural network(SM-PCNN) is proposed for underwater laser image segmentation. The pixel saliency is used as external stimulus of neurons. For improvement of convergence speed to optimal segmentation, a gradient descent method based on maximum two-dimensional Renyi entropy criterion is utilized to determine the dynamic threshold. On the basis of region contrast in each iteration step, the real object regions are effectively distinguished,and the robustness against speckle noise and non-uniform illumination is improved by region selection. The proposed method is compared with four other state-of-the-art methods which are watershed, fuzzy C-means, meanshift and normalized cut methods. Experimental results demonstrate the superiority of our proposed method to allow more accurate segmentation and higher robustness.
