Pickering综合征表现为反复的肺水肿和肾功能损害,与肾动脉狭窄有关。本病例描述了一位82岁女性患者,有高血压和冠心病史,伴有肾血管狭窄,反复出现肺水肿。影像学显示肾血管狭窄从单侧发展到双侧。尽管接受药物治疗,患者仍反复肺水肿。...Pickering综合征表现为反复的肺水肿和肾功能损害,与肾动脉狭窄有关。本病例描述了一位82岁女性患者,有高血压和冠心病史,伴有肾血管狭窄,反复出现肺水肿。影像学显示肾血管狭窄从单侧发展到双侧。尽管接受药物治疗,患者仍反复肺水肿。肾血管介入治疗后,患者病情稳定,心脏和肾脏功能改善。此病例强调识别肾动脉狭窄的重要性,并显示及时诊断和治疗的益处。早期识别和治疗Pickering综合征可有效预防肺水肿和肾功能衰竭。Pickering syndrome is characterized by recurrent pulmonary edema and renal impairment associated with renal artery stenosis. This case describes an 82-year-old woman with a history of hypertension and coronary artery disease, renal vascular stenosis, and recurrent pulmonary edema. Imaging shows renal vascular stenosis progressing from unilateral to bilateral. Patients have recurrent pulmonary edema despite medication. After renal vascular intervention, the patient’s condition was stable and his heart and kidney function improved. This case highlights the importance of identifying renal artery stenosis and shows the benefits of prompt diagnosis and treatment. Early recognition and treatment of Pickering syndrome is effective in preventing pulmonary edema and renal failure.展开更多
为实现核桃中蛋白资源的高值化利用,本研究以核桃分离蛋白(Walnut protein isolate,WPI)和壳聚糖(Chitosan,CS)为原料,利用静电相互作用制备WPI-CS纳米颗粒,并用于稳定Pickering乳液。通过纳米粒度仪及Zeta电位仪、傅里叶变换红外光谱...为实现核桃中蛋白资源的高值化利用,本研究以核桃分离蛋白(Walnut protein isolate,WPI)和壳聚糖(Chitosan,CS)为原料,利用静电相互作用制备WPI-CS纳米颗粒,并用于稳定Pickering乳液。通过纳米粒度仪及Zeta电位仪、傅里叶变换红外光谱仪、差示扫描量热仪对WPI-CS进行表征,探究WPI与CS质量比对WPICS颗粒特性的影响;分析不同颗粒浓度(0.5%~2.5%)和油相体积分数(20%~60%)对Pickering微观结构、流变特性和贮藏稳定性的影响。结果表明:当WPI:CS为5:3时,WPI-CS的粒径和Zeta电位分别为846.43 nm和56.633 mV,具有良好的乳化性和稳定性,熔融温度达到80.16℃;复合改变了WPI的结构,二者通过氢键和静电相互作用结合,形成了紧密的网络结构。当WPI:CS为5:3,油相体积分数为40%,WPI-CS颗粒浓度为1.5%时,Pickering乳液液滴尺寸最小,仅为18.05μm,液滴分布均匀,形状为规则的球形;贮藏15 d后乳液仍未发生分层,表现出良好的稳定性;乳液内部形成了弹性为主的凝胶网络结构,随着频率的增加,弹性凝胶网络结构被破坏。展开更多
传统的亲水材料输送系统在实际应用中仍然面临着严峻的挑战,包括保留能力差和生物利用度低。该工作使用维生素C作为亲水性活性物的模型,将载有维生素C的油包水型Pickering乳液(Pickering emulsions,PE)包封进海藻酸钙胶囊(PE in alginat...传统的亲水材料输送系统在实际应用中仍然面临着严峻的挑战,包括保留能力差和生物利用度低。该工作使用维生素C作为亲水性活性物的模型,将载有维生素C的油包水型Pickering乳液(Pickering emulsions,PE)包封进海藻酸钙胶囊(PE in alginate capsules,PE@gel)中,利用Pickering乳液的纳米界面膜和水凝胶层的双重保护来提高其稳定性。扫描电镜和激光共聚焦显微镜研究证实,胶囊呈球形,Pickering乳液分布在凝胶网络中。傅里叶红外光谱研究表明,维生素C被物理包封在胶囊中,化学性质未改变。更重要的是,在25℃避光静置条件下,PE@gel与维生素C水溶液相比保留率和相对抗氧化活性分别提高了59.4倍和33.87倍;在紫外灯365 nm照射静置条件下,PE@gel与维生素C水溶液相比保留率和相对抗氧化活性分别提高了42.28倍和27.41倍。该方法为水溶性活性物在食品领域的贮存和应用提供了一个有效且通用的平台。展开更多
文摘Pickering综合征表现为反复的肺水肿和肾功能损害,与肾动脉狭窄有关。本病例描述了一位82岁女性患者,有高血压和冠心病史,伴有肾血管狭窄,反复出现肺水肿。影像学显示肾血管狭窄从单侧发展到双侧。尽管接受药物治疗,患者仍反复肺水肿。肾血管介入治疗后,患者病情稳定,心脏和肾脏功能改善。此病例强调识别肾动脉狭窄的重要性,并显示及时诊断和治疗的益处。早期识别和治疗Pickering综合征可有效预防肺水肿和肾功能衰竭。Pickering syndrome is characterized by recurrent pulmonary edema and renal impairment associated with renal artery stenosis. This case describes an 82-year-old woman with a history of hypertension and coronary artery disease, renal vascular stenosis, and recurrent pulmonary edema. Imaging shows renal vascular stenosis progressing from unilateral to bilateral. Patients have recurrent pulmonary edema despite medication. After renal vascular intervention, the patient’s condition was stable and his heart and kidney function improved. This case highlights the importance of identifying renal artery stenosis and shows the benefits of prompt diagnosis and treatment. Early recognition and treatment of Pickering syndrome is effective in preventing pulmonary edema and renal failure.
