In emulsion system, micro-organisms survive in water phase, thus concentration of preservative in water phase directly reflects to anti-fungi efficacy. As preservative easily migrates into oil phase, it reduces preser...In emulsion system, micro-organisms survive in water phase, thus concentration of preservative in water phase directly reflects to anti-fungi efficacy. As preservative easily migrates into oil phase, it reduces preservative efficacy. A common solution is to increase preservative amount in the whole system. However this way always brings safety issues as preservative is a major allergen. Another effective but safety way is to prohibit preservative migrating into oil phase. In cosmetic research area, phenoxyethanol （PE） and p-Hydroxyacetophenone （p-HAP） pair gradually emerges to be a popular preservative candidate. Thus this new preservative system has been focused as the research object in this work. The relative contents （C） of both PE （CPE） and p-HAP （Cp-HAP） in water phase has been carefully determined. Eight commonly used oils have been further employed to check CPE and Cp-HAP in different oil-water system. The other infuence parameters such as polyols, processing parameters are also investigated. Results shows squalane, petrolatum, silicone oil and hydrogenated polyisobutene might be good oil phase candidates for formulation when using PE and p-HAP preservative system. In these oil systems, PE and p-HAP are mainly located in water phase. Besides, increasing percentage of 1, 3-butylene glycol, shortening homogenization time or adding preservatives at the end of processing under lower temperature could effectively increase effective content preservatives in water phase, either.展开更多
文摘In emulsion system, micro-organisms survive in water phase, thus concentration of preservative in water phase directly reflects to anti-fungi efficacy. As preservative easily migrates into oil phase, it reduces preservative efficacy. A common solution is to increase preservative amount in the whole system. However this way always brings safety issues as preservative is a major allergen. Another effective but safety way is to prohibit preservative migrating into oil phase. In cosmetic research area, phenoxyethanol （PE） and p-Hydroxyacetophenone （p-HAP） pair gradually emerges to be a popular preservative candidate. Thus this new preservative system has been focused as the research object in this work. The relative contents （C） of both PE （CPE） and p-HAP （Cp-HAP） in water phase has been carefully determined. Eight commonly used oils have been further employed to check CPE and Cp-HAP in different oil-water system. The other infuence parameters such as polyols, processing parameters are also investigated. Results shows squalane, petrolatum, silicone oil and hydrogenated polyisobutene might be good oil phase candidates for formulation when using PE and p-HAP preservative system. In these oil systems, PE and p-HAP are mainly located in water phase. Besides, increasing percentage of 1, 3-butylene glycol, shortening homogenization time or adding preservatives at the end of processing under lower temperature could effectively increase effective content preservatives in water phase, either.
